Organs symptoms and conditions

2 genetic mutations in the gene that encodes for the transporter protein responsible for moving anti cholesterol statin drugs into the liver to be detoxified. have been identified. This gene is "SLCO1B1" (also referred to in the scientific lit as "OATP1B1"). Drugs must be "detoxified" by organs within the body and then eliminated, otherwise the drug stays in the blood stream, building up to toxic levels. With either of the 2 mutations, statins have been found to be (from various studies) anywhere from 122% to 400% ABOVE NORMAL plasma statin levels. How many people have either of these mutations? (Population genetic studies were done in Finland on Caucasian pop--so all the #'s refer to Caucasian population) 25 % to 38% of ALL Caucasian possess one of these 2 mutations. Thus, for however many yrs someone with one of these mutations has taken a statin, the level of the statin in their blood stream conceiveably could have been 400% ABOVE normal statin levels. ALll those pharmacologic effects of statins--decreased coenzyme q10, depressed manufacture of dolichols, depressed manufacture of selnproteins and thus glutathione, interrupted production of GTPases and glycoprotein function, decreased brain cholesterol levels--neuron synapses and new growth of neurons depend upon brain choelsterol--are intensified unrelentingly for the length of time the drug is taken.

For the last 4 years --I have been on Yasmin. I stopped taking this pill a couple of month ago and could not be more relieved. I say this because during that time I had severe heart palpitations and anxiety attacks. They were so severe sometimes I would cry because I was so scared I was going to have a heart attack. A couple of years ago I went to a Cardiologist and told him about my heart racing, skipping a beat, and or course the constant never-ending heart palpitations. I took a stress exam, Ekg...etc all those test need to find the problem. They came up with nothing and basically said it was stress and anxiety. The Dr. gave me pills for anxiety and pill to slow my heart rate..which looking back was a joke!! Because it was really from Yasmin.I am so much better and happy to know that I was not just going crazy ..because that is how I truly felt. I was only on this medication because I too have ovarian cysts. I am too scared to go on any other birth control pill now. So if anyone out there is on this medication and has these symptoms..please stop this medication and know that you are not crazy. There are so many of us out there that have had these symptoms.Now I have to go to the Dr. and find out if there are any permanent damages to to any part of my organs.. so upset with this company and drug.

I think that I finally figured out why I am so physically and mentally sick. I received the mirena almost 2 years ago and I was a true advocate of the product...I love it!! About 6 months ago I started to have panic attacks and anxiety (i have never experienced this before) it was so bad that I barely made it to work everyday and could no longer handle being out in public. My PCP placed me on different types of anti-depressants (which made me depressed). Currently I take Budeprion which has decreased my anxiety but I do not feel like myself. The past month and a half I wake up with the feeling of morning sickness (the numerous pregnancy test say that I am not), have headaches, low energy levels and little motivation. I was pretty sure that my hormones levels must be "off" but my PCP and OB insisted that there is no way that my symptoms have anything to do with my hormones because my child is almost 2 years old and I am 29 years old. I have gone through numerous tests on my gallbladder and other organs to find the cause of these symptoms that I have and Everything is Fine. After reading the stories on this website I now know that I do not need anti-depressants and I am not going crazy...I just need to get the Mirena removed.

Ok...now I am really angry. I posted in early June. I am 7-8 weeks out from stopping the drug (only took for 2 weeks) and, while I feel better in the am, I continue to have "attacks" mostly at the end of the day after work or when going to sleep. I have minimal dry mouth/cough (keep drinking water/peeing constantly but ok because I am eating foods to dump water which is why doc wanted me on this poison to begin with). The feeling woozy and nausea has subsided. I continue to have racing heart (happens when about to fall asleep and causes anxiety/insomnia), sharp pains all over the chest and in left arm (constantly think I am having a heart attack/stroke), tingling/burning in hands/feet, and to top it off shooting warm burning pain (very annoying) up and down legs (this is new). My doc told me to get off all my supplements (because he knows nothing about them and thinks they are complicating the picture...now I think he is ignorant). I restarted my CoQ10 which is protective for the heart and the racing has stopped so far (been a few days). In my research, most of the symptoms fall under "peripheral neuropathy" which can be caused by toxicity from drugs. Natural treatments suggest making the body more alkaline and detoxing the organs by eating nutritious foods (organic when you can), exercise, drinking lots of water (with lemon and cucumber slices which make the body alkaline and purify the organs) and taking alpha lipoic acid. To treat the neuropathy make sure you are getting enough vitamin C, E, and B complex with B6, B12 and folate/folic acid (I take B100 caps). Please research these before taking anything and make sure its right for you. I used to say check with your doc but, in my experience, most don't know about natural treatments. I will post again in a week to let you guys know how its going. Best of luck to all.

