Medical journals symptoms and conditions

I just recently posted about my experience with mirena and had then read some more posts, and I had a thought. With SO MANY of us experiencing these symptoms-can't we do something about it?? Couldn't we send copies of these thousands of posts to Bayer or whomever is the top of mirena, I think it's Bayer. Or someone who can help us! Obviously we're are not all crazy! There is obviously something going on here. I mean I want to make sure other women are aware that this product may not be the greatest thing in the world. Anyone else who has a thought on this msg or reply please.
Thanks for listening!
And blessing to all.

Hi everyone...

I thought I did all the research I could by going through medical journals but I think I'm going through the symptoms mentioned here. I haven't really gained weight but I'm super hungry all the time. The last time I had sex it burn like hell (I thought the guy I was with just sucked but it looks like it could be the ring), I'm sleepy all the time, and I'm having MEGA itching- an online doctor just told me it could be a yeast infection- my very first one :-(. Honestly, I'll be willing to stick with the ring if these symptoms go away over time since it did lighten my super heavy period (I used to wear an Ultra) but beware because my blood was dark brown for a few days. My nausea lasted 20 min after I put the ring in for the first time and I never had a migraine. Hope someone finds this post just as helpful as the others have been to me...

I am a 46 y/o male whom took lipitor 20mg for about 10 days. It was the first medication taken for me aside from occasional antibiotics. Within a week I began to develop severe nausea, weakness, postural dizziness and worst of all, chest pain at rest! I took my last dose last Saturday 8/9/08. Because of the chest pain, I went to the ER on 8/10/08 and discharged the next day after I ruled out for an MI and a negative exercise stress test. My chest pain recurred on 8/12. This AM awoke with nausea, dizziness and chest pain again. I'm going to have an adenosine stress test this PM. I consulted a pharmacologist yesterday about the metabolism of Lipitor and she told me indeed these side effects are not uncommon and in my case, Lipitor will not be eliminated from my body until probably this Sunday or early next week. Anyone experience what I'm feeling?

Thank you so much for this information. After a year of endless blood tests, specialists and other diagnostics with no answers I have been diagnosed with chronic fatigue to label a concoction of symptoms that include dizziness, extreme fatigue (I have been a runner daily for 8 years but can no longer run), regular 'infections' akin to my vagina being on fire, irregular pap smear, difficulty orgasming (previously never a concern) and so many of the other symptoms listed above that it feels like a checklist reading this amazing site. As I work in a hospital I have undertaken extensive review of medical journals to see if any clinical studies have identified concerns with the mirena - I couldn't find any and so have dismissed my symptoms as unrelated but have always had a gut feeling about it. From being extremely active and passionate about my work, I have had to scale back and back until I now work only three days and rest for the remainder. I can't thank you enough for validating my suspicion that the mirena might be the culprit - it's the only variable my husband and I can think of since the symptoms emerged. I'm going to get this stupid thing out of me as soon as possible.

I have communicated directly with Leslie Hendeles, a leading professor of pharmacology and pediatrics at the University of Florida who's direct quote to me was:
"In response to your last comment, I thing Singulair has modest efficacy, and if we take all of our patients off this drug, THEY WON'T SUFFER. This is NOT an important drug for pediatric asthma, as are inhaled corticosteroids."

Ironically, this is the same individual who was quoted in an ABC news article as saying:
"We have hundreds of children on Singulair and have never heard parents make complaints about psychiatric side effects. Moreover, there is no mechanism for this reaction … We will be telling our patients not to worry about this."

WAKE UP EVERYONE...THIS IS AN ADMITTEDLY OVERPRESECRIBED DRUG THAT HAS WORKED WELL FOR MANY, BUT HAS ALSO RUINED MANY LIVES.

The manner in which this drug is casually overprescribed by so many doctors is freakish. I firmly believe that this drug has caused countless misdiagnoses such as ADHD, Bipolar disorder and others. IT FUELS A GOOD PART OF THE ECONOMY TO PUT SO MANY PEOPLE ON THESE DRUGS. I BELIEVE THE PHARM INDUSTRY IS VERY CALCULATED IN THIS MANNER.

Question what your doctors tell you.
See my other posts under matthewct1. I dealt with a situation where my 5 yr. old son was on the road to being diagnosed with ADHD which couldn't have been further from the truth. Singulair changed him. Since he's been off Singulair everyone (teachers, pediatrician, family, etc.) unanimously agree that he does not show the ADHD symptoms like he did on Singulair.

