Protein symptoms and conditions

2 genetic mutations in the gene that encodes for the transporter protein responsible for moving anti cholesterol statin drugs into the liver to be detoxified. have been identified. This gene is "SLCO1B1" (also referred to in the scientific lit as "OATP1B1"). Drugs must be "detoxified" by organs within the body and then eliminated, otherwise the drug stays in the blood stream, building up to toxic levels. With either of the 2 mutations, statins have been found to be (from various studies) anywhere from 122% to 400% ABOVE NORMAL plasma statin levels. How many people have either of these mutations? (Population genetic studies were done in Finland on Caucasian pop--so all the #'s refer to Caucasian population) 25 % to 38% of ALL Caucasian possess one of these 2 mutations. Thus, for however many yrs someone with one of these mutations has taken a statin, the level of the statin in their blood stream conceiveably could have been 400% ABOVE normal statin levels. ALll those pharmacologic effects of statins--decreased coenzyme q10, depressed manufacture of dolichols, depressed manufacture of selnproteins and thus glutathione, interrupted production of GTPases and glycoprotein function, decreased brain cholesterol levels--neuron synapses and new growth of neurons depend upon brain choelsterol--are intensified unrelentingly for the length of time the drug is taken.

I was on prednisone for 1 year for chronic pericarditis, finally weaned off and no problem with my heart since. It now been 5 month and I now have chronic shoulder and foot pain, I've read that it can take up to a year for your body to adjust and produce the correct levels of cortisone, I'm taking voltaren when the pain is too much, I feel like a 75 year old in the morning and I'm only 48. I feel so sorry for everyone who has had issues as well.

I forgot about anxiety. The anxiety went away too. More protein, B12/red meat.

I was prescribed Loestrin for mood swings and depression during perimenopause. After reading these messages, I decided NOT to try it. I was intrigued by the mention of B12. I've had 2 people suggest I eat more protein. So I put 2 and 2 together, knowing that red meat has lots of B12.......
I started eating red meat and feel 100% better!!!!!!!!!
I had not eaten red meat in years.
Try it!
Try more protein and try B12/red meat.

Sign the petition demanding the facts about Mirena!

There's a petition on another website to try to get 25,000 signatures to demand that the manufacturer of Mirena release complete information and accurate statistics about side effects. The website is for hair loss, but the petition is about Mirena, not just about hair loss. This forum may not let me post a link, but the website is the Women's Hair Loss Project. Or try Googling "Bad Mirena" (the title of the blog is "Bad Mirena, Bad!" and the petition is at the end). I think you have to register before you are allowed to sign the petition -- it took about 24hrs for me to be able to do it.

Also about hair loss: have you told your hairdresser what you've figured out about your hair loss? Would you talk to a group of hairdressing students about it? I'm going to do just that. When women's hair starts falling out for no obvious reason, hairdressers have to be taught not to try to fob us off with "Use a protein pack" or "It's the menopause" !!

I am 43yrs old took lipitor for 2 months.I started having weak muscles,felt like i had worked out all the time.I started gaining weight,which i have always been pretty slim, my feet hurt so bad just to get out of bed is very painful. My legs are weak just to pull myself from sitting position i have to have help.My doctor rechecked my blood the lipitor made my protein,cq-10 very low.I have been off of it for 1 month feeling little relief .Taking cq-10 small improvement i would rather have high cholesterol than feel the pain, by the way i am female i also had stomach pains and heartburn which i have never had this medicine needs to be removed i am very upset for what it has done to me.

I was asked to take Lisinopril by my doctor today, after reading about all of these people bad side effects I want no parts of this drug, and why are doctor's recommending this drug to patient and know that it has so many bad side effects. I really don't know what to do. I'm 58 years old and I'm diabetes. Two weeks go the doctor stated that my kidney was at a 4 and that they found a little protein in my urine. Now to I need more problems add to my health. I looking for answers.

