Politicians symptoms and conditions

I am a 58-year-old woman that changed from zetia to zocor about 6 months ago because of the price of zetia AND I had tolerated the zetia ok but my chol was still elevated. My initial dose of zocor was just 10 mg, even though I had a lot of aches and pains from the slighest exertion I really did not connect this to zocor. After my last checkup, the doctor wanted to up my dose to 20 mg daily because my chol was 228 (liver functions were all ok). I have been doing that for 6 days and my legs have become very achy, my left knee has swollen above my kneecap (which is very painful), and my lower back hurts. I have been having a lot of trouble sleeping and feel draggy all the time. I got on the net to research these symptoms when I found this site. I am going to go off this med and see if my condition improves! I will post an update as to the results.

Moderately high cholesterol and BP 150/90. Was put on Lipitor 20mg and after a week felt more fatigued than usual but nothing much more than this. Had stress test and angiogram which showed 60-70% block in one artery as well as arrhythmia. Cardiologist bumped Lipitor up to 80 mg which I took for 2 weeks. But by then I was suffering most of the effects described in these postings: aches and pains, giddiness, nausea, extreme weakness and fatigue. I took myself off Lipitor and even after one day my head started to clear aches started to diminish, though urine still a reddish color suggesting a lot more flushing out required. And, best of all, the arrhythmia reduced from moderate/severe to mild (which it always used to be before taking Lipitor). This drug is not for me. I'd rather take my chances without it and rely on strict diet, weight loss, etc. It is surprising that the possible side effects are so understated in the manufacturer's descriptions.

Boy, after reading all the negative testimonials on Lipitor, I will throw mine in the garbage. That is what they are meant for. I have severe headache, and muscle pain, and foggy head, and I have only been on the crap for 2 months. I believe a lot of people's health is being ruined, and a lot of deaths are happening as well because of Lipitor and other statins. Mark my word, one day this drug will be withdrawn from the market, and the poor Pharmacutial companies will be in huge trouble.. They have the world convinced that we all need statins to bring cholesterol down.. The era when my parents lived , and lived long lives, and on farms, with butter, bacon, lots of fats, and never heard the word STATIN. I think every one that is writing to this forum and complaining about LIPITOR, should make a phone call to PYzier and tell them your side effects, that is the only way anything positive will come from this forum.. thank you for listening... I have called Pyzier and told them as well.

I have muscle pain, weakness, and chronic lower back pain. Started statin drug, Simvastatin, on 11/21/07. I take no other drugs. Within two weeks, I could not sit without severe lower back pain. Reported problem to family medical doctor on 1/11/08. M.D. sent me to physical therapy for 8 sessions. No relief from physical therapy so I requested an X-ray on 3/20/08. X-ray shows very mild degeneration at one lower vertebrae. M.D. sent me to an orthopaedics doctor who recommended continued physical therapy. Went to a Chiropractor instead. After six chiropractic sessions with little relief, I made an appointment with an Osteopathic doctor. My M.D. sent me to a rheumatologist who prescribed high dose naproxen for two weeks. The rheumatologist ordered and X-ray of my lower back area. The lower back X-ray produced no negatives. The rheumatologist's next step will be to order and MRI of my lower back area. The D.O. suspects statin induced myopathy and because of hyper reflexes he ordered an MRI of my brain and cervical spine. I am now recommended to a neurologist who specializes in the diagnosis of multiple sclerosis. Am I getting the run around? Only one doctor said I might have statin induced myopathy. The rest will not even mention the statin drug theory. I just pray for ache and pain relief. I have some improvement after four months off of the statin which I believe is quite a strong point that it was the statin drug and not some unknown condition. I don't think arthritis or MS conditions improve. All I know is that I had no health issues before taking the simvastatin. Good luck to everyone who has or is taking a statin drug. BEWARE!!!