I think that I can get my head around certain things and try to explain to you that medications do not work for all people or affect all people the same way. Well, that sounds simple enough to say - DUH. But, it is actually quite complicated chemically. Human beings are not chemically the same because we have variations in our genes. Would you be surprised to learn that about 60% of adverse drug reactions involve certain chemicals (in some cases enzymes) that we already know what these chemicals or enzymes are and what the variants are among populations groups? Some times we can predict who would have an adverse reaction to what medications if we knew what gene subgroup the patient was part of. We could also predict whether the patient would metabolize a drug at the same speed as others or not. Metabolize means utilize the drug and then discard the by-products--mostly the liver is the recycling center of chemical waste. Anything that the liver cannot re-use, the kidneys gets rid of in the urine. Speed of metabolism is a very important thing because people who are slow metabolizers might actually experience over-dose. There are other differences caused by genes that can cause different reactions according to the individual person.

I am interesting in following this site because I am wondering if the concept is flawed meaning that other parts of the body were ignored at the expense of controlling asthma and allergies of the nasal passages and lungs. OR - is there just a problem that relates to genetic differences in something such as enzymes and certain populations groups do just fine on Singulair with no problems and other people have some awful problems?

This isn't my area. But, sadly, if I can spend two weeks looking at this and come up with at least a road map of what I am looking for to answer some important questions then people who do this for Merck already know the answers. Why do I say that? Because, the adverse side effects (major categories) correspond to important areas of leukotriene receptor location and activity. Maybe not necessarily this receptor but part of a chemical process that involves this receptor.

The bottom line is that Singulair is the wrong medication for anyone that has adverse reactions. OR, there is a problem regarding the dosage that involves how fast the patient metabolizes the medication. Considering that there is a link to psychiatric adverse drugs reactions in Singulair and some medications for depression are linked to differences in metabolism due to enzymes, then there could be possibly something important to be learned from Singulair adverse drug reactions.

The biggest problem is that pharmaceutical companies are not properly communicating with the doctors who prescribe their medications. Why not communicate to doctors to look out for side effects and be aware that there are gene variations among people that are directly linked to how the patient might respond to the medication?

What happens if the patient belongs to the gene group that will have problems? If the pharm company does not tell the doctor to be on the alert, then the doctor tells the patient that it is not the drug that is causing the problem. Then the gene groups with the problems, go on the war path.

Are you guys for real? In reading through the side effects blogs it really reads like it is all the same person writing, maybe someone trying to beat up on the competition or something. It did scare me out of letting my 24 year old son take it for severe sinus infections, however and I just hope that two days of a 750mg dose per day doesn't show forth the negative effects in the days to come!! Please tell me it's not as bad as it sounds!

Even more information regarding subcutaneous atrophy and the class of drugs which Kenalog fall in to:

"Subcutaneous atrophy developed in a 36-year-old woman at the site of a triamcinolone acetonide (Kenalog) injection for subdeltoid bursitis. Occurrence of local atrophy after corticosteroid injection is relatively frequent yet unappreciated. It is more common in young women and girls who are given preparations with a lesser degree of water solubility. Although the condition is often reversible, instances of long-term disfigurement are well documented. This complication of a useful treatment method can be avoided by following a set of precautions for local injection of corticosteroids."

The above excerpt from a 1986 article in the U.S National Library of Medicine. There is also an article as far back as 1967 in the British Medical Journal (10/14/1967) that puts forward the same theory (though it is argued about in the editorial of the Journal).

Anyone who has experienced this problem should print this out and show it to their doctors. Presumably and hopefully your doctor is aware of medical journals and respects the DATA!

For all of you suffering on this board I strongly suggest you log unto www.fqresearch.org where you will find over 4000 medical journal entries, case reports, etc., that detail the horrendous damage these drugs are capable of. You will also find a link there for a support forum hosted by yahoo that everyone here is invited to join.

We have been fighting with the FDA since 1999 to get "Black Box" warnings as well as "Dear Doctor" letters sent. Had this been done I doubt that most of you would be suffering like this. This class is a drug of LAST RESORT, and it is not approved as a first line agent for ANY disease state.

