Pharmaceutical co symptoms and conditions

My 4 year old son started taking singulair when he was two. I don't think I picked up on his behavior change right away b/c I thought that he was just entering the "terrible two's". But over time, his allergist added on Nasonex (I know the docs say that it doesn't cause side-effects b/c it's a nasal spray, but I don't buy that...it's a steroid, plain and simple) and more recently zyrtec was added on for his hives. Well, the zyrtec was the straw that broke the camel's back. I mean, he has been a real "handful" since the singulair, but after zyrtec was added 5 months ago - let's just say he was completely out of my control. His meltdowns were so bad that I couldn't go ANYWHERE with him. I either got a sitter or just didn't go anywhere. He became aggressive, defiant, emotional, unhappy. And to top it off he started to have serious "autistic-like" self-stimulatory behaviors (grinding teeth, squinting eyes shut, flapping his hands, punching himself...). At this point my life had become a complete nightmare, and my poor 10 month old son was getting NO attention b/c my 4 year old was so out of control and aggressive. I was afraid for the baby's safety...oh, I could go on all night. This medication has impacted my marriage, my finances, my sanity. Shortly after he started Singulair I had to go on an antidepressant b/c it too so much out of me just to be his mommy. Anyway, a week ago I had him scheduled for a psych evaluation (thought for sure we were going to walk away with either autism or bipolar diagnosis), but two days before I decided to look up the meds he is on and BINGO! All of these posts sound like what we have been going through. I stopped all of his meds that night, cold-turkey, and he has been the most pleasant little boy I have ever met!! My husband and I have fallen in love with him over the past week - we had no idea he was such a sweet child.

Now, while I'm ecstatic that we have found the answer to our nightmare, I also feel SO STINKIN' ANGRY! We lost out on 2 years with our sweet boy, there were times when we raised our voices at him when he just couldn't help himself - he was suffering inside!! When I went to talk to the allergist about my findings this past week, he said, "well, maybe he just had a good day. I'd like to see what happens if he goes off all his meds for a week". Well, there you have it, he has been off for one week and he's an absolute angel. He has an amazing heart and is so caring!!!

Singulair is awful (and so is zyrtec). Please don't give this drug to your children. Research other alternatives (I am giving my son Nordic Naturals Fish Oil, Culturelle probiotics, vitamin c, and am changing his diet - increased magnesium and decreased dairy. I came up with this after hours of research...).

There is a woman on this site whose daughter committed suicide after 3 years on Singulair. This is no joke and the FDA needs to get with it.

BTW, I used to date a Singulair rep (I knew there was something I didn't like about that guy:)

If you are having musculo-skeletal symptoms such as soreness, arthritis, tendons, etc., they have known about those side effects for eleven years.

Toxicol Pathol. 1997 Nov-Dec;25(6):635-43.

Links Toxic effects of quinolone antibacterial agents on the musculoskeletal system in juvenile rats.Kashida Y, Kato M. Drug Safety Research Laboratory, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan. JDN07402@niftyserve.or.jp

Quinolone antibacterial agents have adverse effects on the musculoskeletal system in humans, consisting mainly of myalgia and arthralgia, and additionally of tendon disorders and rhabdomyolysis. The present study was conducted to examine the toxic effects of quinolones on the musculoskeletal system in juvenile rats using light microscopy, 5-bromo-2'-deoxyuridine (BrdU) immunohistochemistry and electron microscopy. Single oral administration of 900 mg/kg pefloxacin (PFLX) or levofloxacin (LVFX) was found to induce lesions in the muscle + fascia, tendon + sheath, and synovial membrane, in addition to articular cartilage in the fore- and hindlimbs. Articular cartilage lesions were not necessarily associated with changes in the muscle, tendon, and synovial membrane, or the reverse. Among all lesions, the ankle and elbow showed the highest incidence and severity. Changes were more severe in the PFLX than in the LVFX group. Lesions in the muscle + fascia, tendon + sheath, and synovial membrane were similar and characterized by edema and increased number of mononuclear cells, many of which were positively stained with BrdU, as well as vascular endothelial cells in the Achilles tendon sheath and synovial membrane in the ankle. Electron microscopic examination revealed an increased number of fibroblasts and macrophages and collagen deposition in the matrix of the synovial membrane and tendon sheath. Capillary endothelial cells were hypertrophied, increased in number, and stratified. These results suggest that quinolones have toxic potentials in the muscle, tendon, and synovial membrane in addition to articular cartilage, and that local vascular hyperpermeability may contribute to the development of these lesions. PMID: 9437810

An element of the side effects of Singulair that are listed here are musculo-skeletal symptoms. Quinolones such as levaquin are known to cause those issues. Singulair is a quinoline, while not the exact same category, their roots are similar. It makes the possibility that the symptoms have a common cause worth pursuing.

Here is an example of some poor rats in Tokyo that were selected to prove that the symptoms in humans were real. Maybe we should tell the levaquin board that at least some of their problems have been known since 1997.

