Molecule symptoms and conditions

Same here. Pretty much like a zombie. Numbness and tingling in hands and feet. Spaced out. Stoned like in high school.

Clinical trial of montelukast in the Netherlands.

I noticed two things:

1. The researcher states that sides effects are 10%.
2. The researcher will not allow patients to also take drugs which are metabolized by CYP2C8 because montelukast inhibits that as proved by in vitro (test tube) studies. American studies in vitro said yes montelukast is an inhibitor but in vivo (in people) that it didn't happen. I was always confused by that and would still like to know more
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Flindy is correct. It is easily possible to be just plain allergic to montelukast- Singulair. Where were the other "allergens" that her child was exposed to? It was, at least hopefully, a sterile environment.

Montelukast is a quinoline. Drugs often are built around a core molecular called a pharmacophore, the molecule responsible for the drug's important characteristics. There is an enormous amount of literature regarding adverse side effects for other drugs in that category.

At the time when Merck was pursuing quinoline as the pharmacophore, other companies were pursing other core molecules. So a quinoline core is not the only choice of drugs. The huge problem is that doctors are not aware that Singulair is not an anti-histamine. They are not warned that the core molecule is a quinoline so they don't know to watch out for allergic reactions especially serious ones.

It would be common knowledge that a quinoline radical (in an acid pH) could react with hydrogen peroxide to produce quinilinic acid, a nasty neurotoxin. When I hear of neuro-psychiatric side effects that appear to coincide with times when hypoglycemia could be happening, then maybe there are some genetically pre-disposed people that actually are experiencing times of ketoacidosis. Scientist have known about quinolinic acid since the 1940's. Malaria drugs containing quinoline come with a warning about hypoglycemia and electrolyte imbalance. Which comes first - the chicken or the egg- the reaction to the drug then the hypoglycemia or the hypoglycemia then the reaction? It would be amazingly easy to prove whether quinolinic acid is responsible for these neurological side effects.

I am appalled by two things. One is that Merck has such power over the FDA that the FDA fails to even recognize basic pharmacophore characteristics. Merck manages to snow them somehow with just words - leukotriene receptor antagonist. So what is the FDA reaction? Merck should review their clinical data. How about find some people who are suffering from Singulair side effects and do some tests? Then you might actually find out why.

If it turns out that anyone at Merck or FDA knew that montelukast carried significant risk of allergic reactions due to it's pharmacophore and they chose not to reveal that in the literature for marketing reasons, those people should be prosecuted. It should not be the job of doctors who prescribe medications to do their own research.

I was first diagnosed with hypertension in the late 80's and have been on several different medications to treat it. I think that Lisinopril is the worst that I have been on. I have extreme fatigue and severe dry and burning mouth, sore tongue and difficulty breathing and flu like symptoms. I have anxiety and PTSD so my symptoms have been blamed on that. With all these symptoms,
I sometimes wonder if it would be better off to have the hypertension.
Sometimes my mouth and throat is so dry and sore, I can't eat and I have difficulty breathing which is not addressed with asthma medication. Daytime symptoms are bad at night but when night time comes, it is almost impossible to sleep.
I would be interested if anyone has these symptoms and would like to hear from you.
Jenny

LEVAQUIN is a FLURO quinelone. The fluoride replaces the iron in metalloproteases in your tendons. Remodelling to stress thus fails to occur. It is a molecule shapped like a horseshoe. The base is the formula for an INHIBITORY neurotransmmitter: GABA. It also causes cardiac hyperpolarization. If these dangers are not carefully examined before taking the drug, you are playing Russian Roulette.

But don't just be hysterical. Read. America can't survive as a nation of hedge fund BSers with no grasp of science or math. Doctors are drowning in HMO paperwork and 5 mins. per patient. They can't be thorough and don't have time to read other than the BS of drug salesmen. So don't go by the stupid TV ads. READ-->LEARN-->READ--> and contact the FDA and drug company to get their info on your side effects. If they lie, you have a case. Fight for yourselves instead of just panicking over symptoms. That could kill you whether you stop or not the drugs.

Hi everyone,
Just some info concerning Levothyroxine:
1/ Starting doses vary depending on your doctor's method,
I give 150ug then bring it down if necessary
2/ Anxiety problems are due to pre-existing psychological problems and not the molecule; if you're feeling over anxious you need to consult a therapist, the fact that the drug increases basal rate brings this out more manifestly
3/Hair loss is a symptom uniqueley of Hypothyroidism and not of the drug, as is weight gain

Take Care all

Docteur Jones