It is both shocking and appalling that we see people coming on this site promoting the use of these drugs and chasing you for suffering a reaction. I can assure you this is not "in your head" by any means. These severe adverse reactions have been documented since 1982 within ALL of the leading medical journals. They are THE most toxic and dangerous antibiotic in clinical use today.

But the FDA refuses to provide adequate warnings within the package inserts and Public Citizen has had to SUE them in Federal Court to even have them review their petitions seeking, once again, "Black Box Warnings and Dear Doctor Letters."

Recently Bayer issued a "Dear Doctor" letter in Europe regarding the severe adrs to Avelox. But we find no such letters being written here in the United States.

Anyhow, just a brief note to let you know that you are not alone, your name is "Legions", and we have been fighting on your behalf since 1999.

Regards,

Mr. David T. Fuller
Director
Fluoroquinolone Toxicity Research Foundation
www.fqresearch.org

For all of you suffering on this board I strongly suggest you log unto www.fqresearch.org where you will find over 4000 medical journal entries, case reports, etc., that detail the horrendous damage these drugs are capable of. You will also find a link there for a support forum hosted by yahoo that everyone here is invited to join.

We have been fighting with the FDA since 1999 to get "Black Box" warnings as well as "Dear Doctor" letters sent. Had this been done I doubt that most of you would be suffering like this. This class is a drug of LAST RESORT, and it is not approved as a first line agent for ANY disease state.

It is both shocking and appalling that we see people coming on this site promoting the use of these drugs and chasing you for suffering a reaction. I can assure you this is not "in your head" by any means. These severe adverse reactions have been documented since 1982 within ALL of the leading medical journals. They are THE most toxic and dangerous antibiotic in clinical use today.

But the FDA refuses to provide adequate warnings within the package inserts and Public Citizen has had to SUE them in Federal Court to even have them review their petitions seeking, once again, "Black Box Warnings and Dear Doctor Letters."

Recently Bayer issued a "Dear Doctor" letter in Europe regarding the severe adrs to Avelox. But we find no such letters being written here in the United States.

Anyhow, just a brief note to let you know that you are no alone, your name is "Legions", and we have been fighting on your behalf since 1999.

Regards,

Mr. David T. Fuller
Director
Fluoroquinolone Toxicity Research Foundation
www.fqresearch.org

For all of you suffering on this board I strongly suggest you log unto www.fqresearch.org where you will find over 4000 medical journal entries, case reports, etc., that detail the horrendous damage these drugs are capable of. You will also find a link there for a support forum hosted by yahoo that everyone here is invited to join.

We have been fighting with the FDA since 1999 to get "Black Box" warnings as well as "Dear Doctor" letters sent. Had this been done I doubt that most of you would be suffering like this. This class is a drug of LAST RESORT, and it is not approved as a first line agent for ANY disease state.

It is both shocking and appalling that we see people coming on this site promoting the use of these drugs and chasing you for suffering a reaction. I can assure you this is not "in your head" by any means. These severe adverse reactions have been documented since 1982 within ALL of the leading medical journals. They are THE most toxic and dangerous antibiotic in clinical use today.

But the FDA refuses to provide adequate warnings within the package inserts and Public Citizen has had to SUE them in Federal Court to even have them review their petitions seeking, once again, "Black Box Warnings and Dear Doctor Letters."

Recently Bayer issued a "Dear Doctor" letter in Europe regarding the severe adrs to Avelox. But we find no such letters being written here in the United States.

Anyhow, just a brief note to let you know that you are no alone, your name is "Legions", and we have been fighting on your behalf since 1999.

Regards,

Mr. David T. Fuller
Director
Fluoroquinolone Toxicity Research Foundation
www.fqresearch.org

