Researcher symptoms and conditions

I am starting to think I would like to be a part of a class action law suit, my daughter had to switch schools because of her mood swings, and vague hallucinations. and vague paranoia. She once ran into a parking lot she was so afraid of needles! Took her to a psychiatrist, sensed she was quick to put her on mood stabilizers and left before the eval. Recently her ped refused to up her dose of singulair and told me about depression. I subsequently upped her flovent and took her off her singulair. I did this after I heard her teacher saqy she kept on leaving the classroom to go to the nurse, and was exhibiting defiant behavior. and saying she was depressed, hearing music that wasn't there, etc. Now that shye has been off of it a week, she is a different child, and hasn't argued with me once. Hasn't cried for 5 days. has not argued w2ith her brother either! I feel I have the child back from 5 years ago when she started taking it! unfrigging believable! I would love to sue, because these episodes have almost ruined my marriage, and caused me to miss many days of work, and feel guilty when I didn't Thank-God I just took her off of it on a whim!

I took Yaz for a month and the whole time I suffered from urinary tract infections. After taking 4 different antibiotics and having my doctor say that the cause could not be the birth control pill I decided to discontinue. I'm lucky to be a researcher and have access to journals and research information that helped me figure out that it was, in fact, the pill. Doctors do not know anything and I lived in HELL for a month because of yaz with people treating me as if I'm crazy because they would not admit it was the pill. Their only suggestions was to see a urologist. As I imagined, once I stopped taking the pill the uti symptoms went away. THIS PILL AND THE HEALTH CARE SYSTEM INCLUDING DOCTORS THAT CAN NEVER BE REACHED SUCKS. THE UNITED STATES OF AMERICA HAS THE WORST HEALTH CARE AND THEY TREAT PATIENTS LIKE CATTLE. YAZ is a horrible drug that is overrated.

Has anyone been in contact with any doctors, hospitals, or researchers who are willing to recognize that Singulair targets a receptor CysLT1, with known genetic variations? As you know, I have been posting that I know of researchers who are doing work about how the genetic variations can determine the efficacy of Singulair. If genetic variations cause differences in efficacy, then, of course, these variations can also cause unpleasant to very serious side effects. These seems to be some kind of disconnect. How can the genetic component be recognized in the area of efficacy and ignored in the area of adverse drug reactions?

I definitely could relate.
i like nuvaring. It is the first birth control i've ever been on. i started it when i was 28 - just gotten married..
the only thing recently that have made me doubt it is that i heard in the news that some young woman have suffered blood clots and just die.
But im also reading the other birth controls effects and they are pretty wild as well..
the only side effect so far after 2 yrs and a few month is about 10lbs heavier.., i had mood swings my first week of being on it., occasional headaches when my period is about to start which lasts up to 4 days, low sex drive ( but i still manage to have sex and enjoy it), some dry moments ( i use to be a fountain) so it is different but eventually it goes back to normal. ( harder to have orgasms.., )
so overall nuvaring has worked for me. I just pray it continues to do so.. now i feel like there's no point in switching right now especially - going through a career change.. now is not the time to try a new one just because i hear someone died ( although that 's a pretty good darn reason).
Eventually my goal is once i start having kids God willing.. that i can stay off all these darn drugs and either tell my husband to go tie his dingy or condom it is.. its so not fair that we have to put all that crap in our bodies.. and then we wonder why we have certain weird complications.. "Lord take care of all us..we are just not trying to have 15 little kids running around...".. the researcher..

This is the first time I have actually looked up side effects to NuvaRing. I have been on it since March of 2006, so about 2.5 years. I never really noticed side effects, and I have been to the doctor more than once and told them about the same side effects that have been discussed here. They blamed it on lack of vitamins, lifestyle changes and other random facts of life. Maybe that is the cause of my problems, however, why would they all happen at once???

Until today, I was soooo happy with NuvaRing, and I still am. I am just more aware of why I feel the way I do....It is soo easy to use!! I would NEVER remember to take a pill everyday, I would not like the patch, and the shot wouldn't go with me very well either.

