Montelukast symptoms and conditions

Regardless of whether singular has weight gain listed as an "official" side effect, singular is: Montelukast Sodium (generic name), meaning, sodium is sodium, is Na+! Edema & weight gain WILL occur is individuals sensitive to sodium's effects.

From the FDA's "Updated Information on Leukotriene Inhibitors: Montelukast (marketed as Singulair), Zafirlukast (marketed as Accolate), and Zileuton (marketed as Zyflo and Zyflo CR)"

6/12/2009

Neuropsychiatric events have been reported in some patients taking montelukast (Singulair), zafirlukast (Accolate), and zileuton (Zyflo and Zyflo CR). FDA has requested that manufacturers include a precaution in the drug prescribing information (drug labeling).

Montelukast is used to treat asthma, and the symptoms of allergic rhinitis (sneezing, stuffy nose, runny nose, itching of the nose), and to prevent exercise-induced asthma. Zafirlukast and zileuton are used to treat asthma.

The reported neuropsychiatric events include postmarket cases of agitation, aggression, anxiousness, dream abnormalities and hallucinations, depression, insomnia, irritability, restlessness, suicidal thinking and behavior (including suicide), and tremor.

This information reflects FDA’s current analysis of available data concerning this drug.

Advice to patients and healthcare professionals:

Patients and healthcare professionals should be aware of the potential for neuropsychiatric events with these medications.

Patients should talk with their healthcare providers if these events occur.

Healthcare professionals should consider discontinuing these medications if patients develop neuropsychiatric symptoms.

Background

In April 2009, FDA completed its review of neuropsychiatric events, (mood and behavioral changes) possibly related to drugs that act through the leukotriene pathway (montelukast, zafirlukast, zileuton). As part of its review, FDA reviewed post-marketing reports and also requested that manufacturers submit all available clinical trial data for these products.

The post-market reports of patients on these medications included cases of neuropsychiatric events. Some reports included clinical details consistent with a drug-induced effect. In the clinical trial data submitted by manufacturers, neuropsychiatric events were not commonly observed. However, the available data were limited because the trials were not designed to look for neuropsychiatric events. Sleep disorders (primarily insomnia) were reported more frequently with all three products compared to placebo.

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I have been taking Singulair for one week now due to my exercise induced asthma and allergic asthmatic symptoms. I feel very stressed out and anxious and yell at my parents a lot. Also, I feel kind of paranoid, like I feel as if somebody is watching me at all times. It is scary because I've only been on it a week. Also, my face is red and blotchy and my acne has gone from very little bumps to full blown breakouts all over. I have a barking cough and runny nose now that the doctor prescribed it. When I cough I have a pain on my left side that feels like someone is stabbing me.

I have been doing a trial and error thing w/ all my meds and I suspect that Singulair may be the culprit in my insomnia. Since I went down on Cymbalta, it has helped but last night I did not sleep a wink. I took xanax even and was up all night. Finally got up at 4.

Singulair has some ingredients that are the same as anti-histamines which have always affected my sleep but I have copd and am afraid to not take it.It is supposed to open your airways and I use Advair which has a steroid in it and I have no appetite. I still gain weight even though I'm not eating much.Dont know what to do. jo

On January 13, 2009, the FDA released a Follow-up to their March 27, 2008, Communication about the Ongoing Safety Review of Montelukast (Singulair). Included in this update is the following information:

"Post-marketing reports of neuropsychiatric events associated with montelukast, zafirlukast and zileuton have been reported to FDA’s Adverse Event Reporting System (AERS). Most of the reports of neuropsychiatric events are associated with montelukast, currently the most commonly prescribed drug that acts through the leukotriene pathway. The clinical details of some reports involving montelukast are consistent with a drug-induced effect. Because of the paucity of reports involving zafirlukast and zileuton, assessment of a drug–induced effect with these is limited. Accordingly, at this time, patients and prescribers should monitor for the possibility of neuropsychiatric events associated with these agents."

