April 28th
2009
2:39 PM
My mother, who is in her early 70's, is diabetic and had high cholesterol. She had been taking Lipitor and the doctor increased her dosage. She was experiencing muscle pain for some time, especially when she woke in the morning. The muscle pain worsened and her muscles became very weak. She had been complaining to her doctor for some time. It took a chiropractor to suggest it was the Lipitor. Her doctor finally ordered blood work and her enzyme levels were at 9500. She was immediately hospitalized, tests run and IV's given to flush the Lipitor from her system. She was expected to slowly recover. After weeks, her levels dropped to 6500 then began to rise. Her doctor now says her muscle damage is permanent and plans to give her prednisone to stop the inflammation. This muscle damage is a terrible "side effect" for a drug that was supposed to help her. She can hardly get up or down from a sitting or lying position, can hardly walk and her lifestyle has been severely curtailed. She is also exhausted all the time.
-- By joy2all | Reply | (5) replies | Private Message me
March 18th
2009
1:00 PM
I have type 2 diabetes for a few years and am 59 yrs old-and do not have fibromyalgia or kidney,liver problems or depression or a history of any painful muscles ever. I work up to 90 hrs a week as a doctor for the past 12 years and am a DIY renovator of my home in mt free time. I exercise regularly and am fairly fit, I do have a congenital mitochondrial myopathy characterized by non painful arm and leg muscle weakness- but have not been symptomatic significantly for 20 years. I take vitamins and one aspirin a day and have no medication allergies. weeks ago I started Januvia- my only diabetes medication. I worked well to normalize my mild to moserate elevation of BS.Over the past 2 weeks or so, I have had an increased somnolence without feeling rested upon awakening. I felt like I had been beaten with telephone poles and hammers, More distressing is the insidious onset of neuromuscular pains episodic sharp ones, more persistent aching and burning and tingling tingling, with a dense heaviness in legs more than arms worse with exertion and relieved by rest. 3 days ago it was to the point where I had to stop walking after 8 steps and could not climb a ladder beyond one step . I should not curl 2 lb weights even twice, Typing on a keyboard fatigued my arms after 5 minutes. I stopped Januvia three days ago, slept 30 hours,, felt better yesterday,restarted januvia last pm, Today, after 12 hours of sleep I feel exhausted like I did hard manual labor for a few days without ant sleep. The telephone pole beaten feeling returned, My weakness and pain are back with a vengeance and I cannot walk very well and have to stop typing this every 2 or 3 minutes to rest my arms, and have weakness also in my back muscles with curious sparing of abdominal muscles. Heat and massage do not help and are uncomfortable. I feel tired like I do when my myopathy acts up and my Krebs cycle is disrupted and thus my mitochondria do not make ATP to power my muscles- with the additional new symptom of significant pain. Aside from a mild tachycardia of about 100 at rest, my vital signs are normal, my cpk, Mg, thyroid function tests, comprehensive metabolic panel and sed rate are all normal . Heavy metal screen is negative. I will stop Januvia and probably never take it again, If my glucose goes back up I will go back to metformin which I took a few months about a year ago,
I suspect in my case that Januvia disrupted my mitochondrial function as well as being additionally toxic to my muscles and nerves by some additional pathogenesis, I question whether those individuals who have weakness, somnolence and neuromuscular symptoms might have some underlying mitochondrial dysfunction - a very under diagnosed condition - patients being told that their symptoms are of psychiatric origin.
July 14th
2009
1:28 PM
Cholesterol slightly elevated Dr. recommended 10mg dosage. Began experiencing neck and shoulder pain, dizziness, nausea, foot stiffness and leg numbness up to the lower thigh. Voluntarily stopped the medication after four months. All noticed side effects disappeared except for the foot stiffness and leg numbness. It has been 2 1/2 years and these remaining side effects are constant. Not optimistic for recovery. Anyone else with similar symptoms?
-- By ter204 | Reply | (6) replies | Private Message me