Physiology symptoms and conditions

I haven't found Mirena to be very invasive so far. I got it put in after my daughter was born and since then my periods have been few and far between, but I attribute some of that to breastfeeding the first six months. I have had the Mirena in for almost a year and the only thing I notice is that sometimes I feel moody and hungry and lethargic like I'm about to menstruate but then nothing happens. I haven't had weight gain problems and I do fight off some acne on my chin and sides of my face but I don't know if that has to do with the Mirena- I haven't always had the greatest skin to begin with. I got pregnant because I wasn't on the pill or anything, everything else before this has made me psychotic. Any contraceptive you use will have its drawbacks because you are messing with your physiology and biology and everything. This is the best thing I've tried- so far it hasn't been problematic enough to consider taking it out. I think I am a case of very mild side effects with this method. It sounds like some people's bodies are more sensitive and attack the device as a foreign object in their system. My body is less fussy apparently

I am a 39 year old mother of two teenager daughters. I had my original Mirena inserted in July, 2002 due to extreme bleeding for many months. I would bleed for about 24 days out of every month and felt horrible. As I was only 32 years old at the time, my GYN did not want to perform a hysterectomy and suggested the Mirena. I bled for a couple of months after insertion, but shortly thereafter I had no bleeding and have had no period ever since. This is the side effect that is fantastic!

Shortly after having the Mirena inserted, my marriage fell apart and I was feeling very depressed, EXTREMELY EXHAUSTED and overall "crappy". I assumed that this was all due to my life circumstances. I gained significant weight in my mid-section, I had (and still have) constant headaches, I am always still very very tired, am dizzy, fuzzy-minded, blurred vision, achey, etc. etc. etc. I never once thought about the Mirena being the cause of any of these symptoms.

My doctor has checked my bloodwork numerous time to ensure my iron levels, etc. were okay as well as my thyroid - every time the results were normal so I thought it must all be in my head and all be due to me being somewhat depressed, etc. due to my marital breakdown.

I had my 2nd Mirena put in in December, 2009 as the first one was in for the full 5 years. It was a little painful getting it taken out and the new one put in, but for me the pain was worth it to continue to be period-free for another 5 years!

Recently I have been experiencing hot flashes and night sweats so I asked my doctor if I could be going through menopause. She ordered bloodwork to check my hormones and informed me last week that yes, in fact I am quite far into menopause!!! (remember, age 39)! Because I have not had a period in almost 6 years, I did have the early warning signs of menopause such as missed or irregular periods.

I wondered why I would be going through it so early so googled "Mirena and early menopause" which brought me to this site. When I started reading all the side effects, I wondered if it was maybe the Mirena that cause a lot my problems over the years and it wasn't in fact the dissolving of my marriage and change in life circumstances.

I now have to decide what to do. My doctor stated that I should (because of my young age) go on Hormone Replacement for quality of life. (I am close to my decision and believe that HRT is beneficial for me) - hopefully this will help with the terrible symptoms of menopause I have been having.

I am wondering if having the Mirena inserted had any part in accelerating my body into menopause. I am thinking of having it removed before starting HRT because even though the doctor told me that there is a very low hormone dosage in the Mirena, I don't want to over-do it with hormones as that could cause me even more problems. It would be amazing if I had it removed that I would feel the way I used to feel back 6 years ago (minus the husband)

FYI, before I had the Mirena inserted the first time I read and re-read the pamphlet which contained all the possible side effects, etc. But, as I stated above, my life changed dramatically very shortly after insertion so it never occurred to me that some of my problems may be related to the Mirena.

If this device does accelerate a woman's body into menopause, this should be well publicized as it would be tragic for young women who use this as a form of contraception early in their life to only find out later that they are no longer able to conceive due to their body going though "the change".

I was prescribed Avelox along with Prednisone by my allergy doctor for pneumonia. Even with a prescription insurance program, the Avelox costs $14 a pill. After 13 days on Avelox, my joints hurt so bad I can barely walk. My muscle tone is almost non-existent, and the muscles ache like I've been in training for a marathon. I daily became more depressed, and really thought I was dying. I went to see my internist this a.m. A chest x-ray revealed I still have a raging case of pneumonia, now in both lobes of my lungs. She wanted to put me in the hospital but agreed to put me on a Augmenting and another round of Prednisone to try at home a couple of days. Avelox should be taken off the market. I can not believe this medication which costs over $240 for one round of treatment was ever approved by the FDA. My doctor could not tell me when the side effects of the Avelox will diminish or disappear. DO NOT TAKE THIS DRUG IF ANOTHER WILL DO THE JOB.

