Inflammatory markers symptoms and conditions

It has been almost two years since I took one tablet of 500 mg levaquin for a throat infection. I immediately felt lightheaded, then came the hot prickly skin, rapid heartbeat, insomnia and just a feeling of doom. I did not take another pill. Right after this my ankles started to hurt and podiatrist said had a torn posterier tibial tendon. To this day, I cannot walk without a limp, and can only wear athletic shoes with orthotics. If I stand for or walk for a small period of time I am in a lot of pain and have to sit. I was diagnosed with rheumatoid arthritis from the inflammatory markers in blood tests and rf factor, even though mri of my hands and wrists are normal. My right shoulder and arm hurt, my wrists and fingers hurt, my knees, neck. It is better, but I will never be the same as I was - no more running, walking my dog, going camping with my daughters girl scout troop - can't go hiking. I am 50 and I feel like I am 90. Would like to sue someone.

You are all completely 100 % right
I have a book here called the high blood pressure hoax
the lady that wrote it is 100 % right in her findings we are all living it !!!!
the list of side effects is overwhelming too many too list
I quit all hypertensive meds yes my blood pressure shot up rebound etc

but I can actually sleep and don't feel depressed and tired anymore

it may not be a good thing but id rather live with no side effects my skin is actually clearing up in 2 days from the itching, the nausea is still coming and going brain fog is clearing up as well as a ton of other horrible side effects for the first time i actually feel good .....in 2 years of taking these horrible drugs ,,,,,yes they are keeping us alive but in the long run they will kill us just as fast as the hypertension !!!!!!!!!! good luck with diet and exercise everyone I am starting it myself this weekend

Cholesterol Decline May Be Associated With Early Stages of Dementia

By Will Boggs, MD

NEW YORK (Reuters Health) Jan 19 - A decline in total cholesterol
levels precedes the diagnosis of dementia by at least 15 years,
according to an epidemiologic study reported in the January issue of
the Archives of Neurology.

"Studies like this are extremely valuable because they can provide a
'window' on to processes going on early in dementia, allowing
researchers to look back in time at people's health and other
characteristics and compare these between people who develop dementia
and those who do not," Dr. Robert Stewart from King's College London,
UK told Reuters Health.

Dr. Stewart and colleagues used data from the Honolulu-Asia Aging
Study to compare the natural history of cholesterol level change over
a 26-year period between 56 men who were found to have dementia at
examination 3 years after the last cholesterol measurement and 971 men
who did not have dementia.

Total cholesterol levels at the beginning of the study did not differ
by later dementia status, the authors report, but the decline in
subsequent cholesterol levels was significantly steeper among men who
went on to develop dementia.

Adjustment for potential confounding factors strengthened the
association between cholesterol level decline and the development of
dementia, the results indicate.

The cholesterol level decline was most marked in men with dementia and
the APOE epsilon-4 allele and in those with dementia and worse self-
reported general health at the final cholesterol measurement, the
researchers note.

"The observed associations may not represent direct causal pathways,"
the investigators say. "Hypocholesterolemia is recognized to be
associated with frailty and poor general health. It also has been
found to be specifically associated with inflammatory markers and poor
nutritional status."

Rather, they suggest, "It is possible that the decline in cholesterol
levels is a marker for early processes that reflect neurodegenerative
changes and also lead to a decline in general health status."

The drop in cholesterol was not a result of medication. "Very few of
the participants in this study were receiving cholesterol lowering
treatment at the time the decline in cholesterol levels was observed
(there were few cholesterol lowering medications around at that time
in the 1970s), so medication was not responsible for this," Dr.
Stewart explained.

"The drop in cholesterol was instead probably caused by some other
event and was a 'marker' of risk rather than actually increasing the
risk itself," he concluded.

Arch Neurol 2007;64:103-107.