Hypoglycemia symptoms and conditions

I was started on Bactrim 7 days ago. The first two days I felt fine, but the 3rd night I got cold...very cold and could not stop shaking for about two hours. My heart was racing and I was nauseated and couldn't focus. This went on for about 8 hours before going to the ER. Upon arrival I had elevated BP and pulse, but after a couple of hours it went down to normal. I saw a new doctor who said it sounded like I had a hypoglycemic attack!! I never had one of those before!! So, I'm figuring I'm getting sicker and maybe it is not from the Bactrim so I take it again and last night was another horrible night!! Racing heart, confusion, and urinating every 30 minutes. Thinking maybe I'm having another attack I get up and eat some applesauce and my husband gives me some sweet tea. I promptly threw up a few times and then we went to the computer to look for ourselves the side effects of this drug. Guess what? It causes hypoglycemia, racing heart, confusion and does something to your kidneys and makes you urinate too much and could be very dangerous!! That was it for me!! I didn't sleep the rest of the night but slept on and off during the day and felt like myself today for the first time since taking the drug. I don't know if it has done any permanent damage, but I will let everyone I know about this awful awful drug!!

I always had breakouts, but nothing too severe that a face wash and makeup couldn't handle. Then, about 2 months ago, it started to get really bad! I started breaking out along my jaw line, and neck. It slowly started to spread its way up my face. It was large, red, and very painful. My boyfriend notice that I wasn't my happy go lucky self anymore, due to the acne, and suggested I go to the Derm, his treat, since Im a waitress, with no insurance.
The Derm said I have a severe form of cystic acne, and prescribed me Doxycycline. I was so excited that I was gonna have my skin back, although not perfect, but better. I had formed what looked like bloodclots underneathe my skin, where Im guessing the cysts broken up. (pretty awful, right!)
First day I took it, no problem. I had picked it up after work, so its was later in the day, after of course, I ate. So, I figured the next morning, I would follow the directions to a "T" because I needed to have my skin back. BIG mistake!! DO NOT TAKE THIS ON AN EMPTY STOMACH! Wow!! What an awful feeling! I threw up for about 15 minutes. (not sure why they recommend you to do that anyway, your not supposed to take Tylenol on an empty stomach) But I felt much better, and continued my day.
Yesterday was my 5th day on the medicine, and I noticed that I was very "bitchy" ( my boyfriends exact words ) felt very irritated and moody. But, I can deal with it, its not that bad. Also, had a lump in my throat, but that went away in about 20 minutes. But, we went to the grocery store, and I noticed that my eyes were very dry, and would burn as if you were having a staring contest and would leave your eyes open without blinking. I also noticed that I felt a little dizzy, and my boyfriend said that I felt shaky. I have hypoglycemia, so I figured I was just hungry. But, Im pretty sure that its the medicine now, from those before me listed similar side effects.
Im hoping that I don't get other side effects like other people listed. That would make me stop taking it all together, and would send me marching back to the Derm, for another treatment.
I have noticed that in about a week, my cysts have reduced in size pretty good, and are healing pretty well. My bloodclots are all gone, and Im starting to feel like the beautiful woman I once was! It seems very promising, and I look forward to continuing my Doxycycline!

I've been taking .25 of Toprol XL for about 5 years now. The firs few years were fine but the fatigue slowly starting getting worse. Now for the last 6 months I've been battling hypoglycemia. Does anyone know if the two could be related? It's a pretty awful feeling.

I am a pediatrician and my and I take care of my one year granddaughter is with allergic rhinitis and bronchial asthma. In her past history other than her usual problems she developed an episode of ketotic hypoglycemia after a viral syndrome.
I started her in Singular as she was having nocturnal episodes of cough in spite of having Pulmicort twice daily. As soon as she was started in Singulair she developed restless episodes of irritability. She never behaved that way before. She is now sleeping well all night after she had discontinued Singular.

I have been on Jasmin for 3 years and stopped taking the pill 3 weeks ago after finishing the last pack.