Seems as if every birth control has side effects...here are mine from NR

EXTREME fatigue..
I asked my doctor about this. It has been going on since January. I sleep for 13 hours a day and am still exhausted. I cannot get enough sleep. I am a 20 year old that used to lead a pretty active lifestyle, but it seems the last few months that I have slowed waaaaaaay down. It isn't like me. I usually stay busy

Weight gain
I can accurately say that I have not been as active as I was in the past...but in one year I have put on about 17 lbs, and no matter what I do, the scale keeps climbing....I joined a gym for about 4 months, and I didn't lose a single pound. Before, I was able to LOOK at a treadmill and get in shape, now I spend an hour a day on it, and it does nothing for me.

SEVERE Headaches...with sensitivity to light and sound
I have not had this bad of headaches. EVER. It usually starts in the back of my head and moves to only one side. My doctor told me to wean off the caffeine. I did and they are still there. I drink no caffeine daily and I still am getting these terrible headaches. I work at a casino, so sometimes it really interrupts my daily life, with the lights and sounds and everything.

I AM ALWAYS THIRSTY!!!!!

I have NO sex drive
My boyfriend and I used to have sex every single day when I just started the NR, but now I NEVER want to. I have to pretend that I want to have sex, just so his feelings are not hurt. Sometimes I even catch myself thinking "is it over yet??" That is SOOOO not like me. I was an animal the first few months I was on NR. Now I have no desire.

I feel as if I am just living the motions of life sometimes instead of participating in it. Like I am just here everyday, not always feeling what is going on around me. I am semi moody, but nothing out of the ordinary. Week 3 of the ring is ALWAYS emotional, but the week before my period has ALWAYS been like that. I find it very normal.

My periods are WONDERFUL. I used to have a full 7 day period from hell. Now they last only 3-4 days, and I can basically tell you when I am going to start to the hour. It is AMAZING.

All in all, I love NR still. I am not going to stop taking it yet. I am just glad I found this site so I know the reason behind all of these changes in me. I have never put two and two together....that NR was causing all of these things...but now I know it could be. Or maybe it isn't. Who knows, but as long as I keep an eye on symptoms, I think I will be okay...

If any of you have any questions I have been on NR for quite a while, so feel free to email me at ******

Below is the latest ADR report on Singulair from the United Kingdom. I deleted side effects reports by very small numbers of patients in order to keep the post briefer. This shows the total number of reports since Singulair was approved in the UK.

I don't know the total number of prescriptions for Singulair in the UK. It is considered expensive.

Drug Analysis Print
Drug name: MONTELUKAST
Drug name: MONTELUKAST Report type: Spontaneous
Report run date: 13-May-2008 Report origin: UNITED KINGDOM
Data lock date: 09-May-2008 08:00:02 PM Route of admin: ALL
Period covered: 01-Jul-1963 to 09-May-2008 Reporter type: ALL
Earliest reaction date: 01-Jan-1997 Reaction: ALL

Cardiac disorders-TOTAL 64
Palpitations 29
Myocardial infarction 6
Tachycardia 6
Diarrhoea 84
Dyspepsia 24
Abdominal pain 98
Abdominal pain upper 22
Nausea 84
Vomiting 52
Dry mouth 15
Asthenia 13
Fatigue 45
Malaise 32
Sudden death 1
Pyrexia 10
Chest discomfort 12
Feeling abnormal 16
Influenza like illness 17
Irritability 18
Drug interaction 13
Chest pain 13
Arthralgia 59
Myalgia 38
Muscle spasms 24
Pain in extremity 14
Balance disorder 10
Lethargy 16
Somnolence 23
Psychomotor hyperactivity 25
Headache 221
Dizziness 68
Neuropathy peripheral 7
Convulsion 6
Epilepsy 7
Dysgeusia 7
Hypoaesthesia 6
Tremor 18
Nervous system disorders TOTAL 526
Abnormal behaviour 13
Agitation 12
Anxiety 18
Aggression 30
Depression 23
Insomnia 58
Abnormal dreams 12
Nightmare 49
Hallucination 21
Sleep disorder 15
Psychiatric disorders TOTAL 364
Asthma 36
Allergic granulomatous angiitis 43
Angioedema 12
Swelling face 12
Erythema 13
Pruritus 32
Rash pruritic 17
Rash 55
Urticaria 33

TOTAL NUMBER OF REACTIONS 2841
TOTAL NUMBER OF FATAL ADR REPORTS* 19
TOTAL NUMBER OF ADR REPORTS* 1489

Folks, Lipitor is the most widely prescribed drug. People are blaming their various problems on lipitor. They should see the appropriate specialist to address their specific symptoms vs self-diagnosing and blaming it on lipitor.

