Parkinson s disease symptoms and conditions

An update to my husband's experience after taking Lipitor 10 mgm/day for 4 yrs. He developed Parkinson's disease and stopped taking Lipitor at that time--summer 04. He is taking anti Parkinson's drugs as well as many vitamins and suplements in an attempt to correct some of the damage done by Lipitor. He is fairly stable. My niece's husband who was diagnosed with Parkinson's at the same time as my husband and had been taking Lipitor also, continued on Lipitor for another 1 1/2 yrs. He had a progressive neurodegenerative disease course and died 2 yrs ago. 3 other individuals with whom I am acquainted who have been diagnosed with neurodegenerative diseases have not stopped their Lipitor--one individual's diagnosis has progressed from Parkinson's to Parkinson's with Lewy Body dementia to Multiple Systems Atrophy. this is the same progression my niece's husband experienced. The other 2 individuals are currently diagnosed with Parkinson's disease.
Husband started taking 1200 mgm of coenzyme Q10/day upon diagnosis of Parkinosn's. This amt has been shown to be beneficial to those with early stage Parkinson's--irregardless of their statin status. Seem all parkinson's patients have abnormally low levels of CoQ10 in their blood--and statins DEPLETE CoQ10. What a set up!!!!!

husband and brother in law both diagnosed with Parkinson's disease. dear friend's husband diagnosed with Parkinson's 3 months later . all had been on lipitor for 2-4 yrs. brother in law has died--diagnosis changed prior to death from Parkinson's to Parkinson's with lewy bodies, to Lewy body dementia to frontotemporal lobe dementia (despite NO family history of this disease entity). there are SO many metabolic substrates whose pathways are interrupted by statins--pathways to isoprenoid metabolism resulting in among many other results, a decrease in glutathione reductase; a decrease in production of coenzyme Q10; decrease in dolichol, the lipid consittuting the largest % of fats making up the substantia nigra in the brain (area diseased in Parkinson's ). and lipids constitute the substance that makes up the mylein sheath surrounding nerves, and the largest % of the dry weight content of the brain.
Tremors were the first symptoms. then non swinging arm while walking, flat affect, rigidity of muscles. all symptoms of Parkinson's...

I aged ten years in a month. My legs lost any muscular power and I needed help to get up our 3 steps to the front door. My eyes are sore and my balance is also affected. What I do not know is how long am I going to be affected like this. I began to think that I was starting with either motor
neurone disease or Parkinson's disease.
Muscle weakness, loss of balance, bad dreams,anxiety, irritability.joint pain.sore itchy eyes and difficulty focusing on printed pages.
A., Yorkshire, England.I am 69 years old and prior to Singulaire I was pretty fit for my age.

I was on Topamax for 10 days with a few minor side effects but nothing serious enough to quit it. My husband and I went to the library about 6pm. I am 46 and never wore corrective lenses but was noticing that the shelves farther away were blurry, I didn't worry too much since I had been having ongoing thyroid problems and figured my eyes were swelling (though that normally happened only in the mornings). By the time we got home and were sitting down to dinner I noticed that when standing in the kitchen the people in the other room were completely blurry. By 11 pm I could only see clearly within 18 inches of my face.

I awoke at 2 am with a severe headache and almost complete blurriness, I had to hold the pill bottle very close to my eye to be sure it was correct and even then could not be sure. My husband gave me the meds and I went back to sleep. I didn't wake up until 1pm!!! When I awoke all light was painfully bright and I could see NOTHING clearly! I was rushed to the hospital and was diagnosed with acute angle-closure glaucoma caused by TOPAMAX!!!

Thankfully the docs were able to reverse the symptoms but said one more day I would have been permanently blind. My eyesight has never returned fully, though I can function just fine and do not feel depressed about it.

Please, be very careful on Topamax. The stuff is dangerous to many people though a life-saver for so many others. Also, may I suggest to those with the tingling that you get your calcium levels checked as this is a classic symptom of low calcium. I just wonder how Topamax affects the other body systems, such as the adrenal and parathyroids.