Omega 3 fatty acids symptoms and conditions

Hi I am a 44 year old asthma patient. I have had asthma since the age 2 and have been on & off prednisone since that time. As a child until age 20 I was on predinsone daily. My question is has anyone experienced nerve problems due to long time use? I do have muscle weakness and spasms, but I am interested in if anyone has had nerve problems. Please email me at ****** and refer to prednisone.

This is my story. My daughter 14, the most precious child ever born. She has a wonderful disposition always happy, loving, and determined to succeed in whatever she does. She just brightens everyone’s world.
She suffers from severe seasonal allergies and mild asthma. She takes approximately seven allergy/asthma medicines a day during peak season. Over the past two years she has been taking Singular as one of her medicines. Being 14, sick of taking medicine she would not take the Singular on a regular basis. Approximately four months ago “MOM” says, if you take nothing else take your Singular it will work both for the seasonal allergies and your asthma. She has been taking this regularly four the past four months.
She became paranoid, she became a compulsive eater and bites the skin on her fingers. She would eat and chew on her fingers at the same time, until she choked. She had so much anger, she could not even go to the mall without temper tantrums.(As a child she never had any tantrums ) Always afraid. Severe depression set in. She would cry at a moments notice. She would say, I have a very sad life, sad very sad, nothing makes me like this, I’m just sad. She felt she should go live with the homeless people. I asked her why, she didn’t know, she felt maybe that’s where she belonged. Nightmares and sleepless nights.
She needs help quickly. Before calling the Doctor, I went on the internet and entered Singular and depression and I found 1900 entries, all people telling me what I was experiencing. Could this possibly be the answer for us? I called her Dr and told him what I thought, he said he has never had anyone that this has happened to. He hoped it was the answer, but really didn’t think is. He said if it wasn’t the answer she would need therapy, mood stabilizer and Prozac.

Its day four off Singular, she smiling, no tears today, no temper tantrums, looking forward to school next week, wants to play volleyball next year, singing in the car,
I hear that happy voice again.(Hi, Mommy!!!!!!) Every once in a while a glaze comes over her face. She isn’t a 100% back, but I know it is coming.

To all the people that don’t have the happy ending, I will pray for you and hold you in my heart forever.

June 2, 2008

Many people have asked why I suggested that Omega-3 from fish oil MIGHT possibly help those retrying to recuperate from the adverse side effects of Singulair. It is my opinion, that it MIGHT help the body return to balance. And unless we OD on Omega-3 from dietary sources, (avoid tuna fish high in mercury), then it won't hurt.

Mechanisms and innovations

The science behind dietary omega-3 fatty acids
Marc E. Surette, PhD
Marc Surette is Professor and Canada Research Chair in Cellular Lipid Metabolism, Département de Chimie et Biochimie, Université de Moncton, Moncton, NB

Correspondence to: Dr. Marc Surette, Département

"When cells are activated by external stimuli, arachidonic acid is released from cell membranes and is transformed into powerful cellular mediators such as thromboxanes, prostaglandins and leukotrienes.10 These compounds possess a range of activities, including activation of leukocytes and platelets, regulation of gastric secretions, induction of bronchoconstriction and signaling of pain in nerve cells. The importance of these compounds in health and disease is evident by the range of pharmaceutical products that target their biosynthesis or action.11 Indeed, arachidonic acid metabolism is the target of nonsteroidal anti-inflammatory drugs (e.g., acetylsalicylic acid, ibuprofen), cyclooxygenase-2 (COX-2) inhibitors (e.g., rofecoxib, celecoxib12) and leukotriene antagonists (e.g., montelukast, zafirlukast).13 Dietary omega-3 fatty acids directly affect arachidonic acid metabolism because they displace arachidonic acid from membranes and compete with arachidonic acid for the enzymes that catalyze the biosynthesis of thromboxanes, prostaglandins and leukotrienes.8 Thus, the net effect of consuming foods enriched in omega-3 fatty acids is a diminished potential for cells like monocytes, neutrophils and eosinophils to synthesize these powerful arachidonic acid–derived mediators of inflammation and a diminished potential for platelets to produce the prothrombotic agent thromboxane A2." (Surette, 2008).