Clinical trial of montelukast in the Netherlands.

I noticed two things:

1. The researcher states that sides effects are 10%.
2. The researcher will not allow patients to also take drugs which are metabolized by CYP2C8 because montelukast inhibits that as proved by in vitro (test tube) studies. American studies in vitro said yes montelukast is an inhibitor but in vivo (in people) that it didn't happen. I was always confused by that and would still like to know more
.
******

Hopefully this will prove to the doubters that there are genetic reasons for the variation of efficacy and adverse side effective when taking Montelukast.

I have several areas of concern (concerned citizen is concerned). One of the main areas is the reliability of Montelukast due to differences in genetics among populations. The cysLT1 (Singulair) receptor is a GENE. As I said before, it would be possible to predict those patients for which Montelukast would and would not be effective and those patients whose gene expression profile would cause them to have unwanted side effectives.

I have been looking for a way to give reasonable proof of that which could be used to convince your doctors that Montelukast is not for everybody. I happened to locate a researcher who had invented and patented methods for predicting drug sensitivity and efficacy in inflammatory disease. I have quoted below from his patent application. He intended to provide a method for determining efficacy and drug sensitivity for pharmaceuticals which include leukotriene antagonists - Montelukast.

Quoted from:

Methods for predicting drug sensitivity in patients afflicted with an inflammatory disease
US Patent Issued on December 12, 2006

Methods are disclosed for predicting the efficacy of a drug for treating an inflammatory disease in a human patient, including: obtaining a sample of cells from the patient; obtaining a gene expression profile of the sample in the absence and presence of in vitro modulation of the cells with specific cytokines and/or mediators; and comparing the gene expression profile of the sample with a reference gene expression profile, wherein similarities between the sample expression profile and the reference expression profile predicts the efficacy of the drug for treating the inflammatory disease in the patient.

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The field of pharmacogenomics measures differences in the effect of medications that are caused by genetic variations. Such differences are manifested by differences in the therapeutic effects or adverse events of drugs. For most drugs, the genetic variations that potentially characterize drug-responsive patients from non-responders remain unknown.
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In another embodiment, the invention is directed to a method for predicting the efficacy in a human asthma patient of leukotriene antagonists including, but not limited to, montelukast (a.k.a., SINGULAIR™; Merck, Whitehouse Station, N.J.), zafirlukast (a.k.a., ACCOLATE™, AstraZeneca, Wilmington, Del.), and zileuton (a.k.a., ZYFLO™; Abbott Laboratories, Chicago, Ill.), comprising: obtaining a sample of cells from the patient; obtaining a gene expression profile from the sample in the absence and presence of in vitro modulation of the cells with specific mediators; and comparing the gene expression profile of the sample with a reference gene expression profile, wherein similarity in expression profiles between the sample and reference profiles predicts the efficacy in the human asthmatic patient of leukotriene antagonists.

Many of the cells involved in causing airway inflammation are known to produce signaling molecules within the body called "leukotrienes." Leukotrienes are responsible for causing the contraction of the airway smooth muscle, increasing leakage of fluid from blood vessels in the lung, and further promoting inflammation by attracting other inflammatory cells into the airways. Oral anti-leukotriene medications have been introduced to fight the inflammatory response typical of allergic disease. These drugs are used in the treatment of chronic asthma. Recent data demonstrates that prescribed anti-leukotriene medications can be beneficial for many patients with asthma, however, a significant number of patients do not respond to anti-leukotriene drugs.

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The genes selected are those that have been determined to be differentially expressed in either a disease, drug-responsiveness, or drug-sensitive cell relative to a normal cell and confer power to predict the response to the drug. By comparing tissue samples from patients with these reference expression profiles, the patient's susceptibility to a particular disease, drug-responsiveness, or drug-resistance can be determined.

http://www.patentstorm.us/patents/7148008-description.html

The inventor's website: Hakon Hakonarson M.D. The Children's Hospital of Philadelphia

http://stokes.chop.edu/research/profiles/?ID=251

I am starting a new post in the hopes that others will see what I am trying to say about the delayed reaction in those that took Singulair for allergies.

If it is consistent that Singulair does not stop allergy symptoms immediately, then the pathways that eventually stop allergy symptoms involve a change in the mast cell function, development and migration (or some combination).

