September 1th
2008
1:27 PM
I just read the new article about Cody Miller and Dr. Douglas Briggs, who was taking Neurontin. That further confirms the work that I was doing to collect research regarding problems with GABA and suicide. How these drugs affect the brain chemicals is very complicated. I believe that the pharmaceutical companies do know that it is possible for a series of things to go wrong and create terrible adverse side effects in some people - not all.
I will be extremely disappointed if the FDA allows these companies to sweep this under the rug.
Suicide risks studied in drugs for physical ills
By RICARDO ALONSO-ZALDIVAR – 1 day ago
WASHINGTON (AP) — Cody Miller was a high school football player who was allergic to ragweed. Douglas Briggs was a doctor coping with pain from an old back injury.
Both are now dead, hanging victims driven to suicide, their families believe, when drugs prescribed to relieve physical symptoms upset their mental and emotional balance.
*******
This testimony should help strengthen our case for warnings for Singulair.
Neurologist Sought Warning for Pfizer Drug
By JEREMY SINGER-VINE
June 20, 2008; Page B10
A British neurologist who analyzed effects of the drug Neurontin told a court hearing Thursday that he advised its maker -- now a unit of Pfizer Inc. -- to include a warning on the drug's label for potential side effects of depression and aggression, but his advice wasn't followed.
The University of London neurologist, Michael R. Trimble, was testifying at a hearing to decide whether civil cases brought against Pfizer alleging suicides linked to Neurontin can proceed. The hearing was jointly held by judges for U.S. District Court in Boston and a New York state court who are hearing similar cases. In various lawsuits consolidated in the federal court, plaintiffs allege more than 100 suicides were connected to Neurontin usage.
Dr. Trimble described what he said was a "plausible biological pathway" that could lead from the compound gabapentin -- the chemical name for Neurontin -- to suicidal behavior, hostility, and aggression. Dr. Trimble said that in 1995 and 1996, he was hired to write two confidential reports for Parke-Davis -- now a unit of Pfizer -- because the company "was concerned about psychosis in relation to their drug." Dr. Trimble said he was unable to find a link to psychosis, but noted effects of depression and aggression.
Lawyers for Pfizer argued at the hearing that the evidence linking the drug to suicidal side effects wasn't scientifically sound. Under cross-examination, they challenged his description of a pathway as a patchwork of studies that didn't prove a biological connection. Neurontin and generic forms of gabapentin are approved for treating epileptic convulsions, but have also been prescribed widely "off label" for other conditions.
In five of nine patient cases he analyzed in 1996, Dr. Trimble said he saw depression and aggression in patients who had no previous symptoms of the side effects, so he said he recommended to the company that the drug "should carry some kind of warning" for susceptible patients.
Thursday's proceedings were the initial phase of a hearing requested by Pfizer to challenge the opinions of the plaintiffs' experts. Under cross-examination and a subsequent examination by the plaintiffs' attorney, Dr. Trimble said the biological pathway between Pfizer's Neurontin and suicidal events were plausible and supported by a series of peer-reviewed neurology research.
August 25th
2005
3:45 PM
I can't believe the nonsense going on here with those side
effects. I believe some have become illiterate and professional medical people.
I am sorry but the known side effects are not related to sex
or toes turning upside down. I am on lipitor for many years
and it is the only drug that has gotten me to, I pray, safe
levels of cholesterol. I am averaging around 150-170 now
and my triglycerides and cholesterol were out the roof. They
both are at a good level, and again I pray they stay there.
My doctor is an internal medical doctor with very careful
and precise requirements. He listens to any muscle cramps
I might have had, and they have come and gone, and I
did worry at those times but many of those times it was
probably conditioning and I am an ex high school football
coach and athlete in general for the biggest part of my life.
I am 58. Sometimes, I have a hard time remembering a
name or face, but I take several meds, and I am not as young as I used to be when I could focus on 3 or 4 different
things which was really bad for one's mental health and social
health. Who wants someone not paying 100 percent attention?
My point is that I feel exactly like I did when I went to pick
my car up at a dealer who had repaired it. One of my neigbors started giving me this herbal spill about Himalayan goat milk curing everything! Lipitor is not for everyone. My doctor EVERY 6 months does a thorough liver and blood exam on me.
If you are losing you hair or thinning like mine, welcome to
mother nature. It "aint" lipitor baby ,and those sexual side
effects need to be taken up with a sexual counselor it appears
to me.
Anyone, even with disclaimers, can see that this site once you go to if for some really curious serious intent, is seen
readily as a "natural herbal garden," listing only extremist
side effects for Lipitor.
I am not making fun of twisted toes or sexual disfunction but
please leave it off the herbal network. Go swap if for another
statin and pray that it works and you have no side effects, but
don't tell all those Enquirer type effects. I am sure the herbs would bring your cholesterol down in a week to 150 and cure
cancer, right?
Herbs have a place, but this is not a serious place for someone to learn about Lipitor. Lipitor is prescribed for a
potentially fatal disease or condition. Let it lay there.
Thanks for letting me tell you what I have experienced.
-- By football | Reply | Private Message me
October 20th
2009
3:00 PM
Today the FDAapproved gardasil for its use in boys,it is a mans world so maybe as men start to suffer the consequences of this shot somebody will start to listen
-- By flindy | Reply | (2) replies | Private Message me