Inflammatory response symptoms and conditions

I was given Levaquin for a prostate infection. They prescribed me 750 mg for 30 days. I have been off of the drug for 3 weeks and I still have pain in my tendons. Shoulder tendons, knees, elbow and hands. How long can this last? I feel like I am dying.

I am a 48-year-old male that is still pretty active playing competitive soccer several times per week. I am in good health except that my BP was considered a little high back four years ago and was originally put on a diuretic which made me cramp up easily on the soccer field. I asked my doctor for something different and was changed over to Atenolol. I have been living with the Atenolol side effects for that time and finally had enough. I had recently moved and changed doctors. Now was a good time to complain about the restless nights that I attribute to Atenolol (insomnia is one side effect). My new doctor knowing that I am an athlete suggested Lisinopril.
Again, my research is after the fact and was really spurred by a trip back home and a chat with my brother who is 49 and was just recently put on Liprinopril too. He described some bazaar conditions that he believed were Lisinopril side effects. When researched, he was right. He experienced the blackness or tunnel vision and the feeling of passing out while at work. He felt that he couldn’t drive as the effects where hampering his ability to do so. He stopped taking the drug and started a regiment of fish oil with his other daily supplements. This was two months ago and he is doing great. He too is still an athlete and runs in Masters Track & Field.
For me, it was a little different. I started Lisinopril on a Friday as my Atenolol had just run out on Thursday. I asked the Pharmacist if there was an issue with starting Lisinopril after stopping Atenolol only one day apart. She said there were no issues. 5 days later, Wednesday, while at work I developed an incredible lower back pain on the left side. I began to have nausea and heavily salivate as if I was going to throw up. I ran to the bathroom where I sat on the toilet for a half hour rubbing my back & hip believing it was some intestinal issue or gas. To no avail… When I felt stabile enough, I left work only to sit in my car wondering if was going to be able to drive and if I could should I drive home or to the hospital. Well, I drove home and went to bed for a couple of hours before I felt well enough to function normally. It’s been two weeks and the dull lower back pain that feels similar to a back strain persists. I’ll be heading back to the doctor with this information and will start the fish oil with my daily supplementation program.
Thanks to this website because I was able to find at least five examples out of about the first twenty postings that matched my suspected side effects.

I don't think that anyone can predict a time frame for getting over an adverse drug reaction. Below is my opinion but I see a lot of evidence that it is basically shared by other people maybe not exactly as I state it.

Adverse drug reactions deplete many essential nutrients from our systems. Inflammatory response is very stressful on the body. It is sometimes a very big effort to work on the diet to put back what has been taken away. It can take a long time.

Quinolines particularly deplete B-vitamins, folic acid (B-9), calcium/magnesium/zinc and omega-3 fatty acid. Sometimes the blood-lab work shows elevated homocysteine which proves that the body has suffered inflammation. Cardiologists now use homocysteine levels to show whether someone is at risk for heart disease due to inflammation. Deficiencies of B-6, B-9, and B-12 are known to cause elevated homocysteine.

Here is the pharmaceutical company ZINGER. Now companies such as Merck and Pfizer are going to offer niacin products to lower cholesterol. Well, yeh, duh !. All of these drug reactions are causing depleted B vitamins which elevate cholesterol. Then after they have tried to kill us by depleting our B - vitamins, they want to sell us another pill to give the B vitamins back to us. How many people out there are on some kind of a pill with side effects that cause inflammation? What a business? It is win, win, win.

