August 20th
2008
11:42 PM
I am a 53yr old female, I started with bronchitis in Feb 2008, after two er visits, and treatment with antibiotics/ cough meds/ decongestants, etc. thought I was finally over it after 2/3 weeks, then all of a sudden I would start up with the same tight, non productive cough, twice accompanied by strep throut also, these symptoms started to return almost monthly, without warning. The last episode I had in July I was put on prevacid for acid reflux, (the first dosage of that gave me a slight improvement of symptoms of the cough, then the following week prednisone was added with almost instant improvement, Wow finally, each day better that the last, then as I started to taper off a bit of increase in congestion, nothing that a child's dose of mucinex didn't help. Then almost a month to the day after thinking that I was finally better, I started all over again, up for almost 36 hours straight from coughing, started back on steroids, antibiotics, etc. But this time is tougher, The initial steroids helped right away, but there is a lot more mucous with this episode, My Doctor set me up for a PFT (pulmonary function test) and pending results plan to followup with a Pulmonary specialist, but as I've been tapering off the prednisone again the symptoms have increased, almost back to the beginning of the episode, with more coughing than not. Nervous about the last day of my steroids, my doctor put me on the Advair Diskus, my results of my pft should be in tomorrow, I took my first dose this morning, (quite nervous about it because I have several medication allergies and reactions) Now for my dilemma, my dose went well, I almost thought I felt a little something good, I know it's supposed to take awhile to help, but I felt positive about it and looked forward to my next dose in 12hrs. A little later in the day I started feeling funny, kind of spacey, fuzzy headed. Is it possible that this feeling is from the Advair? I've read the side affects and a lot of feedback from Advair users, and nothing matches what I;m feeling. Is there anyone out there that has felt like this? Please help, I'm almost due for my next dose and don't know what to do.
PMB in CT.
March 18th
2009
1:00 PM
I have type 2 diabetes for a few years and am 59 yrs old-and do not have fibromyalgia or kidney,liver problems or depression or a history of any painful muscles ever. I work up to 90 hrs a week as a doctor for the past 12 years and am a DIY renovator of my home in mt free time. I exercise regularly and am fairly fit, I do have a congenital mitochondrial myopathy characterized by non painful arm and leg muscle weakness- but have not been symptomatic significantly for 20 years. I take vitamins and one aspirin a day and have no medication allergies. weeks ago I started Januvia- my only diabetes medication. I worked well to normalize my mild to moserate elevation of BS.Over the past 2 weeks or so, I have had an increased somnolence without feeling rested upon awakening. I felt like I had been beaten with telephone poles and hammers, More distressing is the insidious onset of neuromuscular pains episodic sharp ones, more persistent aching and burning and tingling tingling, with a dense heaviness in legs more than arms worse with exertion and relieved by rest. 3 days ago it was to the point where I had to stop walking after 8 steps and could not climb a ladder beyond one step . I should not curl 2 lb weights even twice, Typing on a keyboard fatigued my arms after 5 minutes. I stopped Januvia three days ago, slept 30 hours,, felt better yesterday,restarted januvia last pm, Today, after 12 hours of sleep I feel exhausted like I did hard manual labor for a few days without ant sleep. The telephone pole beaten feeling returned, My weakness and pain are back with a vengeance and I cannot walk very well and have to stop typing this every 2 or 3 minutes to rest my arms, and have weakness also in my back muscles with curious sparing of abdominal muscles. Heat and massage do not help and are uncomfortable. I feel tired like I do when my myopathy acts up and my Krebs cycle is disrupted and thus my mitochondria do not make ATP to power my muscles- with the additional new symptom of significant pain. Aside from a mild tachycardia of about 100 at rest, my vital signs are normal, my cpk, Mg, thyroid function tests, comprehensive metabolic panel and sed rate are all normal . Heavy metal screen is negative. I will stop Januvia and probably never take it again, If my glucose goes back up I will go back to metformin which I took a few months about a year ago,
-- By drdoree | Reply | (1) replies | Private Message meI suspect in my case that Januvia disrupted my mitochondrial function as well as being additionally toxic to my muscles and nerves by some additional pathogenesis, I question whether those individuals who have weakness, somnolence and neuromuscular symptoms might have some underlying mitochondrial dysfunction - a very under diagnosed condition - patients being told that their symptoms are of psychiatric origin.