Has anyone experienced vision problems ? Seeing red and green dots ?

It seems most people on here are blaming their "side effects" on the medicine. Could you quite possibly have health issues anyway? what about those people that don't take Singulair and have the exact same symptoms? Is it because they are THINKING about it?
It's one thing to be informed about medication. It's another to go overboard.

Researchers have been doing studies for many years regarding trying to determine the role of genetic factors in patients response to Singulair (Montelukast).

This study from Spain identified the following gene variations hypothesize to be related to leukotriene pathway response. Sixty one patients with asthma were studied. Three gene types were identified:

type 1. Thirty-two patients (52.5%) were homozygous for the five repeats allele;
type 2. 17 (27.9%) were heterozygous (4/5 repeats)
type 3. 12 (19.7%) were homozygous for 4/4 repeats.

The study showed that montelukast was effective for types 1 and 2 but not effective for type 3. Type 3 represented approximately 20% of the group study.

"After the montelukast treatment decrease number of asthma exacerbations, improvement of FEV(1) and decreased use of beta(2) agonists was observed in patients with 5/5 or 4/5 repeats. Conversely, the patients with 4/4 repeats genotype did not modify these data after treatment."

So it seems logical that if it can be identified that montelukast is not effective for certain gene type variations, then montelukast could cause adverse side effects in certain gene type variations.

It is interesting that 20% of this group does not respond positively to montelukast. That is the exact same number that even Merck says gets a headache from montelukast. Headache is the highest incidence of adverse side effects that has been reported. That comparison, however, is just a coincidence because it has not been studied and proven. Maybe.

Where are the studies that pertain to gene type variations and adverse side effects? You would think that somebody could do them.

Respir Med. 2008 Jun;102(6):857-61. Epub 2008 Mar 12. Links
ALOX5 promoter genotype and response to montelukast in moderate persistent asthma.Telleria JJ, Blanco-Quiros A, Varillas D, Armentia A, Fernandez-Carvajal I, Jesus Alonso M, Diez I.
Institute of Biology and Molecular Genetics (IBGM/CSIC), University of Valladolid, Valladolid, Spain. ******

BACKGROUND: It was hypothesized that asthmatic patients with mutant alleles in the leukotriene pathway should not respond to leukotriene receptor antagonists and the concept of a tailored treatment is increasingly supported. METHODS: Sixty-one patients (mean age 24.9 years, range 14-52) with moderate persistent asthma were clinical and immunological assess prior and after a 6-month treatment with montelukast. Tandem repeat polymorphisms were genotyped in the promoter (-147 to -176) of 5-lipoxygenase gene (ALOX5). RESULTS: Thirty-two patients (52.5%) were homozygous for the five repeats allele; 17 (27.9%) were heterozygous (4/5 repeats) and 12 (19.7%) were homozygous for 4/4 repeats. After the montelukast treatment decrease number of asthma exacerbations, improvement of FEV(1) and decreased use of beta(2) agonists was observed in patients with 5/5 or 4/5 repeats. Conversely, the patients with 4/4 repeats genotype did not modify these data after treatment. CONCLUSIONS: It was confirmed that ALOX5 promoter polymorphisms have a clear influence in montelukast response in atopic moderate persistent asthma patients. The genetic study could identify those patients most likely to respond to montelukast.

PMID: 18339529

Does anyone know if Singulair can cause heart valve problems? I just found out that I have Mitral Valve Prolapse, and have never had any problems until after taking Singulair. Any info would be greatly appreciated...especially from Concerned Citizen if he's out there...

Thanks,

K.

