Hip replacement symptoms and conditions

Hi I posted this on the Coumadin site when I should have been here,

I am a 66 year old female and up to a year ago I felt 20 years younger now I feel 20 years older.

I fell and broke my hip June '08. Had a hip replacement and developed a blood clot (DVT) in my left leg.

They put me on Coumadin and when that didn’t do the job they added Lovanox (another blood thinner requiring shots in the stomach).

Not only has they not helped but my blood clot is growing.

My symptoms:
daily headaches, debilitating leg pain (the pain is so bad that it is crippling me), fatigue (an overwhelming feeling of tiredness, I set down for a few minutes and wake up hours later.), loss my concentration (trouble doing simple crosswords), can’t study simple directions, numbness in toes and hands. I can go on.

And the doctors? “It’s all in my head. It can’t be the blood thinners.”

I am going to copy your blogs and take them to my doctor and demand something be done.

Thanks again to this site and all of you. I was beginning to think there was something wrong with my mind.

I'm not crazy!!!! Thank you..

I fell and broke my hip June '08. Had a hip replacement and developed a blood clot (DVT) in my left leg.

They put me on Coumadin and when that didn’t do the job they added Lovanox (another blood thinner requiring shots in the stomach).

Not only has they not helped but my blood clot is growing.

My symptoms:
daily headaches, debilitating leg pain (the pain is so bad that it is crippling me), fatigue (an overwhelming feeling of tiredness, I set down for a few minutes and wake up hours later.), loss my concentration (trouble doing simple crosswords), can’t study simple directions, numbness in toes and hands. I can go on.

And the doctors? “It’s all in my head. It can’t be the blood thinners.”

I am going to copy your blogs and take them to my doctor and demand something be done.

Thanks again to this site and all of you. I was beginning to think there was something wrong with my mind.

I started feeling much better very quickly after being off Lipitor now 7 months. However, the symptoms I had using the RX has cause significant problems. I fell so many times with my weak joints and muscles, that I had severe problems. I now need to have knee replacement surgery after falling so many times injuring my knees and weakened muscles to support myself. I am getting cortisone shots in that knee, as well as physical therapy. My MRI shows a torn meniscus, stretch PCL very thin, cartlidge loss and debris, still swollen with csyt after all these months. With no meds, and lack of being able to exercise, I now have hig-chol back. On and on it goes.... a real catch 22. Take care of yourself, watch out for symptoms. I ignored sx's thinking it was stress but after reading adverse reactions, it fit me to the T.
My original posting re: Lipitor is Forestseaski on Jan. 2, 2009

C.

My healthy, active 55 yr old husband of 30 yrs was prescribed SIMVASTATIN in Aug. of last year. He started having pains in his legs & back and had an appointment in Oct. with the dr. to check on how he was doing with the new drug. When he went in to the office, he was having terrible pains in his chest, legs & back. The dr. immediately called 911 thinking he was having a heart attack. He was in the hospital for a week while they ran a multitude of tests. All came back clear for his heart. He kept telling the dr. that the back & leg pains were still there. They didn't seem to be concerned about anything except his heart. He was dismissed continuing to have pain. The pain steadly increased over his whole body, then in Feb. of this year, he suffered a major seizure and spent another week in the hospital. This time they wrote it off as epilepsy and put him on anti-seziure pills. After he was released, the symptoms increased, his memory, vision & balance are all effected, he has chest pains, depression, and is in constant pain. He's been sent for numerous MRI's, bone scans, blood tests,etc. He has been to neurologists, neurosurgeons, chiropractors, physical therapists, etc. The entire time, his health has declined because he was being poisoned by Simvastatin. Finally, after doing our own research, we found a neurologist that recognized the problem. He told us that this drug distroys muscle tissue and that the damage may be irreversible. My husband can no longer work, drive, or enjoy life. He walks without a cane or walker, and depends on pain pills because the pain is so severe. He stays in bed most of the time due to the pain and lack of energy. He has been off Simvastatin for a week now with no change. We are hoping & praying for improvement over time. PLEASE, if you are your loved one are taking this drug-STOP IMMEDIATELY. The results can be devastating. I can't imagine why the FDA would approve a drug like this that destroys quality of life.