I had 1 panic/anxiety attack 2 weeks before I started the pill but was FULLY FREE of all other symptoms listed below. After I started the pill, the anxiety continued, but not with the same intensity - I stopped having panic attacks and instead felt permanently uneasy and anxious and began having high blood pressure. I cannot be sure that the pill has aggravated my symptoms, but neither can I believe that my fully changed reaction to any stress (I used to be very stress-resistant) has come from that one panic attack (triggered by strained back muscles).

The symptoms have really started about 3-4 months after I began and became gradually worse. I went to every doctor imaginable and they did not find anything at all wrong with me, except high pressure, which they said is from stress. I have been in psychotherapy for months and do not see an improvement and I feel like I have completely lost the last 3 years of my life: I am afraid of everything, I am unhappy despite a great boyfriend and I cannot imagine my life continuing like this.

When I asked my gyn whether this could be caused by the pill (I did not even connect this all to Yasmin), he said it is unclear, but I should stop because of my high blood pressure anyway.

Here are symptoms I have experienced, though whether they are all from the pill is still unclear to me.

1. Elevated blood pressure (around 140/90 or much higher if I am anxious)
2. Permanent anxiety with varied intensity
3. Permanent muscle tension with resulting pain all over the body
4. Hypoglycemia-like symptoms (but my sugar levels are never really low)
5. Headaches occasionally which can last several days
6. Facial muscle spasms
7. Jaw/tooth pain
8. Tremors - shaking all over for several minutes to half an hour
9. All the standard anxiety symptoms - chest pain, lump in the throat, dizziness, numb fingers, etc.
10. Extreme fatigue
11. Sleeping over 8 hours and still feeling tired
12. Inability to concentrate on anything - trouble working
13. Intense fear attacks during stressful situations (client meetings, talking to my boss, etc)
14. Dry eyes
15. Dry skin
16. Very high adrenalin production - cannot drink any coffee at all
17. Red wine intolerance - my throat starts to contract for some reason
18. Pressure in my head and in the nose now and then
19. Pain in my legs and calves - usually after walking for over an hour
20. Irritability
21. Lack of interest in any social activities, I avoid friends and am afraid of doing anything outside my usual routine
22. Cannot go on without carbs for more than 3-4 hours without feeling hypoglycemic
23. Severe stomach pains and nausea (occasionally)
24. Itching skin

I think this is all...but there could be a couple of things I forgot.

Until now, I have not noticed any real improvements, but my skin is gradually getting worse, which I expected. I guess 3 weeks is not enough to reverse what has been happening in my body for the last 3 years and I am trying to to lose faith and continue going to my psychotherapist...

I've been on Topamax for almost a year. I've had auras for years which were misdiagnosed as hypoglycemia episodes, then started having grand mals after detoxing from alcohol (I'm sober now), continued to have them in sobriety (I guess I messed up my brain from alcohol). I tried Tegretol but it made me groggy. Anyway, a few months into using Topamax I stopped sweating completely and got the numbness and tingling in my extremities, which drives me crazy. I also have trouble with urination, I've been put on water pills. I live in a desert climate and during the summer had bad problems with overheating, had to drink so much water that I had trouble with water retention and my electrolytes got messed up. I had no idea that it was the Topamax--the doctors put me through multiple blood tests, I discovered it might be the medicine by doing my own research online. I'm tapering off Topamax and trying the Low Glycemic Index Treatment to see if I can be off meds and not have auras because I don't want to be on seizure meds if I can help it. The withdrawal is pretty bad--anyone else have the problems with no sweating and wicked withdrawal?

I started taking Yaz 2 years ago after my son was born. I didn't have any side effects for a long time and was generally happy with the pill. About a year after being on Yaz I started getting horrible anxiety and depression. It was really beginning to interfere with my life. I always felt on edge, my heart was constantly racing, I felt down, starting binge eating, etc. I also started noticing that my blood sugar was out of wack. I became hypoglycemic and had to eat little snacks every hour to keep myself from having my blood sugar drop too low. I sometimes even had to take a glucose tablet. My thoughts were always racing. I felt like I was going crazy. After going to my PCP and a psychiatrist and not getting any relief from the way I was feeling, I took it upon myself to stop taking Yaz to see if that made a difference. Well, since stopping Yaz my anxiety, depression, and hypoglycemia has completely disappeared. I feel happy again, normal and healthy. I have gained a few pounds and my skin is an oily mess, but I would much rather deal with that than the hell I was dealing with before. I'm not big on taking medicine unless I absolutely have to and this experience has only made me feel stronger about that. I think I will go back to using condoms and give my body a break. (forever)