My wife (66) was using salbutamol inhaler for the last 10 years being a bronchial asthmatic. Even prior to that, she was being treated with a combination of theophylline, cortisones . In 2001 she was diagnosed to be suffering from OCD and citalopram 20 mg was prescribed. With significant improvement, the dosage was reduced to citalopram 10 mg, though we lowered the dosage only in December 2007. However, during the last month, when she had to be admitted in the hospital for a stomach virus the doctors prescribed MONTELUKAST SODIUM 10 MG combined with lEVOCETIRIZINE 5 MG. .
Dramatically,montelukast had a dramatic effect in that my wife never used the salbutalmol inhaler for well over 2 months, about which we were very happy.
But the worst was yet to come.
During the last few days, she again showed symptoms of the dreaded OCD once again, and she suffered like anything. On contacting a well known doctor, we were advised to stop MONTELUKAST and asked to continue citalopram (though escitalopram instead of citalopram ) along with clonozepam 5 mg to be tapered down every week for about a month.
I would like to be advised from a doctor whether (a) discontinuance of Montelukast will be able to bring back normalcy from OCD of course with citalopram or escitalopram. and (b) whether montelukast can be abruptly stopped. For the time being, we have reduced the dosage of montelukast from 10 mg to 5 mg.
PLEASE ADVISE US.

The United Kingdom's Medicines and Healthcare Products Regulatory Agency posts medication adverse event reports on their website.

safety information, reporting safety problems, medicines, reporting suspected adverse drug reactions, drug analysis prints (DAPs), search for "montelukast"

May 16 y.o. daughter has chronic sinus infections and sever headaches. They said it was allergies and put her in Allegra D and Singulair. Headaches seemed better with slightly fewer sinus infections. Once I heard about the mood swings and Singulair I took her off. Then the Allegra did not seem to be able to keep up with keeping the sinus infections at bay. We finally figured out that she has a deviated septum and will need surgery. Anyway, we put her back on Singulair so we can get though the season with as few sinus infection until we can schedule surgery around high school and sports. Then we were noticing how her hair has become so thin. She used to have really thick hair and now her pony tail is to thin and small. After doing internet searching, we found out that other people are having this problem with Singulair. I took her off of it 4 days ago and already the shower has less hair in it. You can't tell a teenager that she needs to stay on a medication and lose a ton of hair. I am hoping that her hair will grow back quickly.

Science has NOT conclusively ruled out a link between Singulair and suicide. In fact, science DID reveal a link between Singulair and depression (a risk factor for suicide). In the clinical trials one montelukast participant dropped out and the investigator cited the reason as depression that was "drug related". Additionally, in the primary and Phase II/BIII Studies, 12 out of 1955 participants taking montelukast reported depression, vs. 5 out of 1108 on placebo, and 1 out of 251 on beclomethasone. This information is presented in the FDA's medical review for Singulair and is available on the FDA website. Depression was not only reported post-marketing as some would like us to believe. As the FDA explained in their update to the investigation, Singulair's clinical trials were not designed to measure neuropsychiatric events so some may not have been reported. Using clinical trial data to prove that Singulair cannot cause a particular symptom or outcome is as foolish as discounting post-marketing reports that show that some neuropsychiatric events associated with Singulair are consistent with a drug-induced effect.

I am 34 years old. I am a pharmacy tech. I have asthma and allergies. I have taken singulair pretty much every day since it came out on the market. I've had asthma since i was about 10 years old. I took theophylline as a kid. Steriods on and off especially during times when my allergies are bad. I still use Advair during the fall and spring. Every drug has a side effect. However breathing is pretty good damn thing. Do I have days when I feel low? Yeah. Do I sometimes have nightmares? Yup. Are "natural" products the answer. Not always. The fish oil that some of the posters are touting can also cause GI problems. Some of the natural products contain herbs and other plant derivatives that can be harmful for a child that suffers from allergies. Not proactively treating asthma can be deadly. Some of the parents are suggesting steriods as the answer - those can cause weight gain, growth suppression and can lead to a worsening of asthma.