I have been taking 40mg lipitor for over 9 years now.

I have had back issues since an injury to one disc (L4?), and had microdiscectomy in 2001? Took about two years to actually get close to normal.

The last few years, I have had multiple issues with shoulder pain, wrist pain, elbow pain, lower back pain, Upper rump muscle pain , and now both hips are killing me (the shoulder, upper rump muscles and hips are by far the worst). And I am now so weak in my lower back muscles, that it feels like I will (and do) pull out my back.

I have seen NO many doctors I can't even name them all. I have had operations, multiple injections (cortisone) taken pain meds, etc. Nothing has helped and in the last year and a half, I have gotten steadily worse. To the point where I can't really do much of any activity. Sleeping at night is painful. Can't lie on left shoulder, and can't lie on either hip for more than a few minutes. If I fall asleep on my side, the pain wakes me up. When I try to walk, 80% of the time, I end up with a pain in my upper right rump (sacroiliac area), that I MUST sit down to get the intense pain to go away, which it does. But comes right back when I walk again.

I have had x-rays, MRIs etc, and never reveals all that much. Disc issues, yes. NOt much else.

Recently, I have begun to get a nasty clicking (catching) on my left jaw (joint?). Not really painful, but something definitely wrong. My dentist sent me to his Chiro. I went and liked him right away. I had gone to another chiro for years and I believe in them. But this one is the best I have seen.

Anyway, one of the FIRST things he suggested, was that it was POSSIBLE that the Lipitor is causing all of my problems. Put me on COQ10, and doing multiple adjustments and treatments. I will be seeing my regular doctor 5/26, and my chiro wants me to see if he will take me off lipitor and put me on Niaspan instead.

I guess my question is: Can Lipitor be fine with me for so long, and then in such a short period of time, turn me into a compete wreck from the pain and wasting away of my body/muscles? I've told doctors for over a year now that there is SOME connection as to all these issues and pain. One Doctor, of course, gave me the "you are getting old" bull. Yes, I am 56 yrs old. But I understand the process of getting old, vs the complete failing of ones body.

Also, IF it is the Lipitor, can it possible all go away? Or should I expect some damage forever?

One more thing, the last ortho I went to the other day for a second opinion, wants me to do a EMG, to see if there is muscle damage. I was not planning on doing it, but wonder now, should I? He was not doing it because of lipitor, as he never even talked about that to me. I had shoulder operation and have not had the results I feel I should have had.

Wow! I must be the latest in a long line of Lipitor users and apparently pain sufferers. I have been on Lipitor for over a year. I am 56 years old, active and healthy (thank God). Around November 2008, I noticed a "twinge" in my left hip while sleeping. This has gotten progressively worse over the months and I thought it was due to arthritis (which runs in my family). But after reading these blogs, I am not so sure. If anyone has anything definitive regarding this, ie: tests, studies, etc., I would really appreciate a point in the right direction for more information. I was thinking (until today) that I was headed for hip surgery or something equally drastic. Now that I have a clue that it may be the Lipitor, I want to investigate further and then, if necessary, change to another medication that won't break me down like this. My heart goes out to anyone that has suffered through hip pain. It is a miserable, painful condition that saps your energy and your desire to even move sometimes. I appreciate any help you can offer. God bless all of you. - L. B. ******

I was prednisone for 6 months, 7 yrs ago & now my Dr. tells me this is why I need a total hip replacement at 50 yrs young. Do not take this med unless it is a life & death situation. Even then I'm not sure I would take it.

