Lung tissue symptoms and conditions

I have been taking lisinopril for about 2 1/2 years now. About 4 weeks ago I was having trouble sleeping, my legs hurt real bad and when I would wake up I would have a numbing tingling sensation in my legs and feet. Went to the doctor asked her if it could be the meds and she said she didn't think so and to continue to take it. I still continue to have problems, tired, weak muscles, hurt and a raw lump in the throat feeling. She sent me for a brain mri that showed white lesions on the brain. She said it could be from high blood pressure but said my has never really been that high or it could be MS. I am right now waiting to see a neuro dr to see if I have ms but after reading all these post I am wondering if it is the lisinopril. Has any one else had these types of symptoms?

Pulmonary Embolism - blood clots in my lungs which were caused by a presumed blood clot in my leg, which was caused by my Yaz. This is a very dangerous situation, and I was very lucky.

I am starting a new post in the hopes that others will see what I am trying to say about the delayed reaction in those that took Singulair for allergies.

If it is consistent that Singulair does not stop allergy symptoms immediately, then the pathways that eventually stop allergy symptoms involve a change in the mast cell function, development and migration (or some combination).

I asked this question for a reason. Are allergy symptoms stopped immediatedly. My question below:

I have a question that will help me continuing looking for information. I can understand that in the case of asthma that Singulair would provide immediate relief. If it is used for seasonal allergies or other allergies without asthma, does it work right away or does it take a period of days or weeks to be effective? If it takes time, could you tell me how long it took in your situation?

My thinking was going in the right direction if the answer below is consistent of everyone or most.

about 2 hours ago on Apr 11, 2008 by catherineevans, #7045
My granddaughter was put on Singulair for allergy symptoms without asthma. Itching, red eyes, terrible congestion, etc. dark circles under her eyes all the time. When we first put her on this, we didn't see any consistent results for 2-3 weeks, then it seemed to 'kick in.' I don't know if this helps. By the way, she was 9, now she's almost 12 and was immediately taken off when this story came out 2 weeks ago.

Then after seeing one response, I gave my reason for asking.

I asked this question because I have a theory of how montelukast really works for allergies as compared to how it works for asthma.

Asthma is a hyper-sensitive state that gets going because the mast cell has a receptor (the leukotriene receptor that Singulair blocks) that sends a signal along a pathway that causes lung tissue to have that extreme response - the wheezing, the airway constriction.

On the mast cell is another receptor the histamine receptor that causes the secretions that make our noses runs and and stuff up. This is not the same immune response as the asthma response. When I saw a post that somebody's doctor said that Singulair is an anti-histamine, NO it is NOT.

So if Singulair does not block histamine immediately and your child's allergies did not go away immediately, then maybe Singulair is working through some other means such as changing normal mast cell homeostasis.
I know that this seems like "what does this mean?" I am really writing this hoping to God that there are people reading this site that know what I am talking about.

Thank you so much for responding. Your answer actually told me what I wanted to know and confirmed my hypothesis. More answers will help. I hope others respond.

PLEASE respond about the length of time that allergies disappeared if you took Singulair for allergies.

I have a question that will help me continuing looking for information. I can understand that in the case of asthma that Singulair would provide immediate relief. If it is used for seasonal allergies or other allergies without asthma, does it work right away or does it take a period of days or weeks to be effective? If it takes time, could you tell me how long it took in your situation.

I too am on Singulair and have no side effects. But the issue is not adults on Singulair it is children it is a drug that affects them differently. My daughter is 8 years old and has been on it for 3 years. She has been exhibiting similar symptoms as all of the other children. I never thought about the Singulair. The doctor had her see counselors. I started wondering if she needed anxiety medicine. She has a lot of fear, anxiety, anger, screams, is very hateful, sad. But if she misses a dose she gets instantly sick. She has an asthma attack. So I want to know alternatives. I don't want these kids abuse any longer with this drug. I feel so bad for them and my daughter. They have suffered too long. We see the doctor on Tuesday. Anybody have any ideas.