Lipid symptoms and conditions

I am 39 years old and work for an interventional cardiology medical device company in Tokyo, and so know the importance of controling one's cholesterol, keeping the LDL's low and the HDL's high. About two years ago, my doctor put me on 10 mg of Lipitor. Several months later I herniated a disc in my neck between C6&C7. From that point onward, I attributed all of my neck and back pain, and newly acquired total body muscle and joint pain, to the herniated disc, it made the most sense. Over the last seven months, I have really worked on my diet and began to exercise more (even though quite painful) and was able to lower my cholesterol. This resulted in my doctor lowering my Lipitor prescription from 10 mg to 5 mg. I noticed a slight alleviation of the pain I felt in my hip joints and calves. About two weeks ago I took myself off Lipitor completely and found further improvements in my total body muscle and joint pain. It's still there but greatly improved. In retrospect, I now believe the Lipitor may have been the culprit (or at least a contributing factor) to my herniated disc due to muscle degeneration in the neck, and all of the subsequent muscle pain, especially in my hips and calves. I fully understand I am not going to die from calf-pain, but may from heart disease. However, I have found my quality of life has improved tremendously over the last few weeks. Less irritability, better sleep, less pain, clearer head. I feel like I have lost two years of my life on Lipitor via personal suffering and lack of ability to do much of anything with my wife and two young daughters. We all need to take charge of our own health and therefore I encourage anyone who feels completely different after taking Lipitor to engage your physician, and make sure its the right option for you. If damage has been done to my musculature I hope I can reverse it. It is evident to me that some serious clinical studies should be done to investigate Lipitor's effect on muscle degradation and hope others will consider carefully whether or not do go on this drug. If you do, monitor yourself closely.

I must be living in a vacuum without knowing it. I have been on Lipitor for a few years now. I do slur words on occasion... the cramps are occasionally unbearable. I get cramps in my rib cage, legs, feet and have to watch myself making move like reaching for something that requires anything other than a normal move or twist.. or I get a cramp. I also get cramps in my hands, muscles knotting up with horrible pain... I have to watch how grasp things my fingers.... occasional just cutting a steak holding the knife or fork and applying pressure... I had a discussion with a complete stranger today who said he had similar side effects with Lipitor... I thought it was old age (I'm 62).... and not very physically active. I looked it up on the internet and found this very informative site.

husband and brother in law both diagnosed with Parkinson's disease. dear friend's husband diagnosed with Parkinson's 3 months later . all had been on lipitor for 2-4 yrs. brother in law has died--diagnosis changed prior to death from Parkinson's to Parkinson's with lewy bodies, to Lewy body dementia to frontotemporal lobe dementia (despite NO family history of this disease entity). there are SO many metabolic substrates whose pathways are interrupted by statins--pathways to isoprenoid metabolism resulting in among many other results, a decrease in glutathione reductase; a decrease in production of coenzyme Q10; decrease in dolichol, the lipid consittuting the largest % of fats making up the substantia nigra in the brain (area diseased in Parkinson's ). and lipids constitute the substance that makes up the mylein sheath surrounding nerves, and the largest % of the dry weight content of the brain.
Tremors were the first symptoms. then non swinging arm while walking, flat affect, rigidity of muscles. all symptoms of Parkinson's...

Despite having a brush with the big C last year (I finished chemotherapy in January) I have been very fit and healthy during my 61 years! A few weeks ago I started having palpitations, hence a visit to the doctor revealed high blood pressure and cholesterol reading of 9.9!!! Shock, horror. He informed me that it was genetic and prescribed Simvastatin 400mg and Bendroflumethiazide 2.5 mg daily.
Not being satisfied with the enclosed leaflets I have looked up more info. on the net. Should I have done this!!! After reading some of the posting on the site I am feeling a bit apprehensive. Last night I had a terrible night couldn't sleep for the pains in my legs and a bit nausea this morning.
But I need to be sensible, I really don't have any choice but to take these drugs just hoping that I won't have to stay on them for the rest of my life and I don't get any of the side effects that some of you have suffered. I also wonder if the chemotherapy could have caused by raised cholesterol?
Hope to keep you posted and would welcome any comments!

2 yrs. ago my husband had been on Vancomycin for an infection from a hip operation. He had an allergic reaction and was given Levaquin in the ER. Not long after the dose was given, he was not able to walk at all his fever spiked and he said he was blind at one point. It did not last but since then he had been slowly declining. He has trouble with his inner ear balance and he can hardly lift his right foot to clear the floor. He bearly feels anything from the knee down on both legs. We have been to many specialists/neuros, MRIs, nerve conduction test and there is nothing to show what is the cause. Can anyone tell me how we could find out for sure if Levaquin may be the culprit.

Sue

To all the people who are just starting to make the connection between their symptoms and Levaquin or other fluoroquinolone antibiotic: There is a lot of information available on the internet. Check out the following websites: fluoroquinolones.org, antibiotics.org, medicationsense.org, fqvictims.org, fqresearch.org. There are also support groups on yahoo for sufferers. Please don't forget to file a medwatch report with the FDA. Finally the FDA is starting to listen to the victims!

