Lifetime symptoms and conditions

i went 2 the specialist yesterday that put me on the prednisone due 2 me having crohns as the joint pain in my ankle has been so painful and his now told me that the prednisone has giving me arthritis im really upset about it im 25 and im in a lot of pain the specialist said 2 go home and rest my ankle for the weekend its been 2days and its still not better iv got 2 go back and see him on Monday and if it hasn't improved which i doubt it will his going 2 change my medication he wanted 2 up the dosage of prednisone to 30mg as im down to 10mgs now and i told him that i have received every side effect possible 2 the prednisone and its just starting to reverse and there is no way im going to le you put me on a higher dosage i want 2 come off this drug as quick as possible and he surgesseted another medication that will help with the arthritis in my ankle but it will make me nausea i told him id rather that then all the symptoms iv been having in the last month then be put back on the prednisone

I am so glad that I am not the only one who has experienced this - not that I want others to experience it, but you know what I mean, it is nice to have some answers!!! I went in to get an allergy shot for my horrible allergies about eight months ago - I have had one done previously a couple years ago, with no problems, and this second one seemed fine too. My allergies are so much better, i can breathe and am not sneezing constantly, etc. However, about a month ago, I noticed this small indentation in my left buttock cheek - I wondered what on earth it could be (cellulite, weight gain/loss from going to the gym I started going to, who knew?) It got bigger and hasn't gone away over these past few weeks, instead getting larger and my skin becoming ever whiter than I already am and the area is sensitive. I had no idea what it was until I stumbled onto this site - I now realize that indentation is the same spot where I received my allergy shot eight months ago!!! I checked my online medical record and sure enough, Tricyclamide Kenalog injection! NOBODY told me that this indentation/muscle atrophy at the injection site was a possible side effect! They warned me about allergic reactions, drug interactions, buildup of steroids in the system, etc, but absolutely nothing about this awful indentation - it is sensitive and unattractive and I really, really hope it goes away or at least shrinks. Not that I am super vain, but it's not all that cute to have a big "hole" in your cheek, especially when that was one of my body areas I actually felt okay about. Just be forewarned allergy sufferers - just because you haven't had a reaction the first time you get the shot, it could happen the second or third or fortieth time. I wish someone had said something about this, so at least I would have been able to make a more educated decision and choose whether to suffer through a few months of allergies or a lifetime butt indentation!

I am a 36 year old women that decided to start taking birth control for the 1st time in my life which was on aug. 1st. I decided this after having my last of 3 kids. my ob doctor prescribed me Yasmin, but I filled the ocella a generic of Yasmin. I was at first concerned a little bit about taking birth control due to my age. But my ob told me that if I smoked than there could be risks of the side effects of birth control. I do not smoke, drink, or eat badly.I used to drink coffee everyday, but stopped because of the b.c. effects. I am not overweight with no other health conditions, except now!!! I don't exercise much or sleep much because of taking care of the baby. I do stress and have anxiety at times. I have had a few mild heart palpitations in my lifetime that occurred at work.
I have never experienced so many and strong HEART PALPITATIONS until I was on the pill. I started experiencing them about 2 weeks after starting the pill they occurred about 3 to 6 times a day about 4 to 5 days in a row. I continued for another few days just to make sure, but still had HEART PALPS. I stopped taking the pill. on aug 17th. I was also more moody and felt like I had pressure in my head at times. I than got concerned and decided to take my blood pressure on aug 31st.which was at 133/88. I said to myself that i have elevated blood pressure that i never had before. I started to worry because i never had HIGH BLOOD PRESSURE. My BLOOD PRESSURE started to raise every day and reached 182/101. I was was so worried and stressed over this, because i know I did not have HIGH BLOOD PRESSURE before. I called my ob to find out my blood pressure before i started the pill and on july 27th it was 120/64 a great and healthy blood pressure. on Sept. 5th I went to urgent care they gave me a clonidine 0.1 to lower my bp when i reached 182/101. and did an ekg which was fine. my pulse if fine. They gave me lisinopril 10 mg to help if my blood pressure continued to be high. I did start it because if was like 172/96 which was close to this # everyday.It is helping a little. My pressure ranges from 128/80's to 156/90's. usually the 2nd #. It's rare that it hits lower. started meds on sept. 6th. I don't have any heart palps since about 3 days ago, which was 11th. but still have hbp. my primary dr does not think it could be my birth control, especially with being on for only 2 & 1/2 weeks. I'm pending blood tests right now. and my dr. thinks it could be my thyroid causing palps and hbp. my dr does not seem to think bc's can raise hbp. I read the package insert of bc's and read on internet it can. I felt completely healthy 1 month ago. and had excellent blood pressure.

Hi I'm 36, with high blood pressure. I have been on 25mg/day hydrochlorothiazide since July 08. I went in for normal 3month check up and Dr tells me that my bottom number is to high, so she gives me yet another pill to take(yep you guessed it) Lisinopril. I filled the RX in the morning, by lunch time, I felt sick to my stomach, dizzy, everything hurt. I thought I had gotten the flu. This was just 2 days before my daughter and my mothers birthday.(both the same day) We had big plans after all you only turn 18 once. I put a smile on and went to the party, but it was living hell. My Fiance' noticed that I didn't start feeling bad until after I had taken that new pill. I only took 1 a day for 3 days and it took me over a month to feel half way normal again.

anyone experience abnormal menstrual cycle?
I stopped getting my period for 2 months and now am off the med for about 6 days, anyone know how long it can take to be out of your system?

