Heck symptoms and conditions

2 genetic mutations in the gene that encodes for the transporter protein responsible for moving anti cholesterol statin drugs into the liver to be detoxified. have been identified. This gene is "SLCO1B1" (also referred to in the scientific lit as "OATP1B1"). Drugs must be "detoxified" by organs within the body and then eliminated, otherwise the drug stays in the blood stream, building up to toxic levels. With either of the 2 mutations, statins have been found to be (from various studies) anywhere from 122% to 400% ABOVE NORMAL plasma statin levels. How many people have either of these mutations? (Population genetic studies were done in Finland on Caucasian pop--so all the #'s refer to Caucasian population) 25 % to 38% of ALL Caucasian possess one of these 2 mutations. Thus, for however many yrs someone with one of these mutations has taken a statin, the level of the statin in their blood stream conceiveably could have been 400% ABOVE normal statin levels. ALll those pharmacologic effects of statins--decreased coenzyme q10, depressed manufacture of dolichols, depressed manufacture of selnproteins and thus glutathione, interrupted production of GTPases and glycoprotein function, decreased brain cholesterol levels--neuron synapses and new growth of neurons depend upon brain choelsterol--are intensified unrelentingly for the length of time the drug is taken.

Ohhh, I thought that I was going crazy. My 5th baby was born May 09, and I felt great for just having a baby. I have only had the Mirena since June 09, but thinking back, it has been since then that most of my issues have arisen. I have a constant pressure in my head, sometimes it is a headache, and occasionally it turns into a migraine. I have my period, and then it lags on with spotting for another week and a half, all the while having the cramps, major moodiness, depression, fatigue. I am having low back pains too. I am tired as heck all the time. I am hypothyroid as well, which can cause you to be tired, so I have went and had my thyroid checked 3 times since the baby was born as I was sooo sure it was off because of my fatigue. I have no libido either. My husband thinks all this stuff is excuses and in my head. I have been on the depo in the past for 5 years, but my blood pressure started to raise, and went back to normal after I changed to the copper IUD. I had that removed to try for another baby. But I did very well on the the copper IUD, which had no hormones and is called Para Gard, or something like that. I did still have my period, with some cramping that was slightly more than what I had without the IUD. But I had a libido, I wasn't fatigued or depressed. My doctor was pushing this Mirena, and against my better judgment I agreed. So please remember that there is another IUD, and it is good for 10 years, which maybe why they don't push that one. I am getting ready to get this hell Mirena out and switch back to the copper IUD.

I think I know how Mirena works now.. You don't get pregnant because you never want to have sex!!.lol.. At least that is my experience. I had it put in about 4 months ago, and have completely lost my sex drive. I have tingling in my arms and hands all the time now, my whole body aches, and I feel flutters in my stomach as if I were pregnant (even though I'm not).My breasts also hurt like heck! I feel confident in its effectiveness but don't want these side effects anymore!! I also was told that using Mirena is like always having an abortion.. does anybody know if that is true?? I wasn't informed this when I had it put in... I was just told that the hormones stop you from getting pregnant, If any of you ladies have any answers to my questions that would be great!!

I am also really glad I have found this website. I had my mirena placed in March 2006. I loved it, told all my friends thought it was a miracle. I have completely changed my mind. I have dizziness, headaches, joint pain and my PCP put on Lexapro for anxiety and mild depression in September 09.
I have a 3 and 4 year old, but am so fatigued at times I don't want to do anything but sit around. I can not lose any weight. I tried nutrisystem and
that didn't help. I am also having having a symptom that hasn't been mentioned on the site. I have done some research and noticed that the mirena can also cause blood vessels to constrict. In December 08 after having some (quite a few) drinks and smoking cigaretts at my husbands
Christmas Party the next morning my forearms and hands were a dusty blue color. I have had this happen one time since. A couple of times the bottoms of my feet were a purple/ bluish color looked as if they were badly bruised. After researching the cause of this, the only thing I can find is that the mirena can also cause constriction of the blood vessels. Has anyone else had this happen???? I had and echocardiogram done, that was fine all my blood work has come back normal. Am seeing a neurologist, he has me scheduled for a nerve condition test, but he thinks
I may need to see a vascular doctor.