For those of you taking this drug and want to get off, please know it takes 3-4 weeks (longer in others depending on your metabolism) to be "totally" out of your system. Don't think you'll feel better in a few days. Give it a least 6 weeks to show significant change in your symptoms. I know, my husband took this and was having mental sluggishness, depression, confusion which led to many other tests. He has been off the drug now since Sept 08 and off the anti-depressant too. Guess what...no depression has returned since being of this drug. He's back to an aspirin a day, what he took before this nightmare began. Anybody taking this drug should stop immediately. It's the drug from hell!

Started with fever, then rashes, then swollen face, then rashes all over the body, then no taste buds and did not feel like eating. Very tired all the time. Stopped taking the drug after the 8th day when fever and rashes started to appear. Took lots of water after that to try to flush out of system. After 12 days, taste bud seem to be coming back. Skin has started to become flaky and peeling. More like extremely dry skin. This was an extremely bad reaction and can cause very bad side effects. See you doctor as soon as an allergic reaction starts. Blood tests seem to be necessary to make sure the drug hasn't affected other organs. Good luck to any one who has to go through this reaction.

Last year I had so much pain that I ended up in the emergency room twice. I was tested for everything and finally my doctor send me to the lab for an ultra sound. I was diagnosed with ovarian cysts and small fibroids. I was scheduled for a surgery and I was diagnosed with endometriosis on January 20, 2009 by laproscopic surgery. The doctor said my endometriosis is severe and the adhesions are all over my ovaries, bowel and bladder. I had another surgery march 3, 2009 to remove an ovarian cyst and endometrioma. The surgery was suppose to take 3 minutes or so and ended up taking 2 hours. The organs were stuck down so bad that the doctor ended up having to remove my right ovary and fallopian tube. The doctor scheduled me to start LUPRON on April 15, but after reading the comments here, I have decided not to try lupron. I am not in any pain now from my endometriosis, so I prefer to weigh my options. I ordered many books on the natural treatment of endometriosis and will try that avenue. I suggest that you read and research before trying any drugs, because at the end of the day we will be the ones suffering not the doctors.

I've been on levothyroxine 150mcg for about 3 months before that it was 100mcg and so on. I have gain lots of weight and tired all the time. depression also, headaches. I hate this gaining weight, sleepy all the time and depression is from gaining weight. I thought this med is to up boost my thryiode but it doesn't seem to be working. my dr. said I'm on the highest dose there is. I don't know what to do any more. I was thinking about taking myself off this but not sure what will happen if i do. I hope there is someone out there that might be able to let me know if they are going through the same things what they are doing and how they feel now.

I am taking Levaquin now, but after reading all of this I plan on not finishing the 3 pills I have left. My head is numb and feeling so weird. I have a constant headache which I hardly ever have and I feel dizzy and really out of it. My stomach is sick and nauseated. Feeling almost depressed which I don't know why. I just don't feel right. My shoulders feel heavy and tingly and I feel more sick now than when I started taking it 7-8 days ago.

terrible ab swelling bloat and pain swelling in different part of body but every thing seems to be on left side.Feel compression of all inside organs in abdomen.making wheezing and breathing not right.Depression - my Prozac didn,t seem to work any more now that I look back on it. I started taking lisinopril about 8 yrs ago.Lately started with headache but that went away as soon as i stopped drug. Luckily over the holidays I ran out of pills and stopped taking and about on the second day (three days after one of my emergency visits where they never find nothing even though I feel like I am dying.) I felt like my old self again .I felt normal. I was so happy Yet so mad at doctors. For getting treated like I was crazy after awhile.I found out about intestinal angioedema fro my pharmacist when on a whim asked about lisinopril .My stomach area is all still sore but not all swelled up .Oh I also had urinary problems Which I still Have off and on But I take Flomax even though i am female. Im going to get bladder scope next week and I know it has to do with compression for so long from angioedema from the lisinopril.

I've been on it for about 2 months, the first month nothing really happened...but the last month its just been getting worse and worse. Light headed, sweaty hands, cold feet, tinglinging in the fingers, heart palpitations, etc...the worst are the heart palps, and light headedness (I feel like I might pass out right now!). I stopped taking it today, my last pill was yesterday morning, so hopefully the side effects will subside today or tomorrow.

for those who went off the drug, how long did it take for the side affects to disappear?

I have taken Bactrim on a few different occasions, all with the same bad reaction.

I am very prone to getting UTIs, especially after sex. It has been like this for years. One of the first times I got a UTI, I was prescribed Bactrim. There were not really any other side effects except for a small area, about the size of 2 quarters, on the side of my stomach, right below my rib, that turned reddish and itched. I told my doctor about it and he dismissed it, saying it couldn't be bactrim as the cause, he's never heard of it, etc. When I was done with the antibiotic, the "rash" or red area faded slowly, but left a grey mark in it's place that has not gone away in 5 years now and counting. It is PERMANENT DAMAGE from this medication.