I must admit I am very surprised by all of the side effects of Advair. I have been taking Advair 250 for years and have NEVER had any problems. I'm 28, healthy, thin, and happy. I exercise several times a week. ALL drugs have side effects. I don't think it's fair for anyone to say "don't take Advair, it's a horrible drug" because it works for some of us. I was taking Flovent before but it didn't work for me. I needed a rescue inhaler several times a week. Since I've been taking Advair I don't even fill my prescription for my rescue inhaler! All drugs have side effects, but they don't effect all people!

I have had my mirena for 3 years now and for the most part enjoy it. The only side effect i have had is i get bacterial vaginosis (BV) quite often. I never had BV in my life until i had the mirena for about 1 1/2 years. i do like the fact that i don't have to worry about taking a birth control pill daily or worry about getting pregnant. It definitely is affective considering my partner and i never use precaution when having intercourse. i guess i would prefer dealing with BV for a week then another child for a lifetime!

It is hard to tell what side effects come from which med but after reading other peoples experiences I think that its easier to put my finger on. I have been taking Lamictal and Lexapro since last spring/summer. I started to feel a lot better as soon as I started the Lamictal. I have a history of being severely depressed all the time. It has been a long road in search of the correct combo of meds. We added Lexapro and I got even better. I was on Wellbutrin and Topamax before this and it was too much drugs in my system causing loads of anxiety. I heard Topamax makes you Dopey so I was happy to get off that. I don't notice Lamictal doing the same thing. I think clearly now, but I do have trouble crying - which is fine with me. I am so sick of fucking crying everyday. Aren't you??? The whole point of treatment is to increase the quality of life and These drugs have definitely helped me to be happy which is all I care about. However, I do still wonder what I would feel like without them. It is tempting to stop once you feel this good. Why cant i just be able to feel this good naturally. WHY WHY WHY .

Has anyone experienced multiple pulmonary emboli (blood clots in the lungs)?

This medication is deadly! I do not understand why they do not pull this one. It handicapped my mother of 55. Leg pain (severe) crippling cannot walk.... need help up and down. She is considering lawsuit! Everyone should. This will effect you the rest of your life!

I am a 39 year old female in relatively good health. In the past year since taking Lipitor, I have had SEVERE thinning of my thick hair. I have lost nearly 2/3 of it, and luckily I had a lot, but I am thinning more quickly on the top of my head and you can now see my scalp. After reading this, I am stopping my Lipitor, tonight. I hope that my hair returns ... I have also had chest pain, leg pain, trouble sleeping, trouble with eyesight, trouble focusing, unexplained weight gain and extreme fatigue. I think I would rather take my chances with high cholesterol than be bald at 40. Nice eh? I complained to my doctor when my hairdresser called this to my attention, and she poo-pooed it and referred me to a dermatologist- who after months of waiting rescheduled. I will be BALD!

My 4 year old son started taking singulair when he was two. I don't think I picked up on his behavior change right away b/c I thought that he was just entering the "terrible two's". But over time, his allergist added on Nasonex (I know the docs say that it doesn't cause side-effects b/c it's a nasal spray, but I don't buy that...it's a steroid, plain and simple) and more recently zyrtec was added on for his hives. Well, the zyrtec was the straw that broke the camel's back. I mean, he has been a real "handful" since the singulair, but after zyrtec was added 5 months ago - let's just say he was completely out of my control. His meltdowns were so bad that I couldn't go ANYWHERE with him. I either got a sitter or just didn't go anywhere. He became aggressive, defiant, emotional, unhappy. And to top it off he started to have serious "autistic-like" self-stimulatory behaviors (grinding teeth, squinting eyes shut, flapping his hands, punching himself...). At this point my life had become a complete nightmare, and my poor 10 month old son was getting NO attention b/c my 4 year old was so out of control and aggressive. I was afraid for the baby's safety...oh, I could go on all night. This medication has impacted my marriage, my finances, my sanity. Shortly after he started Singulair I had to go on an antidepressant b/c it too so much out of me just to be his mommy. Anyway, a week ago I had him scheduled for a psych evaluation (thought for sure we were going to walk away with either autism or bipolar diagnosis), but two days before I decided to look up the meds he is on and BINGO! All of these posts sound like what we have been going through. I stopped all of his meds that night, cold-turkey, and he has been the most pleasant little boy I have ever met!! My husband and I have fallen in love with him over the past week - we had no idea he was such a sweet child.

Now, while I'm ecstatic that we have found the answer to our nightmare, I also feel SO STINKIN' ANGRY! We lost out on 2 years with our sweet boy, there were times when we raised our voices at him when he just couldn't help himself - he was suffering inside!! When I went to talk to the allergist about my findings this past week, he said, "well, maybe he just had a good day. I'd like to see what happens if he goes off all his meds for a week". Well, there you have it, he has been off for one week and he's an absolute angel. He has an amazing heart and is so caring!!!

Singulair is awful (and so is zyrtec). Please don't give this drug to your children. Research other alternatives (I am giving my son Nordic Naturals Fish Oil, Culturelle probiotics, vitamin c, and am changing his diet - increased magnesium and decreased dairy. I came up with this after hours of research...).

There is a woman on this site whose daughter committed suicide after 3 years on Singulair. This is no joke and the FDA needs to get with it.