In September of 2007 my then 13 year old daughter was put on Singular for mild asthma. At the time she was a straight A student, vice president of our school and a popular girl who's guidance counselor described as "the glue of her grade" because she was so well liked. In November she told me that she was struggling with advanced Latin and Science. She asked to drop down to on grade Latin so we did. In December her science teacher notified us that she had a C average. She told me that she thought she had ADD/ADHD and she couldn't keep up. At the same time she was having a lot of problems with friends at school and we just attributed it to being 14. 3 weeks ago we discovered that she is significantly behind in English and it was then that she told me that she is been having horrific night mares. She said that they usually involve someone killing her or her killing herself. She said that they were so graphic that she couldn't repeat it out loud. She also said that she would feel waves of anxiety that would come over her at school and she would act "witchy" to the kids in her class for no real reason. She said that sometimes when she is trying to do her homework she will read the same passage for 2 hours and still have no idea what it's about. She also said that the suicidal thoughts from her sleep happened during they day and that she had thoughts of her harming herself. Fortunately her pulminologist told us that this may be caused by singular and we immediately took her off of it which was 2 weeks ago. She has only had 1 "bad dream" not even a nightmare since. She had one anxiety attack 3 days after she was off it and she describes her moods as the "cloud lifting....slowly". Now, we have to pick up the pieces. Her grades have suffered, her friendships have suffered and most of all her self esteem is very low. I'm grateful that we found out the cause but I feel as if my daughter lost a year of her life and I worry that because Merck won't admit there are side effects we can't find out how long it remains in their system. Is anyone else concerned about the long term affect and has anyone pursued a class action suit to try to get this drug tested properly?

My four old son has been on singulair for about two weeks. The change from wheezing/coughing attacks at night and terrible allergies during the day has been amazing. They are almost non-existent to this point a great plus. However, a i stress however his behavior and speech has been VERY INAPPROPRIATE and quite frankly it concerns me. He now states "im a bad boy" and "i dont listen" and his mornings are very testy to say the least. Granted these sound like normal 4 yr. old sayings that he would pick up from other children on the playground but how do you explain them happening almost simultaneously with his taking singulair. I find it very hard to believe that it is a coincidence and that these are normal things for a 4 yr old to say/do when all other things have remained the same. My advice is to diligently watch your child for these warning signs and find other remedies if you have reservations. Im not promoting natural cures but i am leaning toward a diet change for the whole family and consulting my doctor for food allergen testing. I hope this helps. Be Well.

My 13 yr old daughter was put on Singulair along with Asmanex and Clarinex for her asthma about 6 weeks ago. Everything seemed to be going very well at first and her symptoms were starting to get controlled. I started noticing after about 3 to 4 weeks that her temper and attitude were getting much worse. Anyone with children this age knows what I mean but this was like a 180 degree turn for her. Her actions were becoming totally out of character. Before I knew it she would cry and get highly upset over the least little thing. Week 5 came around and things totally bottomed out. She came home from school and WAS NOT HERSELF. Made comments about how she hated her life and it was not worth living. Later that evening we had a big argument because I was telling her nothing was worth saying that. She went totally out of control and I had to physically restrain her to calm her down. It appeared everything was better so she went to her room. I went down to check on her and she calmly told me that she had taken advil and tylenol pm and things would be better for her forever now. We went to the ER where they made us wait for at least an hour, then finally took her back. She had to drink two cups of charcoal and was poked and prodded repeatedly. They did a catheter to get a urine sample. She was very cooperative but also was in a complete daze so who knows. The poor child couldn't even lift her head up when she started the vomiting to get rid of the drugs. It was very upsetting and sad. Her heart rate and blood pressure went very low and I really thought in the back of my mind that this was it. Finally, after several hours she started coming out of it and they sent us home. The next evening when she was starting to really come around she proceeded to tell me how she had been seeing a man walking around in her bedroom at night and she was afraid to go down there. Breaking down and crying telling me about all of the horrible nightmares she had been having recently and didn't know why. I thought what am I dealing with here? This just isn't her. Three days ago I heard about singulair in the news and looked it up on the internet. OH MY GOD THIS SOUNDED LIKE US!!!!! I immediately had her stop taking it and the next day phoned her asthma specialist who agreed she should stop now. We are going to watch her for two weeks and see if any symptoms return and then decide if she needs something else or will be fine on just the Asmanex. As a side note, she also mentioned being unable to concentrate in school (unable to do even the simplest math problems) and that her brain felt confused or like something was missing. She said this had been bothering her for several weeks. I know it was this drug. They really need to take this off the market NOW and stop flirting with disaster. The only reason I posted this was to let others know they are not alone.

Singulair does interact with the astrocyte in the brain.