I was younger, so I never cared to write down the medication name... later on, I had another UTI and was given Bactrim again. Somewhere during treatment I felt myself itching the same area, I lifted my shirt, and there it was, inflamed again.... again I didn't list it as one of my allergy medications and was prescribed it at least a 3rd time... with the same occurring.

I know for a fact that it was bactrim causing it. It is obvious that the 3 times I took it, the same mark that was caused by bactrim to begin with.. turns red during ingestion of the medication. I do not know why it stays localized to one area and does not spread, I don't know what kind of organs it might have been affecting in that area.. I wish I had a clue because I am very curious...

But bactrim has left a permanent scar on my body, and not only outside, but god knows what it has done inside that has caused this to surface out.

Have been to the ER twice - both times on death's door. Blood pressure dropped dangerously low so I ended up in ICU both times. Liver function was elevated. Blisters on hands and face. Can't sleep at night. Feel exhausted. Got so sick that all major organs were shutting down. Doctor's did not realize that I might have an allergic reaction to this drug until I mentioned it the 2nd time in the hospital.

My 7 year old female Siberian Husky, Niceah is suffering with her second serious flare-up of IBD. She was taking 20 mgs. of prednisone every 12 hours for several days. We are now down to 12 mgs. daily and working towards 12mgs. every other day. She is lethargic and her body and belly have swollen frightfully to the point where it is difficult for her to lie down without grunting and sighing. She pants heavily. She drinks and eats constantly. Her nose is dry. Her tummy grumbles all day and night. I have been boiling chicken breast and mixing it with sweet potato and Enzymes & Probiotics. I am currently working with a holistic advisor concerning Niceah's diet once she has weened off the prednisone. The side effects of this drug are frightening and I am so worried that something more permanent and damaging will occur. Has anybody experienced this?? If so, I would appreciate any advise. Robin. copher370@aol.com

I am 39. I suffered with endo for 5 years until I found a doctor who would operate on me. She did and found that my uterus and left ovary were, in affect, fused to my left side with edno. She could not even move the organs. So, she could not cut out any endo. She suggested Lupron Depot therapy for 6 months in order to shrink the endo by depriving it of estrogen. I just completed the 6 months and it was great. The only side affect I noticed was a few hot flashes each month. They got a little worse in my 5th and 6th months. And, in this 6th month, I experienced some mild spotting. All in all, it was a great experience and I actually lost 5 lbs during the 6 months! It was SO great to be without the pain and without my period for the time. What a breath of fresh air! According to my experience, I would highly recommend the treatment.

I took aldactone (50mg / day) for a little over 6 years for the excess hair growth associated with PCOS. It did make the hair issue much better. About a year into taking it I wasn't sure it was working, so I stopped taking it. All my old facial hair grew back while off of it, so I started back up again.

I had no problems with the medication at all - or so I thought. I have had dizzy spells for years, especially after standing up from sitting or squatting, to the point where I would almost fall over or black out. For 6 years I went on like this, thinking it was no big deal until I went to a new doctor and he mentioned that my blood pressure was low 90/60 (Usually the nurse would say "you're BP is low, that's good") and he asked me if I ever got dizzy spells and I said yes all the time. He told me to stop taking the spironalactone NOW because REALLY LOW bp can cause damage to your organs. Now that I have stopped, my face is more hairy but I'm not dizzy anymore.

It works for PCOS, but keep an eye on your BP.

Only on it for 1 month so far and already having issues. I apparently have the worst case of endometriosis all my doctors have seen, including a cancer specialist that had to do all my surgeries because of the severity. Granted, I am only 31 years old and have had a full hysterectomy. So, after 3 surgeries I am still having severe abdominal pain and bleeding (don't know where that is coming from since I don't have a uterus anymore) so they said try Lupron and I finally gave in. Now I started getting such severe pain in my lower back that I can't stand for longer than 15 minutes and terrible side aches. I started getting headaches (which I already take pills for for years now),and have gotten the hot flashes as well. What are we to do ladies? I am so sick of complaining to the doctors about pain. You feel as if you are a big cry baby. What are my options here and does this ever stop?