BTW, I used to date a Singulair rep (I knew there was something I didn't like about that guy:)

I have been on the NuvaRing for about three years now. It is great, I loved it. For the past year I have been experiencing the most awful cold sweats. They last for about two weeks on and off all day. Then subside for two weeks or so. I can not seem to find an answer as to why. My gyn told me that if it doesn't coincide with my period than it has nothing to do with it. She suggested a tooth infection...it wasn't. I am beginning to think it is the NuvaRing...although not sure because I have yet to find someone with a similar symptom. I just don't understand why now after I have been on it for soo long without a problem? That's the only thing making me wonder if it is a side effect of the NR or not. I took it out about two days ago....Has anyone experienced this reaction? This has really become unbearable.

My son, who is 8, has just been prescribed Lexapro. He's only been on it for 2 weeks and is taking only 5mgs. He was diagnosed with depression. The first four days were wonderful. I had my sweet, loving boy back. Since then, a lot of "crap" we have been dealing with is back, but at least the sadness/aggression/temper have not been as bad as before. He is having horrible stomach pains, but could be caused by allergy drainage or possible intestinal problems that have yet to be diagnosed. Anybody out there with a child going through the same thing?

My son was also taking Singular for 8 months last fall and that was a NIGHTMARE! Don't ever allow your child to be prescribed this medicine, especially if they already have behavior issues.

I'm 19 years old and have been on NuvaRing for 3 months. I am AWFUL at remembering the pill, so my gyno put me on it. I have not experienced any of these side effects...until i read this site! It's odd because I feel like I just shook a lot of things off to normality or just simple bodily changes, but now that I read and think about it, it's made a lot of changes in me too!
I have had blurred vision with distance and kept telling my mom I really think I may need glasses! It was weird because up until recently, I had perfect vision! Not only that, I have had MAYBE five headaches in my lifetime! I find I get AT LEAST one a day now. Not only that, but my sex drive...oooh...it is completely non-existent now! I feel so horrible because my boyfriend asks me more and more if I am not attracted to him anymore. It makes me so sad because he definitely turns me on, but my body doesn't seem to react the way my mind does. It is painful to have sex more than about five minutes because it's dry and just becomes painful friction so we have to stop. I am so mad at EVERYTHING all the time! I feel like I nit-pick everything my boyfriend does and I just get so mad and frustrated over NOTHING! Just one wrong thing said and I'm to boiling point in about .2 seconds! I also have a crazy rash in the last month that I shook off to changing laundry detergent and having a reaction, but it's not gone yet. It's all the way from half way up my sides to my knees and everywhere in between! Including my elbows, forearms, neck, I'm miserable with it! I have to get off this after finally having something bring this to my attention! I am going to the gyno the next open chance! Thanks ladies!

I was prescribed an 11 day supply of Levaquin - 500 mg. I'm on day 7 and struggling to make it 4 more days. The first day I took the tablet around 5 pm. I was up all night. Since taking in the morning, I've been fine. Now, I'm suffering from very sore biceps, heels and stiff knees. The fatigue is overwhelming. I also experience extreme dizziness as well. I may call the doctor tomorrow to see if I can stop this. I've taken various antibiotics throughout my lifetime and never have experienced the side effects such as this one.

Hi all. I'm wondering if anyone can help me. I'm a 34 year old woman. I gave birth to my daughter in October 2005 and in December 2005 I had the Mirena coil inserted. It's due to finish up this December as it's approaching the 5 year mark.. In the last 6 months, my skin has gone from being clear as a frosty sky to that of an acne ridden 15 year old. I'm breaking out on both my cheeks, neck, jawline and chest. Could this be a side effect of the "winding down" hormones in my coil? I've had the coil in almost 5 years but I'm only getting really bad skin now...... for the past 6 month or so. I've always had relatively good skin so as you can imagine, this is most distressing for me. Could it be the "last of the hormones" in the coil? Could anyone shed light on this for me? I would have thought that if my skin was going to "break out" with the coil, it would have done so almost immediately after inserting the coil in in the first place..... Not almost 5 years later! I've no allergic reactions to creams, lotions, foods, etc. My diet is quite good (I've never changed my diet so it's not diet!), I'm not stressed. I get at least one new spot every day. They last for days, or a week. They are really deep rooted so most of them I can't even "pop"! Can anyone help? It's my birthday next week so it would be the perfect birthday present......

Regards and thank you in anticipation

Yvonne xx

Numerous side effects including but not limited to: spontaneous tendon rupture (right distal bicep), CNS agitation accompanied by anxiety and panic, extreme fatigue, digestive problems, on-going fluctuations of blood sugar level, rapid changes in body temperature, nausea, etc.

Some here insist on reporting the "good" this stuff has done (other than lining some peoples pockets with profits). I disagree. As I post this I see 2250 adverse effects have been posted previously. I urge yo all to look deeper ask the question: "Why so many problems with this class of drug?" The 2250 number is only for Levaquin..... don't forget to add in all the responses for all of the other drugs in the quinolone family. And while you are at it, find out how many other drugs have death as a side effect and how many have been reported. This is a defective drug.

Hi Guys

I am taking Yasmin since May 2006. I have been suffering from chronic daily headaches since March 2006 and wondered if Yasmin could be a factor in this? For my headaches I have tried so many different things and not been successful and hadn't looked at the possibility that Yasmin could be a problem until I started to google it. What do you guys think? Could Yasmin be adding to my problem of chronic daily headaches? Cos I have the headaches all the time.

Any responses would be greatly appreciated!

Regards
Warda

Comment: What is behind the ignorance and denial found within the medical community regarding the true safety profile of the fluoroquinolones?

An editorial in response to the FDA's recent addition of "Black Box Warnings" to the fluoroquinolone class.

Written by the Director of the Fluoroquinolone Toxicity Research Foundation, Mr. David T. Fuller.

