Immune memory symptoms and conditions

I am a 54 year old male who started taking Lipitor about 4 years ago. It seemed OK at first, but over the next several years I began to have increasing amounts of joint pain after exercise. Nor muscle pain, joint pain. And it seemed to be a result of exercise. By the time I stopped it, I was hurting after everything, not just exercise. I felt better within the first two weeks, but it took about 4 months for me to be able to exercise vigorously again. Over the years I seemed to have forgotten how much vitality I used to have. I am a physician, and because of the long lag time until I felt better, I wondered whether improvement might have related to other factors, so after about 5 months I decided to restart Lipitor. It surprised me that after just one dose, I got back all of the joint pain and fatigue when I was at my worst on Lipitor. I was really hurting. Needless to say, I didn't take any more.

Coincidentally, a physician friend of mine who had statin induced polyneuropathy had a similar experience. After his symptoms went away he found that after only one dose the entire polyneuropathy came back.

Stopping and restarting the drug is a way to test the correlation between the drug and the side effect. For such a large spectrum of side effects to recur after only a single dose, it argues that the problems that my friend and I had was due to some sort of immune memory response. I have not seen this in the medical literature.

I am off it now for about 8 months and am able to comfortably play singles tennis and jog - much more energy (and I took 200 mg of CoQ10 a day with the Lipitor).