Oral medication symptoms and conditions

My 4 year old Son has had diarrhea from about the last 4 weeks... we have started some tests for Celiac disease but today it only occurred to me today that he has been on Singulair for about that time frame... after all the worry and reading these other storied Im even more convinced that it maybe the Singulair..
Im just hoping that someone might read this sometime today or the next couple of days to tell me if when they come off the singulair how long did it take for the diarrhea to pass. My son had is last tablet 2 nights ago ( so he has only been off it so far for one night. But he still has the diarrhea.. should it have started to come out of his system already.

Sorry, I can't just walk away.

When you find patents or patent applications for certain purposes, then you know that your ideas are well founded. There are several patents for using an anti-malaria drug for asthma. I would bet that somebody had that idea all the way back to the 1960's. So it is very possibly no coincidence at all that a chloroquinoline or other quinoline ring would be part of montelukast's chemical structure.

Here is one of the patents.

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It is well known that quinoline rings can be toxic to some people even very rapidly. As in this very extreme example.
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PEDIATRICS Vol. 27 No. 1 January 1961, pp. 95-102 This Article

FATAL ACUTE CHLOROQUINE POISONING IN CHILDREN
Howard M. Cann M.D.1 and Henry L. Verhulst M.S.1

1 National Clearinghouse for Poison Control Centers, Accident Prevention Program, Public Health Service, U. S. Department of Health, Education, and Welfare
Four cases of acute chloroquine poisoning in children are presented. In three instances death occurred within 2 hours of ingestion of larger than therapeutic amounts of the drug. The rapid occurrence of death in acute chloroquine poisoning is probably explained by complete and rapid absorption of the drug from the gastrointestinal tract resulting in high blood concentrations which depress vasomotor function and respiration. Cardiac arrest follows and may be caused by the direct myocardial action of chloroquine, to anoxia, or to both. The similarity of the manifestations of acute chloroquine poisoning and those of acute quinine and quinidine poisoning suggests that acute toxicity may be attributed to the quinoline ring portion of these drugs.

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I don't think that we are seeing extreme examples. But we may be seeing less extreme immediate reactions or reactions where the toxicity builds up over time.

Quinoline rings are know to cause neurotoxicity. There are theories about how that happens. One of the theories is about blocking connexins which are gap junction proteins in the brains.

I don't know how montelukast could be breaking up so that it causes toxicity. Or if the problem is the how rapidly the liver enzymes can metabolize it. But there is plenty, plenty, plenty of clinical evidence that there is a quinoline ring culprit somewhere in the picture. Or some by-product of that causing problems.

Somehow it was decided that montelukast did not have the safety issues that the other drugs in the same category have. See this.

"The starting point in the development of montelukast appears to be a quinoline-containing structure, likely identified as a weak random screening lead (Figure 3). The Merck group hypothesized that this molecule was mimicking the olefin backbone of cysLTs, and that the addition of mimics for the acid and peptide regions of LTD4, might improve its potency. As a first step, the dithioacetal linkage first seen in some SmithKline compounds was incorporated; this led to a compound with greatly increased in vitro potency but poor oral bioavailability. When one of the carboxylic acids was replaced by an amide, forming MK-571, the new antagonist had even greater potency and good efficacy following oral administration. The enantiomers were resolved to yield MK-679 (verlukast), a compound with better clinical effects than MK-571, but whose clinical development was stopped for safety reasons. Further structure-activity relationship studies led to the development of montelukast (16), an antagonist that appears free of the safety concerns plaguing earlier members of this series."

If we can find out why the earlier versions were not safe and how they thought fixed it, then maybe we can find out what is going on with the quinoline ring in some people.

I would be very surprised if the FDA will address our concerns. Why does it always seem like they wait for enough people to die like in Vioxx? Wasn't Vioxx responsible for thousands of deaths?

Just a quick update about my husbands law suit with doctor who gave him 6 shots of kenalog for gout in his feet, legs, and knees. Russell ended up rushed into hospital with steriod induced diabetes and was told he would be inusulin dependant for the rest of his life, although his records went missing from hospital shortly after he was admitted. the doctor acting for the solictor came to examine him and has told us he has found letters from the hospital to our doctors and the interesting fact that I think everyone should know, he told us that the manufactors of kenalog suggest a maxium dose of 80 ml he told us Russell was injected with 320ml. We were also told that even though what he went through was very frighting because he did not die, we haven't got a positive case for sueing the doctor. ( but we still are continuing with the law suit)
Russell is not using insulin anymore as the steriods have came out of his body and his pancreas started again, although he is now classed as diabetic type 2 ( diet controlled)
Regards
Tina and Russell ***

During a recent acute headache episode, I was given a pain shot as well as an injection of Reglan, and then given Reglan 10 mg QID. After the injection, I began experiencing horrible restlessness and could not seem to sit still. While then progressing on to the oral medication, I soon began experiencing extremely painful muscle spasms throughout my body, as well as weakness, right eye twitching, neck spasms that radiated down the front and back-side of the neck and chest, trouble with swallowing, and developed near lockjaw, only speaking like a ventriloquist. I even thought I had developed tetanus from a recent thorn in my finger. Well, my symptoms were due to REGLAN and should this happen to anyone else, STOP the medication IMMEDIATELY and notify your physician. In my case, I am taking Benadryl to counteract the extrapyramidal side-effects/dystonia. My symptoms all occurred within days of the Reglan; the injection symptom of agitation was more of an immediate reaction that continued to occur with the oral form of medication.