Singulair has never made me feel like I've wanted to kill myself. I was more depressed and angry as kid when my asthma did not allow me to partipate in normal childhood things. I was sad and hated life when I couldn't keep up with friends at recces because I was having trouble breathing. You have to outweigh the costs with the benefits. I am more irritable when I have asthma flareup then I am on a normal day. For me, I choose to breathe. And singulair has been helping me for almost a decade.

I'm not saying the medication isn't causing these symptoms but maybe there is an underlying cause to your child's depression.

Any drug has a side effect. But without medical research and the medications that come with them - people would still be dying of simple diseases and we wouldn't have vaccinations. As a society, as a whole, we are a culture that looks to someone else to fix things and then blames the people who try to fix it. We need to stop being the "hot McDonald's coffee'" society.

My 6 1/2 year old daughter has been on Singulair for 3 1/2 to 4 years now and we have had horrible experiences! She was having night terrors, mood swings, angry issues, self control issues, crying over small things, etc. We have been to psychiatrists and psychologists who have diagnosed her with mood disorder, sensory processing disorder and anxiety disorder! Well she has recently been having stomach problems so we have been going to a GI to figure that out. I got online to research and found numerous sites that told how Singulair causes all these things in children. We took my daughter off the meds and within 3 or 4 days seen a tremendous difference! She is a totally different child! It just really frustrates me and saddens me that all these children and their families are going through all this and the doctors do not seem to care. The allergist or psychiatrist didn't believe me. They say no study has ever proven such things. I don't care what they say we as parents know our children and we are the experts when it comes to seeing how they change when on this medicine, we are the ones that live with them and are with them everyday not the doctors! I think they just don't want to lose out on their money from prescribing this drug 90% of children with allergies and asthma!

To clear up any misunderstanding about the FDA Singulair investigation.
FROM THE FDA STATEMENT ABOUT THE SINGULAIR INVESTIGATION

"FDA has not yet reached a definitive conclusion regarding the clinical trial data on mood and behavioral adverse events associated with montelukast, zafirlukast, and zileuton."

"although (the clinical trial) data do not suggest that montelukast, zafirlukast, or zileuton are associated with suicide or suicidal behavior, these clinical trials were not designed specifically to examine neuropsychiatric events. As a result, some events may not have been reported."

The FDA is continuing to investigate a link between Singulair and suicide .
They stated that they have not "closed the book on suicidality". Any news reports stating there is no conclusive link are incorrect.

Post-marketing reports of neuropsychiatric events associated with montelukast, zafirlukast and zileuton have been reported to FDA’s Adverse Event Reporting System (AERS). Most of the reports of neuropsychiatric events are associated with montelukast, currently the most commonly prescribed drug that acts through the leukotriene pathway. The clinical details of some reports involving montelukast are consistent with a drug-induced effect. Because of the paucity of reports involving zafirlukast and zileuton, assessment of a drug–induced effect with these is limited. Accordingly, at this time, patients and prescribes should monitor for the possibility of neuropsychiatric events associated with these agents..........................................This is the small print that is missing from some news reports

