Organisms symptoms and conditions

Why does Singulair cause these symptoms? I am going to give my explanation which is only a HYPOTHESIS. This should not be categorized as any thing but an educated guess. This is not backed by scientific research because nobody will do any research that would appear to anger
Merck even if people are suffering in the thousands.

1. The original research that preceded the development of Singulair (montelukast) seemed to focus on the theory that asthma was caused by an unusual immune response to certain pathological stimulus. There are many references to the observation that a high percentage of asthma sufferers are people whose asthma is caused by fungus. Many people suffer from asthma and are told that they are allergic to dust mites. Dust mites can live only because the fungus aspergillus pre-digests the
food source that dust mites can then absorb. Other sources of fungus occur in the home due to dampness or problems with wood rot.

2. The body's immune system fights certain categories of pathogens such as bacteria and fungus by creating nitric oxide which kills them at the site where they try to enter the body. The mast cell is the immune cell that is responsible for the production of nitric oxide. Mast cells are found in the skin, airways, intestines etc. The mast cell is capable of many different types of biochemical functions that are designed to signal other cells or other chemical responses. When the mast cell knows that pathogens
are present and nitric oxide is NOT produced, then it signals other immune cells to be sent to the site of the infection. Thus in the case of asthma, it is known that excessive numbers of eosinophils appear in the airways and these cells create inflammation.

3. Singulair was developed for asthma and later allowed to be prescribed for other reasons. I believe that montelukast probably creates a source of nitric oxide that prevents the mast cell from signalling for other immune cells to arrive at the source of infection. I arrived at that conclusion from studying the chemical structure of montelukast, the chemical structure of the gene cysLT1 receptor, and the chemical structure of the cell wall of fungus which would be what the mast cell uses to determine "what to do in order to kill the fungus."

The researchers who invented montelukast first had to clone the gene-cysLT1 receptor meaning that they had to be able to identify the gene and replicate it. Then by trial and error they had a find a "chemical"
that would bind (connect chemically) to the cysLT1 receptor. The theory would be that montelukast would take the place of the fungus or other pathogen and thus prevent the gene from reacting to produce the
responses that the sick patient with asthma produced. Merck says in the literature that montelukast binds with the cysLT1 receptor in order to prevent the mast cell from signalling the eosinophils to arrive in excessive
numbers that cause inflammation. I believe that montelukast is also causing the production of an amount of nitric oxide that is actually killing the pathogens that are present. For one thing, I would think that it
would be dangerous to incapacitate the immune system in that way without providing a way to kill the pathogens. I don't believe that the asthma response is just allergies to something like dust. Pollen from trees and flowers is loaded with fungus spores.

4. IF, IF, IF, montelukast does actually produce nitric oxide, then it does so by binding with the gene. Any place in the body where a molecule of montelukast encounters the cysLT1 receptor (a gene) then the corresponding molecules of nitric oxide are produced before the liver enzymes break the montelukast molecules up. Nitric oxide is TOXIC and
INFLAMMATORY. So let's look at the symptoms in regard to the location of the cysLT1 receptors. The location of these symptoms would not be places in the body where the mast cells normally encounter fungus or bacteria. The cysLT1 also has other functions in that it communicates with the cysLT2 receptors. Obviously, nitric oxide
should not be produced in these locations because of the signalling effect of nitric oxide on other physiological functions.

a. intestinal pain - the cysLT1 receptors are located in the small intestines
b. leg pain actually caused by vasculitis - cysLT1 receptors are found inside blood vessels- consistent with the fact that montelukast causes
Churg-Strauss
c. some people who didn't have asthma develop asthma - the cysLT1 receptors are in the airways
d. nightmares, depression, neurological damage - when montelukast penetrates the blood brain barrier probably due to unusual conditions of blood pH or electrolyte imbalance then nitric oxide in the brain causes neuron damage and excitoxicity

5. Why do some patients not experience side effects? Probably because genetically they are completely compatible with the model that researchers created when they cloned the cysLT1 receptor gene. I didn't not find any information about whether researchers knew that there are many different variations of this gene.

