Pruritus symptoms and conditions

Below is the latest ADR report on Singulair from the United Kingdom. I deleted side effects reports by very small numbers of patients in order to keep the post briefer. This shows the total number of reports since Singulair was approved in the UK.

I don't know the total number of prescriptions for Singulair in the UK. It is considered expensive.

Drug Analysis Print
Drug name: MONTELUKAST
Drug name: MONTELUKAST Report type: Spontaneous
Report run date: 13-May-2008 Report origin: UNITED KINGDOM
Data lock date: 09-May-2008 08:00:02 PM Route of admin: ALL
Period covered: 01-Jul-1963 to 09-May-2008 Reporter type: ALL
Earliest reaction date: 01-Jan-1997 Reaction: ALL

Cardiac disorders-TOTAL 64
Palpitations 29
Myocardial infarction 6
Tachycardia 6
Diarrhoea 84
Dyspepsia 24
Abdominal pain 98
Abdominal pain upper 22
Nausea 84
Vomiting 52
Dry mouth 15
Asthenia 13
Fatigue 45
Malaise 32
Sudden death 1
Pyrexia 10
Chest discomfort 12
Feeling abnormal 16
Influenza like illness 17
Irritability 18
Drug interaction 13
Chest pain 13
Arthralgia 59
Myalgia 38
Muscle spasms 24
Pain in extremity 14
Balance disorder 10
Lethargy 16
Somnolence 23
Psychomotor hyperactivity 25
Headache 221
Dizziness 68
Neuropathy peripheral 7
Convulsion 6
Epilepsy 7
Dysgeusia 7
Hypoaesthesia 6
Tremor 18
Nervous system disorders TOTAL 526
Abnormal behaviour 13
Agitation 12
Anxiety 18
Aggression 30
Depression 23
Insomnia 58
Abnormal dreams 12
Nightmare 49
Hallucination 21
Sleep disorder 15
Psychiatric disorders TOTAL 364
Asthma 36
Allergic granulomatous angiitis 43
Angioedema 12
Swelling face 12
Erythema 13
Pruritus 32
Rash pruritic 17
Rash 55
Urticaria 33

TOTAL NUMBER OF REACTIONS 2841
TOTAL NUMBER OF FATAL ADR REPORTS* 19
TOTAL NUMBER OF ADR REPORTS* 1489

I read that many of you blame Singulair for your side effects when you are also taking multiple drugs. As a public service, I put together a list of side effects from some of the other drugs mentioned on this site. These are by no means all the side effects listed for each drug. The first group is from allergy medications people have mentioned.
Zyrtec & Zyzol -
suicidal ideation, suicide, aggressive reaction, anaphylaxis, cholestasis, convulsions, glomerulonephritis, hallucinations, hemolytic anemia, hepatitis, orofacial dyskinesia, severe hypotension, stillbirth, thrombocytopenia.
abnormal thinking, agitation, amnesia, anxiety, decreased libido, depersonalization, depression, emotional liability, euphoria, impaired concentration, insomnia, nervousness, paroniria, sleep disorder.
accidental injury, asthenia, back pain, chest pain, enlarged abdomen, face edema, fever, generalized edema, hot flashes, increased weight, leg edema, malaise, nasal polyp, pain, pallor, periorbital edema, peripheral edema, rigors.

Benadryl-
Sedation, sleepiness, dizziness, disturbed coordination, fatigue, confusion, restlessness, excitation, nervousness, tremor, irritability, insomnia, euphoria, paresthesia, blurred vision, diplopia, vertigo, tinnitus, acute labyrinthitis, neuritis, convulsions. Epigastric distress, anorexia, nausea, vomiting, diarrhea, constipation, Urinary frequency, difficult urination, urinary retention, early menses

Allegra -
insomnia, nervousness, sleep disorders or paroniria, and hypersensitivity reactions (including anaphylaxis, urticaria, angioedema, chest tightness, dyspnea, flushing, pruritus, and rash). Back Pain, Stomach discomfort, Pan in extremity, Headache, Vomiting, Somnolence/Fatigue, diarrhea,

Claritin -
Hypotension; hypertension; palpitations; tachycardia; syncope, Headache; somnolence; fatigue, nervousness; hyperkinesia; paresthesia; dizziness; migraine; tremor; vertigo; impaired concentration; depression; agitation; anxiety;

I feel like my heart flutters on it and the first time I took it, I couldn't sleep for 2 days. I am giving it another try due to cedar fever.

I found this information from another site.

Post-Marketing Experience

The following additional adverse reactions have been reported in post-marketing use: hypersensitivity reactions (including anaphylaxis, angioedema, pruritus, urticaria, and very rarely, hepatic eosinophilic infiltration); dream abnormalities and hallucinations, drowsiness, irritability, agitation including aggressive behavior, restlessness, insomnia, paraesthesia/hypoesthesia, and very rarely seizures; arthralgia, myalgia including muscle cramps; increased bleeding tendency, bruising; palpitations; edema; nausea, vomiting, dyspepsia, diarrhea, and very rarely pancreatitis. Rare cases of cholestatic hepatitis, hepatocellular liver-injury, and mixed-pattern liver injury have been reported in patients treated with SINGULAIR. Most of these occurred in combination with other confounding factors, such as use of other medications, or when SINGULAIR was administered to patients who had underlying potential for liver disease such as alcohol use or other forms of hepatitis

It looks like it has many side effects.

GOOD LUCK WITH YOUR ALLERGIES!

well this is the exhaustive list of the possible side effects triggered by montelukast sodium given in the leaflet of this medicine....i am so grateful to the distributors of this medicine in my country for keeping the users of this medicine informed. I am stating the side effects as it is for every ones notice here

1. Body as whole: asthenia, fatigue, malaise, oedema, hypersensitivity reactions including anaphylaxis, angioedema, urticaria, pruritus, rash and one isolated report of hepatic eosinophilic infiltration.
2. Digestive system: thirst(pediatric patients), abdominal pain.
3. Nervous system/psychiatric: headache, dizziness, dream abnormalities including nightmares, hallucinations, drowsiness, insomnia, paraesthesia/hypesthesia, irritability, agitation including aggressive behaviour, restlessness, seizure.
4. Musculo skeletal disorders: arthralgia, myalgia including muscle cramps.
5. Hepato biliary disorders: elevated levels of serum transaminases(ALT,AST), cholestatic hepatitis.
6. Digestive system disorders: diarrhea, dry mouth, dyspepsia, nausea, vomiting.
7. Cardiovascular disorders: increased bleeding tendency, bruising, palpitations. Very rare cases of Churg-Strauss Syndrome CSS have been reported during montelukast treatment in asthmatic patients.
8. Mutagenicity and carcinogenicity: No evidence of this have been reported in montelukast treatment.
9. Pregnancy and lactation: no evidence of tratogenicity and there is no suffiecient prove for the excretion of the montelukast in the human milk as many drugs are excreted in the human milk.

After Mucofen my inner thighs were so sensitive that I could not even walk because the pain wa big. First they said it wa pruritus, but pruritus it was not. Waht was it then? Tehy took me off MUCOEN.
I still have burning, ithching sensation on my thighs, cannot wear pants, only skirts.