My daughter has been on prednisone since October, 2006 -today is July 25, 2007. She is a 35 years old with asthma and allergies. Originally the pulmonologist thought she had ABPA (Allergic Bronchio Pulmonary Aspergelosis) and put her on 60 mg daily. This year has been a nightmare for her. That original diagnosis apparently was erronous, but she was kept on the high dose for breathing issues, with instructions to lower it as she could. As of today she is on 30 mg. daily. Side effects? So you know she is no "loser", she is a PhD in Biomechanical Engineering, has two patents to her credit, has spoken at numerous medical conferences (for vascular surgeons and cardiologists), and has had countless articles published in medical journals. Now she can't concentrate much less sit still, has not read a book in months (she used to read at least one book every week), she has two research publications that need to be finished but she can't focus on the work, is totally exhausted and needs to rest after only a couple of hours of mild activity, has a face she has described as looking like a mongoloid. Her beautiful, big, blue eyes are slits in her face. Clothes that fit yesterday wouldn't fit today - and those that fit today won't fit tomorrow. She craves food in the middle of the night and said she usually eats 2 bowls of cereal. She has terrible pain in her torso. Her esophagus has become so eroded she is on 6 different meds for that, and as a result cannot eat salads or raw fruits or anything that might irritate the lining of the esophagus. Her body is covered with huge dark bruises. The latest side effect made evident happened this past Saturday night. She fell striking her shins on a carpeted step. Her skin has become so thin that it actually burst open. She said it reminded her of when we'd blanch tomatoes in boiling water to peel them, and how the tomato skin would just burst open. That's how her leg was. That little fall cost a trip to the ER for stitches, tetanus shot, and antibiotics. Her husband is a career military, so since they married 1 1/2 years ago she's lived in 4 states, there's not much history among doctors. She lives now in Kansas and has started seeing specialists through the university there. We just wish she could go to Mayo Clinic for complete evaluation, but unfortunately military insurance doesn't seem to cover the best.

Who would think an antibiotic would have such effects? I have been experienceing pain in my shoulder for about 3 weeks. This began less than 2 weeks after taking Levaquin for 2 weeks. In addition to that, I experienced side effects during the treatment. This include chest pressure and rapid heartbeat.

Yesterday, I saw an orthpaedist who diagnosed me with a rotator cuff injury.
I have one month of physical therapy to endure 3x per week now. If the pain doesn't improve in 2 weeks, then an MRI will be done. If it is ruptured, there will likely be surgery.

I am a healthy 35 year old woman with no history of shoulder problems. The doctor and others have asked what did I do to hurt myself. My answer is that I made the mistake of taking a drug that shouldn't be on the market. I don't lift weights and I didn't pitch 9 innings before this. So the only connection is a drug whose website states "ruptures of the shoulder, hands, and Achilles tendons have been reported...".

I have woarned all of my friends and co-workers about this drug. I am now on a crusade to prevent others from falling victim to this drug. I understand that the risks to the few outwiegh the rewards to many. However, when you are one of the few who is affected, your viewpoint changes. I am an educated woman and did read the side affects prior to taking the drug. I knew this was a possibility but it was "rare". Who knew an antibiotic could be so helpful and harmful at the same time!

Back from the RE:

We discussed many forms of birth control (none of which appeal to me) and he agreed bcps are not for me do to my reactions to them. He did question my correlating the YAsmin to my anxiety and said if that were the case I should've been like that from the first month on them. I quickly informed him of many of you here and asked that he not jump to conclusions just because the FDA; the warnings in the Yasmin pill pack and his Medical Journals all say that it DOESN'T cause us to be this way. He quickly let that go!

I was FINE before Yasmin. I was energetic, happy, and went with the flow of my hectic life with kids and an at home business. Then BAM I turn into a whole other person with serious issues mentally and emotionally and NOTHING in my personal life changed to cause this. How can anyone not conclude it a pill full of hormones?!!!!

He reluctantly prescribed me Xanax to get me through the next couple of weeks but said he would NOT prescribe me a refill. Which I said was fine because I really dont want to take anything but I can't just keep trying to make it through the day with my kids and me feeling so horrific.

Each day I feel a TAD better; what I wouldn't give for that magic wand to make it all better in a poof. I signed up for a 'Mind, Body & Spirit" (some sort of Yoga) class on Saturday and Wednesday so I am hoping that helps as well.

Enough of my lengthy reply! Hope everyone here continues to improve; all be it slowly. Everyday that passes is a another day we can all be 'us' again.

Denise

cardiologists do not make $$$ from pharm companies for prescribing any drugs, statins included. they REALLY, REALLY believe in the efficacy of this class of drugs--they believe the manipulated statistics published in medical journals proclaiming statins to be better for the population at large than veges. No doc makes $$ from prescribing a medication--it is considered illegal to do so , not to mention highly unethical.