I have an 8 yr old son that has allergies and asthma. The allergist recently prescribed Singulair which my son had taken when he was 5. We took him off of it back then due to anger outbursts. By the way, the Dr. said that was not a side effect, but nonetheless the issues subsided. When it was recently added back to his medication list, within 3 days he had anaphylactic type episodes 2 days in a row. The attack started with stomach pains, chest pains and then he couldn't breath AT ALL and turned blue! There was no time to call 911 so I gave him an Epi Pen. The attacks are still occurring yet milder and all his Dr.'s swear by Singulair and think I am crazy. I took him off Singulair immediately and we are still waiting for it to leave his system. I think that is why the recent episodes have been milder. He has been tested for all sorts of allergens which he did not come in to contact with prior to the anaphylactic events. We still have no answers and if I hear one more Dr. talk about how great Singulair is, I am going to freak out!! To heck with these drug companies and doctor's who get perks for prescribing medications without informing us of side effects.

I have been on the NuvaRing for my 3rd month now. I seriously just went into the bathroom and took it out! I have been having some intense anxiety, and I swear my hair has been thinning out, and feeling depressed. Not to mention I've been gaining weight!!!!!!!!!!!!!!!!!!!!!!!!!!! I looked at the NuvaRing website and seriously I have experienced almost every single symptom. I have not felt like my normal happy go lucky self the past 3 months and was wondering if it was just me. Now I know it's just the nuvaring. I also experienced extreme extreme headaches. My head feels like it will explode, for hours on end. The only way to get rid of those headaches is to sleep. Also I have never been so chubby in my life, I've always had a nice stomach and now it's getting flabby.... like seriously.... this is not even worth it. I'm so glad that I read this website and that everyone is experiencing the same problems with this as I am. I think I'm going to just stick to condoms bcuz that's going to be so much healthier for me! Too bad if my hubby doesn't like it.... I just can't take all these crazy changes... or else I'm going to go crazy! I've also been kind of crazy like totally filled with anxiety or feelings or resentment. Sex kills with the nuvaring! It hurts so bad. I'm not sure why, but it burns like heck. I've also felt fluid retention, big time! And my legs are super achey. Does anyone else have achey legs? And oh my gosh, my boobs hurt so much from the hormones NR injects into me. I feel like their getting like too big. Also over the past three months I haven't had any appetite, which would make you think that you would loose weight... right? WRONG! I have actually been gaining weight! So dumb! Take my advice and don't go on the NuvaRing, it's a waste of your time... and your life. Your life will change when you go on it, and you won't recognize it at first... but believe me, it will. I've also experienced the brown discharge for the first month, and changes in my menstrual cycle. & on my honeymoon I got a yeast infection bcuz the NuvaRing!!!!!!!!! That was pretty much the worst!

My local hospital prescribed Avelox for a sinus infection since Amoxicillin wasn't working. My fever jumped up to 102 the first 2 days so I called my family doctor. He told me to keep taking the meds for 2 more days and if my fever persisted to call him back. I experienced the high fever on day 3 and then was in a world of shock when I took the 4th pill. My body went numb, I was speaking but had no idea what I was saying, dizzy, the fever subsided during the day but spiked back up to 102 that night and I was very irritable. I made a doctors appointment the next day and the doctor told me to take the meds at night and I wouldn't have those reactions. After reading these comments and my day 4 episode, I had it in my head that I was not going to take any more pills. Then I called a nurse friend who assured me that it wasn't the antibiotic making me feel that way.....it was the extra strength Tylenol. She advised me to take the pill. I took the pill and not two hours later, my body went numb, I became dizzy, my tendons in my right knee and left foot swelled and I couldn't sleep. After my body went numb, I took the rest of the pills and flushed them down the toilet. I'm still feeling the affects of the pills and it's been 2 days. I've been swallowing gallons of water to flush it out of my system. I lost an entire week of work and pretty much my normal life. I'd much rather have sinus pressure in my head then deal with these side effects.

