Leg muscle weakness symptoms and conditions

I have type 2 diabetes for a few years and am 59 yrs old-and do not have fibromyalgia or kidney,liver problems or depression or a history of any painful muscles ever. I work up to 90 hrs a week as a doctor for the past 12 years and am a DIY renovator of my home in mt free time. I exercise regularly and am fairly fit, I do have a congenital mitochondrial myopathy characterized by non painful arm and leg muscle weakness- but have not been symptomatic significantly for 20 years. I take vitamins and one aspirin a day and have no medication allergies. weeks ago I started Januvia- my only diabetes medication. I worked well to normalize my mild to moserate elevation of BS.Over the past 2 weeks or so, I have had an increased somnolence without feeling rested upon awakening. I felt like I had been beaten with telephone poles and hammers, More distressing is the insidious onset of neuromuscular pains episodic sharp ones, more persistent aching and burning and tingling tingling, with a dense heaviness in legs more than arms worse with exertion and relieved by rest. 3 days ago it was to the point where I had to stop walking after 8 steps and could not climb a ladder beyond one step . I should not curl 2 lb weights even twice, Typing on a keyboard fatigued my arms after 5 minutes. I stopped Januvia three days ago, slept 30 hours,, felt better yesterday,restarted januvia last pm, Today, after 12 hours of sleep I feel exhausted like I did hard manual labor for a few days without ant sleep. The telephone pole beaten feeling returned, My weakness and pain are back with a vengeance and I cannot walk very well and have to stop typing this every 2 or 3 minutes to rest my arms, and have weakness also in my back muscles with curious sparing of abdominal muscles. Heat and massage do not help and are uncomfortable. I feel tired like I do when my myopathy acts up and my Krebs cycle is disrupted and thus my mitochondria do not make ATP to power my muscles- with the additional new symptom of significant pain. Aside from a mild tachycardia of about 100 at rest, my vital signs are normal, my cpk, Mg, thyroid function tests, comprehensive metabolic panel and sed rate are all normal . Heavy metal screen is negative. I will stop Januvia and probably never take it again, If my glucose goes back up I will go back to metformin which I took a few months about a year ago,
I suspect in my case that Januvia disrupted my mitochondrial function as well as being additionally toxic to my muscles and nerves by some additional pathogenesis, I question whether those individuals who have weakness, somnolence and neuromuscular symptoms might have some underlying mitochondrial dysfunction - a very under diagnosed condition - patients being told that their symptoms are of psychiatric origin.

I posted several months ago on this string and wanted to update. I had bloodwork done for the 1st time since I quit the 20mg of Lipitor in August. LDL went from 123 to 210. Total Chol went from 191 to 285. HOWEVER all shooting pains I had been experiencing in legs, feet, and chst are GONE! Went back to my Dr. today, told her that same result and my serious objection to taking any kind of statin and she prescribed CRESTOR while telling me it was more potent than Lipitor! WTF!!!

I refuse this course, am drinking 30 - 40 ozs. of water each day now like I should have been, doubled my CoQ10 to 200mg/day, finally getting back into the gym to lose weight and get the HDL up from the level of 36 it is now. also started to drink the new yogurt type "shot" of Promise for cholesterol that provides 2 grams of plant sterols per day.

I will not take statins ever. I WILL find a natural way to keep my Chol under control. I've also been convinced that you don't have to be at or under the 200mlg of total chol to be healthy. Look at your C Reactive Protein and Homosiytes (sp?) If they are in range you should be good.

I know Lipitor was the cause of my rupturing each of my Achiller tendons a year apart while playing tennis in my late 40's Muscle pain soon followed.

Had Cortisone shot for left shoulder osteoarthritis. Few hours later pain in left arm began. Next day was worse with excruciating pain in arm when arm muscles used even slightly. 48 hours later, pain subsided; but other side effets still present- hot flashes, increased appetitite, sore throat. One week later still having hot flashes, nausea, and now severe muscle spasms in left leg, muscle weakness and palpitations. Sore throat seems worse also- but no sign of cold symptoms.

I had what a nurse called as a hypertension crisis with a 220/130 bp. I went to the ER in an ambulance. After trying me on several meds over a short period of a few days, I am now on Toprol XL 50 mg. and cardizem LA 180 mg. I have only been on Toprol for 1 day and I already have leg muscle weakness and feel a sense of depression that I never have. I am also dizzy and have some shortness of breath. The doctor says that my heart is strong and that all my blood work was great. I am just worried that it won't stay that way. I have an alternative medicine physician that I will be talking to and looking for safer alternatives. Does anyone know if only 5 days on bp medicine and then weaning myself off will hurt me?

I have been on Lisinopril/HCTZ 20/12.5 twice a day for about three months now. I have been experiencing chest pains, head aches, and fatigue but had not attributed it to this medication, due to the side effects creeping up on me over time, until I read many of the posts on this website. My blood pressure without medication runs around 180/120 at its highest. On lisinopril it runs about 145/80. I am 32 years old and was diagnosed with hypertension when I went in for a reconstruction of a broken nose. The only immediate side effects I noticed was tremors and some muscle weakness.

I was prompted to check side effects for this medicine when my father's doctor recently doubled his dose. He takes Lisinopril as well. (I think he takes 40 mgs per day now along with another bp medication). According to my mother he started the heavier dose yesterday evening and took it again this morning and had to LEAVE WORK due to exhaustion. (He starts work at 8:00 am) He slept out in his car until 1:00 in the afternoon, worked until 4:00 and came home angry, confused, tired, said he felt like he had the flu, couldn't eat and I naturally got worried and decided to check for side effects, and I'm glad I did, man this stuff is bad news!

Has anyone had any good results with natural treatments?

Thanks,

JWC