Pharmacy student symptoms and conditions

I'm a 44 year old female, and I have been taking 40mg. of lisinopril for over a year now. I also take omeprazole 20 mg. (a sub for prilosec) every day. Before taking lisinopril, I did have high blood pressure, but since taking this medication, I have had more problems than that. I have an irritating cough all the time and phlegm in my throat so thick that I feel as if I am chocking to death. I also have a severe rash all over my body and on the bottoms of my feet, and on my hands. I am depressed all the time, have no interest in sex whatsoever, and basically feel like crap all the time. I have a very bad pain in the left side of my neck that I know is not a result of sleeping the wrong way. I have to say, I never felt this way before taking this medication, but today I got to the point that I wanted to look up side effects to see if what I'm taking is hurting me. After reading some of these posts, I believe I know what my problem is. My husband was also on lisinopril, but 20mg and had such a terrible cough that we thought he had pneumonia. He is off the medication now, and his cough had disappeared. For me, the rash, and depression is the biggest thing. I have decided to take myself off this medication on my own, and try to find another way to deal with my high blood pressure. If you know of any herbs, and/or foods that help with blood pressure, I would love to hear about them. Thank you all for the information you have posted here. I'm sure it will help others think about what the doctors and pharmaceutical companies are trying to do to us. Seems the more medications they prescribe, the worse side effects we endure. Thanks again everyone!

Hi, I am a mother of 6. They are 11,9,7,4,and twins 2 1/2. So nothing surprises me as far as kids. I have been through it all. My 7 year old had been taking singulair for allergies and ear pain, for over a year. Did my doctor once ask me about any of the side effect, NO!! This is not ok. My son suffered, decrease appetite, weakness, fatigue, mood swings, irritability, fears of being alone, scary dreams, anger, bone and joint pains. Before he was a loving kid (who had his moments)!!! I had no idea the singulair was causing all these destructive side effects. I just thought this is a phase he is going through, he will soon get over it. Finally I took him to his ped. and we did blood work and x rays. I told her something was wrong with him, he has not been himself over the past 6-8 months. This is one reason why I never suspected his singulair, it did not show up immediately. All of his test came back fine. I just happened to look at the side effects of this medicine. I almost died!!! Every single thing that this poor child has suffered from was on this list. Then more, I found this page and other mothers have had the same experience. I was just amazed that this has happened to so many. I was relieved that my son was normal. He has been off singulair for 6 days now (he doesn't know why I took him off it) . But you would not believe the change. It is AMAZING!!! In only 3 days, I started to see change in his anger. You would not ever in a life time believe that a medication can do this. I have been poisoning my son for a year. I think that Merck should take some of that 4.3 BILLION dollars and do some better research!!!! Concerned citizen you are right on. I have read many pages of this forum and I think you are doing a good job researching this. Maybe Merck should hire you as one of there "experienced personal". It just makes me seriously sick to see that the medical field is not seeing this problem!!!

I could not find the post from the mom of two who is a pharmacy student to reply to her.

My husband is a pharmacist with over 25 years hospital experience. he never questioned the doctors assumption that it would take 6 weeks to totally be out of his system. all drugs have some residual and cumulative or residual effects. it really isn't magically gone from your system in a set number of hours. especially a daily dose and more so in the elderly, and I have seen this first hand , when they are dehydrated or other wise compromised the drugs can stay in their system for a time and accumulate.

i will update on our son later today, he is doing much better two weeks off

Here is one for you Artie. Maybe you can go find the statistical profile of studies regarding montelukast and CYP2C8. Originally it was hypothetized that montelukast would inhibit CYP2C8 thus inhibiting steroid (as an example) metabolize. In vitro studies predicted that. Then studies in vivo didn't confirm. Here is another one done in 2006.

Conclusions: Telithromycin increases the plasma concentrations and blood glucose–lowering effect of repaglinide by inhibiting its CYP3A4-catalyzed biotransformation and may increase the risk of hypoglycemia. Unexpectedly, montelukast has no significant effect on repaglinide pharmacokinetics, suggesting that it does not significantly inhibit CYP2C8 in vivo. The low free fraction of montelukast in plasma may explain the lack of effect on CYP2C8 in vivo, despite the low in vitro inhibition constant, highlighting the importance of incorporating plasma protein binding to interaction predictions.

http://www.nature.com/clpt/journal/v79/n3/abs/clpt2006320a.html

The question would be is that always the case or are there genetic variations among people that influence the outcome? Or is there potentially something else that we should be recognizing and we aren't doing that.

I thought of that again when I read this post. We obviously have many questions that should be answered especially when something that we don't expect happens.

Posted by Mindy Miller
Monday, April 14, 2008 4:39 AM EST

I am a pharmacy student and a mother of two sons that take Singular daily. My six year old has been taking it for 4 years, and my three year old for two years. They both have well controlled asthma. I wanted to reply to the questions many have posted about how long it takes to "get out of your system". The half life of Singular is 3-6 hours, so it is gone in a maximum of 18 hours. I came to this website while searching for information about recent FDA warnings. As far as I can tell, there are very few cases documented of mood changes and suicidal thoughts. There are many reasons why children have mood changes, and not feeling well because they have asthma and allergies could also be the source. I wonder if many who start Singular are also taking Prednisone, a steroid, to treat an asthma flare up. Steroids are definitely known to cause mood changes and is one of the reasons they can't be used long term. Please talk to your doctor or pharmacist before taking your children off of medication that may be helping them feel better in the long run.

http://www.injuryboard.com/national-news/fda-issues-early-warning-on-singulair-and-suicides.aspx?googleid=30278

If we had all of the answers, then there would not be such a wide range of symptoms that manifest themselves as a result of Singulair. So I am not trying to spread any conclusions that may be misleading. These are questions and not answers.

ok...so i was on yasmin from the age of 17 to about 20 for irregular periods and had no problems. i stopped taking it due to forgetting to take it and my periods had become fine. i'm now 23 and just started taking yaz last month for increasing pain, nausea, and mood swings associate with PMS. i now experience extreme mood swings. i have always had some depression, anxiety, and irritability...but since i have started taking it, i have noticed an increase in these feelings. i am a 4th year pharmacy student and don't have the time or energy to feel like this. i become irritable and angry at the smallest things or no reason at all. i also just feel the urge to cry and do for the same reasons...none. i have done some research on mood disorders and the correct diagnosis of such. since my symptoms were present before and i also have ADD and mild OCD, i'm not sure if it is the yaz causing these feelings or if with all that's going on in my life, a underlying mood disorder has come to surface. for most who don't know...mood disorders are most often genetic and are seen with concominant mood disorders (depression with anxiety, ADD, OCD, etc..). my family suffers from most if not all of these (mom- major depressive disorder, ADHD; dad- anxiety, OCD; brother- ADHD, OCD, mild depression). also, most mood disorders show up during the later teens to late 20's. so my big issue is whether or not my feelings/mood swings are attributed to the "pill" or just a surfaced problem. i have looked into a disorder called cyclothymic disorder. this is when you have depression with hypomania (irritability that doesn't fit the criteria for manic-so not bipolar). i just don't know who to see or what to do. i have a psychologist and i am hoping to get in to seeing him ASAP. anyone got any input or advice?