DO NOT TAKE DOXYCYCLINE IF YOU HAVE ANY HISTORY OF DEPRESSION!!!

I do and doxy has sent me over the edge for about a month AFTER i stopped taking it.

I was given doxy by my doctor for a sinus infection for a week and stopped taking it just under a month ago. This past month has been absolute hell for me.

The day I stopped taking it I went from feeling fine into a 5 hour crying fit with suicidal thoughts in less than 30 minutes. During the fit I became convinced that this was how my life always is, that I was depressed, that I had always been depressed and that I needed anti depressant as I spend all my time crying. That was on 2nd Feb.

The next day I was shaky and felt very up and downy but went back to feeling normal pretty quickly and after I did some internet research on Doxycycline (the only change in my diet/lifestyle) assumed it was that. I read some pretty bad stuff on the internet about other people’s experiences which were very similar to the one I had had and I thought that must be it.

So I decided to drink lots of water and have been taking Milk Thistle to cleanse my liver.

Then this Saturday past I had exactly the same thing. I had another one of these 5 hour crying fits and more suicidal thoughts and I became convinced I was bipolar. This time was much worse in a lot of ways.

I felt it again felt like a panic attack and to me the change in my physiology was really noticeable. The noticeable dip in my mood – very sudden from feeling fine to feeling a little bit irritable and then withdrawn with some anxiety – and wanting to be reassured but also being a little aggressive in communication almost like trying to find a fight, then a change in breathing and heart rate and then plunge into dark thoughts and sobbing.

When I went to see the doctor on Monday my mood was still swinging up and down and I just felt crazy so I mentioend to him the doxy and he dismissed this without even asking a question about when or how much I'd taken.

I ask to be referred to a psychiatrist as I do get that I may have underlying issues and these mood swings were so bad and so strong and so by the time Wednesday came with my in and out moods I had convinced myself it was probably to do with my childhood and the difficult heart stuff and repressing how I really feel

Whilst I do have my fair share of childhood stuff and issues of the heart I think I’ve become so self aware and so careful with myself and I think I talk to my inner child so much and check that I am okay with things and I deal with things really well. so this has all come as a bit of nasty shock as I thought I was okay with everything. In fact I know I’m okay with everything as I write this.

But during these mood swings I am definitely not okay. I do not feel like myself. I become convinced that I have been lying to myself about being okay, that I have never been okay that I am mentally ill and that is why I am having mood swings and I start really analyzing everything and linking everything back to the past and trying to make links with things that are happening today and things that happened in the past. I haven’t had any change in my heart situation that this could be a reaction to, its remained the same for a number of months and I don’t have a problem with it but when I have this mood swing I blame that situation and my childhood together. I start wanting to blame people. I start thinking I have two personalities and I just start trying to find reasons and I have no idea what I feel, who I am or what I want, if I’m telling the truth of if I’ve ever told the truth. I start doubting everything and everyone. My head hurts, I get in a state of confusion and I become a little mean to people. I start trying to blame events and situations, anything I can find. It’s an absolute nightmare. Then I get confused about what I have and haven’t said and agitated that I need to say more to make myself understood. I might be stable for hours or even a day but it happens very suddenly and it’s a really physical sensation, first the dip in mood, the irritability, the breathing will change, I will feel anxious and can really feel my heart beating, like when you are really scared about something – that fight or flight feelings. I then get a really strong sense of insecurity and nervousness and will become really awkward at communication and almost aggressive and rude in my communications and then rueful.

The crazy thing is my mood is just absolutely all over the place in a way it has never ever been before, even in my days of deepest darkest moments when everything in life sucked and people were horrid to me. I don’t understand why I would, after all my years of learning how to deal with this and cope with this be even worse when my situation is so much better. It just doesn’t feel like its actually real. I don’t feel like anything I’ve said when I’ve been in these moods is actually a true reflection of how I feel when I am out of the swing.

Then I come back to feeling more like a version of myself but not quite and then I swing again very quickly and go from very hyper and laughing to almost the polar opposite in a very short space of time.

This is the first time in a week that I’ve felt like I am completely normal again. Right now I feel very calm and grounded and rational like I have been feeling for a very long time and I feel very clear in my head that I am completely fine and this is a reaction to some chemicals in my body affecting my mood rather than a psychological issue.