I am a type 1 diabetic and was put on the Lisinopril over a year and a half ago, maybe 2 years. I have my hair coming out when I shampoo and the red patchy skin on my lower legs which is dry making it embarrassing to wear shorts or capris. It makes me feel ashamed. I have laid off both the Lisinopril and HCTZ for a few days now. I got blurry vision, and I think it has made me gain weight. I get the swelling of the angles by this or both meds. Before taking these, I didn't have the swelling. I liked reading through the replys here on this medicine or both. I tried to identify some replies with myself and what I am experiencing. I want to get off this crap and take something else if at all "Alternative" at best. I did take atenylol (sp)? before. If anyone wants to contact me, they can e-mail me at ****** because, I would like to see what others are doing differently now to take care of the situation I am going through.

Anjamaka,
Like you I have taken BCPs since the age of 18 and like you I did not suffer any side effects, I took Yasmin in 2001 with no side effects at all for nearly 4 years when I started to feel really bad :horrendous muscle cramps/ blackouts, hypoglycemia, lost of energy, arthritis, earache, fatigue, heart palpitations etc etc...and I have a very healthy life, I eat well and exercise regularly. When I stopped Yasmin 4 years after, these symptoms went away!! So don't say that we are complaining and wait until your time comes!!
Sylvie

Wow you are all a bunch of complainers who try and blame XYZ on Yasmin which probably have ABSOLUTELY nothing to do with the pills. I have bee diagnosed with PCOS and have been on hormone therapy since age 15, first zovia, which worked well enough but did not get rid of a lot of my symptoms, only lessened them somewhat, so now I am on yaz. My depression has completely subsided, I feel GREAT and only had some nausea which almost EVERYONE gets when taking a hormone therapy birth control pill. Trust me, if you are going to have SIDE EFFECTS it is not going to happen 4 YEARS LATER, please.... grow up and take responsibility for yourselves, rather than trying to blame a pill

I was put on Effexor XR 75mg two years ago. After about a year on it, i decided i needed a stronger dose, so I was increased to 150mg. I felt happier than I ever have, but about six months in I started experiencing side effects. I have very vivid dreams. When they are good dreams, they are wonderful, but more often they are horrible nightmares, the most vivid nightmares you will ever experience in your life. This is the only real side effect, but it is bad enough i am thinking about discontinuing the medication. I know that the higher the dose of a medicine, the more side effects there are. There were no side effects at 75mg, but i felt more depressed than at 150mg. I also sometimes have other milder symptoms, but I also have hypoglycemia, so I don't know if the effects are from the medication or just a sugar drop.

Has anyone experienced excessive weight gain using Januvia? About 13 months ago I started taking J. and I've not lost any weight since that time. I had Lap-band surgery 19 months ago lost 58 lbs the first 7 months, started the Januvia, had what I thought was Lap-band problems, gained a few pounds and the few pounds are now a plus 40. I've spoken to a pharmacist and he says there cannot be any connection to Januvia, however I've begun to question Januvia as the advertisements on TV state that Januvia has not been tested with insulin and I'm taking Lantus at night and Januvia in AM. Januvia can be used with insulin at the description of the Doctor???? I'm very concerned about myself and Januvia. Any comments 2bears

Very disappointed...I became Hypoglycemic!