I want to post this because this site has given me good perspective on this Rx and side effects experienced by others; its good to know I am not alone. As far as an agenda, I have none, in fact I was all for the Singulair initially, because it seemed to be a good alternative to inhaled steriods which I had read could interfere with normal growth. My son, 4 yrs. old, with a diagnosis of Asthma, started Singulair about 2 weeks ago. Asthma seems to have been improved by Singulair. Within a couple days of starting it, though, he reported vivid (but not nightmare-ish) dreams, a week later he dropped his afternoon nap, which we were expecting to happen eventually, so didn't think much of it. He is a wild child generally, but we also noticed an uptick in bad and aggressive behavior within a day or two of starting the Singulair; we really clamped down on him though, so that effect has been somewhat muted. He has always occasionally complained of indigestion stomach aches, but these complaints have increased to several times a day in the last week, also complain of lower abdominal pain which he says is "different" than his earlier indigestion stomach aches. Last week or so he's been up late at night, had trouble going to sleep, looks a little pale with dark circles under his eyes ("he's becoming a Goth" I joked with my wife). Last night he got out of bed late, appeared disoriented and seemed to be half awake, half asleep. He was talking, but not making sense and seemed to be upset and/or confused, but when pressed he assurred me nothing was wrong and nothing hurt--put him back to bed and this morning he remembers getting up, but also keeps telling me he had a "weird" (not scarry) dream and that he keeps seeing it while he's awake. Luckily this weird dream was not scarry for him, but he was clearly a little freaked out by seeing it again this morning. He seemed o.k. heading off to preschool, but we are taking him off the Singulair as a precaution. My advice to anyone else out there seeing similar symptoms in their kids is to go with your gut -- I always tell people that a Doctor's job is to tell you the odds, like only 1 in 500 or 1 in 1000 kids will have a certain reaction, or condition, or illness, it is the parents' job to be sure that their kid is not that 1. So I'm taking my kid off the Singulair because I think he may be that 1 kid who experiences these unusual side-effects. How wide spread they are, I have no idea. I will get on my soapbox and say I think it's time for the FDA to require drug companies to conduct long and short term clinical studies on kids for any drug that will be prescribed to kids--entrusting our childrens' health and well being to a drug company's own short term study conducted on fully developed adults is foolish and insane.

I was shocked last night on the news, when they reported that "there is no link between Singulair and suicide". I guess Merck is going to stick their heads in the sand, and let children continue to be harmed by a drug that I feel should never be prescribed to a child in the first place. I'm shocked at how young some of these children are! It makes me sad that Dr.'s, the FDA, and Merck will continue to put profit before the safety of the people being prescribed this drug and having terrible side effects from it...and most Dr.s are not fully aware of!!!!

Why does Singulair cause these symptoms? I am going to give my explanation which is only a HYPOTHESIS. This should not be categorized as any thing but an educated guess. This is not backed by scientific research because nobody will do any research that would appear to anger
Merck even if people are suffering in the thousands.

1. The original research that preceded the development of Singulair (montelukast) seemed to focus on the theory that asthma was caused by an unusual immune response to certain pathological stimulus. There are many references to the observation that a high percentage of asthma sufferers are people whose asthma is caused by fungus. Many people suffer from asthma and are told that they are allergic to dust mites. Dust mites can live only because the fungus aspergillus pre-digests the
food source that dust mites can then absorb. Other sources of fungus occur in the home due to dampness or problems with wood rot.

2. The body's immune system fights certain categories of pathogens such as bacteria and fungus by creating nitric oxide which kills them at the site where they try to enter the body. The mast cell is the immune cell that is responsible for the production of nitric oxide. Mast cells are found in the skin, airways, intestines etc. The mast cell is capable of many different types of biochemical functions that are designed to signal other cells or other chemical responses. When the mast cell knows that pathogens
are present and nitric oxide is NOT produced, then it signals other immune cells to be sent to the site of the infection. Thus in the case of asthma, it is known that excessive numbers of eosinophils appear in the airways and these cells create inflammation.

3. Singulair was developed for asthma and later allowed to be prescribed for other reasons. I believe that montelukast probably creates a source of nitric oxide that prevents the mast cell from signalling for other immune cells to arrive at the source of infection. I arrived at that conclusion from studying the chemical structure of montelukast, the chemical structure of the gene cysLT1 receptor, and the chemical structure of the cell wall of fungus which would be what the mast cell uses to determine "what to do in order to kill the fungus."