I took Lipitor for about 6 months. Right after I began taking it, my legs, especially my right leg began hurting. I got off the drug at 6 months because my legs hurt so badly I could not sleep at night. I just had X-rays of my right knee done, and I have almost no cartridge left on my right knee cap. I now may have to have knee replacement therapy. My doctor that put me on the lipitor said that it was not the lipitor that caused. I think it is very odd the pain began when I started the drug.

I stumbled onto this website just today looking for information on another drug. Little did I know what I was going to find and so happy I did. I have been taking Zocor for nearly 5 yrs. now. My health has taken a spiral downhill. I too, have been experiencing almost every symptom that has been mentioned. Rt. shoulder pain, hand pain, pain and tingling in hands and feet, leg cramps, muscle weakness, numbness, memory loss, itching, fuzzy headed at time, can't concentrate, and trouble breathing. My doctor has told me my cholesterol is just fine the last two times I've had my checkup, but has never suggested I come off it. I guess I will be calling him tomorrow.

I have been on 20 mg Lipitor for years, and as I also have Rheumatoid Arthritis, all my symptoms have been blamed on that. I have been diagnosed with Fibromyalgia and put on Lyrica because of the muscle aches and depression. My lower back, hurt in a car accident when I was 17 years old, had gotten so much worse that I had 12 steroid shots in my lower spine a couple of years ago. They didn't help my back at all, but my blood sugar went from normal to diabetic levels, and I am now on Byetta to try to lower it.
I am a 56 year old woman who was the math specialist in a school district until last December when I had to retire early. My back pain was so severe that I could no longer go from school to school carting materials. I could barely make it from the parking lot to my office. Mentally I was not ready to retire, but physically, I was (and am) a wreck. I have severe muscle pain in my shoulders, sometimes one or the other, but always present. I have tingling in my right hand, especially in my fingertips, and have trouble gripping and drop things easily. In the last few months the pain in my right thigh and calf has gotten unbearable. I thought at first it was sciatica, but I have had sciatica before, and this isn't the same, although there is tingling, burning , but the pins and needles is so deep in the muscles I have just sat and cried, or wanted to scream. I have wished I could just cut my leg off. And...I am on some pretty heavy duty pain killers for the RA: a small dose of prednisone plus Enbrel, Methotrexate, and Vicodin, and this pain is cutting right through all these meds. I get severe headaches, I went off Lipitor for 5 days and seemed a little better, but then went back on, and it came back.
Since I no longer work, I sleep longer, am exhausted ALL the time, have terrible mental fog, am clumsy, cannot stand for more than a minute or so without wanting to scream, cannot walk more than a few yards...just getting to the car is an ordeal. I tell people that I can only shop in shoe stores and furniture stores...the only stores with places to sit down.
I no longer cook or clean, cannot play with my granddaughter, even holding a book to read can be too much, and I love reading. I feel I am just dying bit by bit as I lose parts of myself.
My doctor is really into lowering cholesterol, and has put me on Zetia in the past few months...and it has been in this time that the pain in my leg has gotten unbearable. He wants my cholesterol to be between 50-60, and has said that the Zetia along with the Lipitor will do that. Is this normal or in any way reasonable??? I am having a full blood workup done tomorrow morning, and I want to go off the Lipitor starting the day after.
I came across this web site tonight while looking up Lipitor side effects, and I am shocked. I have so many of these symptoms, and there are so many I had no knowledge of at all. I knew about the muscle aches, but that's all. I hope someone can help me with what supplements and vitamins I should be taking. I started taking CoQ10 a month or so ago. What else should I be taking for my health? I know vitamin C and fish oil, but don't know how much or anything else. Right now I am just stunned with the thought that all of these problems that have left me unhappily retired, exhausted and in constant pain can all be caused from a drug I have been taking to help me be healthier.