Ok, so I've had it out for 12 days. The day after I had it removed I started my period and bled for 4 days straight, it stopped. And now I started again last night and I am bleeding again pretty heavy. Is this normal? Has anyone else had multiple, back to back periods? How in the heck am I supposed to track my cycle when I can't even figure out when one ends and another one begins. Please help me.

I had the IUD inserted in September to help with heavy periods. It worked awesome for that. I love it in that respect. However, I gained about 15 pounds in two months. I play soccer 2 times a week and was training for a marathon so it didn't make sense. I had sever back pain and joint pain that I blamed running for. I all of a sudden had ZERO focus; tons to do and all I could do is sit and stare at the pile of to-do's. Zero sex drive to the point that I wanted to hit my husband if he even asked. One night I yelled at him so meanly it didn't even sound like me and scared the heck out of him (and me). Super depressed and angry all the time. I try not to talk to people and I don't really know why. For some weird reaso I kinda chalked it all up to turning 40 until I saw this site. I had it removed today and was told that the hormones would be out of my body in around 48 hours-hopefully they take the weight with them!! My husband had a vasectomy so I just did it to help with periods. I wish I would have seen this site before. My doctor wasn't surprised at all at my symptoms and gladly removed it. She said that some women just react badly to the hormones and some are fine. I was NOT FINE!!

Right now I can't sleep, bad cramps, bad lower back pain, cysts, acne mostly around my mouth (which I am usually really clear), headaches, stomach flutters, not to mention mood swings like heck!, more discharge then usual... for starts. I thought it was just something else or me going crazy... after reading all of your comments I am starting to think other wise. I have already been to the ER with horrible stomach pains and cramps, but all the tests came back just fine, just got a 2,000+ bill. I just wanted them to take it out, but they said it wasn't the mirena and it doesn't cause these kinds of things. I have had it almost 9 month... could it be the Mirena causing this?

Alright, listen. There is a light at the end of the tunnel for those who have found this site. My story was posted on June 20th. I would have to say that I cannot trust any doctors for anything since then. This web site has saved me money from the idiot doctors and my insanity. Really. It is so scary that when you go to the doctor they will never investigate your meds you are taking and will send you through many tests and prescribe you medicine that you don't need. I went through 4 different doctors multiple times that prescribed many different things with no effect to my condition. I went off Lisinopril and went back on Diovan and it took 8 days before I noticed any improvement. During those 8 days I got more depressed because I didn't feel any better. Then my symptoms started going away. My anxiety and coughing started to decrease. By the second week i did not need the help of sleeping pills to knock me out due to the anxiety at night and the gagging and coughing decreased.Since then I am almost back to normal. I still though have some symptoms of coughing, but not that bad. If you found this site and taking Lisinopril, please take note that your doctor is probably wrong. You are not going to die. Get off the da#m med and start living again. It may take longer than me. Don't get discouraged.It may take more than a month or so. Stay strong. I am pissed off and would love to beat the s&it out of the ones that created Lisinopril. I know we are the small % that has the effects, but get it off the market. People are dead from this med and the others are going though Hell......I feel for the ones who have had family members that have died from allergic reactions. I had an undiagnosed throat swelling that took me to the ER. I know what it was now...Take care, stay strong, get off Lisinopril, enjoy the rest of your life...

I am a 36 year old and I had the Mirena in for over 2 years. I had it taken out on May 10th 2009 because of 2 periods a month. My doctor seemed to think it was not the IUD. While I had the Mirena in, I had dizziness, headaches, fatigue, more bleeding then not and moodiness. I lost my sex drive and excitability during sex. I was tired all the time and generally not happy. Since I have had it removed I have not had a period ( going on 2 months ). I have noticed over the last 2 months that I am slowly becoming my self again. It is like a cloud has been lifted from my brain. My sex drive is UP and my house is slowly getting back in order. I am hoping that I will start to loose some weight, but not going to depend on it being all the Mirena. I have to get back to the gym. I know my body is not fully adjusted to the Mirena being out because I have not had my period yet and I have no idea how long it will take. I called my OB's office, they did not seem to concerned about the lack of period. They told me they could put me on some meds to bring it on. I told them I would pass. I would rather my body take care of it. If anyone has any input of what it is like after months after having it removed, please let me know.

