Psyllium symptoms and conditions

I have been on Simvastatin for about 4 months now. For the past 2 months, I have been having unexplained muscle/joint pain and tightness in my hips and thighs. I couldn't figure out what I'd done but thought it was just one of those things (slept wrong, stepped wrong, etc.). I've been working with a foam roller to get the knots out, even getting up in the middle of the night to work on the roller because it hurt so much. That helped some. Took Motrin but that didn't work at all! Added Omega 3 fish oil and glucosamine and that did help a little. Have been limping for 2 months now and it finally occurred to me, "I wonder if it's the Simvastatin?" I already knew I was sensitive to chemicals like sodium lauryl sulfate, so everything I see written here makes sense to me. I emailed my MD today and she said to stay off it for 3 weeks and see if I see any improvement, plus get blood work. I sure hope I don't have any muscle damage. Thank all of you for posting your experiences

I have been taking Zocor for 6 months. In the past 3 weeks I have developed intense tingling and burning in both legs from my feet to my knees. I also have a feeling of numbness in my right foot that at times is in the whole ball of my foot but will move to the side of the ball of my foot. I have been to the ER twice and all my neuro checks were normal even though my legs felt like they were on fire. I just this past week had a MRI of cervical and lumbar spine. My doctor is thing the symptoms may be related to the significant arthritis I have in my neck and may be due to nerve compression at one of the discs but I don't think so. I was worried about MS and Guillian Barre as these can be symptoms of those diseases as well but I didn't have any other symptoms of those diseases. At my last ER visit the doctor put me on Neurotin for the burning in my legs. I just happened to think to look on line for med interactions and side effects of the meds I am on and would have never expected that Zocor could be the culprit. I was astounded to find that the tingling and burning was more than likely due to the zocor. I stopped taking it about 4 days ago and am showing some improvement but I am still taking the neurotin. Does anyone know how long it takes Zocor to get completely out of your syste.? I also have nerve conduction studies scheduled.

I am a male of 67 years old. I took Lipitor for a year, and after a few months of taking it, I felt muscle pains in my arms and shoulders, as well as my back. I felt weak and could hardly put my socks on by myself. I told my family doctor that I thought the problem was caused by LIpitor. He said it couldn't be possible, but he couldn't figure out what was wrong, so he sent me to a rheumatologist, who gave me an initial diagnosis of polymyalgia rheumatica. I went back for a checkup, and although the sed rate was normal, the C-reactive protein was elevated. He felt his diagnosis was an accurate one. He prescribed prednisone for me. I had some doubts about it, since I am diabetic, and was concerned about the elevated blood sugar it might cause. Well, it did elevate my blood sugar, and I weaned myself off it within three months. My blood sugar went back to normal, and while the prednisone helped the symptoms of muscle pain and aches, after I stopped it, the pain returned with a vengeance.

About a year passed after discontinuing the prednisone, and I felt worse and worse. Any time I engaged in physical activity, such as yard work, I was almost incapacitated for two or three days. I felt weaker and weaker, and by now, my activity is about ten per cent of what it was three or four years ago. I am unable to do anything physical without paying a heavy price.

I would tell the doctor that I felt the problem was caused by the Lipitor. He would dismiss my comments, saying that the pain should have gone away after discontinuing Lipitor. He sent me back to the rheumatologist with results of recent blood tests. Both the sed rate and C-reactive protein were normal. The rheumatologist touched my back and other areas, which caused me to jump. He said it might be fibromyalgia. I told him again that I thought it was caused by the Lipitor. He said the same thing my GP had said: if it had been the Lipitor, the pain would have gone away when I stopped taking it. I know the Lipitor caused the pain, because I tried red yeast rice for a couple months. The pain increased to almost unbearable, so I discontinued the red yeast rice. If I were not susceptible to the pain from the Lipitor, would the red yeast rice have increased the pain?

So here I am with a fuzzy diagnosis from the rheumatologist, and no clue from my family doctor (that he will verbalize, at any rate). My life has gone steadily downhill. I used to be a strong, active person, but now I can do very little, and my strength is a shadow of what it formerly was. What can I do?

From the Netherlands 2006.

This is the html version of the file http://www.lareb.nl/documents/kwb_2006_4_montel.pdf.

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Nederlands Bijwerkingen Centrum LarebMei 2007Montelukast and depressive symptomsIntroductionMontelukast (Singulair®)is a leukotriene receptor antagonist available on the Dutchmarket since 1998. It is indicated for the treatment ofasthma as combination therapy forpatients with light to moderate forms of chronic asthma which cannot be adequately controlledby inhalation corticosteroids and short-acting ß-agonists. For asthma patients for whommontelukast is indicated as asthma treatment it can also relieve symptoms of seasonal allergicrhinitis. Montelukast is also indicated in asthma prevention, if exercise-inducedbronchoconstriction is the main factor

