Mold spores symptoms and conditions

I don't have any conclusions to report because I have recruited friends to help me. I got over my head as far as my understanding of this type of chemistry. I am particularly interested in what happens to the quinoline nitrogen during the metabolic break down of montelukast. Nitric oxide is an important molecule to the human body. BUT, however, in excess it is very toxic. The year of this study 1998, some medical researchers got the Nobel prize for their work on nitric oxide.

http://nobelprize.org/nobel_prizes/medicine/laureates/1998/press.html

So I am now working with friends to try to further understand the Merck report on the metabolism of montelukast. I found a Japanese researchers opinion of the connections of montelukast and the cysLT1 receptor showing the nitrogen as a key factor. I was also able to find some work done on mold spores that might give some clues because DPA - 2,6 pyridine dicarboxylic acid in the spore case might yield something about the receptor and/or quinolinic acid 2,3 pyridinedicarboxylic acid. I haven't concluded anything about Fenton reactions as of yet but that is always something to think about.

If anyone has any chemist friends, we could use some real experts in this field not just someone like me, CC, who can read and collect research.

J Med Chem. 1998 Apr 23;41(9):1439-45. Links
Development of a three-dimensional CysLT1 (LTD4) antagonist model with an incorporated amino acid residue from the receptor.Zwaagstra ME, Schoenmakers SH, Nederkoorn PH, Gelens E, Timmerman H, Zhang MQ.
Division of Medicinal Chemistry, Leiden/Amsterdam Center for Drug Research, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands.

This paper describes the molecular modeling of leukotriene CysLT1 (or LTD4) receptor antagonists. Several different structural classes of CysLT1 antagonists were superimposed onto the new and highly rigid CysLT1 antagonist 8-carboxy-3'- flavone (1, VUF 5017) to generate a common pharmacophoric arrangement. On the basis of known structure-activity relationships of CysLT1 antagonists, the quinoline nitrogen (or a bioisosteric equivalent thereof) and an acidic function were taken as the matching points. In order to optimize the fitting of acidic moieties of all antagonists, an arginine residue from the receptor was proposed as the interaction site for the acidic moieties. Incorporation of this amino acid residue into the model revealed additional interactions between the guanidine group and the nitrogen atoms of quinoline-containing CysLT1 antagonists. In some cases, the arginine may even interact with pi-clouds of phenyl residues of CysLT1 antagonists. The alignment of Montelukast (MK-476) suggests the presence of an additional pocket in the binding site for CysLT1 antagonists. The derived model should be useful for a better understanding of the molecular recognition of the leukotriene CysLT1 receptor.

PMID: 9554877

My son age 3 was diagnosed with asthma about a year ago. Since then he has been sick constantly. Most recently his doctor has prescribed Singulair. He is aggressively pushing it on us. I stated my concerns to him, and he said there is nothing wrong with the drug.. he gets all the news letters.. and all the things I listed was the first time he heard anything.. I asked for his to refer us to a specialist and he wont.. I cant find anyone for a second opinion..My son needs medicine- at night i cant leave his side cause of his breathing.. The doctor wont suggest any alternate and I am stuck. I keep reading about all the people who are not taking singulair anymore- what what are they taking? I am completely lost here!

UPDATE: Our nightmare with SINGULAIR has not ended! After reading "conerned citizens" report discussing the possiblility of Singulair causing asthma blew me away. My son was put on this drug for food allergies not asthma b/c they thought of his two anaphylaxsis episodes in 5 days. 1 food related the other unknown (maybe outdoor mold?) He had no prior issues with breathing.

He has been off of it for almost 2 weeks however over the last week he has slowly developed some breathing issues. After getting off of it, he still has his ear infection from the second day of being on it and last Friday after playing some basketball began to seem like he was winded so I brought him in. He was having trouble breathing. I called the Dr. and he said it could be excercised induced asthma. He is a very active boy who runs non stop and has NEVER had breathing issues before Singulair! It seemed to pass after a few hours. The next fews days he coughed a few times when playing and I thought what the heck is happening to him. Monday at school they didn't go outside so he was fine b/c he didn't run around. Tuesday, they came to get me b/c he was having trouble breathing and one of his teachers whose son has asthma said I think you better give him an inhaler. I called the Dr. ASAP and he approved us to borrow another child's. He freaked out and wouldn't let us give it to him. After 2 epi-shots in the previous weeks, he wanted nothing to do with that. At school the next day, we made him take the inhaler if he wanted to go out to playso he did. He didn't cough but a few times. No excercise at all. Then last night, he got really bad. He started to cough and couldn't stop to the point of gaging and it seemed as though he had developed a ton of phlem and kept trying to swallow. We ended up in the ER where we were told that he has asthma! I am so furious! I don't get this at all! If this report is accurate and my son got asthma by going on it - this will be devastating. We kept him home today from school and took him into the Dr. b/c he continued to cough all night. He is now on Flovent, Albuterol and has an enebulizer. I'm probably the only one of all of us who child did not have asthma to begin with.

Has anyone who did not have asthma before singulair now have any issues? Please let me know!

ive taken advair for 3 years,ive had a few side effects including: weight gain, pains in my leg, and tiredness. i dont know if these are from the advair or not. i never had these issues before taking it. i really dont know what to do. if im not on advair i have a hard time breathing and have chest pains. Does breathing better out weigh the side effects that it causes??? i have problems with inflamation and advair seems to work well with that aspect. Is there natural alternatives? HELP!!!

I have been suffering from almost consistent sinus infections since moving to the Virginia area. I never had one before moving to this new climate, where I have been told there a more mold spores and other allergens in the spring and summer. Having no doctor here I went to a walk in clinic for some relief. I was prescribes a 10 day course of Levaquin. The course ended three days ago, and the sinus irritation is still present, now it is more like sinus pain.

Although the yellow and green mucus cleared up, I still have the sinusitis it seems AND side effects from the Levaquin including light-headedness, blurry vision, heaviness in my legs and stiffness in my joints/hands. I also for the past few night have not been able to sleep, waking up every few hours with nervousness or anxiety for no reason. I am only 39 and otherwise was healthy. I am taking vitamins, drinking alot of water and taking cod liver oil now hoping these symptoms will go away.