More updates. I post every week with updates. I am now 3 weeks post Mirena. yes I had ALL the side effects everyone else has listed. All side effects have subsided except for the weight gain. My bloating disappeared right away which was severe water retention and possibly blood. For instance my breasts went down and stopped hurting immediately and my belly improved but I have not shed the FAT that my body stored thinking I was prego. So I might have lost 5 or 10 lbs. Thats the only side effect I am still dealing with and will have to start dieting and exercising to jump start my sluggish metabolism. The most recent side effects I want to report at week 3 to disappear is MY SEX DRIVE IS BACK!!! WOW! and....I finally am sleeping soundly through the night!
You will hear from me when I lose all the silly weight I gained. But it might not be until its warm enough to get outside and walk, run and ride my bike and play with the kids. Im in hibernation right now!LOL And Im too wimpy to starve myself at the moment!
To all of your contemplating removal: There is absolutely no benefit to keeping the Mirena that could outweigh the long term destructive side effects. Dont wait, it doesn't get better. Just get it out now.

I was diagnosed with SLE (lupus) when I was 14, I'm 21 now, and I've had to be on prednisone all this while. The dosages alternate between 60mg (the highest) and 2.5mg (the lowest), I just went for a routine check up today and found out that my protein level in my urine is at an all time high. So the doctor is pushing me back up to 30mg of prednisone. Its 2 am, and I am sitting in bed crying because I don't want to have to go through everything again; the weight gain, the moon-face, everything. I know I may sound shallow, because ultimately, the medicine is keeping me alive, but the side effects are terrible. Very few people understand that its not fat that you're gaining, and the remarks that I know I am going to get are enough to drive me insane.Is there anyway the water retention or the weight gain can be stopped or decreased?

I was given Dexpak for a severe sinus infection. I took it for 5 days and could no longer take the side effects, so I quit it cold turkey. I have been off from work almost the whole month because of this drug.

The side effects I had from it were:

• anxiety
• hyperactive
• uncontrolled talking
• severe tremors and shakes
• overheating
• loss of appetite
• sitting still and the room spinning
• loss of vision
• severe headache
• loss of concentration
• unable to think
• no sleep
• all upper body muscles tied into knots
• esophagus swollen and raw
• dizzy
• personality change

After I quit I became ravenous the next day. I ate a lot of protein and fruit. It has almost been a week since quitting. I still have problems sleeping, headaches, a swollen esophagus, sore muscles and my personality is not quite normal. Hopefully I will get back to normal.

My sister at 39 years old recently died from the condition called pulmonary thromboembolism caused by the use of Yaz. Please if you are taking this pill and are experiencing anything negative from it, get off of it immediately. I am currently seeking legal counsel for my sisters death, I believe it is unfair that a product like this can take a human life, and no-one will be held liable. I have been told that it will be virtually impossible to bring a lawsuit against a product that has been FDA approved. My sister left behind three children who love, miss and still needed her. If anyone can give me some type of direction on how to bring a lawsuit against the manufacturer of this product please contact me asap.

I am so glad I found this web site!

Let me start by saying I am a 42 year old female paramedic, so I am not big on taking ANY medications, period! My endocrinologist has been after me for 1 1/2 years to start taking 10mg Lisinopril to protect my kidneys since I am a type II diabetic, and now because of my elevated B/P and the fact that my last set of labs showed a increase of protein, something to do with the kidneys. I have resisted taking the medication, in hopes I would lose some weight and get my B/P down. But due to an injury, exercise has not been an option for me and now that I need a surgery, I had to break down and start the Lisinopril ( the doctor will not be able to operate if my B/P is elevated).
I started the drug 10 days ago, and at first was happy I did not seem to have any of the side effects that I read about. I had researched what I could find at the time, and even talked to my pharmacist about it, since he takes it as well.
After a few days, I saw an occasional drop in my systolic pressure, down in to the 120's from the 140's/ 150's, and not much of a diastolic drop, maybe, down to 90 from 94-100. I did notice my pressure would be high if I had been moving around before checking it, and I was disturbed to find that my pulse was now on occasion running around 104 after only walking through my house to my room where my B/P monitor is. My pulse never runs that high unless I have been very active. A few nights ago, I woke up and turned over in bed, and noticed my heart felt like it was fast ( tachycardia) and this happened more than one night. I decided I was going to discuss this with my doctor this week, until what happened today. I went for an MRI on my neck, and noticed I was anxious when they put me in the tube. I felt like I was breathing heavy and figured maybe I was just nervous. Then tonight I had an acute onset of anxiety, and just felt bad all over. I had some numbness on the left cheek and other symptoms that I knew had to be from the Lisinopril, so I got online and started looking for more info, and found this site.

