Rhabdomyolysis symptoms and conditions

i have never taken lipitor and i never will but here's a warning for everyone- there is actually a company that sells reports for stock investors and they are advising people to invest in the company that makes the one of the only drugs used in the management of ALS. they predict that the ALS patient population (code for customers) will grow as a result of all the people on lipitor.

ok, aside from the fact that it made me sick to my stomach that wall street views the potential suffering and death of ALS victims as a business opportunity (what else is new?), this is a pretty good indication that there is a link. it will probably take years for "science" to conclusively state the connection and for the FDA to take lipitor off the market

in the meantime, save your own life. if you're not taking it, don't start. if you are, stop NOW! cholesterol is not the enemy

Here is my experience, I am confused only because I know part of what happened to me is my own fault.

To make a long story short I overdosed (intentionally) on a different drug called Lamictal. This is a seizure med. When that event happened I was on a course of Levaquin. I was on day four. I was to take it for 24 days for a sinus infection that showed up on a CT scan.

I know that this sounds horrible, but my overdose was small. No overdose is small though, but what happened to me just didn't seem right in comparison to the amount of pills I took. My mind is telling me I have no right to question anything considering what I did.

After taking the pills, I passed out and ended up being flown to a different hospital as my condition was worsening. They told me that before I left the hospital, my urine had already started to turn brown.. I don't know what that means.

When I woke up in ICU the doctor was yelling at me asking me what other drugs I took. He said that an overdose of Lamictal would never have causes what was happening. He asked if I was on meth or had taken Benadryl. I was sweating a lot, my heart rate was 150, my liver and kidney functions were bad, and the worst of it all, I had a CK level of 70,000. I had developed.. excuse my spelling... rhabdomylisis. My whole body hurt. Every single joint in my body was hurting, I could not stand and I could not walk. They told me that I was going to probably have to go on dialysis. I ended up being in the hospital for 8 days. My numbers returned to normal after 7 days of leaving the hospital.

The doctor there still thinks I was lying about what I took because what happened "Makes no sense." When they found me in my apartment they said I had "Serotonin syndrome." Which is caused by antidepressants.They said that the muscles in my body had gone completely ridgid and I was having a seizure that they could not stop. What they told me is they couldn't move one muscle in my body. My doctor said that they assumed that I o'd on my antidepressants too. Which I didn't.

Anyway, it has been a little over a month since the event, and that sinus infection is again being treated with Levaquin. I will take my 2nd dose today. Since that day I have been off all of my meds, but I am starting some of them back up. My Lamictal, my synthroid and now this Levaquin. I am scared to death. I have been searching the internet and all of a sudden I started finding that levaquin caused rhabdomylisis in several patients... although "rare."

Do you all have suggestions for me? The part that makes this the worst is YES I did overdose on pills. I assume this is why no one has really looked into why I had such problems. Should I stop taking this pill right away? I suppose most of you would say yes. I'm just not sure.

This is an update. I have experienced "some" problems trying to get Doctors to believe that my muscle problems are Lipitor related. I was sent this by a nurse. It is not the full page.

"2005 Mosby's Nursing Drug Reference (pg.155)

atorvastatin
Lipitor

Uses: As an adjunct in primary hypercholesterolemia

Interactiions:
*Risk of possible rhabdomyolysis; azole antifungaals,
cycloSPORINE, erythromycin, niacin, gemfibrozil, clofibrate".

Guess what? I have been using an azole antifungal intermittently for the entire time I was on Lipitor. It is not a medication I "take". It is used topically for a fungal nail which refuses to clear up. You may have been using it for athletes foot.
Now one pharmacist says a topical application cannot cause this interaction and another pharmacist says it is almost certain that the azole antifungal gets into the blood stream and will interact with the Lipitor. I have to laugh.
Next week I start Physical Therapy on my left elbow.