I have read the posts below and thank goodness I found this site! I got an injection on Wednesday, 6/17, in my right knee and for the first 24 hours it hurt like heck - more stiff and painful than prior to the injection. On Friday I woke up shaky and started to feel anxious. My face and chest flushed a bright red which lasted all day. Saturday was worse; shaky, heart racing or palpitating, head/neck pressure with headache, hot flashes, nausea and stomach cramping/pain. I even actually had a panic attack (already a predisposition for me). I became uncontrollably weepy and depressed! Today, Sunday, I STILL have major anxiety and headache/pressure. I'm convinced the injection brought all of this on because before this, all I had was knee pain. So, WHEN will these icky symptoms start to subside? I was told the cortisone was good for 4-6 months. I can't live feeling like this everyday for that long!!! Any suggestions or encouragement?

I have been on paxil for ten years . I decided after doing some research and talking to other people that I want to get off of this drug. I am tired of my doctor telling me that it is not addictive. I am seriously thinking on getting another dr.
It has been almost two weeks since I took any pill. My withdrawal seems to be getting worse but I read on one of these forums that withdrawal will not kill me and I keep plugging. I did give up anything with caffeine. I loved my coffee. I just switched to decaf tea or herbal tea. Sooner or later I figure I will start to feel better. It may take months though as i have been on ten mg for years. Then for about 6 months I took a half pill. Then I lowered it to a half pill every other day and then I went to when I could not stand the withdrawal. Now I just said the heck with it and quit. Any advice what I can do yet to help with the withdrawal. I hate the dizziness. That has got to be the worse. I feel like everything has gotten louder to me. And I snap everyone's head off. I hope this wont last much longer. Just need to vent.

I am 16 years old and i have been taking topamax for about 5 months now. I am taking 200 mg a day as a mood stabilizer. I have experienced nothing but horrible things on this medication such as, memory loss, inability to considerate in school or anywhere for that matter, loss of word for example stropping in mid sentence a lot trying to figure out what in the heck i am talking about, also i lost weight on this when first taking it i was 130 lbs now i am 110 lbs, and not only does it not make me hungry but when i eat after i experience nausea. This medication is horrible.

Just started taking Zocor and i am having horrific and very vivid dreams. It wakes me up and scares the heck out of me. I jump/jerk and wake my self up because the dreams are so bizarre and frequent during a single night.

Prescribed 40mg SIMVApoison
stomach doing somersaults....feels like a couple of pygmies inside me clubbing each other to death.
Tiredness/Lethargy chest pains Oh yes this is a wonderful drug!!
Take at your own risk
I certainly wont be taking anymore

Hi, i have 26 yo, im a doctor and my boyfriend too, i started to take Yasmin 3 months ago and ive never been a depressed girl, who cries with every tv show or even a commercial, now I AM, ive been from a funny girl who always had a big smile on the face and make jokes of everything (and thats why my boyfriend love me) but during this last couple of months i just don't know why im crying for every stupid thing..and then i go...why the heck did i cry for that?...im just waiting for my menses and then im switching to evra and see how it works,
Oh...plus i think i have IBS, migraine like headaches, almost no sexual drive and poor lubrication during intercourse, but ive not gain weight and my skin face is without black spots. thats the only good thing about Yasmin, but definitely i think my mood swings are because Yasmin and thats the worst thing.