I was put on Levoquin after 4 days of Bronchitis. My body was not responding to the antibiotic so they added Prednisone. I continued on both medications IV for 8 days. After the second day, I developed a severe pain in my groin. I mentioned it to the NP treating me and she said, "we will worry about that once we get the Bronchitis under control". The pain continued as the medication continued. After the Bronchitis was resolved, the pain in my groin was terrible. My doctor sent me for CT scans and and MRI. The next thing I knew I was in the Orthopedic Surgeon's Office talking to him about a total hip replacement. He said the test showed very mild degeneration and he was not sure a total hip replacement for me was the answer. I opted not to have the hip replacement. Diagnostic Testing continued. Finally, my doctor told me that the combination of Levoquin and Prednisone caused a tendon rupture in my groin. He said it would heal but would take a long time. It is now 8 months since I took those medications and my hip is more painful now than ever. I am on pain medication and it does not help. I see my doctor today and we will discuss other options to relieve this awful pain. I walk with a cane and I feel like I will never walk normally again. It has totally disrupted the activities of my life. My doctor tells me to stay off my feet as much as possible to rest the tendon, this is impossible as I am a registered nurse and I am on my feet constantly. This has destroyed my life!

Being a scientist, I am reluctant to say my symptoms are completely due to the statin (Crestor) that I've been on for 2.5 yrs. Started with a bulging/herniated disk in my lumbar region 4 months ago. Then increasing leg pain and major leg/foot cramping at night. Had my blood checked for electrolytes and CPK. Electrolytes were ok but elevated CPK (muscle breakdown enzyme). Doc took me off Crestor and now a month later, no cramping and much reduced leg pain. Am going in for a cholesterol check next week to see what the levels are. I wonder how much the Crestor played in my herniated disk. Certainly it has played a role in the leg pain and cramping as I no longer have it to the same degree. The FDA and surgeon general talk about putting everyone on statins. BIG MISTAKE!!!! Maybe CoQ helps, but I am done with statins.

Moderately high cholesterol and BP 150/90. Was put on Lipitor 20mg and after a week felt more fatigued than usual but nothing much more than this. Had stress test and angiogram which showed 60-70% block in one artery as well as arrhythmia. Cardiologist bumped Lipitor up to 80 mg which I took for 2 weeks. But by then I was suffering most of the effects described in these postings: aches and pains, giddiness, nausea, extreme weakness and fatigue. I took myself off Lipitor and even after one day my head started to clear aches started to diminish, though urine still a reddish color suggesting a lot more flushing out required. And, best of all, the arrhythmia reduced from moderate/severe to mild (which it always used to be before taking Lipitor). This drug is not for me. I'd rather take my chances without it and rely on strict diet, weight loss, etc. It is surprising that the possible side effects are so understated in the manufacturer's descriptions.

15 years ago, at the age of 35, I had a major heart attack. After testing, the doctors decided I needed a quadruple bi-pass operation, followed by Lipitor, among other things. I was taking 20mg (the doctor ordered 40mg), but due to financial reasons I took only half. Everything was just great for 15 years. During a routine annual physical this year, my doctor noticed that my liver enzymes were off the chart high. He immediately had me discontinue the Liptor, but stay on all of my other medications. One month later, my liver enzymes were normal, and so was everything else; however, my cholesterol had climbed to 204, and I eat no meat, eggs, or other dairy products. They say my liver damage is permanent. Having had 4 lumbar surgeries and 1 cervical surgery to fuse disks in my spine, I have always attributed my back and other muscle pains to that. Now that I have been of the Lipitor for 3 months, I have not noticed in decrease in pain in these areas.

