Medical research symptoms and conditions

My 62 year old husband has had Parkinson's for about 10 years now. The other day he was prescribed Prednisone (20 mg tablets, twice a day) for 5 days. After the first day his pinched nerve problem was greatly improved, and as a side effect, his Parkinson's symptoms disappeared completely and he was like normal again! This is a miracle to us and we are looking for medical research to help prescribe Prednisone for Parkinson's', or some agent similar. Did the Prednisone make the other Parkinson's drugs more effective; or did the Prednisone fix the Parkinson's on its own. We don't know. For 5 days, it was bliss; I hope we can get someone to weigh the side effects against the miracle of being normal without any Parkinson's symptoms!

I just recently posted about my experience with mirena and had then read some more posts, and I had a thought. With SO MANY of us experiencing these symptoms-can't we do something about it?? Couldn't we send copies of these thousands of posts to Bayer or whomever is the top of mirena, I think it's Bayer. Or someone who can help us! Obviously we're are not all crazy! There is obviously something going on here. I mean I want to make sure other women are aware that this product may not be the greatest thing in the world. Anyone else who has a thought on this msg or reply please.
Thanks for listening!
And blessing to all.

This is by far the worst medication I have ever taken. For the first time in my life, I really thought I might die. I had the most violent dreams and am extremely tired. I can't stay awake for long durations. My body is currently detoxing off the drug, but after reading this site's posts, I am now worried about permanent damage. This is an extremely dangerous drug! I worked in medical research and usually check drugs out, but did not this time. The memory loss is no joke. Days 3 and 4, I have complete black out periods where apparently I raided the fridge. Day 5, I collapsed and was bed ridden. I could barely get to bed. There's a law firm out of Dallas conducting a law suit. I plan on contacting them.

I am 34 years old. I am a pharmacy tech. I have asthma and allergies. I have taken singulair pretty much every day since it came out on the market. I've had asthma since i was about 10 years old. I took theophylline as a kid. Steriods on and off especially during times when my allergies are bad. I still use Advair during the fall and spring. Every drug has a side effect. However breathing is pretty good damn thing. Do I have days when I feel low? Yeah. Do I sometimes have nightmares? Yup. Are "natural" products the answer. Not always. The fish oil that some of the posters are touting can also cause GI problems. Some of the natural products contain herbs and other plant derivatives that can be harmful for a child that suffers from allergies. Not proactively treating asthma can be deadly. Some of the parents are suggesting steriods as the answer - those can cause weight gain, growth suppression and can lead to a worsening of asthma.

Singulair has never made me feel like I've wanted to kill myself. I was more depressed and angry as kid when my asthma did not allow me to partipate in normal childhood things. I was sad and hated life when I couldn't keep up with friends at recces because I was having trouble breathing. You have to outweigh the costs with the benefits. I am more irritable when I have asthma flareup then I am on a normal day. For me, I choose to breathe. And singulair has been helping me for almost a decade.

I'm not saying the medication isn't causing these symptoms but maybe there is an underlying cause to your child's depression.

Any drug has a side effect. But without medical research and the medications that come with them - people would still be dying of simple diseases and we wouldn't have vaccinations. As a society, as a whole, we are a culture that looks to someone else to fix things and then blames the people who try to fix it. We need to stop being the "hot McDonald's coffee'" society.

hi i have been on fifty mgs of lamictal for a month, depression was much better,,,,then pmd decided to fiddle faddle and says yes you are better but lets up the mgs to 100 mgs once a day,,,,i have sore throat,,walk into walls, freezing cold....and believe it or not,,,just started this drug yesterday at this dose...now,,i agree that these shrinks are just playing around and love to give out the samples that the drug salesperson brings in...son is into medical research...he told me it is all big business now,,,and to especially watch out for the druggist,,,they make terrible mistakes,,,,also the pharmaceutical companys cut back on active ingredients and this has been prove....my sore throat and sinus problem is very disturbing...in a nutshell ,,,i don't like this dosage and have to take it upon myself to cut down to fifty....we have to be proactive...after all it is our bodies and our minds....

We have all been saying that our issues regard not being informed about all of the possible side effects. And, we know that Singulair works well for some people. Nobody wants to take a good drug away from those for which it probably performs miracles. People who have toxic side effects have a right to know up front.

My observations about montelukast's chemical structure are either general or not quite 100% correct or could be quite vague - so forgive me. I do not claim to be good at organic chemistry. But from doing a little work, I have come up with some observations.

1. It would seem to me that montelukast might work quite well for people who have developed mold category related asthma. I observed that chloroquinolin, a component of montelukast, is a good fungicide effective against Aspergillus, Alternaria, Cladosporium, Penicillium and Candida. Dust mites can only digest if helped by aspergillus so they go into the mold category. Molds produce millions of spores so anyone who lives in contact with mold would be chronically sick from their presence. Then people get hypersensitized to that.