I asked this question for a reason. Are allergy symptoms stopped immediatedly. My question below:

I have a question that will help me continuing looking for information. I can understand that in the case of asthma that Singulair would provide immediate relief. If it is used for seasonal allergies or other allergies without asthma, does it work right away or does it take a period of days or weeks to be effective? If it takes time, could you tell me how long it took in your situation?

My thinking was going in the right direction if the answer below is consistent of everyone or most.

about 2 hours ago on Apr 11, 2008 by catherineevans, #7045
My granddaughter was put on Singulair for allergy symptoms without asthma. Itching, red eyes, terrible congestion, etc. dark circles under her eyes all the time. When we first put her on this, we didn't see any consistent results for 2-3 weeks, then it seemed to 'kick in.' I don't know if this helps. By the way, she was 9, now she's almost 12 and was immediately taken off when this story came out 2 weeks ago.

Then after seeing one response, I gave my reason for asking.

I asked this question because I have a theory of how montelukast really works for allergies as compared to how it works for asthma.

Asthma is a hyper-sensitive state that gets going because the mast cell has a receptor (the leukotriene receptor that Singulair blocks) that sends a signal along a pathway that causes lung tissue to have that extreme response - the wheezing, the airway constriction.

On the mast cell is another receptor the histamine receptor that causes the secretions that make our noses runs and and stuff up. This is not the same immune response as the asthma response. When I saw a post that somebody's doctor said that Singulair is an anti-histamine, NO it is NOT.

So if Singulair does not block histamine immediately and your child's allergies did not go away immediately, then maybe Singulair is working through some other means such as changing normal mast cell homeostasis.
I know that this seems like "what does this mean?" I am really writing this hoping to God that there are people reading this site that know what I am talking about.

Thank you so much for responding. Your answer actually told me what I wanted to know and confirmed my hypothesis. More answers will help. I hope others respond.

PLEASE respond about the length of time that allergies disappeared if you took Singulair for allergies.

Been on Prednisone for 3 years now for ulcerative colitis. At first tolerated the drug quite well. But after a few months started to gain weight, acne. After 3 years of yo-yoing between large and low doses, each increase in dose made me feel worse. I am now at a state of osteopenia and of extreme tiredness and brain fog. I see 80yo with more energy than I. I cant walk up 10 sets of stairs without feeling tired out. I need to sleep 3-5 hours a day just in order to function. As mentioned before brain fog is amazingly bad. I'm a scientific researcher which can no longer work.

Prednisone has introduced to me what panic attacks are, mood swings, joint pain and swelling, extreme muscle fatigue and wasting, blurry vision, in habitual eating habits, depression.

This drug has ruined my life. I would have preferred having surgery to remove the colon and going to the toilet 10 times a day rather than not living as brain fog and tiredness that makes my life a dream-state nightmare.

hi yasmin researcher.
as i mentioned in a previous post i have the same problem with my ears,sometimes it can last days at a time without clearing. my ears first blocked up in august 2005 and have stayed that way up until now. i have been off yasmin for coming on 8 months now. when i looked up my symptoms they lead to a blocked eustacious tube. i have tried everything to clear them but nothing has worked. i am just hoping that it will correct itself in time. you also asked about irregular heart beats..... i have had this ever since i was put on yasmin in jan 2005. i would get it mainly at night where my heart would slow right down,miss a couple of beats then start banging and jumping around then it would race. i still get it now although not as badly now i am off yasmin but i still get what can only be described as a floppy sensation like a lump of jelly wobbling about in my chest. when i saw my gp initially back in 2005 they did an ecg but said all was ok. then when it got worse my gp said it was due to an anxiety disorder (that was what i was diagnosed with when all my anxiety symptoms appreared) as i said i still have irregular heartbeats most days but i am so reluctant to go back to my gp because they diagnosed me with this anxiety disorder thingy they will not even consider the possibility that yasmin caused this so whenever i go to see them now they just assume anything that is wrong with me is all in my head and that i am worrying about nothing and i just can't stand that reaction as i know i do not have an anxiety disorder,the fact that i have improved vastly since i came off yasmin proves that.....but not to my gp. i suppose i really should put my pride behind me to get my heart checked again just in case.
i have asked in a previous post for all ladies in the uk to report yasmin (have typed the web address so if you have not already done it please look up the post and complain about this drug!)
best wishes to you all ladies.

sarah