1: Toxicol Pathol. 1997 Nov-Dec;25(6):635-43.Links
Toxic effects of quinolone antibacterial agents on the musculoskeletal system in juvenile rats.Kashida Y, Kato M.
Drug Safety Research Laboratory, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan. JDN07402@niftyserve.or.jp

Quinolone antibacterial agents have adverse effects on the musculoskeletal system in humans, consisting mainly of myalgia and arthralgia, and additionally of tendon disorders and rhabdomyolysis. The present study was conducted to examine the toxic effects of quinolones on the musculoskeletal system in juvenile rats using light microscopy, 5-bromo-2'-deoxyuridine (BrdU) immunohistochemistry and electron microscopy. Single oral administration of 900 mg/kg pefloxacin (PFLX) or levofloxacin (LVFX) was found to induce lesions in the muscle + fascia, tendon + sheath, and synovial membrane, in addition to articular cartilage in the fore- and hindlimbs. Articular cartilage lesions were not necessarily associated with changes in the muscle, tendon, and synovial membrane, or the reverse. Among all lesions, the ankle and elbow showed the highest incidence and severity. Changes were more severe in the PFLX than in the LVFX group. Lesions in the muscle + fascia, tendon + sheath, and synovial membrane were similar and characterized by edema and increased number of mononuclear cells, many of which were positively stained with BrdU, as well as vascular endothelial cells in the Achilles tendon sheath and synovial membrane in the ankle. Electron microscopic examination revealed an increased number of fibroblasts and macrophages and collagen deposition in the matrix of the synovial membrane and tendon sheath. Capillary endothelial cells were hypertrophied, increased in number, and stratified. These results suggest that quinolones have toxic potentials in the muscle, tendon, and synovial membrane in addition to articular cartilage, and that local vascular hyperpermeability may contribute to the development of these lesions.

PMID: 9437810

When a class action lawsuit is filed, let me know....this drug should be taken of off the market immediately. We started all of this with an OB/GYN that prescribed this “miracle pill” and now have had to go not only to our primary doctor, but also a psychiatrist, gastrenologist, college campus counselors, psychologists, psychiatrist, and the campus medical doctors; All the while, accumulating enormous doctor bills. All the doctors say, "No, Yasmin won't cause those problems" (except the college campus doctors..wonder why? Hmm.. could it be that they are not in private practice?)....well, I beg to differ. Everyone needs to give this website to their doctor so the doctors can hear from the patients that have taken this drug, and not listen to the pharmaceutical companies that are pushing this drug to be the "miracle pill". Maybe if enough people complain and go to the media, we can get rid of this drug!
My daughter who is 18 was put on Yasmin because of irregular periods, hormonal imbalance, etc. We were told it was the new “miracle pill”. It will make you loose weight, regulate your periods, clear up acne, you name it, it will fix it. Yeah, right.
She started taking this pill in March 2007. She was off at college but called to tell me she was experiencing horrible headaches, behind the eyes. She complained about her stomach hurting, but we just figured it was the stress of freshman year at college. Then she said she got where she couldn’t eat when she went to a restaurant. When she came home in May for the summer, I noticed a total personality change. For example, she was always a neat freak, and now she wouldn’t clean her room. The first day when she drove home, she started crying she was so mad about the traffic. Yes, she has always had a little road rage, but this was ridiculous.
By June, not only could she not be in crowds, like at a restaurant, but now she is having full blown panic attacks and IBS. We called the OBGYN and they said, “Yasmin won’t cause this, go see your primary doctor”. I knew that the only thing that had changed with her was taking the YASMINE. I knew it had something to do with all of this so I “Googled Yasmin” and this website (http://www.medications.com/se/yasmin) was the first one I looked at. All of her symptoms matched everyone else’s! I am so glad we found this website, it explained everything and I had her to stop Yasmin immediately.
So we went to the primary doctor, explained about the Yasmin and how we thought it was the culprit of everything. Of course this doctor also says, “Yasmin won’t cause that”. We told him to look it up on the internet and see how there are over 3000 complaints on this drug, more than any of the other drugs on the market.
Besides the emotional problems she starting having, her pulse and blood pressure was sky high, so he puts her on medicine for that, and puts her on an anxiety medicine and sends her to a psychiatrist. She is very thirsty all the time, and develops IBS. She can’t eat without having pains in her stomach. So, now we’ve have gone from having just irregular periods, to all of the above, plus a psychiatrist.
The psychiatrist doubles her medicine (and puts her Pamine for the IBS) because the panic attacks are gone, but she still is having a lot of nervousness, anxiety, can’t sleep at night, crazy thoughts, worrying all the time, etc. A month later he changes her medicine again, to Effexor. The first 2 weeks, she does okay, but the packet doubles the strength after 2 weeks. It takes 4 weeks for it to take full effect. Right after she doubles this medicine, it is like her senses are on hyper-mode. She can taste everything that is in her food (chili powder, seasonings, etc…), taste the metal in water, and she can hear someone’s phone vibrating, in another room.
Then she goes back to college at the end of August 2007, and it’s horrible. The Effexor is having bad, bad side effects. We called the psychiatrist that she was using at home and he doubled the dose. That was the worse thing they could’ve done. The side effects were worse than ever. I had her to immediately go to a psychiatrist on campus. She told him the whole story and he believed her! Needless to say we switched doctors. He then lowered her dose back down to ½ a dose and hopefully can slowly get her off of all this medicine.
The newest thing she has developed is being hypoglycemic. The campus psychiatrist sent her to a campus medical doctor and he told her that they would get to the bottom of this. He tested her for everything under the sun. Low blood sugar is the only thing they found. But, she hasn’t taken the Yasmin since May. No telling what the results would have came back like if it was done at the time she was taking Yasmin.
Thank goodness she has counselors and doctors there at the campus that believes that Yasmin can cause all of these problems, and are working with her. From what I have read from the people that have used this medicine, although most doctors do not agree, Yasmin takes like 6 months to get out of your system. I think I am going to believe the testimonials of the people who take this medicine, over a doctor who prescribes it.
If everyone goes to the media, their doctors, the FDA, congressmen, and make them aware of these horrible effects, surely we can get this drug off of the market! Does anyone know a class action lawyer that would pursue this? For my child to have to go through all of this is ridiculous, not to mention costly. What do we know of the long term effects this drug will have if it is doing all of this when you first start taking it?
If you have the same concerns as me about this drug, and would be interested in looking into a class action lawsuit, please email: ****** I would be interested to see how many would want to pursue this.