6. IF, my theory is even close to being correct, then why doesn't Merck do anything about researching these side effects. Maybe because nobody in the company knows how this drug works but the researchers who created it. All of the Merck literature is very vague about any biochemical information.

Again, this is just speculation and hypothesis. I have made an attempt to put this in simplistic language and therefore sacrifice scientific accuracy. But, I think that you will get the point.

SINGULAIR IS VERY DANGEROUS TO PATIENTS WHO EXPERIENCE NEGATIVE SIDE EFFECTS. DOCTORS SHOULD JUST REALIZE THAT
THOSE PATIENTS ARE NOT COMPATIBLE WITH THE MODEL FOR THE DRUG.

Most of the "side effects" are die off responses (sometimes referred to as a herxheimer response similar to that which occurs when treating syphillis) from bartonella or borrelia. Levaquin is a potent intracellular antibiotic...where these and other organisms can hide. These can be subclinical infections where (at this time) you are not even aware you are infected. If your "side effects" start around the 3rd day into your prescription...rejoice...and suffer for a while, you are killing something really bad.

I am 34 years old. I went to the OB today after having Mirena inserted in August. I had a baby last March and was nursing her at the time. I had asked my OB a few months ago if fatigue was a side effect, as I have been just exhausted for months. She said no. I am exercising, eating exceptionally well, and losing very little weight. I have been extremely emotional--on the verge of tears all the time. My marriage is terrible right now.

I mentioned at today's appt that I had some irritation/itching/rawness feeling in my vaginal area. She did a culture of my discharge and said there was no bacteria/infection, but she saw some "premature" cells, (I don't know recall exactly what she said, is a blur, but she gave me estradiol vaginal insert tablets and told me to use them for 3 months. She said that maybe starting me on Mirena while I was nursing got my estrogen too low and that I "shouldn't have to be on this {estradiol} forever." Am I now experiencing premature menopause? No wonder I've suddenly sprouted gray hairs over the last 6 months!