The Fluoroquinolone Toxicity Research Foundation continues to collect post-marketing reports regarding the non-abating nature of the severe and crippling adverse drug reactions associated with fluoroquinolone therapy via the Internet. Ever since the research forum went on line, the Fluoroquinolone Toxicity Research Forum hosted by Yahoo has received thousands of reports, including numerous associated fatalities. The homepage for the Fluoroquinolone Toxicity Research Foundation, www.fqresearch.org has accumulated over 4000 medical journal entries, newspaper articles, post marketing reports, lawsuits and other such supporting data the clearly shows the rampant ignorance and denial within the medical community regarding the non-abating nature of such events.

For more than forty years, since the introduction of Nalidixic Acid in 1962, the victims of fluoroquinolone toxicity have been denied the medical care they so desperately need as their physicians have routinely failed to recognize, treat and report such events. Peripheral Neuropathy, spontaneous tendon rupture, severe and non abating joint and tendon damage, resulting from such toxicity, are all known, listed and published adverse drug reactions to these chemotherapeutic agents, commonly referred to as fluoroquinolones or quinolones. Yet the victims continue to be told by their physicians "it cannot be the drug".

Numerous news stories since the anthrax scare back in 2001 have documented such injuries, with the most recent being the death of the daughter of one member of the research forum, whose death was the direct result of such careless scripting of these toxic and dangerous drugs. Another forum, the quinolone adverse drug reaction forum, hosted by Yahoo since February 14, 1999, has accumulated over 57,000 such post regarding the damage this class of chemotherapeutic agents can and will do. The law firm of Sheller, Ludwig and Badey, one of the largest class action and medical malpractice firm in the Northeast, had filed a class action lawsuit against Bayer AG, the manufacturer of Cipro. This suit was filed on behalf of all those who have suffered such damage including the Capitol Hill Staff, the Washington Postal Workers, and the employees of the American Media who were exposed to Ciprofloxacin as a result of the Anthrax Scare. This suit was later withdrawn alleged to be the result of the astronomical cost of such litigation.

In spite of the overwhelming evidence of the non-abating nature of such injuries, the FDA continues to approve new drugs within this class together with new indications for those already on the market. Ignoring the 9,711 reports that include 806 associated deaths and 39,128 total reactions found within the AERS reports for Levofloxacin. (Levaquin Nov. 1997 - May 30, 2007) In 2004 these numbers were 5,276 reports, 473 associated deaths and 19,792 total reactions respectively. Together with the 8,766 reports which include 837 associated deaths and 40,395 total reactions for Ciprofloxacin found within the AERS reports as well. (Nov. 1, 1997 - June 5, 2007) Where as these numbers were 4,995 reports, 480 associated deaths and 20,890 total reactions in 2004. As well as the following:

Floxin: Nov. 1997 - May 30, 2007

Total reactions: 13,495

Total death outcomes by case: 311

Total individual safety reports: 2,962

Proquin (ciprofloxacin) Nov. 1, 1997 - June 5, 2007

Total reactions: 40,151

Total death outcomes by case: 831

Total individual safety reports: 8,688

Tequin: Nov. 1997 - June 5, 2007

Total reactions: 15,494

Total death outcomes by case: 196

Total individual safety reports: 5,307

Factive: Nov. 1997 - June 5, 2007

Total reactions: 1,979

Total death outcomes by case: 7

Total individual safety reports: 1,108

Avelox: Nov. 1997 - June 5, 2007

Total reactions: 30,160

Total death outcomes by case: 337

Total individual safety reports: 7,391

Almost fifty percent of such chemotherapeutic agents have been removed from clinical practice or their use severely curtailed, due to toxicity issues. Yet, Mr. MacCarthy, the 2001 Vice President of U.S. Medical Science at Bayer's West Haven facility stated in 2001"If you are telling me that someone had these effects and they were persisting, long term, months to years after treatment I would be surprised."

The members of the Fluoroquinolone Toxicity Research Foundation had been telling Mr. MacCarthy's employer exactly that for years prior to him making such a statement to the press. Those within the media who have an interest in interviewing those who "had these effects and they were persisting, long term, months to years after treatment" are welcomed to visit our website and forum. For we state unequivocally that Mr. MacCarthy was being less than forthright in the statements he had made back in 2001. Such documentation has been made available to the firm he works for year after year. The adverse reactions experienced by the members have shown to be both persistent and non-abating, "year after year", contrary to what Mr. MacCarthy had stated publicly. As one member of the forum so eloquently stated, "Mr. MacCarthy is mistakened"(sic) as we have the documentation as well as hundreds of such victims to prove all that we state here which is available for public scrutiny.”

Those within the media who have an interest in interviewing those who “had these effects and they were persisting, long term, months to years after treatment” are welcomed to visit this any one of the thousands of such websites found on the Internet as well. Mr. MacCarthy apparently could not be bothered to take the time to do so prior to making the comments that he had in 2001, in my humble opinion.

Here we are SEVEN years later, and we still continue to hear such denials from the manufacturers and the medical community even though these numbers have increased dramatically. Levaquin has been reported as having the most numerous, non-abating and severe adverse drug reactions associated with its use on Mediciations.com

A review of the online adverse drug reaction reporting forum: www.Medications.com (October 2002 – February 2004) revealed that Levaquin was associated with approximately 17% of ALL adverse drug reactions being reported to this site, irregardless of the drug being reported upon. Medications.com started receiving such reports as of October of 2002. Medications.com is an Internet community that allows people interested in commonly prescribed drugs to interact so that they can discuss the implications -- both positive and negative of using these important tools in modern medicine. Medications.com list over 4,500 drugs in common use to date, users have posted thousands of side effects and messages about many of these drugs.

