Ncbi symptoms and conditions

Known Side Effects of Doxycycline: (source: drugs.com)

•severe headache, dizziness, blurred vision;
•fever, chills, body aches, flu symptoms;
•severe blistering, peeling, and red skin rash;
•urinating less than usual or not at all;
•pale or yellowed skin, dark colored urine, fever, confusion or weakness;
•severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;
•loss of appetite, jaundice (yellowing of the skin or eyes); or
•easy bruising or bleeding, unusual weakness.

Less serious side effects may include:
•swollen tongue, trouble swallowing;
•mild nausea, vomiting, diarrhea, or stomach upset;
•white patches or sores inside your mouth or on your lips;
•sores or swelling in your rectal or genital area; or
•vaginal itching or discharge.

Comparative Research Results:
SOURCE: http://www.ncbi.nlm.nih.gov/pubmed/3684731 -- Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77550

“Results from both monitoring methods consistently indicated at least a 3-fold higher frequency of nausea or vomiting with doxycycline relative to the other antibiotics. Complaints of skin rash also were at least 4 times more frequent with doxycycline, depending on the particular sample.”

More: ******

There are all sorts of verified reported side effects, most of which were on the packing slip that came with my prescription. However, not all side effects are listed on the insert. I’ve come across depression and anxiety listed as side effects on other drug profiles for Doxycycline, so if they are among the symptoms you're experiencing, they very well may be due to the drug. My experience has served as a greaet reminder to research any pharmaceutical I put in my body so that I may make informed decisions.

Like many of you, apart from my current breakout from Doxy, I too experienced stomach upset, and, to a lesser degree, cranial pressure.

Be well. Cheers.

03/11/09 went in to have a blood test the MD had ordered. I met with the Md-- told him that the metoprolol 100mg twice a day had not agreed with me. I asked to change my prescription to what i had been taking before -- Norvasc 5mg twice a day along with a diuretic. A week later I went for my lab results. The AST(SGOT) 232 and ALTSGPT) 516, being dangerously high. Md asked if I had ever had hepatitis B. My answer was no. I asked him to check my blood test results of 11/08. The results were AST(SGOT) 24 and ALT(SGPT) 37. I told him I thought it could be the Metoprolol. The Md told me he wanted for me to have CAT scan and to refer me to a GI doctor. Went home praying to the GOOD LORD and received peace about this whole situation. I searched on the internet and found on ****** Metoprolol-induced hepatitis: is the rate of oxidation related to drug-induced hepatotoxicity?L. MS.
University Department of Pharmacology and Therapeutics, Royal Hallamshire Hospital, Sheffield, United Kingdom. Hepatology. 1989 Jan;9(1):163-4. Also found Hepatic toxicity is reported in at least one case report. ******
" 56-year-old female with a history of migraine headaches developed seronegative hepatitis associated with metoprolol. Her signs and symptoms resolved within 48 hours after discontinuing metoprolol, and were reproducible on rechallenge."
My results for hepatits were negative.On 3/31/09 I had lab tests and 4/01/09 the Md faxed my results AST(SGOT) 29 and ALT(SGPT) 43. I have not gone back to the doctor. I am taking milk thistle daily. I have learned a valuable lesson and am passing it on to others.

A smaller recent study from Spain showing a genetic component of montelukast efficacy.

1: Respir Med. 2008 Jun;102(6):857-61. Epub 2008 Mar 12. Links
ALOX5 promoter genotype and response to montelukast in moderate persistent asthma.Telleria JJ, Blanco-Quiros A, Varillas D, Armentia A, Fernandez-Carvajal I, Jesus Alonso M, Diez I.
Institute of Biology and Molecular Genetics (IBGM/CSIC), University of Valladolid, Valladolid, Spain; Department of Pediatrics, University of Valladolid, Valladolid, Spain.

BACKGROUND: It was hypothesized that asthmatic patients with mutant alleles in the leukotriene pathway should not respond to leukotriene receptor antagonists and the concept of a tailored treatment is increasingly supported. METHODS: Sixty-one patients (mean age 24.9 years, range 14-52) with moderate persistent asthma were clinical and immunological assess prior and after a 6-month treatment with montelukast. Tandem repeat polymorphisms were genotyped in the promoter (-147 to -176) of 5-lipoxygenase gene (ALOX5). RESULTS: Thirty-two patients (52.5%) were homozygous for the five repeats allele; 17 (27.9%) were heterozygous (4/5 repeats) and 12 (19.7%) were homozygous for 4/4 repeats. After the montelukast treatment decrease number of asthma exacerbations, improvement of FEV(1) and decreased use of beta(2) agonists was observed in patients with 5/5 or 4/5 repeats. Conversely, the patients with 4/4 repeats genotype did not modify these data after treatment. CONCLUSIONS: It was confirmed that ALOX5 promoter polymorphisms have a clear influence in montelukast response in atopic moderate persistent asthma patients. The genetic study could identify those patients most likely to respond to montelukast.

PMID: 18339529

http://www.ncbi.nlm.nih.gov/pubmed/18339529

Results: DNA was collected from 252 participants: 69% were white, 26% were African American. Twenty-eight SNPs in the ALOX5, LTA4H, LTC4S, MRP1, and cysLT1R genes, and an ALOX5 repeat polymorphism were successfully typed. There were racial disparities in allele frequencies in 17 SNPs and in the repeat polymorphism. Association analyses were performed in 61 whites. Associations were found between genotypes of SNPs in the ALOX5 (rs2115819) and MRP1 (rs119774) genes and changes in FEV1 (p < 0.05), and between two SNPs in LTC4S (rs730012) and in LTA4H (rs2660845) genes for exacerbation rates. Mutant ALOX5 repeat polymorphism was associated with decreased exacerbation rates. There was strong linkage disequilibrium between ALOX5 SNPs. Associations between ALOX5 haplotypes and risk of exacerbations were found.

Conclusions: Genetic variation in leukotriene pathway candidate genes contributes to variability in montelukast response.

http://ajrccm.atsjournals.org/cgi/content/full/173/4/379

Hi Everyone,

Doctor put me on Geodon about 3 months ago. I started out 60 mg in the sample package the Doctor gave me. After using the sample pack I was prescribed 2 60 mg tablets (120mg) at night. It worked well for awhile and all of a sudden it seemed to stop working for me. I read a lot about how this drug is a nasty one and decided to cut down to 1 tablet (60 mg at night) The very next day I was trembling and having hot and cold flashes along with "brain zaps" and heart palpitations. I was hoping the Lamictal would cushion the side effects of the Geodon. Well it sure didn't do that and I know as the day goes I will have the same symptoms as I did yesterday.
The Geodon website makes this drug sound like a miracle drug but does state that heart related issues are there especially for the elderly people. This is a nasty drug that I hope I can get off and maybe go back to Lexapro because I have ADHD and not Bi-Polar.