As you read this you may wonder what this has to do with you or the drug Levaquin.Read on and you will see. Simply put \"Antibotics are poisons that are meant to kill. Only licensed physicans can prescribe antibiotics; we mere mortals cannot. Antibiotics are used to kill bacteria. Certainly,many have benifited from thier use; but if bacteria was the only organisms that antibiotics killed, this site would be unnecessary .We take antibiotics when we are sick, when our \"immune systems are down\".Yet all mycotoxins are immunosuppressants. I contend that any poison that kills small organisms in small doses can also kill big organisms in big doses.You and I are big organisms.
An adult has approximately three to four pounds of benifical bacteria and yeast in the intestines. Each competes for nutrition from the host-you.The competion from the benifical bacteria keeps the ever present yeast into check and allows them to produce necessary nutrients,including B vitamins. When antibiotics upset the delicate balance of the interestinal terrain, yeast grow unchecked into large colonies and the intestines are inhibited by hostile mircrobes, a condition called "dysbiosis".
Every time, not just sometimes, antibiotics are swallwed, they kill benifical bacteria within the intestines.Yeast are opportunistic organisms. As the intestinal bacteria terrian terrain erodes, yeasts thrive, especially when thier dietary cravings are met.\"with grains\",sugar is also a grain. Tendrils on the yeast, called hyphae literally poke holes through the lining of the intestines, a syndrome called leaky gut. It is known that (NSAIDS) Like Naprycin and Tylenol can enhance the gut leakage.
As early as 1950, two female researchers in Albany,NY,understood the adverse Physiological events caused by antibiotics.For years they worked on a soil-based organism that prevented dysbiosis caused by antibiotics. They called thier discovery "Nystatin" after New York State. This antifungal drug kills organisms, hence the term antibiotic is applied to it as well. But this revolutionary antibiotic stopped yeast overgrowth caused by all other antibiotics and was 100 percent safe to use . Amazingly, Nystatin caused no side effects. though it can cause a "die off " A responce which is often confused to side effects.
In 1957, 340 antibiotics were tested for thier toxicity. As described in The Handbook of Toxicity, editor Dr.William S. Spector used mice and rats to determine antibiotic toxicity.He stated,\"by using a larger number of animals of comparitive weight and sex for each level tested,attempts are now bieng made to determine more percisely the dose which will kill 50 percent\".This is referred to as\"LD50\", or lethal dose for 50 percent of the mice.One must wonder how perscriptive doses of these very same antibiotics were established in humans before 1957! We beg the question that if a given dose of penicillan will kill 50 percent of the mice tested,isn\'t it logical to assume that a larger dose,perhaps repetitive doses extended over forty years, might prove fatal to human? It is the time span between taking antibiotics and death that intersest me.Do people really die of heart disease and diabeties, or do antibiotics cause these diseases? A death certific!
ate will state the probable cause of death and never question whether the deceased had a history of taking antibiotics! the fact that antibiotics are fungal metabolites and have been implicated by scientic literature as contributing to death in man should be considered. Why does it seem to be so difficult to assume antibiotics are directly or indirectly linked with death when immunodeficiency and and death are so intimately linked?Max Planck , Nobel Prize winning Physicist , probably answered these questions best when he surmised as to why science is slow to change even in the presence of so much factual date, such as indicated here on this site.Planck said,\"A new scientific truth does not triumph by convincing its opponents and making them see the light, but rather because its opponents eventually die off and a new generation grows up that is familiar with the ideas from the beginning.\"
That a new generation will grow up knowing the dangers inherant in taking antibiotics is a good thing. That Dr.s will continue randomly prescribing fungal toxins should teach us the importance ofknowing medical facts before blindly accepting any new prescription.Please study the antimircrobial benifits and the immune system stimulants that nature provides.If you have reached the point where no alternitive exist,i recomend that you ask your Dr. to prescribe \"Nystatin\" and use it with your antibiotic.Also restoring the intestinal terrain with a Probiotic.
The reason for such a lenthy statement ,is that I care that there are people suffering because of this toxin that is gladly given to us. I recieved Levaquin pre-op, before a surgery,I was prescribed Bactrim DS for two weeks prior to surgery for an ruptured occulted epidermal cyst, I could not take the drug for nausea I took two tablets.No more. At time of surgery they tried to administer Leviquin.I had had it in my IV for about three - to five minutes and started to have an allergic reaction to it.Itching redness to the arm ,hand and wrist. I am thinking they stopped it.The nurse told the Dr. she stopped it. Thay supposedly ordered a differant antibiotic. And prescribed Biaxin XL. I never took any of the antibiotics at home.Just what was given to me in surgery.I came home from out patient surgery same day.For three days my arm where the IV administered the Leviquin was sore in joints that I could hardly move and it has been two weeks and it is still the same, but more, my
rib cage and neck was so sore that I felt like I had been in a wrestling match. The surgery was in the perineal area. No reason for anything above to be painful. I immediately started using my alternitive medicines, Probiotics and Olive Leaf Extract , an antifungal. With fairly good results. You see, I didn't need those antibiotics after all.The key to life is a good diet.Go figure! Be Blessed And Well.