I have had progressive muscle weakness, pain in my joints with swelling of the knees, ankles and hips. My doctor said it is not related to the antibiotic and to continue taking it. The symptoms are so disabling I can barely make it to the bathroom alone and I have had to miss work. I also told him the inside of my throat felt swollen, and my tongue is turning white. It just isn't a pleasant drug to be on.

After 3 days of Levaquin at one 500 mg pill per day for a sinus infection and swollen lymph node, I suffered severe pain in the calf muscles of both legs and am only able to walk short distances, if at all. This started yesterday and I have stopped the drug, am icing my calfs, relying on friends to help me, and praying that there has been no permanent damage.

since taking Levaquin I am not able to smell or taste...anyone else have this happen?

I have been on 500mg of Levaquin for 8 out of a 10 day course. I can barely hold my head up, have a headache and severe neck and muscle pain. My stomach is so queezy and I have been unable to get a full night sleep.

Anyone experiencing the same?
I am afraid to take the last 2 days of the course.

I took CIPRO for an inflamed gall bladder for two weeks. Two days after I stopped I started to get pain in my left ankle, both elbows, neck and shoulders. I could hardly sleep at night as the pain would not leave. I never knew that CIPRO did this much damage to your body.
J.Nunez
Violet, LA

I did not think I had an adverse effect from Levaquin until I read that it can cause tendon ruptures. I had a year long experience including extensive
surgery from a torn tibialis tendon. I did not take Levaquin unitil I had a slight tear that resulted in a full rupture, tendon transplant, heel breaking and arch rebuilding.
I had taken Levaquin after I was put in cast to try to heal my tendon, which never happened. Could Levaquin have had something to do with this.
My problem with my foot happened in 12/06 and my first dose was during the month of January 2007. After I had recouped in November of 07 I also took levaquin in March of 08.
Please let em know if this could have had an adverse effect on my situation
and what I could do about this.

My husband has COPD and was prescribed Levaquin along with prednisone for bronchitis. He developed acute tendinitis in both achilles tendons and then the right achiiles totally ruptured about 6 weeks later. It has been a nightmare for him.

It is so important that everyone who has suffered an adverse affect report it to the FDA. Unless they receive these reports, they do not know how serious this problem really is and most doctors are totally oblivious.

July 8,2008
In October 2007 I had surgery to remove a salivary gland. Due to severe infection, I was on 500mg of Levaquin for 20 days and an additional 10 days of Avelox. While taking the medication I suddenly had severe leg and knee pain. At times I could hardly walk. I would be awake a night with severe pain in my knees and legs. I also had the tendon in my left shoulder start "snapping" while sitting in a chair. My shoulder became so bad at one point that I could not lift my arm. I never related any of this to Levaquin until at a later date learning of this kind of damage. My shoulder finally got better after weeks of not using it. I still am experiencing pain in the muscles and tendons in my legs. I have just started seeing my doctor about it this past week. She has me taking Celebrex, which has helped somewhat. I keep hoping that tendons will heal eventually.

It is quite amazing how when the story hits the news, the number of postings here jumps up! How sad it is that many people now realize the same things that many of us have known for quite some time. I only hope that the floodgate have now opened and that everyone will now keep the pressure on to limit the use of thee dangerous chemicals.

After 20 months I have had my right distal tendon surgically repaired, I endure tremendous pain in my left arm daily, and I fight the other unmentionable adrs. A black box warning is a start but it is not nearly enough.

New side effects: intense anger with the FDA and drug manufacturers, distrust of the medical community, and the required development of pain management skills.

I took Cipro many times but in November I took it with a prednisone dose pack, this seems to make the tendon issue worse according to todays report.

I have had severe achiles tendon pain for 7 months now. I can't bend my ankle when I walk. I also had surgery for a torn rotator cuff in December, no injury to my shoulder, it just tore.

I have wide spread tendinitis an now I know why. Is this a temporary situation? I hope!!!
ksquared

I have taken Levaquin on and off for the past few years for sinus infections. I am now recovering from my third aquillies tendon surgery where they had to remove/replace the tendon because it was torn beyond repair. I didn't understand how this could happen until I saw the news release yesterday. I will never take this again.