I have muscle pain, weakness, and chronic lower back pain. Started statin drug, Simvastatin, on 11/21/07. I take no other drugs. Within two weeks, I could not sit without severe lower back pain. Reported problem to family medical doctor on 1/11/08. M.D. sent me to physical therapy for 8 sessions. No relief from physical therapy so I requested an X-ray on 3/20/08. X-ray shows very mild degeneration at one lower vertebrae. M.D. sent me to an orthopaedics doctor who recommended continued physical therapy. Went to a Chiropractor instead. After six chiropractic sessions with little relief, I made an appointment with an Osteopathic doctor. My M.D. sent me to a rheumatologist who prescribed high dose naproxen for two weeks. The rheumatologist ordered and X-ray of my lower back area. The lower back X-ray produced no negatives. The rheumatologist's next step will be to order and MRI of my lower back area. The D.O. suspects statin induced myopathy and because of hyper reflexes he ordered an MRI of my brain and cervical spine. I am now recommended to a neurologist who specializes in the diagnosis of multiple sclerosis. Am I getting the run around? Only one doctor said I might have statin induced myopathy. The rest will not even mention the statin drug theory. I just pray for ache and pain relief. I have some improvement after four months off of the statin which I believe is quite a strong point that it was the statin drug and not some unknown condition. I don't think arthritis or MS conditions improve. All I know is that I had no health issues before taking the simvastatin. Good luck to everyone who has or is taking a statin drug. BEWARE!!!

I had a hip replacement in June, then contracted a staph infection after that (non-MRSA, thank goodness!), for which I have been on a 12 week antibiotic protocol, in addition to having the hip opened again for cleaning and replacement. For the first 6 weeks, I had a PICC line in my arm, which was infusing Oxacillin every four hours 24/7, as well as two oral doses per day of Rifampin. After the removal of the PICC line, I was put on a daily dose of 750 mg of Levaquin (I was also on Levaquin in the hospital, and couldn't sleep for weeks after coming home from the hospital). I have now been on Levaquin for 4 weeks and have incredible pain. The first symptom and most annoying was insomnia, as well as EXTREME rotator ruff pain, stiff fingers, tendor pain in my left elbow, and right knee. I can't walk well, the bottoms of my feet hurt (what's up with that?), and I can't even put on my bra by myself, my shoulders hurt so much. I thought I could take the pain because I just DO NOT want to have the staph infection come back and have another hip replacement, but I think I will actually have to go off of it. It's just too much pain. And I'm worried about long term damage.

I started using lipitor from my doctor, it lowered my cholesterol all around but I started to have lower back pains. At first I thought it might be prostate cancer, but after having to MRI's done they found no cancer, thank god. But I went to an orthopedic surgeon to see what the problem was. He looked at the mri's and saw lower dics hitting my nerve endings. He also thought that it might be muscle problems so he gave me 3 epidurals and that helped for a while took away about 50% of my pain, but I still have the pain, It is hard for me to get comfortable when I sit or even when I am sleeping. I don't want to think that it is the lipitor that is doing it to me but after talking with others I feel it is time to talk to my doctor about it. My doctor said that lipitor is the safest one that will do very little harm to my liver. I am not a doctor so I would not know.. My cholesterol level was 246 at one time now it is 175. I am now facing possible spine fusion to help correct my disc problem. But will also ask doctor to prescribe something else.

Alan

I started taking Lipitor 12 years ( 1997 ) ago as my Cholesterol was at 315. I was always athletic but had a crappy diet. My Cholesterol dropped to 200 within a year. However, in 2001 I ruptured my left Achilles playing tennis. Thought nothing much and that I hadn't stretched enough. Recovered from that and started playing tennis again in 2002. Within three weeks of playing again, I ruptured my RIGHT achilles! At that point I started to question the effect of Lipitor on muscles/tendons with various medical "professionals". ALL said it was nothing to do with medication. I quickly developed a tingling/numbness in both feet that doctors said could not be happening but it WAS!

I've had MRI's, nerve conduction tests, wondered if it was diabetic, alcohol, etc. Finally found sites such as this where real life experiences validated my concerns over this statin. I told my Dr. I was quitting Lipitor last Monday, she had no problem with that. This is Saturday night and I'm sitting here with a NOTICEABLE decrease in my numbness/tingling in both feet that I've had for the past TWELVE YEARS!!

I hope that the statin did cause my "mild sensory polyneuropathy" as was diagnosed in 2002. As of right now, it seems to be getting better in less than one week! I can flex my toes with NO pain and my feet don't feel like dead weights.