My story: I became Hypoglycemic within weeks of having the Mirena inserted. My symptoms were; anxiety, shakiness,irritability and nightmares.
I went to a primary care doctor and then to a endocrinologist complaining of that my blood sugar was becoming a problem. I was aware of the feeling of low blood sugar because when I breast feed my two boys (ages now 7 and 10) I then easily became hypoglycemic. However, I have not had this problem since.
Both physicians thought that i had reactive hypoglycemia because my fasting glucose was within normal limits.I have a healthy diet but i changed my eating habits even further (e.g. gave up all caffeine, sweets, alcohol. I started eating more whole grains and had small meals every 3 hours).
Even though I change my eating habits the side effects still became worse.I was starting to get panic attacks, I had never had these before. During one of my worst panic attacks (9 months after I had the Mirena inserted) I called my sister. I kept saying "I don't know what is causing me to be so anxious, I have never been like this before." Well, that statement sank in, I started to think about what was different. The only thing was the Mirena. That night I look up side effects of the Mirena and came across several blogs all describing their disappointment and many speaking about anxiety related issues.
I have to say I felt relief. It was not going crazy. The following day I read the official FDA Mirena web-site and that is when I found out about the effects on blood glucose. It is stated that Levonorgestrel may effect glucose tolerance and the blood glucose. However, my gynecologist never mentioned this side effect so I was not aware of this potential reaction. Btw, I had told both the primary care doctor and the endocrinologist that I had a Mirena IUD but neither of them new about the effects to the blood glucose.
The other interesting thing I noticed on the official FDA Mirena site is that when the list the Adverse reactions (depression,nervousness, weight gain etc...) they say reported by 5% or more subjects...hmmm, MORE...i think that is a key word!
I had it removed one month ago and I am starting to feel better. From what I understand, it may take up to 3 months to get the Levonorgestrel to get completely out of the system. however, my hypoglycemia is starting to diminish, I recently had a cup of coffee without getting the shakes and I can now enjoy a glass of wine at night too. My anxiety is almost completely gone.

What a relief to have figured this out!

I have only been taking singulair for about a month. I have noticed that I have become more irritable, grouchy, hateful and just numb, not really wanting to be around anyone, not caring about anyone else's feelings much. I also noticed I have become extremely lethargic, to the point of falling asleep at work as well as heart palpitations and stomach pains. I just started new birth control pills so at first assumed they were causing these side effects, that is until I looked up the side effects of this drug! I have over half of the side effects so I stopped it immediately and can already tell a difference in my mood. I have to sons age 11 and 14, both who have asthma and allergies. The took this medication for a few years with no side effects but have not taken it for about a year now. My youngest son however, has been diagnosed with ADHA and ODD and possibly BiPolar disorder. As I read the other posts, I realize the description of how their children act while on this drug is exactly how my son acts. I wonder if there can be irreversible permanent damage from taking this medicine? He has been on a number of ADHD drugs, none have helped except to make him stop eating and lose weight and he is small for his age, so I have taken him off everything. Has anyone else out there experienced what could be permanent damage from this drug in their children? Even after being off the drug for a year or so? If it could make me miserable within a month, what can it do when one takes it for years? Its sometimes hard to tell the effects of medicine on small children. My son prob starting taking it around 4 yrs old and took it til he was about 8 or 9. Just wondering if anyone else out there has had this happen to them or their children.

Clinical trial of montelukast in the Netherlands.

I noticed two things:

1. The researcher states that sides effects are 10%.
2. The researcher will not allow patients to also take drugs which are metabolized by CYP2C8 because montelukast inhibits that as proved by in vitro (test tube) studies. American studies in vitro said yes montelukast is an inhibitor but in vivo (in people) that it didn't happen. I was always confused by that and would still like to know more
.
******

Flindy is correct. It is easily possible to be just plain allergic to montelukast- Singulair. Where were the other "allergens" that her child was exposed to? It was, at least hopefully, a sterile environment.

Montelukast is a quinoline. Drugs often are built around a core molecular called a pharmacophore, the molecule responsible for the drug's important characteristics. There is an enormous amount of literature regarding adverse side effects for other drugs in that category.

At the time when Merck was pursuing quinoline as the pharmacophore, other companies were pursing other core molecules. So a quinoline core is not the only choice of drugs. The huge problem is that doctors are not aware that Singulair is not an anti-histamine. They are not warned that the core molecule is a quinoline so they don't know to watch out for allergic reactions especially serious ones.

