Muscle cells symptoms and conditions

My daughter had a kenalog shot for itching on May 2009. The doctor never mentioned any side effects to her. Now she has a huge indentation in her left buttock. She is only 18 yrs old and she is scare and afflicted because the dent is getting larger and disfiguring that part of her body. I read enough complains. There must be an action lawsuit against the company distributing, selling and benefiting from this drug. Some doctors also should be liable for neglecting to release the accurate potential damage (as it is known) cause by this drug. It is causing mental pain and anguish due to the disfigurement that it leaves and also constant concern about the growing destruction of the muscle cells.Enough damage have been done. Who will pay to correct the damage? ******

I started feeling much better very quickly after being off Lipitor now 7 months. However, the symptoms I had using the RX has cause significant problems. I fell so many times with my weak joints and muscles, that I had severe problems. I now need to have knee replacement surgery after falling so many times injuring my knees and weakened muscles to support myself. I am getting cortisone shots in that knee, as well as physical therapy. My MRI shows a torn meniscus, stretch PCL very thin, cartlidge loss and debris, still swollen with csyt after all these months. With no meds, and lack of being able to exercise, I now have hig-chol back. On and on it goes.... a real catch 22. Take care of yourself, watch out for symptoms. I ignored sx's thinking it was stress but after reading adverse reactions, it fit me to the T.
My original posting re: Lipitor is Forestseaski on Jan. 2, 2009

C.

Has anyone experienced muscle loss of the heart since they are on vytorin? In 15 months on Vytorin my heart ejection fracture went from 48 to 30.

I am 51 and very athletic and in admiral shape. 3 months ago, I began on Lipitor for cholesterol control. I just tore a calf muscle. Coincidence? I'm going off Lipitor until I know for sure. At the time of the muscle tear, myself and my muscles were warmed up. I didn't do anything harsh to provoke a tear. That's what scares me. It just went rip.

I am a 65 year old female taking 20mlg of lipitor for almost 10 years. All of a sudden I started having severe pain, shaking and weakness in the calf muscle. The pain is unbearable. Doctors after doctors including a cardiologist, rhoumatologist and internist don't know the reason. I have stopped lipitor for 3 days. I cry and pray to god to help me everyday. I cannot exercise which is my passion for many years. I am hoping the lipitor is the reason and not something else. I have to wait and see. But I suspect it is.
SR
I do have nausea, depression and low back pain and arthritis and frequent headaches.

Hopefully this will prove to the doubters that there are genetic reasons for the variation of efficacy and adverse side effective when taking Montelukast.

I have several areas of concern (concerned citizen is concerned). One of the main areas is the reliability of Montelukast due to differences in genetics among populations. The cysLT1 (Singulair) receptor is a GENE. As I said before, it would be possible to predict those patients for which Montelukast would and would not be effective and those patients whose gene expression profile would cause them to have unwanted side effectives.

I have been looking for a way to give reasonable proof of that which could be used to convince your doctors that Montelukast is not for everybody. I happened to locate a researcher who had invented and patented methods for predicting drug sensitivity and efficacy in inflammatory disease. I have quoted below from his patent application. He intended to provide a method for determining efficacy and drug sensitivity for pharmaceuticals which include leukotriene antagonists - Montelukast.

Quoted from:

Methods for predicting drug sensitivity in patients afflicted with an inflammatory disease
US Patent Issued on December 12, 2006

Methods are disclosed for predicting the efficacy of a drug for treating an inflammatory disease in a human patient, including: obtaining a sample of cells from the patient; obtaining a gene expression profile of the sample in the absence and presence of in vitro modulation of the cells with specific cytokines and/or mediators; and comparing the gene expression profile of the sample with a reference gene expression profile, wherein similarities between the sample expression profile and the reference expression profile predicts the efficacy of the drug for treating the inflammatory disease in the patient.

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The field of pharmacogenomics measures differences in the effect of medications that are caused by genetic variations. Such differences are manifested by differences in the therapeutic effects or adverse events of drugs. For most drugs, the genetic variations that potentially characterize drug-responsive patients from non-responders remain unknown.
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In another embodiment, the invention is directed to a method for predicting the efficacy in a human asthma patient of leukotriene antagonists including, but not limited to, montelukast (a.k.a., SINGULAIR™; Merck, Whitehouse Station, N.J.), zafirlukast (a.k.a., ACCOLATE™, AstraZeneca, Wilmington, Del.), and zileuton (a.k.a., ZYFLO™; Abbott Laboratories, Chicago, Ill.), comprising: obtaining a sample of cells from the patient; obtaining a gene expression profile from the sample in the absence and presence of in vitro modulation of the cells with specific mediators; and comparing the gene expression profile of the sample with a reference gene expression profile, wherein similarity in expression profiles between the sample and reference profiles predicts the efficacy in the human asthmatic patient of leukotriene antagonists.

Many of the cells involved in causing airway inflammation are known to produce signaling molecules within the body called "leukotrienes." Leukotrienes are responsible for causing the contraction of the airway smooth muscle, increasing leakage of fluid from blood vessels in the lung, and further promoting inflammation by attracting other inflammatory cells into the airways. Oral anti-leukotriene medications have been introduced to fight the inflammatory response typical of allergic disease. These drugs are used in the treatment of chronic asthma. Recent data demonstrates that prescribed anti-leukotriene medications can be beneficial for many patients with asthma, however, a significant number of patients do not respond to anti-leukotriene drugs.

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The genes selected are those that have been determined to be differentially expressed in either a disease, drug-responsiveness, or drug-sensitive cell relative to a normal cell and confer power to predict the response to the drug. By comparing tissue samples from patients with these reference expression profiles, the patient's susceptibility to a particular disease, drug-responsiveness, or drug-resistance can be determined.

http://www.patentstorm.us/patents/7148008-description.html

The inventor's website: Hakon Hakonarson M.D. The Children's Hospital of Philadelphia

http://stokes.chop.edu/research/profiles/?ID=251

I'm aged 51 and have had high blood cholesterol for years, diagnosed in my mid thirties. Over the years I have tried changing diet but it didn't reduce tha bad cholesterol. Three years ago I decided maybe I better reduce the cholesterol as they say it clogs up you arteries etc. I went to the doctor and he put me on Lipitor and within a few months my levels were down to normal. I got joint pains in my hands, back, neck , legs and had sore heels after long walks. The doc then decided I'd go off the Lipitor to see if my levels stayed normal but they went back up. After a week the new pains had gone away. I came up with a plan to take 3 x 10mG a week rather than one each day and this worked with a lot less joint pain. The last test I had my levels are back up again so he put me back on 10mG a day and now three weeks later the pains have built back up and I don't like them. Desperate for a different solution I was listening to one of the Juice Plus promotions and something they said set me thinking. They said that having a high level of bad cholesterol doesn't always mean it will badly affect your arteries as it has to react with free radicals in your body to cause the damage. Their theory is that a diet rich in antioxidants will combat the free radicals and generally reduce the risk of disease which also includes any bad effects from high bad cholesterol. Now I'm wondering two things, how do I know if my high cholesterol is causing me any harm? is there a test I can get done to measure how it is or is not affecting me? Can anyone throw any more light on this?

I have had extreme pain in my left arm. I went to the dr. and she told me it was from my Provachol. She immediately took me off it and put me on Perocet for the pain. This was just yesterday. I'm hoping the pain to go away soon. She stated that the toxins from the Provachol had settled into my muscles in my arm and was breaking down the muscle enzemes in the muscle cells. I hope if you read this and you are on Provachol to stop taking it immediately and seek medical attention.
Dawn