Plasma symptoms and conditions

2 genetic mutations in the gene that encodes for the transporter protein responsible for moving anti cholesterol statin drugs into the liver to be detoxified. have been identified. This gene is "SLCO1B1" (also referred to in the scientific lit as "OATP1B1"). Drugs must be "detoxified" by organs within the body and then eliminated, otherwise the drug stays in the blood stream, building up to toxic levels. With either of the 2 mutations, statins have been found to be (from various studies) anywhere from 122% to 400% ABOVE NORMAL plasma statin levels. How many people have either of these mutations? (Population genetic studies were done in Finland on Caucasian pop--so all the #'s refer to Caucasian population) 25 % to 38% of ALL Caucasian possess one of these 2 mutations. Thus, for however many yrs someone with one of these mutations has taken a statin, the level of the statin in their blood stream conceiveably could have been 400% ABOVE normal statin levels. ALll those pharmacologic effects of statins--decreased coenzyme q10, depressed manufacture of dolichols, depressed manufacture of selnproteins and thus glutathione, interrupted production of GTPases and glycoprotein function, decreased brain cholesterol levels--neuron synapses and new growth of neurons depend upon brain choelsterol--are intensified unrelentingly for the length of time the drug is taken.

Last week I had an issue with my INR - it has always been unstable, but this time was weird. My INR had been 6 and so I stopped the warfarin for 4 days, and went back on my regular 2 mg dose. Then we went on holiday to Washington DC for a week. 3 days in, my pee was the colour of cherry kool aid. Went to the local hospital (thank god for travel insurance). My INR was 7.89 - In the US this is considered critical and I was admitted, and treated with Vitamin K and 2 units of plasma. Within 8 hours my INR had dropped to 1.8 - now too low. The next day down to 1.25, and a week later I am still 1. I am taking fragmin now until I can get my INR theraputic again but Fragmin shots are even worse than warfarin.

An ultrasound showed now issues with my bladder or kidneys, but I do not understand why I was bleeding.

Guess that this just shows the importance of regular checking of INR levels while on warfarin.

WARNING be aware of H.I.T.

IF YOU ARE ON CLEXANE PLEASE MAKE SURE THE DOCTORS CHECK YOUR PLATELET LEVELS BEFORE STARTING THIS DRUG.DO NOT BE AFRAID OF ASKING AS THIS IS STATED IN GUIDELINES.

THE GUIDELINES SUGGEST IF YOUR PLATELET COUNT FALLS 50% FROM WHAT IT WAS BEFORE YOU STARTED THE TREATMENT THEN H.I.T. SHOULD BE SUSPECTED AND ALL FORMS OF HEPARIN SHOULD BE DISCONTINUED AND AN ALTERNATIVE ANTICOAGULANT BE USED.

THIS IS VERY IMPORTANT; PLEASE DO NOT TRUST YOUR DOCTOR TO AUTOMATICALLY DO THESE TESTS. WE TRUSTED MY GRANDMOTHERS DOCTORS, THEY DID PART OF THE TESTS BUT FAILED TO ACT ON THE RESULTS!!!!!

My grandmother died from heparin induced thrombocytopenia (HIT).
This is an adverse reaction to the drug Clexane. Guidelines suggest platelet count should be monitored, unfortunately the hospital Doctors did not monitor her blood whilst she was on this drug. A 50% fall in platelet count should have alerted Doctors to act on their findings and discontinue the drug, instead they carried on giving it to her for a further 6 days. Her symptoms were as follows;
itchy
drowsy
bruises
nausea
vomiting
diarrhea
Because her reaction to Clexane had gone unnoticed she was still being given this drug her symptoms became worse they were as follows;
Black bruises (necrosis)
gastrointestinal haemorrhage
spontaneous bruising
slurred speech
confusion
falling platelet count
When the Doctors discovered the internal bleeding they stopped the Clexane but did not offer her an alternative anticoagulant and her symptoms after this were as follows;
Deep vein thrombosis, arterial thrombosis, she was still hemorrhaging, her platelets fell to 5 and her HB fell to 6.9 INR was normal.
She was transfused with platelets and red blood cells and then died. (Clexane heparin induced thrombocytopenia) is on her death certificate AFTER A FOUR YEAR BATTLE FOR AN INQUEST INTO HER DEATH! My research has led me to believe that most Doctors believe HIT is very rare and they don't bother to check for this condition, if the doctors had checked her blood test and realized a sudden 50% fall in her platelet level was more significant than the actual platelet count itself , then she would not have died.The 50% drop was a serious side effect of this drug.
PLEASE ASK YOUR DR TO CHECK AND TELL HIM/HER TO CHECK IF YOU HAVE GOT BETWEEN 30-50% DROP IN PLATELETS THEN MAKE SURE YOUR DOCTOR KNOWS WHAT HE IS DOING.

Jill (Lancashre UK)

I was on augmentin for 6 days for an ear infection. I did not develop diaharrea but severe pain in my upper abdominal, with nausea and some vomiting. I will never take it again.

I have been told by my dermatologist that the extensive brown patches on one cheek and line of patches along the other cheek, along my jaw line and brown mottling around my lips are a reaction to Doxycycline after being in the sun. I was prescribed 100 mg daily about mid-May for six weeks by my family physician as an anti-malarial treatment when I went to South Africa. I took them a few days before, for the two weeks I was there, and about 4 weeks afterward.

This dermatologist had completed a plasma resurfacing on my entire face the last of December. I thought this was the reason for my skin splotching that occurred when I started being in the sun beginning in June. I'm still wondering.

Has ANYONE had the facial reaction I described from Doxycycline when combined with sun exposure?