I think that from reading through the posts and getting more information about different points of view regarding this drug, I am more inclined to think that if it works for you and you are happy taking the Prednisone and it has helped you overcome your disease whatever it may be, then keep taking it if it helps you. Treatment using Cortisone is a personal choice and if you experience very bad side effects maybe your Doctor can put you onto something that will have the same healing but less risk? Everything in life is a personal choice, the best way forward is to get as much information on the drugs you are taking as possible and make sure the information is from a reputable source, eg. Medical Journals etc. I don't want to scare anyone into not taking Prednisone, personally for me it made me feel ill but we are all individuals and we all need to take responsiblity for our choices in life.

So just make sure that whenever medication is prescribed to you that you research it first, and ask your Doctor about it he/she is there to help you get well, not make you feel worse.

Please remove the ignorant comment from the July 11th entry. People like that should not be kept on this site, she has no clue that the issues that are being discussed are actually true side effects that are now being written in medical journals. She should keep her opinions to herself.

I've only been on the pill for a month and I just started my period yesterday. I felt fine for the first few hours, then found that my period was very heavy. Before taking Yasmin, my periods were irregular, but light. I never felt anxiety or nausea. However, today I find that I can't even look at food without feeling nausea; where as before I could eat fine while on my period. I'm shaking and feeling very anxious today, like I can't stop my arms from shaking.

I'm not sure if this is from the pill or not, but it seems so strange for this to be happening for no reason. I've checked medical journals on Yasmin and find that many times Yasmin can cause anxiety and depression, even though those symptoms are not listed.

I've decided that once my college summer session is over, I'm going to make an appointment with my OB/GYN. It's interfering with my classes and studies and it makes me feel horrible! I'd choose irregular periods and acne over feeling the way I do.

-Sharon

"it is your responsibility to ask about potential side effects, interactions with other drugs you are taking, etc. It is also your responsibility to read the detailed informa tion that comes with every prescription from a pharmacy that lists possible side effects"

Excellent advice but with one FATAL flaw. The majority of the information recieved from the physician and/or the pharmacy is wholely inadequate regarding the side effects of these drugs. (the majority of them are not even listed) When asked about the potential side effects the physicians routinely state that these are safe and effective drugs with minimum side effects. Nothing could be further from the truth. The monographs indicate once again that such events are rare and occur at rates approaching 1%. Once again, not true, in reality they rapidly approach 27%. One recent study indicated 65% (Cipro when given for prostatitits) When such events manifest again the medical community denies any and all such assocation stating that they have never heard of such things, even though it has been reported in medical journals for almost forty years. Of the hundreds and hundreds of adrs reported within this forum you will not fnd ONE that is not a known, listed and published adverse event. It has been only through forums such as this that such knowledge is shared. You certainly will not find such information readily available from your physician or from your pharmacist. Herein lies the problem. Nor will you find it within the monographs as such warnings are couched in antiquated descriptions such as uticaria (itching) and other greek and latin terms for common medical conditions. This has been done deliberately to mislead the general public regarding such events. It is not lack of common sense that these victims are lacking, it is the trust that they have placed in their physicians to have an intimate knowledge regarding toxic chemotherapuedic agents that they hand out like Halloween candy. Such ignorance is rampant and to expect a physician who routinely fails to recognize, treat and report such events to be of any value during such a discussion is asking far too much. Patients are routinely handed free samples of these drugs, with no risk vs benefit discussion ever taking place, no monograph or any other information provided by the physician, and then told when such events manifest "..it cannot be the drug.." are instructed to continue taking it. The majority of the medical community has no idea what a fluoroquinolone is and what drugs make up the class let alone what the potential side effects may be. If the lack of common sense is found to be so disturbing then perhaps the lack of common sense regarding the prescribing of these toxic drugs that needs to be addressed. Not the ignorance of the patient who trust the FDA, the manufacturers, the physician and the pharmacist, only to find that thier trust has been grossly misplaced. There are anything BUT a safe and effective antibiotic with minimum side effects. They in fact are not even true antibiotics. They are a toxic and dangerous form of chemotherapuetic agents of last resort. ONLY to be prescribed when nothing else has proven to be effective. They are not and never were intended to be a first line agent. These are one form of such therapy that indeed have the potential to do far more harm than good when carelessly prescribed. Such ignorance cannot possibly be considered the fault of the patient. It is the fault of the prescibing physician. Should one wish to attack the lack of common sense I suggest that they start there. The victims of such scripting abuse have enough problems to deal with without adding such nonsense to thier never ending list.