The researchers who invented montelukast first had to clone the gene-cysLT1 receptor meaning that they had to be able to identify the gene and replicate it. Then by trial and error they had a find a "chemical"
that would bind (connect chemically) to the cysLT1 receptor. The theory would be that montelukast would take the place of the fungus or other pathogen and thus prevent the gene from reacting to produce the
responses that the sick patient with asthma produced. Merck says in the literature that montelukast binds with the cysLT1 receptor in order to prevent the mast cell from signalling the eosinophils to arrive in excessive
numbers that cause inflammation. I believe that montelukast is also causing the production of an amount of nitric oxide that is actually killing the pathogens that are present. For one thing, I would think that it
would be dangerous to incapacitate the immune system in that way without providing a way to kill the pathogens. I don't believe that the asthma response is just allergies to something like dust. Pollen from trees and flowers is loaded with fungus spores.

4. IF, IF, IF, montelukast does actually produce nitric oxide, then it does so by binding with the gene. Any place in the body where a molecule of montelukast encounters the cysLT1 receptor (a gene) then the corresponding molecules of nitric oxide are produced before the liver enzymes break the montelukast molecules up. Nitric oxide is TOXIC and
INFLAMMATORY. So let's look at the symptoms in regard to the location of the cysLT1 receptors. The location of these symptoms would not be places in the body where the mast cells normally encounter fungus or bacteria. The cysLT1 also has other functions in that it communicates with the cysLT2 receptors. Obviously, nitric oxide
should not be produced in these locations because of the signalling effect of nitric oxide on other physiological functions.

a. intestinal pain - the cysLT1 receptors are located in the small intestines
b. leg pain actually caused by vasculitis - cysLT1 receptors are found inside blood vessels- consistent with the fact that montelukast causes
Churg-Strauss
c. some people who didn't have asthma develop asthma - the cysLT1 receptors are in the airways
d. nightmares, depression, neurological damage - when montelukast penetrates the blood brain barrier probably due to unusual conditions of blood pH or electrolyte imbalance then nitric oxide in the brain causes neuron damage and excitoxicity

5. Why do some patients not experience side effects? Probably because genetically they are completely compatible with the model that researchers created when they cloned the cysLT1 receptor gene. I didn't not find any information about whether researchers knew that there are many different variations of this gene.

6. IF, my theory is even close to being correct, then why doesn't Merck do anything about researching these side effects. Maybe because nobody in the company knows how this drug works but the researchers who created it. All of the Merck literature is very vague about any biochemical information.

Again, this is just speculation and hypothesis. I have made an attempt to put this in simplistic language and therefore sacrifice scientific accuracy. But, I think that you will get the point.

SINGULAIR IS VERY DANGEROUS TO PATIENTS WHO EXPERIENCE NEGATIVE SIDE EFFECTS. DOCTORS SHOULD JUST REALIZE THAT
THOSE PATIENTS ARE NOT COMPATIBLE WITH THE MODEL FOR THE DRUG.

I am re-posting this from June. I believe that we have many reasons to suspect that Singulair does indeed penetrate the blood brain barrier. I personally believe that under certain unusual conditions that Singulair can cause neurological damage. I tried before to put together a scenario of brain biochemistry that could explain how this can happen. Of course, I am just hypothesizing and all of my ideas will not prove to be totally correct. From the number of postings here regarding neurological symptoms, I believe that there is an answer out there somewhere. Why the FDA is not searching for this answer is a complete mystery to me.

I believe that it is possible that Singulair causes the same biochemical response in the brain that is cited in this study -- thus causing neurological damage.

"Thus, elevated NO production leading to mitochondrial dysfunction, glutamate release, and excitotoxicity may contribute to neuronal death in neurological diseases."

IS SINGULAIR CAUSING THE DEATH OF NERVE CELLS IN SOME PATIENTS? DOES THIS HAPPEN - ALTHOUGH INFREQUENTLY- BECAUSE OF GENETIC OR BIOCHEMICAL FACTORS OR BOTH?

June 12th
2008
2:56 AM
I have stated many times that I am not an expert. I just post what I find. This has been a mind boggling journey for me. This is way over my head but I struggle to read and understand. Finding answers to why children are suffering from neuro-psychiatric side effects is worth the effort.