I can absolutely believe everything I have read here. I have taken so many patients to the hospital in my career just because they were having side effects from a medication they were taking. And that is exactly why I did not want to take this or any other medication unless I was forced to.
I am not taking this stuff again, and calling my doctor first thing in the morning. In fact, I am going to tell her that I want my cardiologist to handle my hypertension medication from now on.

I must say to EVERYONE who reads this, please, do not just take ANY medication just because a doctor gives it to you. Research all you can, ask questions, and if the doctor does not want to answer you or tries to make you feel crazy or stupid, CHANGE DR.'S!!!!! I have seen way too many bad doctors out there, and I have seen some outright kill patients. I am not saying not to trust anyone, just be very careful, and follow your instincts. I am very happy to have found this site, and I hope it helps others that read all the posts here. If I get any good info from my doctors, I will let you know.

my 12 year old daughter received 2 shots and we noticed a bald spot on the back of her head. A couple weeks later, it is getting worse, she now has at least 3 bald spots. She has very fine hair and is trying really hard to hide the bald spots, 2 in the front of her scalp. I know this is a result of the Gardasil shot. She will not be getting the 3rd shot. All of the doctors recommend this shot. Its only been out on the market a few short years, and i believe more research is needed. My daughter is to the point of tears every morning trying to fix her hair to cover up the bald spots. A dermatologist has diagnosed her with alopecia areata. There are new spots appearing all the time and I am worried that she will lose all of her hair.

Hi I am a 44 year old asthma patient. I have had asthma since the age 2 and have been on & off prednisone since that time. As a child until age 20 I was on predinsone daily. My question is has anyone experienced nerve problems due to long time use? I do have muscle weakness and spasms, but I am interested in if anyone has had nerve problems. Please email me at ****** and refer to prednisone.

I suddenly had high blood pressure. I was put on a heart monitor for 21 days because I was experiencing frequent palpitations. I was given 25 mg Metoprolol ER the genic for Toprol XL on June 6, 2008. I had the usual symptoms extreme fatigue, headache, constipation,swelling, weight gain for the first month. I am 59 yrs. old.
The second month I started to have horrible nightmares, and headaches that would not go away. On Aug.12 while driving home I started to hear voices, had blurred vision and hallucinations. I was driving fast and screaming to make the voices stop.. I ended up in a parking lot. I was crying and for a minute I had a bit of reality. I called the cardiologist office and told the nurse what was going on. She said to immediately stop the meds because I was having a rare serious side effect. I sat crying for awhile and was able to call a friend to pick me up. I stayed at home for 4 days. The entire time my hands shook and my headache was horrible. It was one week before I was able to function properly.
I called my pharmacist and she told me that this drug affects the central nervous system. 2 % of 100,000 people have this side effect. I told her that it was not written on my paper with the prescription. She said that because it is so rare they do not have put it on. She printed out the side effects for me from her web site. A site that is only accessible to pharmacists or Dr.'s. My Dr. wants me to try Cardizeim now and I do not want to because I am afraid. I told him that the BP was down to normal but he still wanted to because of the palpitations. I was given the option of the Cardiziem or seeing and Electrical Man at the Cardiology office. As of yet I have not taken the Cardiziem. This is the first time I have read this web site and I hope that this information may help someone. I finally feel good again except for the rapid heart beat and glad to be alive.

I have been on omeprazole for 2 months. I noticed I would get dizzy and hot flashes. I quit taking it and have been off for 7 days. I'm wondering how long it takes for these side effects to stop?? I feel light headed all the time sometimes I feel good and then I get dizzy again?? Please Respond??