I was prescribed Niaspan ER, and the first night I took the 81 mg aspirin an hour before. So this was 11 pm. I tried to get to sleep, as I do usually have a hard time getting and staying asleep anyway.. BUT, four hours later, I had this severe face flush, I had burning in my ears, my face, my neck and as I was told I might have this, I tried to remain calm.. then the ITCHING started up, I wanted to rip off my skin, I itched so badly! I scratched my wrists, then my upper legs, my stomach area.. even ripped open a little sore there... this itching almost drove me crazy! I admit I got panicky.. and my heart started racing and I felt like my throat was closing up.. this is something I experience with my allergy to contrast dyes... I swore I'd never take another Niaspan! Scared the heck out of me. I don't know what else I will be able to take to lower my triglycerides and total cholesterol. I am 56 and just found out with an EKG that I have had a heart attack already. So this is all scary to me, but the burning and itching and rapid heartbeat don't seem worth it to me! Anyone else have this kind of experience? What did you do? thanks

I am soooo glad I found this website.

I had mine inserted in March of 2006. I was so uncomfortable for about three months after. I swear I could feel it bonking around in there and nearly had it removed then.

Since the insertion, I have been slowly gaining weight - with a majority of it in the past year. I was down to my fighting weight in December of 2006 and have packed on nearly 20 since then. The odd thing is - I eat a very healthy diet and I exercise. I'm a massage therapist, so I am always busy and on my feet. There is NO reason for the weight gain. My ring size is smaller than before I got the device inseted, my legs are slim and most of the weight is around my middle which scares the heck out of me for health reasons. I have NEVER had weight issues before the Mirena.

I have struggled with depression and severe anxiety, I have hair growing on my face, I have no energy, a low sex drive, I have tingling in my hands and feet, I'm moody most of the time, and now I think I am starting to get ovarian cysts. I was doubled over in pain about two weeks ago and that is what prompted me to do some research.

I'm making an appointment to have the Mirena removed.

I have been on Birth Control since May 29, 2007. I was first put on Errin Tab .35mg, which went well, but was very depressed and angry. I had very few symptoms, but very severe headaches, and mood swings with this birth control. Then on August 4, 2008 I had the Mirena IUD inserted.
About 1 ½ months after insertion of the Mirena IUD, my mood starting really getting severe and bad. Now, this was the biggest issue for me because I have always been a person to lets things roll off my back. I have never once in my life felt the least bit depressed. Other than PPD with the birth of my daughter. I am noticing that I am just not feeling myself mentally or emotionally and I am crying very easily. I even yell at my husband and my daughter about the stupidest things and it’s like I am watching myself from the outside doing this and wondering why the heck am I yelling, but I can’t seem to make myself stop. I know something is wrong. I am also very lethargic and fatigued all the time. I also feel that I can’t ever seem to catch my breath. This still continues today, and is very distressing to me. My PCP has diagnosed me in the past week with Asthma, with no conclusive proof that Asthma is the issue. I haven’t had allergies since I was about 12 years old.( I am 35 now) I can only catch my breath when I lay on my left side. I constantly struggle for air, which cause’s panic, heart palpitations, and anxiety.
I have severe depression due to this situation and have been put on 5 different anti-depressants and sleeping aids as well, however it seems like I am a basket case, over anxious and often times a nervous wreck. There are days when I have uncontrollable crying episodes, off the handle severe mood swings. I have no patience with anyone or anything. This is usually around when my menstrual cycle will begin, then at the time it begins, I have horrible persistent bleeding, pain, cramping, coffee ground blood clots the size of a quarter. I will bleed for about 10 days and then stop and start again in about 8 more days. I have persistent abdominal pain, occasional fever, and unusual vaginal discharge, itching, and odor. It makes it very difficult to have sexual relations with my husband. It is very painful to have sex, and I just don’t have the libido for it as well. Sex drive is completely gone.
Since the insertion of the Mirena IUD, August 4, 2008, I have had horrible constipation, that will last for about 1 to 1 ½ weeks, and then for 2 days, I will have horrible and severe diarrhea, and then have no BM’s for the next 1 to 1 ½ weeks again. I also have severe headaches, that hit at anytime. I have lost a lot of my hair, it used to be very thick and strong. I break out in hives, rashes. I also have swelling of my face, hands, tongue, throat, and ankles. Not to mention again the not being able to breathe.
I also have a horrible time eating, I will eat, and then feel like vomiting for the next couple of hours. Sometime’s I do have to vomit, so I try not to eat at all, cause I just hate feeling that way. It just isn’t worth the discomfort for me.
I am withdrawn, and scared to socialize with friends, which that is not me at all. I am always depressed, have anxiety, severe acne, NO sex drive, angry all the time, very easily angered, and I have basically become a totally different person. I used to be a confident women and now I am a total train wreck.

