Large intestine symptoms and conditions

This is to serve as a personal warning to ANYONE taking
Effexor XR or thinking about taking it.

After my husband and I experienced HORRIBLE withdrawal symptoms within a week from coming off of our medication, and has continued for 4 months now. I feet compelled to inform people about the risks that this drug carries with it.

This drug helped my husband and I immensely while we were on it, but I just wish that I had been more knowledgeable about the risks of going off this medication so abruptly.

I understand that the medical professional that is prescribing you the drug is supposed to inform you that you are not to stop taking the medication abruptly (which is exactly what I was told). IN NO WAY was I told the consequences of NOT taking the medication.

So here are some of the symptoms that I experienced within the first two days (there are many more symptoms that other Effexor XR patients have experienced, but I feel that it is only right to list mine):

• Akathisia - a syndrome characterized by unpleasant sensations of "inner" restlessness that manifests itself with an inability to sit still or remain motionless.
• Ataxia – Loss of the ability to move the body with coordination.
• "Brain Zaps", "Brain Shocks," "Brain Shivers" or "Head Shocks" Descriptions include dizziness, electric shock-like sensations, sweating, nausea, insomnia, tremor, confusion, and vertigo.
• Cold Sweat – The skin is clammy and moist and you feel chilled. This is a reaction to a shock or pain as well as to fear and nervousness.
• Colitis – A condition where the large intestine becomes irritated from the use of the drug.
• Dehydration – An extreme loss of water from the body or the organs of the body as in sickness or not drinking enough fluids.
• Depersonalization - A feeling of watching oneself act, while having no control over a situation. (A sufferer feels that he or she has changed and the world has become less real, vague, dreamlike, or lacking in significance.)
• Diplopia – A condition where a person is looking a one object and instead of normally seeing just the one object he sees two. This is also call double vision.
• Disequilibrium - Dizziness, light-headedness and vertigo with a sense of losing balance.
• Dysarthria – The inability to control the mouth muscles when forming words so the words are not clearly spoken and heard.
• Gastric Irritation – An inflamed and sore stomach.
• Hyperhidrosis – The triggering of an excess of sweat being produced on the soles of the feet and/or the palms.
• Hypoesthesia – A partial loss of sensation or general loss of awareness.
• Influenza-like - Fatigue, lethargy, chills, sweating, headache, weakness and palpitations.
• Insomnia – Not able to fall asleep or sleeping for a shorter time than desired, thus not being able to properly rest and feeling un-refreshed. As a result, a person can become irritable, have difficulty concentrating and feel a lack of energy.
• Irritable Bowel Syndrome – A painful condition where the either the muscles or the nerves of the lower intestines, are not responding normally. This results in an alternating condition of diarrhea followed by constipation, back and forth.
• Mania – Unusually irrational, excessive and/or exaggerated behavior or moods ranging from enthusiasm, sexuality, gaiety, impulsiveness and irritability to violence.
• Mood Swings – An emotional shifting as from a state of happiness to a state of depression for a period of time.
• Night Sweats – With night sweats you become wide awake in the middle of the night shivering and cold and wet with your sheets/pajamas soaked in perspiration making it difficult to go back to sleep.
• Nightmare – Dreams that make you afraid or leave feelings of fear, terror, and upset long after waking up.
• Abnormal Orgasm – Unable to have an orgasm with normal sexual stimulation.
• Pain in Extremity – A painful feeling in the legs, arms, hands, and/or feet.
• Paresthesia - A sensation of tingling, pricking, or numbness of a person’s skin with no apparent long-term physical effect.
• Photopsia – A condition where a person sees lights, sparks, or colors in front of their eyes.
• Pressure of Speech – A condition where the individual cannot voice his ideas fast enough with the pressure of there being not enough time to say it.
• Pyrexia – Fever or the increase in body temperature that is usually a sign of infection.

Now some of you may be thinking that I might be overreacting, but I assure you that I am not. Quite the opposite actually, I feel that there are probably more symptoms that I am leaving out.
When I went online to research the symptoms that we had been experiencing, there was little information that I could find. I went onto the website for Wyeth (the company that produces Effexor XR) and the only thing that I could find was, and I quote,

“When people suddenly stop using or quickly lower their daily dose of EFFEXOR XR, discontinuation symptoms may occur. Talk to your doctor before discontinuing or reducing your dose of EFFEXOR XR.”

Wyeth also states that Effexor XR is, and I quote AGAIN,

“ Effexor XR Is Not Addictive. Effexor XR and other antidepressants are not addictive. You cannot become addicted to an antidepressant even if you take it for long-term maintenance therapy. An antidepressant is not a controlled substance like a narcotic or a stimulant.”

I am very sorry Wyeth, but I disagree.