I have made the following observations.

1. Some quinolines are known to be able to cross the blood brain barrier.
2. Molecules that ionize are known to be more likely to be able to cross cell membranes. So if montelukast ionizes as a result of change in blood pH to sufficient acid conditions, then it could be possible that it does in fact cross the blood brain barrier.
3. We know that there are cysLT1 receptors in the brain.
4. We know that researchers believe that montelukast may bind at the arginine of the cysLT1 receptor.
5. We know that arginine contains four nitrogens. And montelukast contains one.
6. We don't know what happens to those nitrogens. Are those nitrogens converted to nitric oxide?
7. We do know what macrophages create nitric oxide as I posted.
8. We do know that if something cause excessive nitric oxide to build in the brain that there would be damage to the neurons.

Some people may remember when I got stuck at the astrocytes, the cysLT1 receptors and glutamate. I keep looking for research reports that may shed more light on this.

Titre du document / Document title
Nitric oxide causes glutamate release from brain synaptosomes
Auteur(s) / Author(s)
MCNAUGHT K. S. P. (1) ; BROWN G. C. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Department of Biochemistry, University of Cambridge, Cambridge, ROYAUME-UNI
Résumé / Abstract
We determined the ability of pathological levels of nitric oxide (NO) to cause glutamate release from isolated rat brain nerve terminals using a fluorometric assay. It was found that NO (0.7 and 2 μM) produced (4 and 10 nmol/mg of synaptosomal protein) Ca2+-independent glutamate release from synaptosomes (after 1 min of exposure). Spermine/NO complex (spermine NONOate; a slow NO donor) and potassium cyanide (an inhibitor of cytochrome oxidase) also caused Ca2+-independent glutamate release. Preincubation of synaptosomes with 5 μM 1H- oxadiazole quinoxalin-1-one (an inhibitor of soluble guanylyl cyclase) had no effect on NO-induced Ca2+-independent glutamate release. Ca2+-independent glutamate release produced by NO was greater in a low-oxygen medium. NO, spermine NONOate, and potassium cyanide inhibited synaptosomal respiration with a similar order of potency with respect to their ability to cause glutamate release. Because NO has been shown previously to inhibit reversibly cytochrome oxidase in competition with oxygen, our findings in this study suggest that NO (and cyanide) causes glutamate release following inhibition of mitochondrial respiration at the level of cytochrome oxidase. Thus, elevated NO production leading to mitochondrial dysfunction, glutamate release, and excitotoxicty may contribute to neuronal death in neurological diseases.
Revue / Journal Title
Journal of neurochemistry ISSN 0022-3042 CODEN JONRA9
Source / Source
1998, vol. 70, no4, pp. 1541-1546 (29 ref.)

INIST-CNRS, Cote INIST : 4037, 35400007527188.0230

My 5 1/2 year old son began taking 4mg Singulair in the p.m. and an inhaler (asmanex) in the a.m. We were still having trouble controlling the asthma and his Sing dose was raised to 5mg. & within 1 week of the increase he began having terrible facial tics and aggravated behavior (defiant, poor listening, easily frustrated and angered) The tics were in the form of opening and closing his mouth, as if you were trying to clear your clogged ears after a plane flight. This caused him much pain in his jaws and facial muscles, so he would tic and then cry as he was in pain. This ramped up his anxiety and it made the ticking worse. He has been off of all asthma medication (cold turkey) for 5 full days. He has episodes where the tics happen for 10 min -1/2 hr, other times during the day it is one here and one there. He does not want to leave the house to do anything, even his favorite activities. Thank god I found this site (and others like it), as I got some answers and some hope. We went to see my cousin this week who is a neurologist and he never heard of the correlation of Singulair and neurologic side effects like these. He said that (hopefully) the medication side effects will cycle through and resolve the ticking and behavioral changes. If not we are probably looking at a Tic Disorder which is in the Tourettes Family.He put my son on a very low dose of Klonopin to mellow out his anxiety and help reduce the tics, but has only been on it for 1 1/2 days and it usually takes a wk or 2 for full absorption and results.I have since sent him and my pediatrician and allergist links to this site and others. I think that I see some improvement in my son, yesterday I thought he did better and my husband thought it was a worse day, I think we have totally lost our perspective and objectivity on this. If anyone out there has a time frame on when they saw significant recovery and positive changes I would love to hear from you. This is a total nightmare and if it is this drug, someone is going to pay. My prayers go out to all who are going thru this.