It would be common knowledge that a quinoline radical (in an acid pH) could react with hydrogen peroxide to produce quinilinic acid, a nasty neurotoxin. When I hear of neuro-psychiatric side effects that appear to coincide with times when hypoglycemia could be happening, then maybe there are some genetically pre-disposed people that actually are experiencing times of ketoacidosis. Scientist have known about quinolinic acid since the 1940's. Malaria drugs containing quinoline come with a warning about hypoglycemia and electrolyte imbalance. Which comes first - the chicken or the egg- the reaction to the drug then the hypoglycemia or the hypoglycemia then the reaction? It would be amazingly easy to prove whether quinolinic acid is responsible for these neurological side effects.

I am appalled by two things. One is that Merck has such power over the FDA that the FDA fails to even recognize basic pharmacophore characteristics. Merck manages to snow them somehow with just words - leukotriene receptor antagonist. So what is the FDA reaction? Merck should review their clinical data. How about find some people who are suffering from Singulair side effects and do some tests? Then you might actually find out why.

If it turns out that anyone at Merck or FDA knew that montelukast carried significant risk of allergic reactions due to it's pharmacophore and they chose not to reveal that in the literature for marketing reasons, those people should be prosecuted. It should not be the job of doctors who prescribe medications to do their own research.

In Feb 2007 my primary doctor took blood tests and put me on a diet because I was 100 pounds overweight with fatigue symptoms. Blood Tests indicated I had diabetes (126 mg/dl) based on an FPG, and high cholesterol. The FGS was repeated and it dropped to 115 mg/dl. I have been on a low sugar low fat diet since Feb 2007.

In June 2007, I was put on Vytorin (Statin Drug) for Cholesterol. I also saw an Endocrinolist who determined I was a Predibetic and had also Reactive Hypoglycemia based on an OGTT, and determined my fatigue and neuropathy problem was not due to diabetes. She recommended a Rheumatoligist to me in September of 2007.

In late September of 2007. I saw a Rhematolgist for my sleep problems and fatique problems. I had severe muscle fatique (firing pains and numbness), chronic sleep disorder. breathing difficulty during day and when sleeping, difficulty swallowing, vision problems, fluctuations in FBS between hypoglycemia and hyperglycemia symptoms.

He determined after physical examination I had Fibremalagia since all test points on my body were sensitive to touch. He also had his lab do repeat and other blood tests (CPK, Aldolase, etc..), and prescribed a sleep study done by a specialist in my area. He took me off all Caffeine and Vytorin immediately (As I have been off it since that date). He prescibed Diclofenac for Inflamation, Citalopram 40mg for stress and anxiety attacks, Zolpidem 10 mg for Sleeping, and he requested I continue monitoring my blood gluecose twice a day.

After Leaving his office I made an Appointment with the Sleep Study Hospital to have the test done the following week. The study indicated I had Chronic Sleep Disorder where my breathing would stop anywhere from 30 seconds to two minutes during the night. The Sleep Order doctor also indicated that there was something else wrong with me out of his expertise.

In early October 2007, my Rheumatologist contacted me by phone and requested me to leave work and come to his office that afternoon to discuss my blood work. I was scared since they would not discuss it over the phone. The doctor dislosed my blood results and was concerned with a CPK of 2600 (should be less than 155) and my Alolase was six times higher than normal. He suspected I either had Polymyositis (not cureable, but treatable) or Inter-myositis (not cureable or treatable). He said he did not want to start treating me with a medication for it until he knew exactly which one I had. He said the only way to find out was to do a muscle biopsy (about the size of a pencil) on one of my large muscles preferribly a Thigh muscle.

In mid October 2007, I was scheduled to see a general surgeon and a week later I had a minor operation to remove a pencil size piece of my left thigh muscle. It was analyzed by the Childrens Hospital in New Orleans who were experts in the muscular diseases.

In Late October 2007, I was diagnosed with severe myopathy caused by the Statin in the drug Vytorin.