The total number of adverse reactions, regardless of the drug mentioned, as of 2-11-2004, totals approximately 4,469. Levaquin, by far, received more such post than ANY other fluoroquinolone drug listed on this site. Of the 774 adverse reactions reported for all of the fluoroquinolones listed, 752 were for Levaquin. The only fatality listed for a fluoroquinolone was for Levaquin. 97.5% of all adverse reactions to the fluoroquinolones were reported for Levaquin. As such reports are received anonymously the verification of such reports was not feasible nor did we attempt this. But one can assume that receiving this many reports over a sixteen-month period that the majority of such reports are indeed valid. This study also lacks the necessary controls required to present the above as fact and as such should be viewed for debating purposes only.

A review of the side effects posted on Medications.com (October 2002 – February 2004) for the fluoroquinolones used in clinical practice in the United States revealed the following:

Avelox 8 post

Ciprofloxacin 7 post

Floxin 5 post

Levaquin 752 post w/(1) fatality

Tequin 2 post

The predominate adverse reactions reported for Levaquin are as follows:

Nuerotoxicity

Tendon Damage and or rupture

Insomnia

Non abating injury (multiskeletical)

Peripheral Neuropathy

Gastrointestinal

Anxiety and Panic attacks

Vision Problems

Rash, sweats, taste perversions, hearing loss

ALL of which those who suffer such reactions are being told by the treating physician to have no association with fluoroquinolone therapy. This trend is repeated on a number of adverse drug reaction forums dealing with the adverse drug reactions as they relate to the Fluoroquinolones. As the above data has not been verified other than visiting this site and doing a physical count the absolute accuracy has not been determined.

Since the time that this analysis was performed the numbers have increased so dramatically to the point that it is no longer feasible to even attempt such a comparison today. And yet the NUMBER ONE drug with the most adverse reactions, as well as the most severe adverse reactions, continues to be levaquin on that site.

In spite of the overwhelming evidence presented at that 62 Meeting of the Anti-Infective Drugs Advisory Committee that the fluoroquinolones cause irreversible joint damage in the pediatric population the FDA has recently added the use of Ciprofloxacin in the pediatric population, Treating children as young as one years of age. We are currently faced with a clear and present danger regarding these drugs as the FDA, ignoring the tragic results of such careless scripting, has now authorized this use knowing full well that the physician will continue to abuse their discretion.

I challenge the FDA to explain to me how they expect a child who cannot even walk or talk yet to register a complaint of joint and tendon pain. Numerous studies have indicated that such use in a pediatric patient runs the risk of crippling the child for life. One such patient has undergone numerous surgeries to repair this damage and remains crippled to this day. Yet additional clinical trials continue aided and abetted by the FDA, for other drugs in this class other than Ciprofloxacin. A disaster that is detailed within the 62nd meeting of the Anti-Infective Drugs Advisory Committee where it was so eloquently stated:

“…when we talk about the issue of arthropathy that potentially includes a number of things, ranging from simple effusion, for instance, of a knee joint, which might rapidly resolve after the conclusion of therapy, to a more permanent disability. ..” (sic)

“…in September of 1997 there is now a ciprofloxacin suspension which is available, and although it continues to have the same warning statements about arthropathy in juvenile animals and the potential concern in pediatric populations, obviously, the issue of off label use will extend over to pediatric populations in this formulation….”(sic)

“…An important safety question is, what adverse events should be monitored, and Doctor Goldberger alluded to this earlier. This is some of the examples I present. One is permanent lameness, reversible lameness, joint effusion, joint pain, and even latent articular disease or damage that may occur months or years following drug exposure, and there may be others….”(sic)

“…And, data submitted to the Agency, as well as data from the scientific literature, indicate that these lesions don't appear to be reversible…”(sic)

“…Doctor Stahlmann in Berlin is working on an idea that it may be an effect between the endocrines, the magnesium and the matrix and the quinolone. And that data is just coming out now. But as to the exact mechanism, I think you're right. I don't think we have a handle, as far as I know, on the exact mechanism. If there's anybody else that does, I'd sure like to hear it…”(sic)

“… Relating your personal experience, I was wondering about the potential for a delayed effect that in fact one might have a patient who had some histologic changes that would not be manifest clinically for many years. Is that a potential?” (sic)

“… I think it is a potential…”(sic)

“… In trying to assess toxicity with a very sensitive assay, obviously you've got tissue that you can look at in your animal models. There is some human data that were collected by Doctor Urs Schaad using MRI scanning in children and I'm wondering if you can correlate some of your histopathologic findings with MR in the animal model to give us an idea of how sensitive it would be sort of as a follow-up to Doctor Klein's question is the MR something that will be able to predict long-term outcomes, even if there are no clinical symptoms during therapy….”(sic)

“… That I don't know. I'll just be perfectly frank. I don't know. But on the slides I've seen from the animals from the chronic study, the repaired articular cartilage that is there is principally fibrocartilage yet it will provide the same joint margin and it has a calcified base and when we stain it with safrain O screen there's no proteoglycans there so it's going to make it an extremely chondromalaistic area and beyond the one year I can't tell you what the results will be…”(sic)

“…Anyway, it was by a group in Vienna where they looked at the articular cartilage of postmortem specimens of articular cartilage from kids with cystic fibrosis that had been on quinolones for a period of time and they found that there was damage in the chondrocytes….”(sic)