I WILL NEVER USE A STATIN AGAIN!

Can Statins Cause Chronic Low-Grade Myopathy?
Statins (hydroxymethyl glutaryl coenzyme A reductase
inhibitors) are highly effective drugs for reducing serum
cholesterol and low-density lipoprotein cholesterol levels.
Clinical trials have shown that they also reduce risk for
coronary heart disease events, coronary procedures, and
stroke by about one third (1). Millions of people in the
United States and worldwide are being treated with statins.
In clinical trials and in clinical practice, statins have proved
to be remarkably safe.
The one notable side effect of statin therapy is myopathy.
A small fraction of patients who are treated with
statins will develop severe myopathy (2). In the worst cases,
severe myoglobinuria, acute renal failure, and even death
can occur. The incidence of severe myopathy is low, perhaps
1 in 1000 patients (2). Predisposing factors for severe
myopathy appear to include advanced age, relatively low
body weight, female sex, certain medications, use of multiple
medications, multisystem disease, and acute illnesses
or major surgery (3). If statins were avoided or used in low
doses in these circumstances, it is likely that the incidence
of severe myopathy could be greatly reduced.
Less severe forms of myopathy undoubtedly occur. In
some patients, fatigue and muscle pain and weakness develop
with moderately high serum creatine kinase levels
but not acute renal failure. In these cases, the myopathy
resolves when statin therapy is discontinued.
Still more patients report various muscle symptoms—
fatigue, pain, and muscle weakness—but have normal creatine
kinase levels. These symptoms probably are unrelated
to statin therapy in many patients. In middle-aged and
older people, muscle, joint, and tendon symptoms are very
common. Naturally, if a patient takes a medication that is
believed to produce muscle problems, symptoms are often
attributed to the medication. On the other hand, the major
controlled clinical trials have not detected a higher prevalence
of muscle symptoms during statin therapy versus placebo
(1). This failure of detection has generally led clinical
trialists to conclude that statin-associated myopathy with
normal creatine kinase levels essentially does not exist or
that, if it does exist, it cannot be detected above the “background
noise” of muscle symptoms in the general clinicaltrial
population.
Many physicians in clinical practice nonetheless believe
that they can identify a subset of statin-treated patients
who have a unique set of statin-related muscle symptoms.
Some patients clearly relate the onset of muscle
symptoms to initiation of statin therapy. These symptoms
may abate after discontinuation of therapy, only to reappear
when statin therapy is restarted. The number of such
patients is not large, and thus it may have been impossible
to identify them in large clinical trials.
In this issue, Phillips and colleagues (4) report on a set
of studies in four patients who had muscle symptoms during
statin therapy that resolved during placebo use. Quantitatively
measured muscle weakness also resolved during
placebo use. Muscle biopsies were performed in three patients
during statin therapy and then during placebo use.
Several pathologic changes were seen on biopsy specimens
obtained during statin therapy: increased lipid content of
mitochondria, fibers that did not stain for cytochrome oxidase
activity, and ragged red fibers. The authors suggest
that these patients had statin-associated myopathy with
normal serum creatine kinase levels.
Despite the study’s small size, we cannot dismiss these
observations as random variation in muscle structure.
However, these highly suggestive results are clearly preliminary.
The number of patients was small, and all appropriate
controls were not used. Nonetheless, this study is novel
because it used quantitative measures of muscle strength
and muscle biopsy to address the question of myopathy
with normal creatine kinase levels during statin therapy.
To be confirmed, the current data would have to be
extended to many more patients in whom muscle symptoms
are closely correlated with statin use. Reproducibility
of symptoms during therapy and symptom resolution after
