Psychiatric problems symptoms and conditions

PLEASE REPORT SIDE EFFECTS OF SINGULAIR TO THE FDA: https://www.accessdata.fda.gov/scripts/medwatch/medwatch-online.htm.

The FDA is continuing to monitor ongoing reports of suicide and other psychiatric problems.

From the FDA's "Updated Information on Leukotriene Inhibitors: Montelukast (marketed as Singulair), Zafirlukast (marketed as Accolate), and Zileuton (marketed as Zyflo and Zyflo CR)"

6/12/2009

Neuropsychiatric events have been reported in some patients taking montelukast (Singulair), zafirlukast (Accolate), and zileuton (Zyflo and Zyflo CR). FDA has requested that manufacturers include a precaution in the drug prescribing information (drug labeling).

Montelukast is used to treat asthma, and the symptoms of allergic rhinitis (sneezing, stuffy nose, runny nose, itching of the nose), and to prevent exercise-induced asthma. Zafirlukast and zileuton are used to treat asthma.

The reported neuropsychiatric events include postmarket cases of agitation, aggression, anxiousness, dream abnormalities and hallucinations, depression, insomnia, irritability, restlessness, suicidal thinking and behavior (including suicide), and tremor.

This information reflects FDA’s current analysis of available data concerning this drug.

Advice to patients and healthcare professionals:

Patients and healthcare professionals should be aware of the potential for neuropsychiatric events with these medications.

Patients should talk with their healthcare providers if these events occur.

Healthcare professionals should consider discontinuing these medications if patients develop neuropsychiatric symptoms.

Background

In April 2009, FDA completed its review of neuropsychiatric events, (mood and behavioral changes) possibly related to drugs that act through the leukotriene pathway (montelukast, zafirlukast, zileuton). As part of its review, FDA reviewed post-marketing reports and also requested that manufacturers submit all available clinical trial data for these products.

The post-market reports of patients on these medications included cases of neuropsychiatric events. Some reports included clinical details consistent with a drug-induced effect. In the clinical trial data submitted by manufacturers, neuropsychiatric events were not commonly observed. However, the available data were limited because the trials were not designed to look for neuropsychiatric events. Sleep disorders (primarily insomnia) were reported more frequently with all three products compared to placebo.

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Everybody here knows that I have been interested in trying to find out if Singulair (montelukast), which is a quinoline, ionizes and forms quinolinic acid under physiological conditions that lower blood pH. Some researchers have also mentioned that another montelukast metabolite that occurs is known to be a toxin. In other words, until someone can get blood tests that confirm what the toxic metabolic is, we are just guessing but I would bet that it is a good guess.

One of the strongest cases for that argument would be what happens to some people during sleep. There are some people whose CO2 levels rise. If the levels rise enough to cause change in pH to a more acid condition, then montelukast can possibly ionizes just enough to create minute amounts of neurotoxins that could cause bad dreams, hallucinations, sleep deprivation or a number of other neuro-psychiatric problems. Compound the effect of night after night of minute amounts of neurotoxins caused by CO2 and montelukast ionization then it would be easy to understand how depression and personality change results. There are other conditions that cause elevated CO2 levels and acidosis such as COPD.

If anyone has any data regarding their CO2 levels from sleep studies or other bloods tests, would you please send me a private message?

Hi guys,
I came to this forum after a client at our firm told me to check out whats happening with singular. I am not a lawyer, but I am a secretary for a med mal firm and I can tell you that we have already started taking these cases. I saw a few questions posted about whether you had to wait 9 months for the investigation to finish, but that doesn't stop you from filing suit. If it were my baby boy, I would switch meds, but if you can't--make sure you journal EVERYTHING. Take videos of outbursts, etc. We have one client who's son is self mutilating after using singular. If thats happening to you, try to document the episodes. Like I said, im not a lawyer, but I work for some so I can answer a lot of questions and I would be more than willing to help. I am so disgusted by what I have read. Please email me if you have any legal questions, etc. If i can't answer them, my boss will and if its a medical question, we have a staff nurse so I will give her a call. Again, I am so sorry for what everyone is going through. I pray to god I can help in some way.

As a pediatrician I write for Singulair every day.
The medication is for allergies.
Allergies cause a cascade of event that I will describe:
adenoidal swelling, leads to snoring + sleep disturbances. Poor sleep makes the child tired the next day leading to less attentiveness, hyperactivity and eventually acting out.
Almost 4 out of five kids with allergies have those subsequent symptoms, and more.
Over the years the child poor behavior his parents, teachers and peers respond of criticism/ ridicule, and punishments, cause the child to feel inadequate, embarrassed, frustrated and eventually depressed and suicidal.

Yes, Singulair does cause behavioral change but they appear within the first couple of pills, the rest is due to allergies and lack of medical care, i.e. sleep, Singulair, and Zyrtec deficiency.
Allergy shots cause 4 times the incidence of suicidally than Singulair, and Ritalin 10 times more.
Check it, it's true.

confusion and disorientation in a previously normal active adult with no memory or psychiatric problems? this occurred right after the Lipitor was increased from 10 to 20 mg day within a couple days??? HELP WANTED!!!!

gabitril oh what a lovely drug .... last year i put on gabitril, multitude of psychiatric problems here . started at 4 mg then 8 suddenly they bumped me up to 16 then 24 mgs a day, well all was fine or so it seemd.... i noticed the increased sweating the forgetfulnessand i lost a ton of weight about 60 pounds in a few months.....then one night while out at a club(i dont drink) i started to feel not so well. my friends walked me to my car and that is all i remember. i woke up in the hospital 2 days later, i apparently had several dozen petite and grandmal seizures associated with the gabitril. I had sense enough to pull the car over at a hotel and go in and ask for help and then i had collapsed . when i started to come around inthe hospital i was told what happened and that i didnt even know who i was and the only thing i was able to do was tell them my sister's phone number i couldnt even tell them her name . I have not had another siezure since stopping that med. I hope everyone on it will be careful and we beaware that seizures in patients that don't have seizures to begin with can and will happen. Good luck and god bless

My 8 year old daughter was prescribed a low-dose of Reglan each night at bedtime to prevent morning nausea and motion sickness. For that it worked. Unfortunately, over time she became more and more "worried' then "anxious" and even developed obsessive-compulsive symptoms and became nearly psychotic. The doc who prescribed it did mention to look for "tics" but not anxiety (altho he did confirm later that it "occassionally" occurs). She was on it for three weeks before we made the connection. The psychiatrist refused to entertain the thought that her psychiatric problems were due to Reglan reaction, but after consulting other physicians and researching internet sites, we were convinced this is what she indeed suffered. It took nearly three months for her anxiety to completely vanish and I am happy to say, she is fine now. Her stomach aches come and go, but treatment with diet and allergy elimation seems to help. This drug can be dangerous but doctors should be better informed and equiped to deal with a very-real side-effect.