“…There were no deaths reported in U.S. pediatric zero to 18 year old cases where a flouroquinolone was reported as the suspect drug. However, there are eight deaths in the whole cohort of suspect and concomitant flouroquinolone drug reports in the system. Five of these deaths reported ciprofloxacin as a concomitant drug and not the suspect drug. These five were U.S. cases with ages ranging from seven months to six years. The remaining three deaths were all foreign, all 18 year old patients with either ofloxacin or norfloxacin reported as the suspect drug….”(sic)

“…There are 14 reports of arthropathy or arthralgia in the pediatric zero to 18 year old flouroquinolone reports. One report of a 14 year old girl had both ofloxacin and lomefloxacin as the suspect drug so there is an extra count because of the two flouroquinolones on this one report. This particular report indicates that a pediatric orthopedic surgeon diagnosed femoral anteversion as the cause for the girl's arthralgia, therefore you see it listed twice, and not the flouroquinolones. Most of the reports indicated that either an involved knee or elbow with or without other joints was involved….”(sic)

“…One interesting case which is not included on this slide for arthralgias was a 15 year old boy who received ofloxacin IV for an emergency appendectomy and had not grown more than his 70 inches in height over the last year. The 15th percentile for height for a 15 year old boy however is 66.5 inches and the expected growth rate is about two inches per year…”(sic)

“…Three patients had their seizure after the first dose of flouroquinolone, one on ciprofloxacin and the other two on ofloxacin, one of which had received ofloxacin several months earlier…”(sic)

“…The 15 psychiatric reports are a loose grouping of reports which include events ranging from euphoria to psychosis. The ages range from five to 18 years with the median at 15 years. There were two suicide attempts, one on ofloxacin and the other on norfloxacin, three reports of hallucination, one each on ciprofloxacin, ofloxacin and norfloxacin, and one report of aggressive behavior with confusion in a patient who had a psychiatric history and was on norfloxacin. The seven cases of photosensitivity were reported with lomefloxacin with one case on ciprofloxacin and two cases on ofloxacin. …”(sic)

“…I will mention that there were 152 U.S. cases aged zero to 18 years in the U.S. AERS system suspect flouroquinolones in the WHO line listing. The country with the most pediatric reports in the WHO foreign reports is the United Kingdom with 177 reports followed by Germany with 72 and France with 71. The rest of the countries had 20 or fewer reports….”(sic)

“…And with regards to muscular-skeletal events, 21 percent of the patients had an event in ciprofloxacin…”(sic)

“…We have focused our analysis on joint disorders and pefloxacin. 79 cases were reported and consist mainly of arthralgia. I don't know the pronunciation of hydrarthrosis -- 49 persons. It involved the knee in 52 cases, the wrist in 20 cases, the elbow in 20 cases, the shoulder in 6 cases, the ankle in 5 cases, and the hip once. It is associated with a functional discomfort in all cases, and when the duration of this discomfort is known, it can persist more than one month in 61 percent of these cases. But the outcome was favorable in 58 cases without discontinuation in two cases. …”(sic)

“…There have been sequelae in three cases with knee effusions persisting one year later in one case with discomfort following 8 months later in the second case. The third case is articular. It is a 17-year-old patient who experienced arthropathy and the drug was not suspected and the treatment was continued two following months. It leads to destructive arthropathy of the knees and the hip and prothesis was performed three years later. He was treated for a cerebral abscess. The outcome was unknown in 18 cases. In 9 cases, there was no follow-up. In the 9 last cases, we had a follow-up three months later and patients were not -- were still with disabilities and after we have no evolution….” (sic)

“… It is my understanding that one of the children had a joint replacement, is that correct?”

“ Pardon me?”

“ One of the children with the complications had an artificial joint replacement?”

“Yes.”

“…If an irreversible cartilaginous lesion can occur, it is very likely that is going to cause problems down the line and we can't even anticipate what they are like…” (sic)

In spite of the following proven horrendous side effects:

Permanent disability

Permanent lameness

Joint effusion

Joint pain

Latent articular disease or damage that may occur months or years following drug exposure

Lesions that don't appear to be reversible

Potential for a delayed effect that would not be manifest clinically for many years

Damage in the chondrocytes

Eight deaths (five of which involved Ciprofloxacin)

14 reports of arthropathy

Seizures

Stunted growth

Suicide attempts

Hallucinations

Photosensitivity

Knee effusions persisting one year later with destructive arthropathy of the knees and the hip

(And with regards to muscular-skeletal events, 21 percent of the patients had an event in

Ciprofloxacin)

As one member of this advisory committee stated “…If an irreversible cartilaginous lesion can occur, it is very likely that is going to cause problems down the line and we can't even anticipate what they are like…”

As such the FDA has no idea what risk these children face nor how to treat such events once they occur.

Yet in conclusion this committee stated “…We clearly want to encourage development of these drug for use in pediatrics…”.

Within the newest package insert for Ciprofloxacin we find peripheral neuropathy being added as a severe, non-abating adverse drug reaction. A disease state in which the peripheral nerves are so badly damaged the patient will spend the rest of their natural life in severe, non-abating pain for there is no treatment protocol available for such a disease state that offers any relief. But we see no “Black Box Warning” concerning this. Of additional concern is the fact that there are also ongoing clinical trials regarding the use of other chemotherapeutic agents within this class involving pediatric patients as young as six months of age.

For more than forty years since the introduction of Nalidixic Acid in 1962, severe and permanent injury to the patient has been documented. Not one year in the past twenty six has gone by without additional articles being published in the leading medical journals documenting the horrendous damage these drugs can and will do since the introduction of Nalidixic Acic. Now the FDA has given their blessing on the use of chemotherapeutic agents within the pediatric population.