I am fully prepared for another full scale attack of mood swings and totally losing the plot again though.

I am lucky in that I have a good friend who called a doctor friend of his in the US and the first thing the doctor friend said when asked about Doxycline was 'don't tell me, you know someone who's had anxiety attacks and suicidal reactions'. According to this doctor this is VERY common and very well documented. There should be no lasting effects or permanent damage and now the doxy is out of my system I should not be experiencing these moods swings.

HOWEVER - he thins that because I have a history of depression due to my childhood issues the doxy has basically destabilised me and driven me to the edge again.

I did some really lengthy research because I really feel like this is a brain chemistry issue rather than a psychology issue and knowing I've dealt with everything and I just don't get why these issues would re-arise. I'm going to go get some therapy no matter what but I just wanted to know the brain chemistry.

Obviously if my GP doesnt even recognise that doxy can have this affect there is going to be no interest in helping me figure this out so I will figure it out myself.

From what I can understand Doxy decreases some amino acids in the brain which is important as simply put, amino acids get converted into neurotransmitters which play a critical role in your brain. Neurotransmitters are the chemicals which help your brain cells 'talk' to each other. Low levels of certain neurotransmitters have been associated with depression and anxiety.

I feel like I am 'back' from the Doxy but to be honest, I have no idea what it has done to my brain and I doubt there has been that much research into it...if so why on earth would they prescribe a drug that does this to people?
Particularly people who have a history of depression.

I am going to try taking amino acids to see if that helps - it can't hurt.

If anyone else is going through the same thing please get in touch and let me know!
This site totally helped me!! Thank you everyone who has posted on it. It really makes a huge difference to know that there are other people out there going through the same thing. I have felt like I am absolutely crazy! Thank you so much :-)

Been on Zocor for two years went from 20mg to 40mg and since being on the 40mg I have increased leg & foot cramps so severe @ night that I have trouble getting out of bed, the foot locks up. Even getting up after sitting is a problem, sometimes my feet and legs go numb and I even fell a few times. I get very tired during mid day. The newest problem is my sight, I have notice that there is a blurriness that I don't know if it ever clear up, after telling my doctor this she said it was the arthritis and to take arthritis nonasprin and to stop the zocor for about a week, I am going to stop period.

Researchers have been doing studies for many years regarding trying to determine the role of genetic factors in patients response to Singulair (Montelukast).

This study from Spain identified the following gene variations hypothesize to be related to leukotriene pathway response. Sixty one patients with asthma were studied. Three gene types were identified:

type 1. Thirty-two patients (52.5%) were homozygous for the five repeats allele;
type 2. 17 (27.9%) were heterozygous (4/5 repeats)
type 3. 12 (19.7%) were homozygous for 4/4 repeats.

The study showed that montelukast was effective for types 1 and 2 but not effective for type 3. Type 3 represented approximately 20% of the group study.

"After the montelukast treatment decrease number of asthma exacerbations, improvement of FEV(1) and decreased use of beta(2) agonists was observed in patients with 5/5 or 4/5 repeats. Conversely, the patients with 4/4 repeats genotype did not modify these data after treatment."

So it seems logical that if it can be identified that montelukast is not effective for certain gene type variations, then montelukast could cause adverse side effects in certain gene type variations.

It is interesting that 20% of this group does not respond positively to montelukast. That is the exact same number that even Merck says gets a headache from montelukast. Headache is the highest incidence of adverse side effects that has been reported. That comparison, however, is just a coincidence because it has not been studied and proven. Maybe.

Where are the studies that pertain to gene type variations and adverse side effects? You would think that somebody could do them.