.ReportsOn September 20, 2006 the database of the Netherlands Pharmacovigilance Centre Lareb contained four reports of depressive reactions associated with theuse of montelukast.Patient A is a female aged 55 who used montelukast 10 mg once daily for asthmaassociated with COPD. Concomitant medication included ipratropiumbromideinhalation, salmeterol inhalation, fluticasone inhalation, acetylcysteine, budesonide nose spray and desloratadine. Two weeks after montelukast therapy was initiated the patient experienced nightmares, a depressive symptoms, fatigue and increaseddyspnoea. When montelukast was withdrawn, the first three symptoms resolved. Itis not known if the dyspnoea resolved. The reporting pneumonologist stated thatthe increased dyspnoea also could be a sign of progressing COPD.Patient B, reported by a pneumonologist, is a female aged 39 who used montelukast 10 mg once daily for asthma. Concomitant medication included salmeterol/fluticasone inhalation, mebeverine and psyllium seed. One week afterstarting montelukast treatment the patient experienced chest discomfort, malaise,depressive symptoms and dizziness. Montelukast was withdrawn, patient outcomeis unknown.Patient C, reported by a pharmacist, is a male aged 46 who used montelukast 10mg once daily for asthma. Concomitant medication included omeprazole,salbutamol inhalation and budesonide/formoterol inhalation. Six days after startingmontelukast treatment the patient got in a depressed state. The patient continued to use montelukast for four weeks but the depression did not resolve. Whenmontelukast was withdrawn, the patient recovered.Patient D, reported by a pharmacist, is a female aged 59 who used montelukast 10mg once daily for mild to moderate asthma. Concomitant medication included mometasone nose spray, salmeterol/fluticason inhalation, oxazepam and paroxetine. Three days after starting treatment with montelukast the patientexperienced insomnia and aggravation of her depression. When montelukast waswithdrawn the symptoms resolved.
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Nederlands Bijwerkingen Centrum LarebMei 2007Other sources of informationLiteratureSeveral drugs are known to cause depressive symptoms. However montelukasthas not been associated with depressive symptoms earlier . A Medline searchbased on the MeSH terms montelukast, leukotriens, depressive disorder and mooddisorders did not yield any relevant publication.DatabasesOn September 20, 2006 the database of the Netherlands Pharmacovigilance Centre Lareb contained four reports of depression associated with the use ofmontelukast (ROR 2.1 95% CI 0.8 - 5.7). The same day the database of the WHOcontained 3466 reports on montelukast, 43 of these concerned depression (ROR1.2 95% CI 0.9 – 1.6)MechanismThe mechanism of montelukast-induced depressive symptoms is unknown.However montelukast has earlier been associated with adverse drug reactionssuch as abnormal dreaming, nightmares, hallucinations, agitation with aggressive behavior, irritability and restlessness, which suggests that montelukast can penetrate the blood brain barrier and exert an effect in the brain .Discussion and conclusionLareb received four reports of depressive symptoms in patients using montelukast.Possible confounding includes that asthma itself has been associated with the development of depression . Inhalated corticosteroids can also exert effects onthe central nervous system. Fluticason in combination with salmeterol which isused by patients A, B and D, is associated with hyperactivity and irritability where as budesonide, which is used by patient C also has been associated with depression . The latency of montelukast-induced depressive symptoms variesfrom 3-14 days. In three of the cases a positive dechallenge was seen.The fact that the patients (except for one) did not suffer from depressive symptomsbefore they started montelukast, the short latency, and recovery after withdrawal ofthe drug all strengthen our hypothesis that depressive symptoms are an ADRrelated to the use of montelukast. According to the Marketing Authorisation Holderof montelukast, depression will be added to the product information.References1. Dutch SPC Singulair®. (version date 11-7-2005) http://www.cbg-meb.nl/IB-teksten/23164.pdf.2. M.N.G Dukes and J.K Aronson, editors. Meyler's Side Effects of Drugs. 14 ed. Elsevier; 2000.3. Price D. Tolerability of montelukast. Drugs 2000;59 Suppl 1:35-42.4. Goldney RD, Ruffin R, Fisher LJ, Wilson DH. Asthma symptoms associated with depression and lower qualityof life: a population survey. Med J Aust. 2003;178(9):437-41.5. Dutch SPC Seretide®. (version date 12-8-2005) http://www.cbg-meb.nl/IB-teksten/23529-23530-23531.pdf.6. Dutch SPC Pulmicort®. (version date 20-10-2003) http://www.cbg-meb.nl.
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Nederlands Bijwerkingen Centrum LarebMei 2007

I am 60 years old female & have been taking Lipitor for about 4 years. I recently went off the drug for 3 months, & in that time much of the muscle pain I was experiencing began to lesson. I have pain in both arms from the below up to my shoulder. Hip pain & leg cramps. I have trouble sleeping & absolutely no sex drive. Of course, my Cholesterol went sky high, over 300. I have only been back on 80 mgs for a month and a half, & all of the aches and pains are back ten fold. I feel a hundred years old.I have to make a big decision...die of high Cholesterol, or live a life of constant pain and sleep deprivation. This is really bad. I f I had to run or crawl to save my life, I'd never make it.

I have been taking the initial dose of Niaspan for 4 weeks, one 500 mg tablet at bedtime. I really experienced no side effects at all. This week I started on the second step and increased the dose to two 500 mg tablets at bedtime. Every night I have been waking up with diareaha. It always seems to subisde during the day, but after taking my bedtime dose, I'm up again in the middle of the night. Any suggestions?