Nitrate symptoms and conditions

The Journal of Immunology, Vol 146, Issue 4 1294-1302, Copyright © 1991 by American Association of Immunologists

ARTICLES
Urinary nitrate excretion in relation to murine macrophage activation. Influence of dietary L-arginine and oral NG-monomethyl-L-arginine

DL Granger, JB Hibbs Jr and LM Broadnax
Division of Infectious Diseases, Duke University School of Medicine, Durham, NC 27710.

Murine macrophage oxidation of L-arginine guanidino nitrogen to nitrite/nitrate yields an intermediate effector, possibly nitric oxide, with antimicrobial activity. Total body nitrogen oxidation metabolism (NOM) was measured in vivo by determining the urinary nitrate excretion of mice ingesting a chemically defined nitrite/nitrate-free diet. As reported previously, mycobacterial infection with bacillus Calmette- Guerin led to a large increase in urinary nitrate excretion. This increase was temporally related to macrophage activation in vivo. The substrate for macrophage nitrogen oxidation metabolism in vitro, L- arginine, was deleted from the diet without ameliorating the urinary nitrate excretion response induced by BCG. This suggested that L- arginine was synthesized endogenously because there are no other known natural substrates for NOM. A competitive inhibitor of NOM, the L- arginine analog, NG-monomethyl-L-arginine was fed to mice in their drinking water. NG-monomethyl-L-arginine ingestion blocked both basal and bacillus Calmette-Guerin-induced urinary nitrate excretion over a 2- 4 week time span. These experimental conditions should prove useful for further investigation on the role of macrophage NOM in host defense against intracellular microorganisms.

I get intense headaches and neck aches when I take Adderallxr and Adderall (i have tried both). when i stop taking it, after 2-3 days the head aches are gone, and the neck aches greatly diminished. However, I also take Isosorbide - a long acting nitrate like nitro glycerine. I have discovered that the two probably interact. if i stop the isosorbide, the headaches and neckaches are at a much lower level. I have found that relaxation techniquies help lower the neck pain and headaches also. I suspect that Adderallxr makes one more susceptible to anxiety (of which i have a lot right now due to challenges in job).

I also have trouble sleeping. I will try orange juice an hour before I go to bed to see if that helps.

When i get the dose right, Adderallxr is great. I am much more focused, calmer, and get a lot more priority things done. I wish I had known about ADD 40 years ago. I will somehow figure out the right dose and how to diminish the side affects. The benefits are too good for me to quit taking Adderallxr.