I am probably wrong but I could imagine that montelukast is: 1) a ligand that binds to an empty cysLT1 receptor for a period of time 2) 7-chloroquinolin-2-yl which either acts intact or breaks down into a quinoline fungicide so that it kills the chronic mold/fungus infection and 3) a sulphur/methyl anti-inflammatory component that tells the t-cells that they are not needed so they will die. Wow, that would be great for mold asthma if it was completely non-toxic. It would be also great under controlled circumstances for many people who are mold-miserable. If I am wrong, I better go out into my garage and start inventing such a drug.

This is my visualization to try to explain the side effects of neurotoxicity. So adverse reactions could be to the quinoline component as an allergic reaction or dose related so that it just built up to a toxic level over time. There are many signs that t-cell populations are significantly reduced by montelukast. The fact that the Italians can do it in the test tube might be that it's a chemical component of montelukast designed to cause the t-cells to die.

Montelukast is a large molecule so Artie says it cannot penetrate the blood brain barrier. That would be an argument if nobody was complaining about neuro-psychiatric side effects. The neuro-psychiatric side effects are identical to quinoline and quinolones. When I read about Lariam, it just sounds like a more extreme version of Singulair side effects. Chloroquinolins were used before they invented Lariam, which is stronger. The malaria Plasmodiums became immune. Hallucinations, anxiety, depression, suicidal thoughts are completely consistent in all of the quinoline/quinolones. If montelukast breaks into sub-molecules then quinolines easily penetrate the blood brain barrier.

I find clinical evidence that montelukast may act as more than more molecule. And, that there is a rational for the existence of the chloroquinolin and evidence that it may be the source of toxicity.

I am glad to risk being called crazy. That is what the internet is for. We can present our ideas and discuss. So, just take this with a grain of salt. If I am close to the truth, this post will find it's proper home.

Hi all,

My first time on this site, it's quite interesting to see how people have very similar side effects. My case is I fought with a Poison Ivy and lost, my left arm shows the battle scars. Before going to the doctor, I tried Calamine, Caladryl, Cort Aide, Ivarest, Aveeno Oat Meal Baths & Tee Tree Oil. All failed to help, so off to my doc I went. After what I told him I tried using, he told me to stop. He noted those things do nothing to help Poison Ivy rashes to go away, he prescribed for me to take 20mg of Prednisone 3x a day for 4 days, then knock it down to 2x for 4 days and then 1x for 4 days. He also prescribed Cortisone Cream and to buy OTC Doneboro to soak my arm, it smells just like vinegar..I wonder! I have been taking Prednisone since Monday, so far the only side effects that have shown up is Insomnia and coughing. I do have A LOT more energy than I used to have, my job is enjoying my spitfire mode. The question is, what will happen once I am off this stuff? I've read and heard a lot of nasty things about this drug and I guess I will find out in another 9 more days, I've never been on Prednisone before, I do watch for changes in my body. Making sure I am not growing a beard or mustache, that my boobs don't expand (even though it would make my husband VERY happy). I am sorry to see many on here are having a bad time with this, maybe some of you should get a second opinion. Some doctors today are babied by pharmaceutical companies to push drugs, with some issues some of you have you may want to research your health problems more. Never take the word of your doctor as concrete, they are human too and make mistakes. I believed one fertility doctor until I researched my condition to find out I would never be able to have children, they milked my health plan until I faced them with my findings of medical research sites and online articles by universities. Never again! Fool me once, shame on you, fool me twice, shame on me. Don't be fooled, research for yourself. I will keep you posted as to my next 9 day countdown.

Alison

As I read through these posts, I had mixed feelings between thinking they were a little too whiny (please, no offense) to too many memories sweeping back in.
Here is my story... I was on Yasmin for a few years, a few years ago, from ages 18-21. I am now 26. I'd always been active and in shape, no major health problems. At 19, I started to get weird leg pains, tingling and numbness. It got much much worse. Long story short, I had two herniated discs in my lower back which was causing pinched nerves. I had steroid injections localized to my herniations. At this point my adrenal gland stopped working, my face swelled up like a balloon and I lost a ton of weight. Eventually, I had surgery on my back, but went to specialist after specialist to figure out what was going on with my non functioning adrenal gland. We figured that somehow the steroids had gotten into my bloodstream, which doctor after doctor told me was next to impossible. They were ready to do a write up in a medical research journal about my case. Eventually my 3rd Endocronologist (sp?) FINALLY told me to get off Yasmin. Somehow, this small bit of information was missed. My adrenal gland eventually kicked back into shape, my bloating went away and I finally and slow got healthy again.
So... coming back to Yasmin. After reading this site and continuing research on the effects of an influx of potassium, all of my symptoms lead straight to this source. The potassium increase caused the face swelling, muscle spasms, possibly even the nerve weakness (Only speculating, could have caused the herniation.) , from what multiple web sites state.
I must say that this is all speculation; however, light bulbs have just gone off in my head.
I was considering getting back on Yasmin because I now live in Thailand and they offer this pill. I have been on the NuvaRing and I love it, but I cannot find it here. If Yasmin was the cause of what happened to my body or not, I will not take my chances. Most of the symptoms listed by other women are effects of increased potassium. Please research this fact to become more informed about what is happening with your body. It helped me. I hope my story will in effect, help someone else.
And, I'd love to hear if anyone else had something similarly severe...