I remain on the same medications, have my blood tested every three months, and the CPK last indicated a reading of 900 (still very high, but it dropped all most 2/3 of what it was six months ago. It can usually take a year or so for most folks my age to fully recover, some do not. I still have the same symptoms, but the firing pains have subsided. My vision had also drastically changed, so I saw an Opthomoligist after providing her all my past records. She indicated I did not have any Renal disfunction which is good.

All the doctors agreed I should continue the stress, sleep, and inflamation medication and none of them have any reported inter-related problems. I am also on an AUTO CPAP machine when I sleep because I have two kinds of Atnea that affects my breathing (muscular and brain related). My breathing patterns seem to change quite a bit and my pressures vary from 7 to 20 and more so on the high side.

Our son started taking Singulair when he was 2 for severe allergic rhinitis and cough variant asthma (in addition to Zyrtec, which didn’t control all of his symptoms). He is 5 now. For the last three years, he has been an increasingly violent, difficult, defiant, argumentative, volatile child who has intense mood swings--one minute he’s laughing uncontrollably, the next he’s weeping over nothing. His doctor and therapist recommended that we see a psychiatrist to have him evaluated for bipolar disorder, which used to be unknown in children. Because he has such chronic sleep problems, the doctor also suggested we take him off Singulair (and increase his Zyrtec dose) to see if it improved his sleep issues. Within a week, he was sleeping much better and was a calmer, happier, gentler boy. He suddenly could take “no” for an answer without flipping out and trying to hurt me. We thought that we were just in an unusual, calm window that would shift either to mania or intense sadness or both, any minute. We also thought that his behavior change might be due to sleeping better. We were enjoying the rare reprieve. Over the last weekend, his springtime allergies really flared up. We gave him Singulair on Monday and by noon, he was completely out of control. I had to strap him into his car seat at one point to keep him from hurting either me or himself. It finally occurred to me that Singulair might be causing his “bipolar” disorder. Of course, we stopped the Singulair. After two days he was a new boy. Yesterday, I Googled “Singulair bipolar children” and got a few hits. I am stunned to read how similar other families’ experiences have been to ours and I feel sick that we gave this drug to our child for three years.

In response to all the brain research theories, I just wanted to say that when my son (at age 6) was on Singulair there was a noticeable relationship between food and mood. Although his weight was not affected noticeably he would almost predictably have meltdowns if he skipped a snack or we had dinner late. And I remember that I would do almost anything, including spoon feeding him like a baby, in the morning, knowing that, after a few bites he would become 100x more manageable.

I mention this because even though one could argue that this phenomenon happens with many kids and adults it really was sharply apparent in my son - and of course his behavior was more extreme. Like the mother who mentioned a hypoglycemic-like reaction, I felt that my son's explosive behavior and intolerance at these times quickly improved after eating.

By the way, he has been off more than a year now and does not have this problem any more. Also he is much less lethargic.

Singulair does interact with the astrocyte in the brain.

The role of the cysLT1 receptor (Singulair blocks this receptor) and the astrocyte in the brain has been studied. For anyone from Merck to say that there are no mechanisms by which Singulair can affect the
brain is ludicrous. If the Chinese researchers are correct, then Singulair very clearly affects the brain. Certainly, we don't know exactly how or when the effect would be good or bad. Under what circumstances would it be beneficial and under what circumstances would it be harmful.

For quite a while, researchers have been hypothesizing about the role of the astrocyte in brain function. If we go to look for theories, we will find them. Here is the theory of Dr. Dale Antanitus. I am no here to promote anyone's theory in particular but just to point out that they exist.

http://www.antanitus.com/hypothesis

We can see that the Chinese researchers have gone forward to look at potential links between the cysLT1 receptor (Singulair receptor) and inflammatory response in the brain. The 2008 study showed a link between the astrocyte and the cysLT1 receptor (Singulair receptor)

1: Glia. 2008 Jan 1;56(1):27-37. Links
Activation of CysLT receptors induces astrocyte proliferation and death after oxygen-glucose deprivation.

Huang XJ, Zhang WP, Li CT, Shi WZ, Fang SH, Lu YB, Chen Z, Wei EQ.
Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, People's Republic of China.