Thanks

Didn't have bad side effect but kept a constant look out for what they listed on the paperwork. But I was in so much shoulder pain that I needed this too bad. (I've used it before (5 yrs) so I knew people had bad experiences).

Hunger pains were the worse but I kept food in the house and with me so that I could eat (protein) when the SHARP hunger pains happened.

Centocor, the maker of Remicade, aggressively pushed physicians to set up infusion clinics, write for the drug and promised huge profits.Most of these infusion suites are run by nurses. The drug dose is calculated by a nurse and mixed into the iv bag by a nurse NOT A PHARMACIST. The drug, which can put patients at risk for serious infections and tuberculosis is not even mixed in a sterile IV hood !!! It is mixed out in the open air and exposed to contamination. In the meantime,Centocor downplayed the severity of the side effects. This drug actually caused LUPUS in a patient who subsequently won $19,000,000 in a lawsuit. The drug can greatly increase the risk of lymphomas and blood disorders with fatal outcomes. But the literature does not adequately educate patients and physicians on how to properly monitor the drug! The drug can cause memory problems, visual changes, and increased sed rate and increased c-reactiv protein.

I have only been taking singulair for about a month. I have noticed that I have become more irritable, grouchy, hateful and just numb, not really wanting to be around anyone, not caring about anyone else's feelings much. I also noticed I have become extremely lethargic, to the point of falling asleep at work as well as heart palpitations and stomach pains. I just started new birth control pills so at first assumed they were causing these side effects, that is until I looked up the side effects of this drug! I have over half of the side effects so I stopped it immediately and can already tell a difference in my mood. I have to sons age 11 and 14, both who have asthma and allergies. The took this medication for a few years with no side effects but have not taken it for about a year now. My youngest son however, has been diagnosed with ADHA and ODD and possibly BiPolar disorder. As I read the other posts, I realize the description of how their children act while on this drug is exactly how my son acts. I wonder if there can be irreversible permanent damage from taking this medicine? He has been on a number of ADHD drugs, none have helped except to make him stop eating and lose weight and he is small for his age, so I have taken him off everything. Has anyone else out there experienced what could be permanent damage from this drug in their children? Even after being off the drug for a year or so? If it could make me miserable within a month, what can it do when one takes it for years? Its sometimes hard to tell the effects of medicine on small children. My son prob starting taking it around 4 yrs old and took it til he was about 8 or 9. Just wondering if anyone else out there has had this happen to them or their children.

More evidence of what I have been saying about genetics and the leukotriene pathway that Singulair blocks. FLAP's as mentioned below are actually the same era as Singulair (late 90's)--many scientists were looking at this pathway.

The genetic component is so "in your face" every where that I am quite appalled that Merck has not at least addressed that issue by now.

Monday, June 02, 2008
Amira Pharmaceuticals Achieves Milestones in FLAP Inhibitor Program With GlaxoSmithKline
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SEND ComtexDigg It StumbleUpon Newsvine Reddit SAN DIEGO, Jun 02, 2008 (PR Newswire Europe via COMTEX) ----GSK exercises option for AM803, a FLAP inhibitor which recently completed phase I studies

Amira Pharmaceuticals today announced that under the terms of a worldwide exclusive agreement entered into in Feb 2008, GlaxoSmithKline (GSK: 43.65, -0.88, -1.97%) will exercise its right to a second FLAP compound, AM803. Under the original agreement, GSK has rights to develop, manufacture and commercialize FLAP (5-Lipoxygenase Activating Protein) inhibitors for the treatment of respiratory and cardiovascular disease. The decision to develop AM803 follows the successful completion of a phase I study by Amira, which demonstrated its potential as a once-daily FLAP inhibitor.

"Exercise of this option by GSK caps a productive first few months during which Amira has hit a number of near term milestones. Hitting these milestones early has not only further strengthened our relations with GSK, but has resulted in meaningful economic benefit to Amira," said Hari Kumar, Chief Business Officer, Amira. "The project has started extremely well and we are very pleased at the commitment of GSK and the progression of development."