Saw Levaquin on the news yesterday. I was very pleased to see that they are putting a warning on this med. I thought it was just me with a problem with Levaquin. I have allergies to antibiotics anyways so I attributed my problems to just another allergic reaction to an antibiotic. Wow!
I took Levaquin in April 3 years ago for a respiratory infection of some kind. I then had the same experience I have with allergies where my tongue felt swollen. I called the nurse and she told me to take the next dose anyway. I did so and my chest/esophagus felt like it was on fire. I couldn't breathe. I went into the Emergency room and they gave me a lidocaine/maalox combo that would take the pain away for a while and diagnosed me with reflux.
I went on some reflux medications later that caused more problems for digestion. The more we tried to solve it the more my system reacted. I ended up in the emergency room about 5 times that year. Two were for chest pain from the esophagus and two were from severe allergic reactions (anaphylaxis). I became allergic to many categories of food and lost down to 110 lbs. I went to naturopaths and other specialists and none of them could pinpoint any problems. I was tested for Celiac and had two upper GI and one lower GI that year alone, My Dr. bills totalled more than $5,000 for that year.
The next year I had given up. The only doctor that I would go to was the allergist and the new GI doctor I had found. I still worked but was in such severe pain that I did nothing but sleep when I got home. I cried and begged God for death or healing all night long. I was losing my hair in great handfuls. They put me on ativan and I became addicted to the stuff. I was allergic to most foods. I had a diet of about 6-10 foods that I would cook homemade and I would never eat out unless I knew what and how the food was prepared. I took vitamin c in very high doses and that took the pain away.
I slowly re-introduced food back to my system. Now I have a less restrictive diet but it still is limited. I am now allergic to all nuts, rice, sunflower seeds (sunflower oil is used in most potato chips), some other grains, and melons. I still have problems with legumes and some other foods.
It took 2 years for the pain to subside and I still have digestive problems with diarrhea on and off. I am fine just as long as the pain stays away. I don't mind being limited on my diet.
I had noticed that my legs and joints hurt during that time too- but the other pain was so severe and my diet was so limited that I attributed that to diet.
If there is a class action lawsuit on this stuff I would like to be involved.

Sorry, meant to say -"The warning packet and the website for Avelox both state not to combine Avelox and Prednisone, as well as using caution when prescribing for the elderly, which i see some of your doctors have NOT done"

On 7-1-08, I went to the doctor for ETD(tubes blocked) and a Sinus infection. The doctor prescribed Avelox for my symptoms. I began taking this in the evening and by the following morning I developed mild stomach pains. I went through the day in discomfort but did not think that I needed to go back to the doctor. By the evening (2nd pill) the pain in my stomach increased 10 fold. The pain would come in waves about every minute. It felt as if someone was sticking a knife in my stomach.

This continued through the night and into the morning. At 8am, on th 3rd, I was back in my doctors office to see what was going on. They told me to stop taking the Avelox and put me on a different medication. I then went and spoke with the pharmacist who suggested that I try some over the counter gas relief medicine. I took the gas relief medication and it decreased the pain to a mild stomach ache.

It is now the 7-5-08 and the mild stomach pains are still here. I thought about going to the E.R. to have blood work done to see if there is some sort of medication that can counter-act the Avelox. I will wait one more day. I will never take this medication again.

within two days of taking metronidazole for a gum infection i had horrible pins and needles the worst crushing headace ive ever had anxiaty panic attacks and couldt sleep for a week this medicine is the nastiest side effects ive ever had .i just got back from hospital where ive been for two days as my symptoms were so bad docs thought the infection in my gum had traveled to my brain, but after a ct scan,lumber puntcture, blood tests all came back clear they decided it was the tablets. it will take me a long time to get over this , i would advise anyone with a history of panic attacks,depression or headaches not to take metronidazole.

My Dad,a 78 year old highly functioning man, was admitted to the hospital last Wednesday evening, June 25, with a case of bacterial pneumonia. They gave him his first dose of Avelox, at 10:00PM. Twelve hours later, he was hallucinating, agitated, had an irregular racing heartbeat. He also had severe tremors, shaking. They gave him more medication for his heart and transferred him to the cardiac unit. They put him on a blood thinner, heart medication. Tested his heart and examined his brain. All tests came back negative. Thank God my father's heart is strong, or we probably would have lost him. 3 days later, I was on the internet researching Avelox, and noticed immediately that all of his problems were side effects of this drug. My family notified the doctor immediately and demanded that they switch my father's meds. The doctors did so reluctantly. They had never heard of these kind of side effects related to Avelox, even though it affects almost 3% of the population. My father had his last dose of Avelox on Sunday. Today, Tuesday, he is still having some "visions" and is confused. I don't know how long it is going to take for these side effects to disappear. The doctors are no help. This medication has caused my father and family severe stress, and prolonged his stay in the hospital. It has cost the insurance company extra money, since they had to do unnecessary testing on my father to try and determine the cause of his symptoms. He was also given additional meds that he never would have needed if they had just prescribed Zithromax from the beginning. AVOID AVELOX - IT COULD KILL YOU!

I took Cipro and had a persitant leg twitch, and did not think anything at the time. many symptoms came around a month later. all over body twitching, burning skin, muscle pain, tendon pain. maily on left side of body. Also, insomnia, dark circles under eyes, horizontal depressions in fingernails...just to name a few. It has been almost 2 years and I have sense been diagnosed with fibromyalgia by PC, I need to go to a ruemy. I have never had these pains until cipro and I still have all of them most of the time.
I told my mother not to take Cipro or any in the same class. She was prescribed Levaquin and called the nurse and said she did not want anything in the same class as Cepro, and thew nurse said "Oh no it is not, I did hear Cepro was bad". So she took them unaware. She was so sick after first pill. she thought it was severe flu. She could not even move her arms because of terrible shoulder pains.