The use of these drugs will NOT be restricted to the approved indications either. The FDA has stated “…obviously, the issue of off label use will extend over to pediatric populations …” So now a child with a minor ear ache or sore throat will risk being crippled for the rest of their lives and the FDA will continue to turn a blind eye to such abuse for it is NOT within the legal rights of the FDA to control how such drugs are used once they have been approved. The FDA has no say in the manner in which a physician chooses to utilized a drug once it has been approved.

As such we now look forward to a whole generation of pediatric patients being destroyed by the careless manner in which such drugs are utilized and the treating physician will continue to fail to recognize, treat and report such events. Just as they have been doing for the past forty six years. Numerous forums now exist on the Internet in which the adult patients have been reporting such severe reactions since 1999. We can all now look forward to the distraught parents of these children joining such forums as a direct result of this total and complete failure of the FDA to protect the health and welfare of the pediatric population. Ignoring their own research and the findings of their advisory committee, they have approved a proven dangerous and toxic drug for the use in children.

The Fluoroquinolone Toxicity Research Foundation continues to collect post-marketing reports regarding the non-abating nature of the severe and crippling (and at times fatal) adverse drug reactions associated with fluoroquinolone therapy via the Internet. Since one of the first such forums went on line back in 1999, over nine years worth of horror stories regarding the damage these drugs can and will do have been forwarded to the FDA. In spite of the overwhelming evidence of such severe and at times fatal adverse reactions, the FDA continues to refuse to take action. In a letter we received from the FDA, (circa 2004) Frances T. Gipson, FACHE Office of Executive Programs Center for Drug Evaluation and Research, stated that “…we will weigh all risks and benefits associated with Fluoroquinolone Class Drugs prior to taking any additional action…We will continue to monitor future adverse events reported to us.” To add insult to injury regarding such inaction by the FDA, Gipson also states “…It was also noted that the majority of those adverse events reported are well-known side effects of the Fluoroquinolone class of drugs…” Three years later (circa 2007) Public Citizen received a reply from the FDA to their petition seeking Black Box Warnings stating the very same thing almost word for word. So did the Attorney General of the State of Illinois in response to their petition filed a year earlier.

For more than forty six years, since the introduction of Nalidixic Acid in 1962, the victims of fluoroquinolone toxicity have been reporting such “well-known side effects”, only to be denied the medical care they so desperately need as their physicians have routinely failed to recognize, treat and report such events. Peripheral Neuropathy, spontaneous tendon rupture, severe and non abating joint and tendon damage, as well as fatalities resulting from such toxicity, are all known, listed and published adverse drug reactions to these chemotherapeutic agents, commonly referred to as fluoroquinolones or quinolones. Yet the victims continue to be told by their physicians “it cannot be the drug” and the FDA continues to “monitor future adverse events.” It surely does not get any sicker than this.

Numerous sites continue to be added to the Internet dealing with these reactions in an effort to draw media attention to those of us who are left outside the city gates, like lepers to be pitied and ignored. On any one of these sites you will find tens of thousands of case histories, posted in the very words of the victims themselves, which describe the horrific suffering they or their loved ones have endured as a direct result of the FDA’s failure to prevent such carnage. You will also find postings regarding those who have forfeited their lives due to the rampant ignorance regarding the adverse reactions associated with these chemotherapeutic agents.

The recent addition of this frivolous “Black Box Warning” only emphasizes the fact that such adverse reactions experienced by such victims have shown to be both persistent and non-abating, “year after year”, contrary to what Mr. MacCarthy had stated publicly seven years ago. The comments made within the video presented by the good doctor from John Hopkins emphasizes the fact that NOTHING has changed since then either when it comes to the rampant ignorance found within the medical community.

Since 1999, over nine years ago, we now have added over fifteen different sites to the Internet that deals with these issues. All dealing with what Mr. MacCarthy claimed to have no knowledge of. Perhaps he may wish to read the postings under “In Fond Memory Of” on the fqvictims site. It has been stated that “dead men tell no tales” but thanks to the efforts of those involved with bringing this new site on line; they have been given a chance to do exactly that. For you will find post after post detailing the horrendous manner in which such fatalities related to the careless and thoughtless use of these dangerous drugs, have occurred. No doubt Mr. MacCarthy has no knowledge of the permanent nature of such reactions either. Over a thousand documented fatalities, forty thousand severe adverse reactions, four thousand medical journal entries, fifteen new adverse reaction websites, nine years worth of post marketing reports, and the FDA continues to state that they intend to “continue to monitor future adverse events reported to us”. The victims continue to report the carnage, yet no one is listening. Perhaps with this “new” warning, somebody, somewhere, will. But somehow I rather doubt that we will find that they work at the FDA.

You would also note that Internet sites that published this new warning and allowed people to post a comment have been overwhelmed with patient’s complaints. I rather doubt that this would be taking place unless the drug in question is truly defective. People have far better things to do with their time I would imagine.

Mr. David T. Fuller

Director

Fluoroquinolone Toxicity Research Foundation

www.fqreseach.org

fqresearch@aol.com

davidtfull@aol.com

About the Fluoroquinolone Toxicity Research Foundation

The foundation is a non profit organization consisting of those who have suffered irreversible and non-abating injury as a direct result of fluoroquinolone therapy. The foundation is dedicated to presenting the research regarding these issues in the hope of preventing such injury to others and to make such research readily available to those who have shown a prior interest. We strive to present accurate and up to date information to the victims of such scripting abuse so that they may be in a position to receive the medical care such rampant ignorance has denied them. Such documentation is readily available via the forum or the homepage www.fqresearch.org

The author of this Editorial has NO financial ties whatsoever with anyone found within the legal or medical field. There are no known conflicts of interest to disclose, and the Foundation has never accepted any donations, of any kind, from any person, corporation, or special interest group since it's inception.