Welcome a board singulairsurvivor. I received back an email from the woman at the lung association,she was of course sorry for our experiancr,and went on to say the scientist that reviewed the data were some of the best,and the association has no ties to any product.then as i am watching the updates on the hurricanes,i am inendated with singulair commercials as once again it is allergy season,so what a windfall for Merck that this article came out this month and not next....Coincidense i think not shame shame shame on you.To all those unsuspecting people about to get their prescription .i am sorry

I am astounded that this study of old data is being used to reinforce the message that Singulair is not connected to depression / suicide. The study is disputed by the fact that those suffering from the life threatening and incurable "Mental Illness Side Effect" see a complete return to normalcy within 7-10 days off the drug.

My own personal story, like many others, was a complete and total nightmare for my family over many years. In short, I went from a 10 year successful career as an art director with tremendous responsibility at a top international arts museum, to 2 years of full-time disability unable to leave my home with crippling anxiety/panic/depression. I was very lucky to have a loving wife and supportive doctors intervene before I took my own life.

The last few years is a blur of toxiPharmacological hell. A frustrating long string of tests, medications and treatments were attempted without any success... much to the consternation of my care givers. Not one of the dozens of doctors that I saw raised any question about the 10mg of Singuliar they knew I was taking daily.

Financial ruin, forced me off medical insurance. So I stopped all the psychoactive medications and came full circle back to suicidal ideation with more determination. A few months later, in March of 08' I could no longer pay out of pocket for may asthma medication Singulair and was surprised to find the mental illness begin to lift. A few days later the stories broke on the wire that this drug was perhaps connected with the unfortunate suicide of Cody and other teens. A week or so later, I felt myself again after many lost years.

Merck may have quietly updated the patient info several times over that period, but they made no attempt (still haven't) to reach out to prescribing doctors and pharmacists to let them know about potential issues. It seems that Montelukast interacts differently in individuals, and while it may be beneficial for many folks it is criminally dangerous not to increase the awareness of the side effects.

My General Practitioner pointed out that the original Montelukast study was quite large as these things go, but considering that it is prescribed to millions of people it is truly an irresponsibly small fraction sampled over a short period of time. Adding insult is the fact that these studies are conducted by the very company that seeks to benefit from positive findings.

The ALA has done a terrible disservice to the people the ought to represent. Downplaying the verifiable risks of suicide by recycling old data is completely and totally heartbreaking. I am ashamed to say that since I've been off the drug, I have been so preoccupied with trying to rebuild my life that I haven't been as forthcoming an advocate for the issues associated with Singlair. Misbelieving that others would take up the charge of spreading awareness and information so that new patients and their families would at least know the risks and be ever watchful.

Since that no longer seems the case, I offer myself and my well documented medical experiences with this drug, to anyone trying to get the message out. The media will pounce on the ALA study, giving many families a false sense of security.

Be well.

Everyone please go to the American Lung Association home page to read the article on their "research study" into the association between montelukast and depression/suicide and write to: ****** with your experiences. I wrote a letter with my son's negative experience, stating why I thought their study was flawed - they only studied 569 children and adults (I think there are more posts of negative reactions in children on this site alone) and urging them to do a more exaustive and statistically singificant study before releasing the results. This drug is unsafe and we need to take action to get it identified as such by the medical community.