Heaviness in legs symptoms and conditions

I have been on Lamictal 200mg per day for about 3 years along with Wellbutrin and Lexapro. Over the past few months, I have noticed numerous things happening to my mind and body and finally put the pieces of the puzzle together...side effects of Lamictal. Short term memory is gone which is the scariest. Difficulty putting coherent sentences together. Fumbling for words. Spelling is awful. Heaviness in legs. Trouble writing. Inability to communicate well with the spoken word. Slow thought process. Shakiness - Hands shaking - Tremor. Speech disturbance. Weight gain. Coordination problems. Dry mouth is worse. Back pain. Increase in sweating including night sweats. Irritability. Impaired concentration. Forgetfulness.

This is so embarrassing when I'm in meetings. I start to sweat and can't seem to get my words out. I am also in a master's program and it is getting really hard to concentrate enough to write the papers. I am starting a doctorate program in Aug. which will not happen if these side effects don't go away. I called my doctor on Friday and we cut the dose in half and evaluate in 2 weeks. I want off of this drug! I need all of the symptoms described above to go away, especially my short term memory loss. I am very scared at this point.

I have type 2 diabetes for a few years and am 59 yrs old-and do not have fibromyalgia or kidney,liver problems or depression or a history of any painful muscles ever. I work up to 90 hrs a week as a doctor for the past 12 years and am a DIY renovator of my home in mt free time. I exercise regularly and am fairly fit, I do have a congenital mitochondrial myopathy characterized by non painful arm and leg muscle weakness- but have not been symptomatic significantly for 20 years. I take vitamins and one aspirin a day and have no medication allergies. weeks ago I started Januvia- my only diabetes medication. I worked well to normalize my mild to moserate elevation of BS.Over the past 2 weeks or so, I have had an increased somnolence without feeling rested upon awakening. I felt like I had been beaten with telephone poles and hammers, More distressing is the insidious onset of neuromuscular pains episodic sharp ones, more persistent aching and burning and tingling tingling, with a dense heaviness in legs more than arms worse with exertion and relieved by rest. 3 days ago it was to the point where I had to stop walking after 8 steps and could not climb a ladder beyond one step . I should not curl 2 lb weights even twice, Typing on a keyboard fatigued my arms after 5 minutes. I stopped Januvia three days ago, slept 30 hours,, felt better yesterday,restarted januvia last pm, Today, after 12 hours of sleep I feel exhausted like I did hard manual labor for a few days without ant sleep. The telephone pole beaten feeling returned, My weakness and pain are back with a vengeance and I cannot walk very well and have to stop typing this every 2 or 3 minutes to rest my arms, and have weakness also in my back muscles with curious sparing of abdominal muscles. Heat and massage do not help and are uncomfortable. I feel tired like I do when my myopathy acts up and my Krebs cycle is disrupted and thus my mitochondria do not make ATP to power my muscles- with the additional new symptom of significant pain. Aside from a mild tachycardia of about 100 at rest, my vital signs are normal, my cpk, Mg, thyroid function tests, comprehensive metabolic panel and sed rate are all normal . Heavy metal screen is negative. I will stop Januvia and probably never take it again, If my glucose goes back up I will go back to metformin which I took a few months about a year ago,
I suspect in my case that Januvia disrupted my mitochondrial function as well as being additionally toxic to my muscles and nerves by some additional pathogenesis, I question whether those individuals who have weakness, somnolence and neuromuscular symptoms might have some underlying mitochondrial dysfunction - a very under diagnosed condition - patients being told that their symptoms are of psychiatric origin.

Been taking 10 mg of Lisinopril for about 3 months now for BP that was 160/70...Last reading was 130/70...BUT for the last 5 weeks I have experienced stomach upset followed by an Upper Respiratory Infection whcih took 4 weeks to resolve followed by muscle weakness in my arms and legs followed by urinary issues (too much urination, too little, urine color change, etc. Before these episodes I had not even had a clod in years...Any connection to Lisinopril???

Hubby has been sick for weeks now. I went to the pharmacy to pick up yet another prescription of an antibiotic (Levaquin 500mg 2nd 7 day dosage) for him. He has bronchitis. They decided to do one of those prescrition counceling sessions just in case this was a new perscription for him. The lady was very nice and explained the possible side effects to me! One of which is fatigue (heaviness in legs and arms) and drowsiness, shortness of breath and more. I was
shocked!!! These are all the problems my hubby has been describing! He thought he was going to have a heart attack. I said "I'll bet hubby didn't pay attention when you all told him this the first time!" She said well it's also written right here, and there was the huge long read out of all the possible side effects etc!!!! I said oh he wouldn't read that it's too small of print and far too much information!

Well guess what! I told him about it. He stopped taking it
yesterday, just to see if the meds were the cause of him feeling so horrible. LOL, more than 30 hours after he stopped taking Levaquin...he just read the entire newspaper including the horoscopes, funnys and all (HE NEVER DOES THIS) and now wants to take me out for Breakfast! We're both laughing at how much better he feels! I can't tell you the huge relief to see him feeling better, and I know he's as thrilled or more than I am!!!!

HOLY CROW! Who'd have thought his "antibiotics" would have caused him to feel so miserable!!! Be cautious and watch for side effects if you ever have to take Levaquin. The doctor had seen my husband again before giving him the new prescription and he has an appointment now with a Neurologist and a Proctologist for alot more testing. WHY didn't the doctor see that the symptoms he was hearing and seeing were side effects of Levaquin??????

Thank You for this forum, it's shed alot more light (scarey as it all is) on what my husband was taking and the side effects that he was having. I'm putting the word out to all my family and friends of the experience and especially cautioning them before taking the medication.