Level of anxiety symptoms and conditions

I was prescribed this for Epididymitis (sp?) about 4 weeks ago (100mg 2x a day). After a week or so on the meds, I began to have a striking number of the symptoms that everyone else has listed previously: Chest/Ab cramping, feelings of swelling in random places, loss of appetite, dramatic mood swings, a high level of anxiety, crying for no reason, confusion and panic attacks...I called my GP today for a psych referral, and when he calls me back I'm going to ask to be taken off the Doxy. Thanks to everyone who posted, it helped me for sure!

I've just started taking sertraline a couple months ago, I've worked up from 25mg to 100mg, and I see a bit of difference in my mood levels. The best way I can describe it is that my low points aren't as low as they used to be and my general level of anxiety has eased. I just recently changed over to the 100mg dosage a couple days ago and I'm feeling what I hope to be the initial numbness, which I hope will go away soon. One thing that is fairly concerning is that I havent' been able to cry since I started on this medication. I'm usually prone to crying jags during low points and within the last couple of months I havent' had one or had the urge to have one.

I think it's from my inability to stay concentrated on a single subject for a period of time, like others mentioned, I've noticed that I zoloft has decreased my attention level. Eh, but I"m not sure if the fact that I can't cry is a good or bad thing, we'll see how everything turns out once my dosage is stabilized.

Here is an example of the fact that the medical community recognizes that there are gene based drugs. Because Singulair is modeled to be a receptor antagonist to the cysLT1 receptor and the cysLT1 receptor is a gene, I'd say that Singulair should be described as a gene based drug. I don't really care how anybody wants to play with the definition. CysLT1 is a gene with known variations. Why isn't there just an "across the board" warning for all gene based drugs that unexpected side effects are possible???? And, that doctors should watch out for individual reactions.

WMJ. 2005 Aug;104(6):61-6.Links
Gene-based drug prescribing: clinical implications of the cytochrome P450 genes.Musana AK, Wilke RA.
Department of General Internal Medicine, Marshfield Clinic, WI, USA.

The Institute of Medicine recently mandated an increased effort to improve patient safety and reduce medical error. With the description of genetic polymorphisms in the drug metabolizing enzymes, the field of pharmacogenetics may improve medical care through a reduction in both therapeutic failure and adverse drug reaction. Investigators at the Marshfield Clinic in central Wisconsin are piloting the process of gene-based drug prescribing in a variety of contexts. This paper reviews the field of cytochrome P450 (CYP) genetics and explores factors that impact the utility of this information in clinical practice.

PMID: 16218319

My 13 yr old daughter was put on Singulair along with Asmanex and Clarinex for her asthma about 6 weeks ago. Everything seemed to be going very well at first and her symptoms were starting to get controlled. I started noticing after about 3 to 4 weeks that her temper and attitude were getting much worse. Anyone with children this age knows what I mean but this was like a 180 degree turn for her. Her actions were becoming totally out of character. Before I knew it she would cry and get highly upset over the least little thing. Week 5 came around and things totally bottomed out. She came home from school and WAS NOT HERSELF. Made comments about how she hated her life and it was not worth living. Later that evening we had a big argument because I was telling her nothing was worth saying that. She went totally out of control and I had to physically restrain her to calm her down. It appeared everything was better so she went to her room. I went down to check on her and she calmly told me that she had taken advil and tylenol pm and things would be better for her forever now. We went to the ER where they made us wait for at least an hour, then finally took her back. She had to drink two cups of charcoal and was poked and prodded repeatedly. They did a catheter to get a urine sample. She was very cooperative but also was in a complete daze so who knows. The poor child couldn't even lift her head up when she started the vomiting to get rid of the drugs. It was very upsetting and sad. Her heart rate and blood pressure went very low and I really thought in the back of my mind that this was it. Finally, after several hours she started coming out of it and they sent us home. The next evening when she was starting to really come around she proceeded to tell me how she had been seeing a man walking around in her bedroom at night and she was afraid to go down there. Breaking down and crying telling me about all of the horrible nightmares she had been having recently and didn't know why. I thought what am I dealing with here? This just isn't her. Three days ago I heard about singulair in the news and looked it up on the internet. OH MY GOD THIS SOUNDED LIKE US!!!!! I immediately had her stop taking it and the next day phoned her asthma specialist who agreed she should stop now. We are going to watch her for two weeks and see if any symptoms return and then decide if she needs something else or will be fine on just the Asmanex. As a side note, she also mentioned being unable to concentrate in school (unable to do even the simplest math problems) and that her brain felt confused or like something was missing. She said this had been bothering her for several weeks. I know it was this drug. They really need to take this off the market NOW and stop flirting with disaster. The only reason I posted this was to let others know they are not alone.

I posted this on Mar 15th regarding my experience with Topamax...

I took Topamax for only 4 days. I ended up in the ER on Feb 22nd because I felt like I was going to pass out, getting dizzy, couldn't concentrate or think, numbness, rapid heart beat, shortness of breath and this was intensified by anxiety from all this stuff going on. I stopped taking it immediately. I have had episodes of these same side effects since then. I had these side effects last week and missed 3.5 days of work. I have been doing pretty good this week but today I had to leave work because the same side effects came back. I had to have someone come pick me up form the side of the interstate half way on my way home because it got so intense I could not drive. My doctors have done blood work and I am waiting for the results.

Since then, here is an updated on my side effects and what has been found by my doctors. I really hope this helps someone since this was very devastating for me. It got so bad I had to go on Medical Leave from work due to the side effects.