We recently found that 5-lipoxygenase (5-LOX) is activated to produce cysteinyl leukotrienes (CysLTs), and CysLTs may cause neuronal injury and astrocytosis through activation of CysLT(1) and CysLT(2) receptors in the brain after focal cerebral ischemia. However, the property of astrocyte responses to in vitro ischemic injury is not clear; whether 5-LOX, CysLTs, and their receptors are also involved in the responses of ischemic astrocytes remains unknown. In the present study, we performed oxygen-glucose deprivation (OGD) followed by recovery to induce ischemic-like injury in the cultured rat astrocytes. We found that 1-h OGD did not injure astrocytes (sub-lethal OGD) but induced astrocyte proliferation 48 and 72 h after recovery; whereas 4-h OGD moderately injured the cells (moderate OGD) and led to death 24-72 h after recovery. Inhibition of phospholipase A(2) and 5-LOX attenuated both the proliferation and death. Sub-lethal and moderate OGD enhanced the production of CysLTs that was inhibited by 5-LOX inhibitors. Sub-lethal OGD increased the expressions of CysLT(1) receptor mRNA and protein, while moderate OGD induced the expression of CysLT(2) receptor mRNA. Exogenously applied leukotriene D(4) (LTD(4)) induced astrocyte proliferation at 1-10 nM and astrocyte death at 100-1,000 nM. The CysLT(1) receptor antagonist montelukast attenuated astrocyte proliferation, the CysLT(2) receptor antagonist BAY cysLT2 reversed astrocyte death, and the dual CysLT receptor antagonist BAY u9773 exhibited both effects. In addition, LTD(4) (100 nM) increased the expression of CysLT(2) receptor mRNA. Thus, in vitro ischemia activates astrocyte 5-LOX to produce CysLTs, and CysLTs result in CysLT(1) receptor-mediated proliferation and CysLT(2) receptor-mediated death. (c) 2007 Wiley-Liss, Inc.

PMID: 17910051

The astrocyte has been studied to see how it functions in the brain. The astrocyte:

1. may perform a role in the physical structuring of the brain
2. may perform a role in providing neurons with nutrients
3. may perform a minor role in the maintenance of the blood brain barrier
4. may perform a role in neurotransmitters
5. may perform a role in the regulation of ion concentration in the extracellular spaces
6. may perform a role in neuronal regulation of blood flood
7. may perform a role in the protection and repair of neurons

TO LIE TO PEOPLE REGARDING THEIR HEALTH IS CRIMINAL AND SHOULD BE PROSECUTED. PEOPLE OUT THERE ARE GETTING SICKER IF THEY ARE EXPERIENCING SIDE EFFECTS BECAUSE MERCK IS LYING. SOME PEOPLE MAY NOT EXPERIENCE SIDE EFFECTS BUT WHY NOT TELL THE TRUTH AND SAY THAT THERE COULD BE SOME PEOPLE WHO HAVE PSYCHIATRIC SIDE EFFECTS BECAUSE THERE IS A PATHWAY FOR THAT TO HAPPEN.

Here is one for you Artie. Maybe you can go find the statistical profile of studies regarding montelukast and CYP2C8. Originally it was hypothetized that montelukast would inhibit CYP2C8 thus inhibiting steroid (as an example) metabolize. In vitro studies predicted that. Then studies in vivo didn't confirm. Here is another one done in 2006.

Conclusions: Telithromycin increases the plasma concentrations and blood glucose–lowering effect of repaglinide by inhibiting its CYP3A4-catalyzed biotransformation and may increase the risk of hypoglycemia. Unexpectedly, montelukast has no significant effect on repaglinide pharmacokinetics, suggesting that it does not significantly inhibit CYP2C8 in vivo. The low free fraction of montelukast in plasma may explain the lack of effect on CYP2C8 in vivo, despite the low in vitro inhibition constant, highlighting the importance of incorporating plasma protein binding to interaction predictions.

http://www.nature.com/clpt/journal/v79/n3/abs/clpt2006320a.html

The question would be is that always the case or are there genetic variations among people that influence the outcome? Or is there potentially something else that we should be recognizing and we aren't doing that.