About FLAP Inhibitors

FLAP (5-Lipoxygenase Activating Protein) is a key component early in the leukotriene pathway, a complex signaling process that exerts control over biological processes, such as inflammation and immunity. Excessive production of leukotrienes exacerbates inflammatory diseases, such as asthma; the FLAP gene has also been linked to a significant increase in the risk of myocardial infarction and stroke. AM103 and AM803 bind to FLAP, inhibiting the synthesis of leukotrienes that cause inflammation.

About Amira

Founded in 2005 and headquartered in San Diego, Amira Pharmaceuticals is a small molecule pharmaceutical company focused on the discovery and early development of compounds to treat inflammatory disease linked to the eicosanoid pathway.

The company combines the rigor of a big pharmaceutical company with the ingenuity and energy of a small company, creating an environment for efficient and effective pre-clinical and clinical program decisions. Its scientific founders have successfully worked together for more than a decade and were pivotal in the discovery of a number of inflammatory drugs, including Singulair(R: 73.05, -0.38, -0.51%). The drug hunters at Amira are now actively leveraging their history of success to create high-value compounds for the future. For more information, visit http://www.amirapharm.com.

Web site: http://www.amirapharm.com

i am a 21 yr old female taking 60 mg of prednisone for to much protein in my urine i am having severe nightmares and to look in the mirror i tell everyone i am ugly cause i have moon face and buffalo hump along with a lot of other symptoms i am looking for answers on to how to decrease or eliminate my nightmares i am in nursing school and to wake up with a nightmare till i get back toi sleep its time to get up for school and my exam grades have gone down hill since i started taking it cause of wanting to sleep all the item and not study now i sleep and my nightmares wake me and i am afraid to sleep if u have ne suggestions let me know i would appreciate it

I have been on Jolessa for 3 months now. As of now I have been experiencing this "breakthrough bleeding" for a full 2 months now. Once every two weeks I have mild cramping and I have gained at least 10-15 lbs. Each time I call the doctor I am told to give it a little while longer and that if I am still bleeding by 4th month that we will have to do something else. Also I am told to take 3 Advils 3 times a day as well and eat a lot of food filled with iron and protein (for energy). I am tired all the time, headaches and unusually depressed. I cry at the drop of a hat too. I am not happy about this at all and all of this was to control the bad cramping and clotting of the regular 7-10 day periods I was having. Any suggestions out there? Each Birth Control Method I click on on this web page seems to have the similar side effects. Is there any relief from this?

I am a 25 year old, who was perfectly healthy prior to recently when I was diagnosed with Nephritic Syndrome and Minimal Change Disease and possibly FSGS (kidney diseases) I was put on 60 mg of Prednisone for 1 month then I was lowered to 40 mg for one month and I am then dropping to 30 mg. I am also taking Fosamax for my bones and a Vitamin D pill because my last lab test showed low vitamin D levels.

I am dizzy constantly and can not live a normal life, I can not drive or do any activities that I had previously done. My chest is so tight and constricted all of the time, my heart rate is so fast and pounds at my chest. I have no energy to do anything, I can barely open a door at times. I am beginning to grow unwanted hair on my face. My abdomen is always bloated. I have pain in my rib cage, and shoulders. I feel very sore throughout my entire body. I do not really sleep at night, so I look very tired all the time.

I have actually lost weight, I have no appetite at all. I am down 10-15lbs.

Now for the Pro- my Kidney Diseases are currently in remission and this has happened much faster than the Nephrologist had thought.

I am very anxious to getting my life back to normal and getting off the Prednisone.

Has any one else experienced increased heart rate, chest tightness, or rib pain?

I wish everyone the best in their roads to recovery!!

My daughter started the 1st Gardasil shot in mid July. By the beginning of August she had a lot of health problems. She had a rash all over her face, neck and chest. Her face was so swollen that she couldnt hold her eyes open. She had protein in her urine that couldnt be explained. Shes constantly complaining of a head ache, stomach ache, joint pain and fatigue. She has finished the shots. I didnt make the connnection until I loooked back at my calendar and saw the dates for the shots. I wish I had never consented for her to have them now.