Hi all. I would just like to agree that PredniSone sucks but it is the best out there for these diseases especially the auto-immune diseases. Drug companies do not make any money on prednisone because it is generic and there is no patent. I know I picked up 98 10mg prednisones yesterday for $5.00. Believe me when there is a better steroid that works as well and has less side effects it will be available to us all. It will cost tons but it will be sold. Researchers have been working for so many years trying to find an alternative, some have been found but do not work well enough. As bad as the prednisone makes us feel it does work on the diseases. You always have the choice to say no - that is why we should all have a health care power of attorney - just remember that when you decide not to take the prednisone you are agreeing that the disease may worsen and may be life threatening. I hate to sound so morbid but patients must be informed. When you are at the physician ask about the side effects, ask if they can give you something to counteract any mood swings, ask what lotion is best for the itchy skin (AmLactin works well for me and is over the counter). Also, my physician advised me yesterday that the side effects are worse on women due to our precarious hormones. I have told my husband to just stay out of the way and don't piss me off because I am not sure how this next 7-8 weeks is going to fare for him. I am 4ft 10in 110lbs and he is 6ft 1in 200lbs and believe me he is scared for his life. I am using prednisone for my ulcerative colitis so now that I am feeling better physicially I can return to exercise and that has definitely helped. So has turning up the music really loud and dancing and singing poorly. Yelling at the tv helps me whether it be politicians, soap operas or idiots on game shows who get the wrong answers. I also have been keeping a journal of all the rage I have and what kinds of things I could do to people who keep getting in my way at the store, on the road, in line at the pharmacy - I guess I need to put that in a safe place so it can't be used for evidence :}

I think that I can get my head around certain things and try to explain to you that medications do not work for all people or affect all people the same way. Well, that sounds simple enough to say - DUH. But, it is actually quite complicated chemically. Human beings are not chemically the same because we have variations in our genes. Would you be surprised to learn that about 60% of adverse drug reactions involve certain chemicals (in some cases enzymes) that we already know what these chemicals or enzymes are and what the variants are among populations groups? Some times we can predict who would have an adverse reaction to what medications if we knew what gene subgroup the patient was part of. We could also predict whether the patient would metabolize a drug at the same speed as others or not. Metabolize means utilize the drug and then discard the by-products--mostly the liver is the recycling center of chemical waste. Anything that the liver cannot re-use, the kidneys gets rid of in the urine. Speed of metabolism is a very important thing because people who are slow metabolizers might actually experience over-dose. There are other differences caused by genes that can cause different reactions according to the individual person.

I am interesting in following this site because I am wondering if the concept is flawed meaning that other parts of the body were ignored at the expense of controlling asthma and allergies of the nasal passages and lungs. OR - is there just a problem that relates to genetic differences in something such as enzymes and certain populations groups do just fine on Singulair with no problems and other people have some awful problems?

This isn't my area. But, sadly, if I can spend two weeks looking at this and come up with at least a road map of what I am looking for to answer some important questions then people who do this for Merck already know the answers. Why do I say that? Because, the adverse side effects (major categories) correspond to important areas of leukotriene receptor location and activity. Maybe not necessarily this receptor but part of a chemical process that involves this receptor.

The bottom line is that Singulair is the wrong medication for anyone that has adverse reactions. OR, there is a problem regarding the dosage that involves how fast the patient metabolizes the medication. Considering that there is a link to psychiatric adverse drugs reactions in Singulair and some medications for depression are linked to differences in metabolism due to enzymes, then there could be possibly something important to be learned from Singulair adverse drug reactions.

The biggest problem is that pharmaceutical companies are not properly communicating with the doctors who prescribe their medications. Why not communicate to doctors to look out for side effects and be aware that there are gene variations among people that are directly linked to how the patient might respond to the medication?

What happens if the patient belongs to the gene group that will have problems? If the pharm company does not tell the doctor to be on the alert, then the doctor tells the patient that it is not the drug that is causing the problem. Then the gene groups with the problems, go on the war path.

This medication f----- me up! It made me hate my job so much that I had panic attacks before going to work. I've had extreme mood swings and severe paranoia. I am a nurse and I have never been worried about catching anything but all of a sudden I thought I had all sorts of diseases. Also, I was exhausted all the time!! It got so bad that I felt like I couldn't get out of bed. I had no motivation and I couldn't concentrate on anything. Then I started getting a rash that would come and go which only fed into my paranoia. I've never had any of these problems and I couldn't figure out what could be wrong with me until I saw this website. I have been off of singulair for several days and I have already noticed a difference in my mood.

symptoms ---- paranoia, nausea/stomach pains, depression, rash, anxiety