In conclusion I am incredibly concerned about is the emotional side effects that I have experienced! I have slowly become a basket-case. I have at different times experienced the following side-effects : anxiety, minor paranoia, racing heartbeat, MOOD SWINGS! unexplained crying episodes, foggy thinking, and panicky feelings.

I took Avelox for the first and LAST time today!! I have had 4 ear infections in the last 4 months. My sinus drains into them every nite. My ent prescribed Avelox b/c she want to kick the heck out of this infection. I was abit nervous about taking a different antibiotic because within the last 2 yrs I've developed food allergies. I took it and drank a big glass of water with it. Very soon after I started to feel strange. My throat felt tingly and I felt very anxious and thought I was going to throw up. I calmed down enough to get my son to a neighbors house and get to the ER. Of course I had to wait there I did get a hold of my anxiety. Right below my adam's apple inside my throat felt like the pill was stuck there. I would feel like it was a burp or gas that just couldn't make it out. My stomach felt queasy. I thought I might puke in the waiting room. 4 hours later I am home and feel like crap. My body is achy. My head feels like I've taken percaset(sp) I'm shakey and tired. Climbing the stairs it hard, my legs feel like sandbags. The dr. in the er said he doubted it was an allergic reaction because of how fast it came on. Reading about others experiences makes me think the DR. is wrong!! I did take it on an almost empty stomach. My co-pay on this crap was $55!!!!

I have been on 10 MG of Lipitor for almost 3 years. Since I began taking it I have had recurring issues with an anxious feelings, my lower GI is constantly churning and I feel like I am stressed out. I have a low stress job, a stable happy family life and yet I feel nervous all the time. I sleep for 3-4 hours and then wake up and am unable to get back to sleep. I have been forced to take a nap ever day after lunch just to get through the day. Additionally, I developed tremors in my hands and was diagnosed with something called Benign Essential Tremor and put on another medication to control the shaking.

Yesterday I decided I had enough of this and went to see my cardiologist to discuss the symptoms. I stopped taking the Lipitor on my own 2 days before. The doctor told me that none of my symptoms were related to Lipitor! I replied that I was convinced that they were all in fact caused by this drug. He suggested I stop taking the statin for 2 weeks and see if the symptoms stop. I am now on day 4 without lipitor and am already feeling less anxious.

I went to the Nuerologist 2 weeks ago and got her to discontinue the anti-tremor medication. I am going to get all this crap out of my system and hopefully get my life back.

I have had my Mirena for 2 years.I have not periods but i still do have cramping sometimes. It is bearable though, it is a good option for me. The first few weeks were painful, but it does get better, give it a few months before getting it out if you are considering that route. The only real problem i have had, is mine "creeped". It is moved up high in my uterus and the strings are no longer visible. I have to get a ultra sound every year to determine the location. This will cause me to be put under and have day surgery to have it removed. I will cross that bridge when i get there. HAs anyone had one removed that had creeped?

Hi ladies

I am sitting here in tears reading all your posts! I haven't felt myself since I had my Mirena IUD inserted in Nov 2006! I had it done after the birth of my third child thinking it would be the perfect solution in not getting pregnant. Boy was I wrong! I feel like my life has fallen apart. I'm constantly moody, aggravated, irritable, angry, impatient, little sex drive, foggy and blurry vision, weight gain in places I didn't think possible, lower back pain, headaches that never seem to end and the list goes on! I have had a feeling about the Mirena being the cause for some time now and am not sure why I haven't researched it yet (I'm a research junky).

I'm making a phonecall right now to my midwife to get this thing out of me and claim my life back. I'm definitely doing a detox on top of that too!
Thanks for sharing all your stories and WHEN THE HECK ARE WE GOING TO TAKE SOME LEGAL ACTION!!???