Respir Med. 2008 Jun;102(6):857-61. Epub 2008 Mar 12. Links
ALOX5 promoter genotype and response to montelukast in moderate persistent asthma.Telleria JJ, Blanco-Quiros A, Varillas D, Armentia A, Fernandez-Carvajal I, Jesus Alonso M, Diez I.
Institute of Biology and Molecular Genetics (IBGM/CSIC), University of Valladolid, Valladolid, Spain. ******

BACKGROUND: It was hypothesized that asthmatic patients with mutant alleles in the leukotriene pathway should not respond to leukotriene receptor antagonists and the concept of a tailored treatment is increasingly supported. METHODS: Sixty-one patients (mean age 24.9 years, range 14-52) with moderate persistent asthma were clinical and immunological assess prior and after a 6-month treatment with montelukast. Tandem repeat polymorphisms were genotyped in the promoter (-147 to -176) of 5-lipoxygenase gene (ALOX5). RESULTS: Thirty-two patients (52.5%) were homozygous for the five repeats allele; 17 (27.9%) were heterozygous (4/5 repeats) and 12 (19.7%) were homozygous for 4/4 repeats. After the montelukast treatment decrease number of asthma exacerbations, improvement of FEV(1) and decreased use of beta(2) agonists was observed in patients with 5/5 or 4/5 repeats. Conversely, the patients with 4/4 repeats genotype did not modify these data after treatment. CONCLUSIONS: It was confirmed that ALOX5 promoter polymorphisms have a clear influence in montelukast response in atopic moderate persistent asthma patients. The genetic study could identify those patients most likely to respond to montelukast.

PMID: 18339529

I just got a very condescending private message from a doctor on this site who said that while my articles from Europe are very helpful that I don't know what I am talking about and that I could mislead the public. Then I see how many parents and patients got a condescending attitude from their own doctors.

Well the public has been mislead but it is not my fault. I don't see any experts in this field stepping up to the plate to acknowledge that these side effects exist, have been reported by authorities in other countries, and that these experts are interested in learning why they are happening. This is an extremely widely prescribed medication that involves the lives of millions.

Merck's research director was quoted as saying that they know of no mechanisms by which these side effects could be related to psychiatric adverse drug reactions. That was a flat out LIE. So what if I quoted you a research article from China that was very complicated and yes, could possibly be misinterpreted by somebody? I just needed to give you an example. The only expert so far that had the guts to give you a truthful statement was Dr. J. Douglas Bremner. Thankfully, he corrected a misunderstanding about saying that it was "unclear."

I hope that we will all hang in there and something will be said by somebody, anybody on this site that will make the FDA listen and investigate Singulair (montelukast) all the way back to the very original studies done in test tubes not on people. And, then take a new look at it from the standpoint of what we now know about human genetics. I guess I will keep repeating myself about one size does not fit all.

I would also PRAY that all clinical studies on Singulair (montelukast) would be suspended until the FDA decides why these side effects occur. And that they would issue a statement to doctors to make conservative decisions regarding treatment with Singulair until the results of the investigation have been reported.

I hope that nobody thinks that I am trying to mislead anyone. The answers are either unknown or being hidden by Merck. How would I know the answers? I don't work for Merck. How many other people are out there trying to translate articles in foreign languages to see what's going on? American doctors are calling Merck and being assured that there is nothing to these claims.

I wonder how many experts there are that just don't want to be another Jeffrey Wigand or don't know what is wrong?

I know that I am ranting but somebody should do it.

Are there people that have not experienced any side effects of Singulair I saw a question, and the answer is that they are the ones that are not going to post here. Millions of people and especially kids are fine with this medication and have no reason to look for this site. Will some people get side effects from Singulair, yes, but unfortunately there is not a drug out there that will cause no side effects.

People saying this could cause all kids to suicide is a bit disturbing. If you want to take a look the most popular allergy medication, Zyrtec has had suicide listed in their information for awhile. The reason these allergy medications have to have them listed is because they are heavily prescribed because of the great amount of allergy sufferers and any time some one passes in a car crash, accidental death, or unfortunately even suicide they have to list all medicines they are on. Obviously with popular medications more people from these cases will exist than the less popular ones. Drug companies are protecting themselves because of the litigious society we live in and have to place all kinds of occurrences there and not to say in this case, but a lot of people are always looking to blame others for something instead of taking responsibility for themselves.

I don't think doctors are prescribing these medicines because they do not want what is best for each of their patients. There is no conspiracy, and I would trust their view and years of studying and practice to someone's inexperienced diagnosis on this forum when I have no idea what their background and job is on here. I do not look to consult my son's teacher to fix a leak in my roof, so I go to my doctor for advice on medicine and not consult someone not in the field.

Sorry about this harshness, but someone showed me this board and as a parent who has their son on Singulair with great results and even trusted my doctor when they suggested to try it in my one year old son I will continue to listen to their advice. I have heard numerous people in the medical community tell me Singulair is one of the cleanest drugs out there, but again there isn't a drug with no side effects. I am sorry that not all parents have achieved the great effects my kids have had with this drug, but I think most have and thus not had the need to find this board.

