April 18th
2008
9:48 AM
One of the most important questions we should be asking as parents is:
How does Singulair - a leukotriene receptor antagonist (blocks the receptors) affect the normal function of the mast cell?
The mast cell is the FRONT LINE DEFENSE against invading micro-organisms. When Singulair was invented, there was limited knowledge regarding the mechanisms by which the mast cell performed it's function. In my opinion, the focus was very narrow - those interested zeroed in on how the leukotriene receptor performed a role in the cause of asthma attacks and how ashma attacks could be prevented. Well, that's good preventing asthma attacks. But what happens to the mast cell if that receptor is blocked on a long term basis. I am not suggesting that blocking the receptor is bad but what if the long term effect is different than what we are are lead to believe-which is this is a safe medication with no known long term effects. What if the leukotriene receptor was just blocked short term a week or two to allow the body to clean up the mess from the last attack?
I seriously question what is going on with all of these infections. Are they related to crippling the mast cell? Parents should be allowed to question. If Merck doesn't want to answer questions regarding what happens to the mast cell (including are the numbers of mast cell decreased on Singulair), then something really BIG is missing. If by any chance (unknown at the moment) that the mast cell is significantly changed and therapy by montelukast is proper on a short but not long term basis, so freakin' what if Singulair is not a huge money maker any more.
Parents deserve every answer possible when decisions regarding their child's growth and development is on the line. I hope that we get some answers.
Of course, what was there in 2002 were new questions-not necessarily answers about the mast cell. Did anybody apply this to Singulair studies?
May 2002
From Journal of Clinical Investigation
Pattern recognition receptors on mast cells
The Toll-like receptors (TLRs) fit the definition of pattern-recognition molecules, which were originally postulated to allow the innate immune system to detect the 'molecular signatures' of various infectious agents. Although the innate immune system has no memory, it shows a degree of specificity, in part because the various TLRs recognize different sets of pathogen-associated molecules. Dermal mast cells are usually associated, not with the innate immune system, but with atopic dermatitis, but Supajatura et al. have found that these cells also express TLRs. They report here that TLR4, which binds the gram-negative product lipopolysaccharide (LPS), and TLR2, which binds peptidoglycan (PGN) from gram-positive organisms like Staphylococcus aureus, induce distinct mast cell responses. Staphylococcus is known to exacerbate allergic dermatitis, but it has generally been thought to act by inducing antibacterial IgE's, which trigger mast cell degranulation by stimulating the IgE receptor. Interestingly, the authors show that the interaction between PGN and TLR2 can provoke mast cell degranulation directly, sidestepping the need for IgE receptor engagement.
September 11th
2007
9:45 AM
I have been on lipitor for a little over two years now. I experience extreme joint and muscle discomfort. I am also picking up weight at an alarming rate. No matter what I do to lose the weight, it's not working. I've had several blood tests, but all come back fine..but I know I don't feel well and I'm having trouble remembering things....
-- By almaesmith | Reply | (1) replies | Private Message me
February 28th
2005
9:26 PM
Had 60 mls. of kenalog injected into painful scar tissue on my lower abdomen. I was not told of any side effects by my doctor, he said he had never heard of side effects from kenalog. At first I saw alot of what appeared to be brusing around the scar. Then the tissue all around the scar began to shrink away, I was left with a large hole in my stomach. I went back to my doctor this month, feb. 2005. He said he had never seen that happen to anyone before. I asked him how it could be fixed, he said he would cut out the damage tissue and repair the hole. I went back to have the procedure done last week, I wish I had not let that doctor touch me again. He did not cut out all the damaged tissue and now the incision looks horrible. I feel like a freak. I also ended up in the emergency room the night of the surgery because the doctor did not close the incision completely. I am going to go to a lawyer to find out what I can do. He should not be allowed to treat his patients this way. The day of the surgery he told me that he had talked with other doctors about my case and none of them had ever heard of any side effects from kenalog. He even said he talked to a doctor from Harvard medical school. It appears to me he is a liar. After reading the letters posted on this website I feel sorry that most of the letters were about the negative effects of kenalog. I believe we had the right to know about side effects before we were injected.
-- By jackiew-2 | Reply | Private Message me
April 29th
2009
4:36 PM
Frantee, I was a near fatal victim of statins. A few weeks ago I met a fit 70 yr old retired builder customer, who was wreaked in pain, couldn't walk to his letterbox or stay awake or do weeze etc etc. I gave him the Medsafe (New Zealand government) print out of statin adverse effects. He and his wife then knew without doubt that it was his statins killing him. They went to their doctor who put the fear of God into them "if you stop taking this medicine (statins) you could well have a heart attack or stoke and die" this fellow's golden years are painfully and avoidably ruined, end of story. This is despite Medsafe telling all doctors in NZ "... if a patient presents unexplained muscle weakness or pain to cease the medicine immediately" Undisputably criminal negligence. Like yourself I have been blackmailed, when I've gotten a bit niggly with my GP I get very very scared that my supply of oxycontin will be cut off. If I were to loose my pain killer any time in the last 14 months I would definitely have suicide out,at the worst I could not walk 500 metres without pain killer even with the medicine I came very close to suicide a couple of times. The only solution for survival is to have your blood tests etc done with your doctor, accept the prescriptions, agree with everything he says then study or visit a qualified natural path before taking medicine. There is currently major dissention at Harvard medical school where the medical students are saying "the information we are receiving is not at "pure" as it should be in such a "protected" environment. It seems like the pharmaceutical finance structure, stocks, bonds, shares debentures etc is in the top 3 or 4 finance structures on the planet. We've seen oil cause war and the largest frauds of all times in the financial banking sector I have no doubt the largest and cruelest genocidal crime has yet to be fully exposed. help yourself and help others, best for your recovery.
-- By oldcarpetcleaner | Reply | (1) replies | Private Message me