The role of the cysLT1 receptor (Singulair blocks this receptor) and the astrocyte in the brain has been studied. For anyone from Merck to say that there are no mechanisms by which Singulair can affect the
brain is ludicrous. If the Chinese researchers are correct, then Singulair very clearly affects the brain. Certainly, we don't know exactly how or when the effect would be good or bad. Under what circumstances would it be beneficial and under what circumstances would it be harmful.

For quite a while, researchers have been hypothesizing about the role of the astrocyte in brain function. If we go to look for theories, we will find them. Here is the theory of Dr. Dale Antanitus. I am no here to promote anyone's theory in particular but just to point out that they exist.

http://www.antanitus.com/hypothesis

We can see that the Chinese researchers have gone forward to look at potential links between the cysLT1 receptor (Singulair receptor) and inflammatory response in the brain. The 2008 study showed a link between the astrocyte and the cysLT1 receptor (Singulair receptor)

1: Glia. 2008 Jan 1;56(1):27-37. Links
Activation of CysLT receptors induces astrocyte proliferation and death after oxygen-glucose deprivation.

Huang XJ, Zhang WP, Li CT, Shi WZ, Fang SH, Lu YB, Chen Z, Wei EQ.
Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, People's Republic of China.

We recently found that 5-lipoxygenase (5-LOX) is activated to produce cysteinyl leukotrienes (CysLTs), and CysLTs may cause neuronal injury and astrocytosis through activation of CysLT(1) and CysLT(2) receptors in the brain after focal cerebral ischemia. However, the property of astrocyte responses to in vitro ischemic injury is not clear; whether 5-LOX, CysLTs, and their receptors are also involved in the responses of ischemic astrocytes remains unknown. In the present study, we performed oxygen-glucose deprivation (OGD) followed by recovery to induce ischemic-like injury in the cultured rat astrocytes. We found that 1-h OGD did not injure astrocytes (sub-lethal OGD) but induced astrocyte proliferation 48 and 72 h after recovery; whereas 4-h OGD moderately injured the cells (moderate OGD) and led to death 24-72 h after recovery. Inhibition of phospholipase A(2) and 5-LOX attenuated both the proliferation and death. Sub-lethal and moderate OGD enhanced the production of CysLTs that was inhibited by 5-LOX inhibitors. Sub-lethal OGD increased the expressions of CysLT(1) receptor mRNA and protein, while moderate OGD induced the expression of CysLT(2) receptor mRNA. Exogenously applied leukotriene D(4) (LTD(4)) induced astrocyte proliferation at 1-10 nM and astrocyte death at 100-1,000 nM. The CysLT(1) receptor antagonist montelukast attenuated astrocyte proliferation, the CysLT(2) receptor antagonist BAY cysLT2 reversed astrocyte death, and the dual CysLT receptor antagonist BAY u9773 exhibited both effects. In addition, LTD(4) (100 nM) increased the expression of CysLT(2) receptor mRNA. Thus, in vitro ischemia activates astrocyte 5-LOX to produce CysLTs, and CysLTs result in CysLT(1) receptor-mediated proliferation and CysLT(2) receptor-mediated death. (c) 2007 Wiley-Liss, Inc.

PMID: 17910051

The astrocyte has been studied to see how it functions in the brain. The astrocyte:

1. may perform a role in the physical structuring of the brain
2. may perform a role in providing neurons with nutrients
3. may perform a minor role in the maintenance of the blood brain barrier
4. may perform a role in neurotransmitters
5. may perform a role in the regulation of ion concentration in the extracellular spaces
6. may perform a role in neuronal regulation of blood flood
7. may perform a role in the protection and repair of neurons

TO LIE TO PEOPLE REGARDING THEIR HEALTH IS CRIMINAL AND SHOULD BE PROSECUTED. PEOPLE OUT THERE ARE GETTING SICKER IF THEY ARE EXPERIENCING SIDE EFFECTS BECAUSE MERCK IS LYING. SOME PEOPLE MAY NOT EXPERIENCE SIDE EFFECTS BUT WHY NOT TELL THE TRUTH AND SAY THAT THERE COULD BE SOME PEOPLE WHO HAVE PSYCHIATRIC SIDE EFFECTS BECAUSE THERE IS A PATHWAY FOR THAT TO HAPPEN.