First I want to say that I very much liked and appriciated the responce to the "Dr." from david t fuller
director ; fluoroquinolone toxicity
research foundation. Mon, 10 Feb 2003-
As you read this you may wonder what this has to do with you or the drug Levaquin.Read on and you will see. Simply put "Antibotics are poisons that are meant to kill. Only licensed physicans can prescribe antibiotics; we mere mortals cannot. Antibiotics are used to kill bacteria. Certainly,many have benifited from thier use; but if bacteria was the only organisms that antibiotics killed, this site would be unnecessary .We take antibiotics when we are sick, when our "immune systems are down".Yet all mycotoxins are immunosuppressants. I contend that any poison that kills small organisms in small doses can also kill big organisms in big doses.You and I are big organisms.
An adult has approximately three to four pounds of benifical bacteria and yeast in the intestines. Each competes for nutrition from the host-you.The competion from the benifical bacteria keeps the ever present yeast into check and allows them to produce necessary nutrients,including B vitamins. When antibiotics upset the delicate balance of the interestinal terrain, yeast grow unchecked into large colonies and the intestines are inhibited by hostile mircrobes, a condition called "dysbiosis".
Every time, not just sometimes, antibiotics are swallwed, they kill benifical bacteria within the intestines.Yeast are opportunistic organisms. As the intestinal bacteria terrian terrain erodes, yeasts thrive, especially when thier dietary cravings are met."with grains",sugar is also a grain. Tendrils on the yeast, called hyphae literally poke holes through the lining of the intestines, a syndrome called leaky gut. It is known that (NSAIDS) Like Naprycin and Tylenol can enhance the gut leakage.
As early as 1950, two female researchers in Albany,NY,understood the adverse Physiological events caused by antibiotics.For years they worked on a soil-based organism that prevented dysbiosis caused by antibiotics. They called thier discovery "Nystatin" after New York State. This antifungal drug kills organisms, hence the term antibiotic is applied to it as well. But this revolutionary antibiotic stopped yeast overgrowth caused by all other antibiotics and was 100 percent safe to use . Amazingly, Nystatin caused no side effects. though it can cause a "die off " responce which is often confused to side effects.
In 1957, 340 antibiotics were tested for thier toxicity. As described in The Handbook of Toxicity, editor Dr.William S. Spector used mice and rats to determine antibiotic toxicity.He stated,"by using a larger number of animals of comparitive weight and sex for each level tested,attempts are now bieng made to determine more percisely the dose which will kill 50 percent".This is referred to as"LD50", or lethal dose for 50 percent of the mice.One must wonder how perscriptive doses of these very same antibiotics were established in humans before 1957! We beg the question that if a given dose of penicillan will kill 50 percent of the mice tested,isn't it logical to assume that a larger dose,perhaps repetitive doses extended over forty years, might prove fatal to human? It is the time span between taking antibiotics and death that intersest me.Do people really die of heart disease and diabeties, or do antibiotics cause these diseases? A death certificate will state the probable cause of death and never question whether the deceased had a history of taking antibiotics! the fact that antibiotics are fungal metabolites and have been implicated by scientic literature as contributing to death in man should be considered. Why does it seem to be so difficult to assume antibiotics are directly or indirectly linked with death when immunodeficiency and and death are so intimately linked?Max Planck , Nobel Prize winning Physicist , probably answered these questions best when he surmised as to why science is slow to change even in the presence of so much factual date, such as indicated here on this site.Planck said,"A new scientific truth does not triumph by convincing its opponents and making them see the light, but rather because its opponents eventually die off and a new generation grows up that is familiar with the ideas from the beginning."
That a new generation will grow up knowing the dangers inherant in taking antibiotics is a good thing. That Dr.s will continue randomly prescribing fungal toxins should teach us the importance ofknowing medical facts before blindly accepting any new prescription.Please study the antimircrobial benifits and the immune system stimulants that nature provides.If you have reached the point where no alternitive exist,i recomend that you ask your Dr. to prescribe "Nystatin" and use it with your antibiotic.Also restoring the intestinal terrain with a Probiotic.
The reason for such a lenthy statement ,is that I care that there are people suffering because of this toxin that is gladly given to us. I recieved Levaquin pre-op, before a surgery,I was prescribed Bactrim DS for two weeks prior to surgery for an ruptured occulted epidermal cyst, I could not take the drug for nausea I took two tablets.No more. At time of surgery they tried to administer Leviquin.I had had it in my IV for about three - to five minutes and started to have an allergic reaction to it.Itching redness to the arm ,hand and wrist. I am thinking they stopped it.The nurse told the Dr. she stopped it. Thay supposedly ordered a differant antibiotic. And prescribed Biaxin XL. I never took any of the antibiotics at home.Just what was given to me in surgery.I came home from out patient surgery same day.For three days my arm where the IV administered the Leviquin was sore in joints that I could hardly move and it has been two weeks and it is still the same, but more, my rib cage and neck was so sore that I felt like I had been in a wrestling match. The surgery was in the perineal area. No reason for anything above to be painful. I immediately started using my alternitive medicines,Probiotics and Olive Leaf Extract , an antifungal. With fairly good results. You see, I didn't need those antibiotics after all. I try to eat a healthy diet,no grains. I do indulge on occaision. My diet is much like the Adkins diet. The key to life is a good diet.Go figure!Be Blessed And Well.
Sharon C.