******

Just reporting back with some information.
I've been off of Yasmin for over a month now. Overall I've been better but there have been a few "relapses" where I've become so dizzy/lightheaded that I hard-core started to panic. Those days can be disheartening.
I've read some previous posts from an RN who said that Yasmin in particular, suppresses your androgens (testosterone) which causes many of these symptoms. This also explains why sometimes it takes a while for these symptoms to "catch up" I know I was feeling great when I first started.
I'm a lot better now that I stopped Yasmin, but I know it's going to take up to six months to get back to normal. Have your doctor check your hormone level. Even if it's " low normal" that isn't healthy for say, a 20, or 30 year old.
For herbal supplements I would suggest Ashwagandha. It's supposed to help production of your androgens. Also keep hydrated and have plenty of Omega-3 fatty acids.
What I also encourage is to talk about your situation. Once you open up, you'll never know who you'll find that had the same issue. We women can be a very helpful resource for one another.
I'll keep you posted on the progress and I hope the best for all of you.

Some common sense observations about Singulair side effects. (As everything on the internet, this is only my opinion.)

Conclusion up front: Ethics in science SUCKS these day. Put enough money on the table and what happens? I don’t mean all scientists, just the few. But, the Merck ghost writers are the tip of the iceberg for those in the schm#ck category. Maybe, if we reveal the extremes of abuse of laboratory animals, the ASPCA will organize and save us all. How about if they find out about the pharma labs that just beat the cr@p out of the lab animals to produce a stress response to find out what chemicals are produced? What was that all about?? Probably military—send our soldiers out to war over politics/oil, then we will have a pill to give them every night to put them back together again for the next day??

1.The cysLT1 receptor, which Singulair blocks, is a gene, found on the x chromosome (?), part of our inherited innate immune system. It is evolution. The hypersensitive individual overreacts to environmental stimuli causing unpleasant or dangerous symptoms. It is advantageous to intervene to prevent that. Merck’s idea was to block cysLT1 so that the chemicals secreted by the mast cell cannot reach the tissues in the lungs and nasal passages to cause the inflammatory responses-asthma being the more severe.

2.How did Merck develop such a drug? The cysLT1 receptor , a gene, has a profile, a chemical map of the components. Montelukast, was modeled to chemically bond with the receptor so that it does not function. That bond will endure until the liver enzymes break it down. Montelukast blocks the leukotriene response until it is time to take another pill. All that sounds good so far.

3.Now comes the first of the too good to be trues. Montelukast was formulated for a specific gene profile. However, cysLT1 has variations, numbers unknown, but more than several. Even Merck recognizes that it is not effective for everyone because the clinical data shows that. Mis-matches with the gene profile can cause montelukast to be recognized as an allergen. Then, the body mounts an immune response against montelukast.

4.Many of the symptoms that we see here are allergic reactions to montelukast, headache (18%), types of neuro-muscular (10%), hives, nausea, vomiting, leg pain, stomach cramps, and more. Some people will recognize montelukast instantly as an allergen. If the mis-match is slight, the allergic reaction could be acquired or build over time. Montelukast will ALWAYS be an allergen to those people. Doctors will do great harm if they treat allergic reaction to montelukast with other drugs. Those people must STOP taking montelukast.

5.The second too good to be true, is that cystLT1 receptor, involved in the leukotriene response, is only a very tiny part of the immune system, genetically programmed to function as a WHOLE. Now what? It is highly unlikely that montelukast can block the leukotriene receptor - cysLT1 in the brain, lungs, spleen, intestinal mucosa, etc. and not cause some kind of re-structuring of the immune system to compensate for that. Those who take Singulair can expect that they are a new adaptation of human being who can operate without the cysLT1 receptor. Or, they can expect long term damage. How scary is that?

6.What would happen if Merck revealed that montelukast, by definition , cannot work for everybody because it is based on a gene profile with variations? What would happen if patients and doctors started to think about the immune system as a whole? Then Singulair – which means “single thing you need for air – breathe” the logo is even Singul-AIR, would not be the huge money maker that it is. Doctors would find a way to use it, for whom it is effective, in an appropriate way to consider the long term effects. For some people, this drug could have a place. But this drug does not deserve to be a CASH COW-money, money, money!

7.What in the heck is wrong with the FDA? Are they under a spell or hiding under a rock?

I have been taking Lipitor 20 mg for 4 months. Six to eight weeks ago I developed exema, allergic conjunctivitis and burning/swelling of my lips. I saw a PA at my doctor's office today and we are stopping Lipitor for 10 days to see if it is the culprit. Has anyone else experienced these problems while taking Lipitor?