I am 26 years old and I was diagnosed with endometriosis last year (2008). I had pain in my lower abdomen for years and doctors always told me nothing was wrong but I knew there was. Finally a doctor did an ultrasound and found a 7cm mass on my left ovary. I also had a slightly smaller mass on my right ovary. My doctor told me that he would need to do a lap to remove the masses and possibly remove my left ovary because he could hardly see any ovarian tissue on the ultrasound. Thank goodness when he did the lap I was able to keep but ovary but he told me that I had one of the worst cases of endo he had seen. My right ovary was stuck to the wall of my abdomen due to the endo and I even had endo on my bowel. He removed what he could but not all of it was removable. He suggested that I go on Lupron for 6 months to "shrink" the rest of the endo. I have been on Lupron for 3 months. I just went and got my second 3 month injection. I have had some side effects such as Headaches, Bone pain, Hot Flashes, Insomnia, Drowsiness, Increased appetite and major Mood Swings. All of which come and go. I try to stay active but I don't over do it. It seems to help with the joint pain. Most of my side effects were in the first 2 months of getting the injections. I am told all the time that everyone reacts differently to Lupron and there is a pill you can take to reduce the side effects of Lupron but it does reduce the effects of the Lupron so my doctor suggested that I not take it unless the side effects were unbearable. I don't remember what it is called but if you are one of those people having major side effects ask your doctor.

I had open heart surgery August 23rd 2006 for a conginital heart defeat (Aortic Valve replaced with mechanical St Jude valve). I wanted a bio valve but Drs insisted I should have the mechanical valve because of my age (45 at the time).

Prior to my heart surgery I was a performer, singer/songwriter/actress/comedianne and I loved what I did. It was my life. Now, after 2+ years post-op and on Warfarin (7.5 mg daily for life) I feel like life has ended and I'm just a walking dead person. The effects I feel daily are as follows...

Dizziness
Severe Headaches
Blurred vision
Memory Loss
Fatigue
Weight Gain
Trouble concentating
Fluttering effect in my head/ears- Hard to explain
Hair loss
Unexplained pains in chest & left side of my body
Unable to sleep well
Tiredness- even when I've done nothing to be tired for
Nausea
Gas & Diarrhea off and on
teeth pain- Like I've drank something very cold
feeling in my head similar to a brain freeze- like you ate ice cream too fast
Night bleeds in my month- wake up with a mouth full of blood daily
What do think, is that enough??

I'm going in tomorrow for a cat scan because the headaches have been so bad they feel I need to be checked for brain tumor and/or internal bleeding. When I tell the Drs I think this is due to Wafarin they pratically laugh in my face as if to say, "Silly silly woman, don't be foolish! We know whats best for you. Remember, we saved your life!" Really? Did you?!

I want nothing more than to get off this rat poison and regain my life, but to do so could mean a stroke or heart attack. I would go under the knife again to have the mechanical valve removed and replaced with a biological valve, but do you think my insurance company (Kieser) would pay for a "silly" thing like that? Right!

Welcome to the greatest country in the world!

I'm going to start a website to help people like us. I want your stories, please send me your info, together we might make a change, what can it hurt to try? Email me ******

B.

I originally posted about my 9 year old son on January 5th. Refer back to this for the symptoms. He had his upper and lower endoscopies on the 12th, and the lower showed numerous ulcers in the large intestine and at the beginning of the small intestine. The doctor insists that it has to be Crohn's disease based on just this and the blood work, which showed eosinophilia and elevated sedimentation. He is insistent that this has nothing to do with the Singulair and the dosage change. It's just a coincidence .... He' in the hospital for a week now. Watch for those stomach complaints! His started with poor appetite, complaining that he was full when he had hardly eaten, and vague complaints about eating giving him a stomach ache. It progressed to occasional diarrhea. It got worse quickly after that, just a few weeks.

Up to 50mg for supraventricular tachycardia. Also clinically depressed and extremely stressed. Now having more depression, anxiety, mood changes, fatigue but insomnia at night, Also, gross diarrhea and increased ringing in my ears. Somehow, I think it may be better to have the ablation procedure, which I am told can totally fix my electrical rhythms in my heart. Am thinking of it as I already have struggles with diarrhea from ahivng Crohns disease and having a few feet of large intestine removed. Also, lack of appetite, not increase.

I had my first infusion of remicade with the benadryl on Tuesday since then I have had a very bad headache, stemming from the back of neck all the way over my left side to my eye and also a very painful stiff neck. I am literally inches away from surgery to remove my large intestine and this was my last chance. The good news is that it seems to be working for the UC but I am not sure I want to live with these headaches it is awful.

I'm a 37 year old female and have severe asthma and allergies and have used pregnisone on and off for 30 years. I believe I am the poster child for the long term side effects. My immune system is shot to the point that my normal medicines for asthma (ventolin, advair) and allergies (tylenol sinus, claritan, visine A) and ezcema (elidel, hydrocortisone, etc. - - NOTHING works!

In the past 6 months, I have developed various infections that the doctors have not been able to identify. My eyes are swollen and red with large amount of white/yellow secretions. Vaginal secretions. Face swollen. Skilled covered in a rash with ezcema out of control. Sharp pains in my back and stomach. Constant asthma. Abnormal hair growth. It is to the point that it is impossible to function and each doctor just wants to prescribe more pregnisone. I feel as if my body is a walking time bomb and it is so full of all the cortisone from over the years and has just decided no more.

I admit that I too readily believed in the doctors when they would rapidly prescribe the pregnisone. Only now am I paying attention to the long term side effects.

Has anyone had tests done to test their immune system and other organs for damage? Thanks and best to our pregnisone club.