June 23th
2009
5:01 PM
59 year old female. A history of hypertension started on Lisinopril in April of 2009..I am so GLAD I found this site! I have developed a severe chronic cough. This cough keeps me up at night ( and everyone else in the home)
Severe soreness in every joint in every part of my body. I can not sleep, serious fatigue, I have had mental confusion, short term memory loss I NEVER had the mental confusion or memory loss. I went to my Dr. 2xs he put me on antibiotics, told me I possibly had aspirated mucous in my lungs or had "silent reflux" no matter what I have taked or done none of the above symptoms lessened. Therefore, I started to do my own research and wound up here on this site. I am going to my doctor tomorrow informing him of the side effects ( which I would have thought he knew) and asked to be put on another medication for my hypertension. My question I have that there does not seem to be a easy answer is how long will it take to reverse all these symptoms? Truthfully I put all these symptoms in to the "just getting older" category. Thank You so much for sharing
October 7th
2006
8:45 AM
statins trigger neuromuscular disorders--there are many many neuromuscular disorders thought to be due to mitochondrial dysfunction (which underlies all the disorders mentioned here--including ALS, Parkinson's, Alzheimer's, as well as all the mitochondrial cytopathy disorders:
NEW YORK (Reuters Health) Jul 26 - Patients with asymptomatic neuromuscular disorders may have their condition precipitated by statin use, according to investigators from the University of Athens Medical School.
Dr. Panagiota Manta and colleagues describe four such cases in the July 24th issue of the Archives of Internal Medicine.
Case 1 was a 46-year-old man with a history of hypertension and diabetes mellitus who was prescribed pravastatin for hypercholesterolemia. Three months later, he complained of fatigue, muscle pain and stiffness. Serum creatine kinase levels were persistently elevated. After stopping the drug, creatine kinase levels fell somewhat and there was mild symptom improvement. Mild myopathy was seen on needle electromyography and muscle biopsy showed numerous internal nuclei, nuclear clumps and variations in fiber size. Genetic testing revealed myotonic dystrophy.
Case 2 was a 62-year-old man with a history of MI and diabetes. Hypercholesterolemia was treated with simvastatin. Creatine kinase levels became persistently elevated and did not return to normal after drug discontinuation. Biopsy was positive for muscle enzyme activity. He was eventually diagnosed with McArdle disease.
Case 3 was a 51-year-old man with hypertension and hypercholesterolemia who was hospitalized with acute rhabdomyolytis after taking atorvastatin for 18 months. Exercise intolerance and muscle pain persisted for months after discontinuation of statin therapy. Some time later, he was diagnosed with mitochondrial myopathy.
The last case was a 58-year-old man with a history of hypertension, hyperuricemia and coronary artery disease. He began treatment with pravastatin. Shortly after a dose increase, he developed muscle twitching, muscle cramps and difficulty walking. Like the other cases, there was only mild symptom improvement and a modest decline in creatine kinase levels after the statin was discontinued. He was eventually diagnosed with Kennedy disease.
Statin-induced neuropathy is well recognized and reported more and more often, Dr. Manta's group notes. These four cases show that statins can also trigger underlying neuromuscular conditions.
The investigators suggest that if neuromuscular symptoms persist after discontinuation of statin therapy, clinicians should "pursue further diagnostic evaluations for the detection of underlying neuromuscular disease."
Arch Intern Med 2006;166:1519-1524.
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November 1th
2009
1:05 AM
I just happened to do some research about lisinopril, and happened to stumble into this website. I am 43 years old, newly diagnosed with type 2 diabetics, i also have a history of hypertension and migraine which is under control. my physician just switch my medication from Norvasc to lisinopril, Im already on my 3rd week of taking it, 20mg a day, however, i noticed that i have more frequent headaches, more of a migraine headache that pulsate in one side of my head, i tried taking some over the counter medicine, but with no relief, i went back to see my doctor, and i was given some sumatriptan for the migraine, but at the back of my mind, i already suspected that the lisinopril might have triggered my migraine headaches, i have a relief when i take the sumatriptan, however the migraines keeps coming back. and its been seven days already, i was not able to work one day, because the migraine made me nauseated and vomit. i was doing well with my other medication, and never had migraine like this that last for 7 days up to now.after reading the comments. i have second thought of taking this medication.it seem like it might be the one that triggers my migraine headache. what do you think?
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