I thought of that again when I read this post. We obviously have many questions that should be answered especially when something that we don't expect happens.

Posted by Mindy Miller
Monday, April 14, 2008 4:39 AM EST

I am a pharmacy student and a mother of two sons that take Singular daily. My six year old has been taking it for 4 years, and my three year old for two years. They both have well controlled asthma. I wanted to reply to the questions many have posted about how long it takes to "get out of your system". The half life of Singular is 3-6 hours, so it is gone in a maximum of 18 hours. I came to this website while searching for information about recent FDA warnings. As far as I can tell, there are very few cases documented of mood changes and suicidal thoughts. There are many reasons why children have mood changes, and not feeling well because they have asthma and allergies could also be the source. I wonder if many who start Singular are also taking Prednisone, a steroid, to treat an asthma flare up. Steroids are definitely known to cause mood changes and is one of the reasons they can't be used long term. Please talk to your doctor or pharmacist before taking your children off of medication that may be helping them feel better in the long run.

http://www.injuryboard.com/national-news/fda-issues-early-warning-on-singulair-and-suicides.aspx?googleid=30278

If we had all of the answers, then there would not be such a wide range of symptoms that manifest themselves as a result of Singulair. So I am not trying to spread any conclusions that may be misleading. These are questions and not answers.

I've been taking Metformin on and off for the past year, and I honestly think it's great now that I'm taking it regularly and eating right. I was prescribed Metformin for my PCOS and IR.

When I was first prescribed Metformin, I thought it was causing my hypoglycemia. I didn't eat right when I first began Metformin. I didn't eat horribly, but I wasn't eating right. It'd make me shaky, dizzy, and weak, so I wasn't taking it as prescribed and eventually stopped taking it.

I began exercising regularly and lost some weight while off it, but noticed that stomach fat seemed to go away faster while on it even when I'd stopped exercising. I was only taking 500mg a day then. One thing that it fixed right away was my period. I used to only get my period every three months or so, but the second I began Metformin, it did wonders to regulate my period. I was going through personal issues and again stopped taking it, but then was prescribed 1,000mg a day.

I was determined to take it as prescribed this time and started out slow with 500mg. Even though the previous times I'd never had any reaction to it, I had very bad stomach issues. I kept taking it regardless, and they eventually went away. I upped it to the 1,000mg then. I improved my eating habits by including more low GI and fiber-rich foods and ate more regularly throughout the day.

My periods are regulated, and I haven't had any hypoglycemic episodes. My stomach fat is going down, especially now that I've added in Yaz, and I'm hoping, along with improved diet and exercise, that this helps me lose these last 15 pounds, particularly the belly fat.

Well, I am not posting a side effect. I actually stumbled upon this website while trying to look up whether hypoglycemia is a side effect of Levaquin. I am a physician assistant and routinely prescribe this medication. Unfortunately ALL medications have the potential for causing many many many different side effects. Obviously one has to weigh the benefits of using the medication with the risk of side effects. And certain side effects are obviously more common than others. While I appreciate the point of a website like this, it is very frustrating for me, as a clinician, to read someone posting things that are absolutely untrue which can potentially cause undue distress or worry for everyone who may read it. I am referring to the person who wanted "to let everyone know of the relationship between levaquin and vancomycin." Her only source for this WRONG information is a nurse who told her daughter. Did she ever think that the nurse could be wrong and that maybe before posting something like that she should ask a pharmacist or a physician. Vancomycin and floroquinolones are not related pharmacologically!!!!

I just started using a prescription of Welchol. After two days, I am seriously thinking of discontinuing taking it. I am not prone to anxiety at all, and since I started using this, I have some anxiety and I am generally uncomfortable. Some gas and constipation. My heart rate is up a little. I really don't like this feeling of anxiety at all. I am taking Synthroid and Benicar.

Generic Glyburide used in treating type 2 diabetes mellitus and to control the blood sugar level. Generic Glyburide also causes serious side effects like hypoglycemia, hunger, nervousness and breathing difficulties. There are drugs that interact with generic Glyburide and increase side effects. For more information visit http://www.internationaldrugmart.com/glyburide.html