discontinuation of statin therapy would be necessary. A
definitive study would have to be carefully designed and
executed. It would need to be double-blinded and placebocontrolled
and include sufficient numbers of patients to
provide a valid statistical comparison. In addition, investigators
would have to carefully consider the appropriate
selection of patients. The development of a registry of candidate
patients at multiple sites could facilitate a multicenter
study.
Is a carefully controlled, sizable study of this type
worth the investment of time and effort? To date, no evidence
indicates that prolonged statin therapy leads to permanent
muscle damage or progressive myopathy in patients
with normal creatine kinase levels. Controlled
clinical trials attest to the general safety of statins, and
symptomatic side effects appear to be limited to a relatively
small proportion of treated patients. In addition, no therapy
prevents or treats statin-induced myopathy, short of
withholding the drug. On the other hand, statins are being
prescribed to millions of people, and are usually continued
throughout the patient’s lifetime. It is certain that statins
cause myopathy in some patients. For these reasons, a valid
argument can be made for a more extensive study of lowgrade
myopathy in patients treated with statins.
In the meantime, physicians should recognize the great
benefit of statin therapy in high-risk patients and their
documented safety for most patients. For high-risk persons,
the proven efficacy for preventing cardiovascular disease
outweighs the unlikely possibility of permanent muscle
damage. Phillips and colleagues’ preliminary results
certainly do not provide adequate information on the spec-
Editorial
www.annals.org 1 October 2002 Annals of Internal Medicine Volume 137 • Number 7 617
trum, scope, or prognosis of myopathy with normal creatine
kinase levels during statin therapy. For these reasons,
prescription of statins for eligible patients should continue
despite the current results. Moreover, before discontinuing
therapy, physicians should carefully evaluate any patient
receiving statins who reports muscle symptoms. In most
cases, the symptoms will be found not to be consistent
with chronic myopathy, and often they will not be related
temporally to statin treatment. High-risk patients in particular
should not be deprived of major cardiovascular risk
reduction just because they display symptoms not clearly
documented to be closely related to statin therapy.
Despite these comments, the actions of statin on muscle
metabolism and structure deserve further investigation
to clarify the confusing area of low-grade myopathy apparently
associated with statin use in a few patients.
Scott M. Grundy, MD, PhD
University of Texas Southwestern Medical Center at Dallas
Dallas, TX 75390-9052
Current Author Address: Scott M. Grundy, MD, PhD, Center for
Human Nutrition and the Departments of Clinical Nutrition and Internal
Medicine, University of Texas Southwestern Medical Center at Dallas,
5323 Harry Hines Boulevard, Y3.206, Dallas, TX 75390-9052.
Potential Financial Conflicts of Interest: Honoraria (from Merck &
Co.; Pfizer, Inc.; Bristol-Myers Squibb; and Bayer); Grants (from Merck
& Co. and Pfizer, Inc.)
Ann Intern Med. 2002;137:617-618.
References
1. Executive Summary of The Third Report of The National Cholesterol Education
Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment
of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. 2001;
285:2486-97.
2. Staffa JA, Chang J, Green L. Cerivastatin and reports of fatal rhabdomyolysis
. N Engl J Med. 2002;346:539-40.
3. Pasternak RC, Smith SC, Bairey-Merz CN, Grundy SM, Cleeman JI, Lenfant
C. ACC/AHA/NHLBI clinical advisory on the use and safety of statins (1)
(2). J Am Coll Cardiol. 2002;40:567-72.
4. Phillips PS, Haas RH, Bannykh S, Hathaway S, Gray NL, Kimura BJ, et al.
Statin-associated myopathy with normal creatine kinase levels. The Scripps Mercy
Clinical Research Center. Ann Intern Med. 2002;137:581-5.
© 2002 American College of Physicians–American Society of Internal
Medicine
Editorial Statins and Low-Grade Myopathy
618 1 October 2002 Annals of Internal Medicine Volume 137 • Number 7 www.annals.org