I have been using Yasmin for almost 10 years. Recently I have began getting migraines (never had them before), nasty vaginal discharge and an embarrassing increase in facial hair. I can somewhat deal with the migraines, but the other two symptoms are extremely irritating.
I have been to my gyno for both. She told me that the discharge was "normal" with the use of Yasmin. I don't think snotty goo coming from your vagina for a straight week before your period is "normal". She assured me that all testing came back negative and it was just something I would have to deal with. As far as the facial hair goes...I can't leave the house without standing in front of a mirror and plucking my poor chin and neck for up to an hour each day. My gyno suggested that I get laser treatment, which would be grand if SHE were paying for it.
I don't know if I want to continue taking Yasmin or not. I have ovarian cysts and used to have severe periods lasting for a week and a half at a time, and Yasmin had helped with those problems.
Has anyone else had these problems...and what are you doing for them?

WELL I HAVE BEEN READING EVERYONES SIDE EFFECTS THAT THEY CLAIM TO HAVE EXPERIENCED SINCE BEING ON WELLBUTRIN.FIRST OF ALL WELLBUTRIN IS A VERY EFFECTIVE DRUG FOR DEPRESSION AS WELL AS BEING PROVEN TO HAVE SOME OF THE FEWEST SIDE EFFECTS OF ALL ANTI-DEPRESSANTS.THIS DRUG DOES NOT CAUSE SEIZURES,WHAT IT DOES IS LOWER SEIZURE THRESHOLDS,WHICH MEANS IF YOURE PRONE TO SEIZURE(LIKE STOPPING DRINKING WHILE ON IT)YOU MAY HAVE A SEIZURE.IF YOU SEIZURE WHILE ON THIS MED ITS BECAUSE YOU MAY HAVE A CONDITION THAT YO ARE EVEN UNAWARE OF THAT MAKES YOU PRONE TO SEIZURES,WHEN AN ALCOHOLIC DRYS OUT THEY ARE PRONE TO SEZIURE SO IF ON THIS MED THEY ARE ACTUALLY TOLD TO NOT STOP DRINKING.EACH PERSON IS DIFFERENT IN CHEMICAL MAKE UP,SO WHAT ONE HAS AS SIDE EFFECTS OTHERS MAY NOT.IT JUST SEEMS TO ME THAT YOU ALL HAVE READ POSSIBLE SIDE EFFECTS AND HAVE CONVIENCED YOUR SELF YOU HAVE THEM.EVERY DRUG HAS A SIDE EFFECT BECAUSE ITS NOT NATURAL IN THE BODY.HOW DO I KNOW?? WEL I AM A PSYCH NURSE IN A PSYCH WARD AND SEE WELLBUTRIN USED AND RECORD AND OBSERVE SUCH MEDS AND THE EFFECTS THEY HAVE ON PEOPLE,AS WELL,I HAVE BEEN ON WELLBUTRIN FOR SOME TIME NOW AND HAVE HAD VERY LITTLE SIDE EFFECTS AND THE ONES I HAVE ARE ANNOYING BUT NOT SERIOUS.I BELEIVE ALOT OF YOU PEOPLE DEPEND ON YOUR MEDS TOO MUCH AND THINK THAT THEY ALONE IS WHAT WILL MAKE YOU BETTER,THEY CAN ONLY HELP YOU,NOT CURE YOU.WELLBUTRIN IS ONE OF THE BEST YOU CAN TAKE,JUST TRY TO COME OFF SOME OTHERS OUT THERE AND YOU'LL SEE.IF YOUR ON WELLBUTRIN COUNT YOURSELF LUCKY AND STOP LOOKING FOR THINGS WRONG WITH IT,WORK WITH IT.

My mother is aged 72 years old,she was unfortunately diagnosed with osteoporosis about 10 years ago, at the time her hospital was undertaking the FOSAMAX drug trial which unfortunelty she was asked if she would participate. She started the trial and was still taking the medication until about 8 months ago.

Around 18 months ago she started showing signs of the side effects but none of the doctors she saw would say if this drug was the cause of her presenting symptoms. These were inabilty to breath correctly, unable to swallow, on set of spasms in her throat and chest. She is now in hospital recovering from surgery which we all thought was going to be simply an hernia repair but I now fear that the long term taking of the drug has caused more serious damage than a straight forward hernia operation. She is after the 3rd day since surgery still mostly on bedrest, having morphine, intravenous antibiotics, not able to eat or drink, There is talk of her kidney being stuck to her stomach. This is a very serious matter for my mother. She was never ever seriously ill in her life until her diagnosis of osteoporosis, I really wish she had never been approached to take part in this trial.
I am at a loss for what to do within the field of medical research it seems no one wants to help or advise but just hope we bury our heads in the sand and not say an more. But this should be made clear to other women who are being asked to start on this treatment what could happen after a few years down the line.
Please could you help and give my mother advise.

MANY THANKS
CHRISTINE