Update on my post of Aug. 11th. I did see a neurologist who was a bit skeptical, but after looking it up did acknowledge that this drug can cause tendon ruptures, etc. Later that week he did a nerve conduction study, both the one with the needles and the one where they shock the muscles. He was happy to report that I did not have any "nerve" damage. I had already told him that I did not think I had neuropathy as the numbness had gone away and was just replaced by the constant pain in my joints, etc. I then went to see my rheumatologist who was also just as skeptical that the drug could be causing all the pain I was describing. She said she had had three patients with tendon ruptures, but nothing else. I really don't care what she believes, and I told her so. I know what happened and what horrible pain I have been in ever since. I hate to report that the pain in my feet, knees, hands, hips, back and now my neck are not any better. My insomnia is some better, but I am taking more Lyrica. I tried a different antibiotic yesterday for the sinus infection called Clindamycin. OMG! I took one pill and within a few minutes had unbelievable heartburn. That lasted for 12 hours, along with reflux, burping, weird stomach noises. Now, I can't take that. Doctor called in a prescription for Augmentin this morning. Afraid to try anything now, but guess I will give it a shot. Is anyone getting any better from their joint or muscle pain? Some encourgement would be good. Thanks.

I have had mirena since Mar 07 and I also have pain during intercourse, sharp pains in my pelvic area, my face started breaking out (never had ache) and horrible discharge gummy and clear. Has anyone else experienced the discharge. It is so uncomfortable for me I do not want to have intercourse with my husband of 6 years. I think I will have this removed on my 8/25 appointment. Any advice in regards to the discharge would be great. Thanks!

I had the Mirena put in May'08. I've noticed increased acne, cramping in my legs, and spotting. I am also dealing with symptoms of bladder infections, however, there is no infection. My OBGYN says there is no correlation between the Mirena and my bladder problems, however, the urologist said that the Mirena could cause problems to other organs around the uterus (including the bladder). He stated it could be traumatic to our bodies, causing muscles in our pelvic area to tighten, nerve damage, etc. My OB diagnosed me with Interstitial Cystitis, a disease of the bladder lining that is without a cure, but my urologist didn't buy off on this and so now I'm having other tests done to make sure it's not bladder cancer, etc. Again, my urologist believes it's related to the Mirena. All I know is that I didn't have bladder problems until I had the Mirena inserted, which was the most painful experience aside from giving birth to my children! After reading the postings on this website, I'm definitely removing this device from my body ASAP! Good luck to all of you women who have had similar experiences. I pray that our bodies will return to some sense of normalcy.

I've taken Ultracet for about 4 years almost every day, morning and night time and sometimes in the afternoon depending how severe my pain is. I take 2 pills each time. It does help take the edge off my pain. My doctor said my Fibromyalgia is as bad as it can get, plus I have severe arthritis through my whole body. I can hardly stand up straight and trouble walking. Ultracet seems to help better then Ultram for me. I'm concerned about how long I've taken Ultracet and damaging my liver or other organs. Does anyone know how long you can continue using Ultracet before it does damage. I'm very concerned about that issue because it does somewhat help with pain. I haven't noticed any side effects using Ultracet. If anyone knows how long you can stay on Ultracet without any harm, please post your knowledge or experience. Should I also have my blood monitored periodically?

I suffered with pre-menopausal symptoms for 2 years before having the Mirena inserted in May 2007. My symptoms included bad menstrual cramping, heaving bleeding, hot flashes, night sweats, moodiness and lack of libido. But since having the Mirena all those symptoms have gone away. My OBGYN is using it for Hormone Replacement because I am too young (34 yrs old) to have menopause. I felt a lot better after about 3 months, I still have some side effects like hand numbness (mostly when I wake up in the morning or at night). Every couple of months I have some mild break through bleeding and I have PMS symptoms before it happens. I would have gone crazy without Mirena. I do have 1 symptom that I haven't heard anyone mention. Increased bladder infections, I don't know if this is caused by the Mirena or maybe its something else. If anyone has had this symptom can you post it?

My father had such severe mouth sores that he could not eat for 2 weeks which eventually led to his organs shutting down which in the end led to his death in 2 weeks time. Please make sure to insist your doctor does something to help with the mouth sores before they get so bad that you cannot eat! Actually, if any loved one of mine gets cancer, next time we are heading to Mexico to the Hoxsey Clinic. I will never again subject a loved one to the poison of chemo again!!!

I started on 40mg of simvistatin 3 and a half months ago,after being on them for a week i started to get bad headaches and felt really fatigued,so when i told my gp she said its just a matter of your body getting used to them,so i continued taking the pills i seemed ok for a while but 5 weeks ago i started with palpitations,then i got indigestion, and general discomfort in my chest,weakness in my arms and legs, headaches and the fatigue came back worse than ever,i haven't been back to see the doctor,i stopped the pills yesterday,the indigestion has gone already,i want to lose about a stone and try to lower my cholesterol myself ,but how can you exercise when you feel so weak and tired,my cholesterol level is 5 but because i suffer high blood pressure the doc said it needs to be 4.3,does anyone else suffer from the same and is on this medication?