I had 10 tests run on my blood and tests and pictures done on my heart and everything checked out to be normal. Apparently since this medicine messes with the chemicals in your brain, it also has the capability of turning on anxiety, depression, panic attacks, etc. My primary care doctor, my neurologist, my cardiologist and a stated licensed counselor/therapist all have diagnosed me with anxiety leading up to panic attacks. Basically what I was told by my counselor was that my level of anxiety in my brain was turned on so high, it didn't know to come back down after I stopped the medicine. Now anything can set it off and it's quickly escalates into a panic attack without control. I was so bad that I was having anxiety/panic attacks about merging into traffic, going to work, going through the drive thru at McDonald's, going to WalMart and just anything in general. I started a medicine that controls anxiety and I have been on it for a week. Although I still get anxiety, I am able to control it and it's not escalating into the panic attacks. The best thing is with this type of medicine is that it can take "a couple of weeks" before it's built up into my system, so this should take care of it. I was advised with some counseling to learn how to control my anxiety and some medicine, this can be taken care of. I just have to allow my brain to get the levels of anxiety back down to normal levels and then I can eventually stop taking the medicine.

Yasmin - Sudden Panic/Anxiety-

I have been on Yasmin for 7 years. I started a new box and pack 3 weeks ago and 72 hours later had what I thought was a "panic attack". I had never suffered panic or anxiety before and I am 32. Then, the chest pain and anxious feeling wouldn't go away (not normal with panic I hear). I went to the Dr and my bloodwork was all "great". I went to a cardiologist and they tested my heart. It was indeed beating "extra" so I had to be one a monitor. Still, the entire time I was miserable and wondering what the heck had happened to me. How could I go from being a normal, well adjusted women to a crazy lady in one day. I was crying and couldn't function, concentrate or eat. I felt like an "out of body" type of experience almost, like it wasn't really me who was feeling all this. Very disoriented feeling. Well, the Dr gave me anxiety pills and I was going to take them. But, in the meantime I went on the "sugar pills" of my Yasmin and guess what? 72 hours after I stopped the pills I felt normal again!!! I'm still not 100%, I'm 90%. Now I have no hard evidence that Yasmin caused this, particularly since I've been on it so long but I can't help wondering if they changed the dosages or something. I have NEVER experienced any level of anxiety or panic before this and going off the pills was the only thing I changed when I started feeling better. Sounds like more than a coincidence to me.

Has this happened to anyone else recently???

I took my ring out this morning. I have dealt with anxiety and some depression to varying degrees in my past, but lately it has been much worse for no apparent reason. I started having panic attacks and heart palpitations last fall, they told me I was fine physically, and there was no other explanation. I have irregular periods, so I was hesitant to stop using the ring, but I've made my decision. Before I spend hundreds of dollars going to specialists to try to help me, I'm going to see if taking the ring out improves anything, and based on all of the other posts here I suspect that it will.

Just another FYI, I started the ring in the first place because my doctor told me it was a lower does than the Pill. The Pill gave me GALLSTONES 4 tears ago at 19 years old and I had to have my gallbladder removed! Then, when I was on vacation in Mexico, I had to go to the emergency room b/c I had symptoms of a blood clot in my leg. UGH! I was hoping the Ring would be different, but my elevated level of anxiety and depression and mood swings leads me to believe that it's not different at all.

Overall, birth control is just not worth it. It is not worth sacrificing my sanity. Condoms here I come! lol.

About 4 months ago I was put on a 10 day treatment of 500 mg Levaquin, because of an on going sinus infection. I took the pills for 5 days and experienced muscle twitching, weakness, dizzyness, upset stomache, irregular fast heart beat, extreme anxiety, I had this weird tingling numb feeling from my knees down and couldnt sleep at all. I called my doctor after 2 days of the medication and told her about my side affects and she told me to continue the medication. After 5 days went by I looked up this web site and was shocked to hear that I wasnt alone. I threw away the rest of the medicine and prayed I wouldnt have long lasting affects. I continued to have muscle twitching, cramping, and weakness for the next 3 months and my leg muscles would ache and tighten by themselves. I have played sports my entire life and had just gotten done my season of college basketball before I got sick and after I took this medication I could barely walk up the stairs without feeling like I was going to pass out. I was in and out of the hospital having blood tests they tested me for lyme disease, and did 2 cat scans of my head. I went to a neurologist and had tests done worrying it was ms or als and they sent me to have an MRI of the brain and my neuroligist asked me if I had been on any medications and I told him levaquin. After 3 months of crying myself to sleep being put on about 8 different medications to control my anxiety my neurologist diagnosed me with BFS. BFS is a neaurological disease that affects your nerves. It is not life threatening but many people suffer because of the anxiety that comes along with the disease and I get muscle twitching all over my body and feel tired most of the time. It took me to get a long time to feel even a bit better but I began taking magnesiun, B12, Potassium, and other ones to help nerve function and a mild anxiety medication and I have felt a little better. Nobody believed me when I told them my illness was from levaquin but after I was diagnosed I realized that just 5 pills may have ruined my life. Now today I have my good days and bad. I just turned 21 but I cant drink or have caffiene because of BFS. I met the love of my life about 3 weeks after I got out of the hospital and I knew we were meant to meet because his step father had passed away a month before. His step father took levaquin for an infection and his kidneys and liver failed 11 days later and he passed away. I was so devastated when my boyfriend told me about this and called my parents to tell them how SCARED I WAS. I am dealing with what this medication has done to me by staying positive, and telling as many people as possible about how bad this medication is. I wish I would have rad this site before I took those 5 pills but I didnt. Levaquin should not be on the market and I will pray for those who have had the same heartbreaking experience as myself.