Wow, I had no idea that Levaquin affected so many people. My daughter had knee surgery a couple of years ago. They gave her vancomycin before the surgery. She had an allergic reaction to the stuff. She also found out from one of the nurses that levaquin is related to vancomycin.

I had a total hip replacement 3 years ago and they gave me vancomycin just before the surgery. I was laid up in the hospital for a week. When I arrived home I noticed that my skin was really itchy (mostly my arms). Whenever I scratched it left whelps and turned extremely red. Now after 3 years my skin is still itchy, but not as frequent as it used to be. Has anyone had this problem with their skin?

I wanted everyone to be aware of the relation between vancomycin and levaquin.

Good luck to all.

After my father's office was flooded by an AC backup at his workplace in June 2006, and as a result mold grew in the carpeting & walls. He got very, very sick & his doctor put him on Prednisone for almost a year. No local doctor nor specialist told us of the dangers of being on a steroid for more than a few weeks. My father kept getting sicker & sicker until one day in March of 2007 we had to rush him to the ER. There his doctor arrived, put MORE prednisone directly into his veins and as my father grew weaker & sicker we knew we had to get him out of there. We took him to Shands in Gainesville and they immediatly began their magic. It took a good week or so to undo the immediate damage that Prednisone had done to my father. It took until this month (October) until his liver & vital organs started working properly again and reached safe levels. In fact, he's still being carefully monitored by his Shands doctor to ensure his body will continue healing itself. His new doctor told me that if we hadn't taken my dad to Shands that day, he would absolutely be dead. Prednisone is a very lethal, dangerous drug if perscribed for more than a few weeks at most! Please, if your doctor wants you to take this steroid any longer than that, go see another doctor immediatly! It will save your life.

I have Grave's disease which effects your thyroid. I got radiation therapy for my hyperthyoidism.My numbers are still hyper and I'm taking Topral. I take 25 MG in the morning and 25 Mg at night. I have gained 8 lb's in 3 wk's.If you are familar with hyperthyroid, I should be losing weight.My face and ankles are puffy and my legs are crampy. I'm going to ck into other beta blockers until my thyroid gets regulated.

Symptoms which were not in existence prior to staring on warfarin although my doctors say they don't think it's warfarin I'm sure it is. I usually need to take around 9.5 to 10mg but my INR is never stable.
Side effects are extreme fatigue, fuzzy thinking, forgetfulness, hot rosy cheeks.

i have been on pred for 3yrs. following surgery for retro peritoneal fibrosis. started at 30mg twice a day experienced over appetite, excess energy. weight gain after 2 1/2 yrs i had a full hip replacement, due to effects of prednisone. i am now on 05mg i should mention that the rpf caused renal failure. kidney function was reduced & pred was the only drug that stabilized my condition. would be interested in any help finding another drug in place of pred. i am 69 yrs. old & in fairly good health otherwise.

I'm so happy I stumbled upon this website! I was prescribed Linsinopril in 2004 and within a few months began to feel lousy. The drug never seemed to lower my blood pressure to "acceptable" levels and I developed a rash, which sent me to three dermatologists in six months until I finally decided to go to an accupuncturist. The accupuncture treatments seemed to work at first, but the rash returned. Then my leg started giving me problems. In fact, my hip/leg hurt so badly I was considering hip replacement! It felt like my leg was going to fall off. Rising from sitting positions made me feel like a cripple and the pain was excruciating! Xrays and ultrasounds showed nothing. I finally begin going to a chiropractor but I'm not getting better -- I'm just managing the pain a little differently. All along I kept thinking it must be something I'm ingesting that's giving me these problems. I have suffered the same symptoms as many of you, though the coughs weren't nearly as bad. Last year a new doctor (I "fired" the other one because her bedside manner sucked and I wasn't getting any better no matter how I tried) took me off Lisinopril and prescribed Enalapril maleate and even though the rash has gone away (somewhat) the pain in my hip and leg is still awful, and that hacking cough is still there -- in addition to the fatigue, dizziness and swelling. I think this medication isn't much better than the Lisinopril. Since I'm also taking furosemide, I'll stick with that until my next appointment and see whether I can feel like my old self again.