When my bp, which had always been VERY low, rather suddenly skyrocketed at age 48 (possibly as a long-term effect of the preeclampsia I had 23 years ago when pregnant with my daughter), I was put on 10 mg of Lisinopril. I had diarrhea by that evening. The next day, the diarrhea thankfully disappeared, but other flu-like symptoms set in--mostly nausea and muscle weakness/fatigue. The nausea often made it hard to eat, and the muscle weakness was so bad that sometimes I'd have to stop what I was doing---even typing on the computer--and go lie down. Fortunately, these symptoms abated after one week, and I've been fine for the last two weeks. But now, as my bp is still too high, my Lisinopril is being increased to 20 mg, so I fear getting sick again.

After a lifetime of good blood pressure, I was so reluctant of surrendering to the fact that I needed to be on blood pressure medicine but finally did so for the fear of a risk in having a stroke. My doctor put me on Lisinopril about 6 weeks ago. The good news is that my blood pressure is now 120/60 HOWEVER....I have had the most unusual, annoying, dry, itching cough that simply stops me in my tracks!!! It just sneaks up on me without warning and I suddenly feel like a lint ball is stuck in my throat and I can't swallow and the tears pour down my face. I cannot even walk into the post office without a bottle of water in my hand for fear of an attack coming on. The only relief I can get is to drink water. It really hits me at night when I am trying to sleep...so guess what I DON't get much sleep!!! I went thru 1 gallon of water 2 nights ago!!! Along with this condition, I have also felt extremely irritable!!!! I did have enough sense to know that the level of anger or the amount of tears I was experiencing seemed to be over amplified. Thanks to my good friend for caring enough about me to discover this web site so I can discontinue this medicine. No more high blood pressure but I may just choke to death!!!

Wow, had I seen this webpage before last year I would have never had my Mirena put in.... that was April 2007. Since then:
1. I have had constant extreme fatigue, sometimes to the point I feel I am in actual 'pain' just to walk from one end of the house to the other.
2. I have noted a serious increase in gray hair all of a sudden, which does not run in my family on either side.
3. I have had a significant weight gain, and I too appear to be several months along due to the bloating.
4. I have inconsistent rashing that flares up on my face. Seems to be triggered by being in direct sunlight, but it is almost always on my chin area and feels as if my skin is on fire when it happens.
5. I cannot seem to get enough sleep.
6. I cry for absolutely no reason, something of which I never did before.
7. I have had, the past few weeks, had severe pain in my lower back area. I've never had pain like this before down there.
8. I've had numbness in my left foot, but I attributed it to a skating injury, something my trainer said had never happened to any of the other girls before... doctor said it should have healed in a month. It didn't.
9. I have never in my life had acne before, and I think in the past year I've had more zits than I've had my entire lifetime.

That's it for me that I can think of. I have an appointment to have it removed in a few months. I'm done with this thing.

I too had HORRIBLE experiences on Toprol-XL. I was put on it after I walked into a doctor's office and my BP was 235/152. Yep..you read that right! Scary times. I started taking the med, and I too gained 35 pounds with no change in diet. I was tired, weak, groggy - I honestly felt like I was slowly dying. At that point, I decided that high blood pressure was far better than the experience I had on Toprol. It ruined my marriage. Can you say ZERO libido? I decided that I would try a different form of metroprolol - metroprolol tartrate versus succinate. I did this when I went out of town - I honestly thought my heart was going to pound out of my chest - coming off this medication was horrible, and if the other posts are true about this being worse to come off than opiates, I REALLY feel for addicts now. I have been off the Toprol now for about 9 months, and I feel so much better. I've lost what I call the Toprol weight, and I made some life changes. I did the following: (A) I purchased a rebounder (mini-trampoline) and have built up from 5 minutes per day to 15 minutes per day (goal = 40 minutes per day) - there are HUGE health benefits in rebounding and it's really easy on my joints (google the benefits - I promise you won't be disappointed). I turn on the TV or turn on my Ipod and bounce away. (B) I joined Freelife International, and began drinking Go Chi juice (www.pbowen.freelife.com) because it has three scientific studies proving its effectiveness. (C) I stopped drinking caffeinated soda and began drinking a homemade blend of green (matcha) & darjeeling teas (if you want the recipe, e-mail me and I'll send it pamela.bowen@gmail.com), and (D) I bought a device called RESPERATE (www.resperate.com). I HAVE MY LIFE BACK!!! Don't think you have to live the way you are forever!

I've been taking Topamax for a couple of months now to help with my lifelong (I'm 47) migraines. I had been taking at least 10 Axerts each month, using Amyltriptyline about twice a month, and had completed one lifetime's supply of Aleve (my belly revolted so it's only Tylenol for me from now on). I'm on 100mg and have very mild tingling, which I tell myself is a message that I don't have a migraine (hooray!). For me, this is a wonder drug - it nearly completely prevents my suffering. The problem is that I have absolutely raging diarrhea. I've spent weeks on the BRATTY diet & using probiotics to no avail so I've begun dropping my dosage to 75 mg to see if that helps. I would do nearly anything to continue taking Topamax.

Interestingly, I had more fuzzy brain problems taking excess Axert & Amiylriptyline than I do now on Topamax. I feel much less like I have ADD now. Amazing how differently meds affect different people.