Wow, am I glad I started doing research and found sites like this and others. I have been on Singulair for 1.5 years. A little over a year ago, I started having HUGE problems with anxiety and depression. My psychological problems have been so bad that my life has basically come to a halt. I gather enough emotional energy to make it through the working day every day, then I go home and collapse, barely accomplishing anything before bed time. On weekend, I sleep a lot more than usual and basically have no life. I just didn't feel well and did not feel like myself.I had trouble sleeping, joint aches, low grade fevers, complete loss of motivation, difficulty thinking/focusing, and a huge loss of self esteem. I started to question my career decisions (I'm nearly done with a 6 year PhD in biomedical research/physiology), gained 20 pounds, and lost my sex drive. I really felt like I was a sorry excuse for a human being. In the past year, I have been on no less then 3 psychoactive drugs to try to treat my anxiety and depression. Never once was it suggested to me that this could be the results of Singulair!!!! Last week, I started having trouble with chest pressure/pain and was diagnosed with GERD (acid reflux). My dr. was not available, so I saw someone else, and he suggested that I research all my meds (I'm 27 and take 4 Rx's a day, 3 of which I can probably cut out now that I am no longer on Singulair!!!) and see if any of them could cause GERD. That's when I found out that, not only can Singulair cause gastric problems, but I am an exact match for most of these lists of side effects!!! Wow, I am so glad I started doing my research about this medication! My regular doctor confirmed this morning that I started Singulair about 4 months before I finally sought help for my anxiety and depression (and they were terribly severe at that point). Basically, I've lost 1.5 years of my life trying to fix what this med did to me. I quit taking it as of last week. I hope things return to normal soon.

I'm so happy I found this site. I've been thinking I'm crazy or just getting old for the last 3 years while on Yasmin. I started taking it at age 29 and almost immediately after started having mood swings, extreme irritability and depression. I had previously been on Ortho Tri Cyclen and the Ortho Cyclen before Yasmin and was on them for MANY years and never had one side effect. I only switched in the first place because I like to have very very few periods and I run all my active pills together to forgo periods very often and I was having breakthrough on the Cyclen. Hence, the Yasmin trial.

I'm actually a doctor (which is why I CANNOT have frequent periods with all the accompanying issues), but I didn't even realize the possible connection between IBS and Yasmin. This needs to be studied and taken seriously. I never once had IBS symptoms until a few months after starting Yasmin. Now, 3 years later I have almost constatnt trouble, to the point everytime I eat I run for the bathroom, yet my weight has never been higher. I asked a GYN friend at work if they could be related and she said definitely no, but reading all of these "real life" examples, coupled with my own experience has made me think otherwise. Often, the symptoms will occur shortly after taking the pill, even when I haven't yet eaten breakfast. It's crazy!!

I'm going to switch either back to Ortho Cyclen or to something new ASAP and will report back. I'm both excited at the thought that my "IBS" might really be Yasmin related but also scared that it might not go away and therefore might really be IBS. I'll report back... It honestly never entered my mind that all of it could be the Yasmin. I had just moved, started a new job in a town I hate and I thought it was all stress related.

I've also had an interesting side effect no one has mentioned yet- my hair texture has dramatically changed. It isn't falling out, but has gone from VERY curly with a nice soft spiral curl pattern to very dry, straight and hard to manage. Nothing else has changed and now I'm wondering if it's not the DRSP. If pergnant women can have hair changes, why not women on the pill?? It's all hormones.

As always with a drug, there are always possible side effects. No one drug is perfect, and humans are so complex in their make up and they way they process drugs. Therefore, please don't judge your family docs or GYNs too harshly as not even the best doctor in the world can predict every side effect.

This is my second post to this site. About a month ago, I stopped taking the drug because I was coughing 24 hours a day and it was disturbing my sleep. The cough has taken most of the past month to subside.

Having said that, I do find it hard to believe that lisinopril can be held responsible for all the side effects listed here.

I think the best way to battle the side effects of drugs in general is to live your life better. I have HBP but have managed to keep my cholesterol low (and therefore stay off those drugs) by diet alone. Think about what these drugs have to do to achieve their objectives. By taking these drugs you are messing with your physiology and there will always be a price to pay. That's why lisinopril is still on the market. The drug companies can always say, "well you were warned."