THE P.ORANGI REPORT
VERY VERY VERY ANGRY.
THE FOLLOWING IS AN abbreviated EXTRACT FROM MED SAFE NEW ZEALAND.
A watching brief for health professionals from the New zealand goverment's web site called MEDSAFE. I assume our equivalant of the FDA.
The centre for Adverse reactions Monitoring (CARM) is receiveing an increasing number of reports of psychiatric reactions occurring with statins, fibrates and ...ezetimibe. ...... aggressive behavior, memory impairment mood cognitive sleep and perception disorders. In Australia 9 cases of depression 3 cases of depressed mood ....... with ezetimibe use ..... onset happened within 4 days in 7 of the cases.

This reminder goes on to STATIN REMINDER to PRESCRIBERS of myopathy rhabdomyolysis and interactions.

In my small town this last week alone I have personally met 4 statin sufferer's. The last one yesterday was a charming wonderful 79 yr male, who could not see or hear properly, was aggressive to his wife and having hallucinations so severe in his words "I was to f'n scared to go to bed at night and wanted to leave (sell) his house. He stopped his medication (Fiblap 200 mgs) and the hallucinations stopped his other problems are improving.

It is now very obvious to logical people that not just statins but most cholesterol lowering medicines cause an extremely unacceptable amount of cruel dangerous adverse events. It is also very clear and almost undisputable by the statistical and very definitely UNDER reported number of these adverse effects that unnecessarily interfering with the body's cholesterol is extremely dangerous to all of us.

I can right at this moment show 3 middle aged men who are a complete danger on the road - their memories are completely shagged, they are agitated, not remembering simple landmarks and they are driving.

We have pilots in the air on this stuff, I would rather my pilot was on cannabis than this this shocking stuff.

Mr and Mrs prescribe it is you that are NOT reading the instructions it is you that are criminally negligent when the presentations are given to you and you fail as the safe process of elimination to cease this medication to your patients.

We the younger middle age are accepting of evolution, the trial, error and mistakes made in the pathway to achievement. Their is no shame in error, error in develpoment aids development and the end result.

BUT Messer's prescribes your negligence in failing to report adverse events, failing to take notice of your own government's warnings and consequently destroying the quality of life of society's grandparent's golden years is shameful and criminal and you can expect little sympathy as this debacle is inevitably exposed.

My own case in brief over a 5 year period shut down my weeze pooze and manhood. Gave me excruciating pain in every joint muscle and spasming eyeballs. Rashes, itching,muscle spasms, tremors. Insanity stopping a car and smashing my walking stick over the roof with a lady inside, hearing voices and stalking the house with an axe, being sexually suggestive to elderly lady customer, abusing customers, wife mother and friends. Driving with no recollection of towns I'd been through. Leg muscle cramps that dropped me. Decrease eye sight and hearing, when swallowing the food going down the wrong pipe. Unable to speak coherently, crying, hugging people in a special needs manner, selling my cars (2) for fear of failure of a warrant of fitness. An unnecessary hip replacement, that had me on a crutch for 6 months and 18 months later still severely limping and unable to lie on the THR side (weaken muscle). I swallowed almost 3000 pills in a 6 month period. Terrifying hallucinations, sweats that soak the bed. Completely unable to think, unable to print my own name, unable to remember neighbors names etc etc etc. Burst out in a totally deranged fit of laughter in a solicitor's face in the swimming pool changing shed. Obscene language in places where I never in my life used before To scared to go to bed at night for hallucinations and my heart stopping. Unable to keep up with my 6 yr old mate on our push bikes Almost 12 months since ceasing statins I have All the same problems though substantially reduced, I still need oxycontin, predisone coq10 fish oil. I am embarrassed about going out because of what I have done and because I'm still scared about what will come out of my mouth. I still blackout and "whiteout" (I know what is around me but I can't speak) I still have micro hallucinations and loose touch with reality.

DRUG COMPANIES, you have bought us fantastic medicines thank you. We know with development there are inevitable failures so why not own up do not cover up. The oxycontin makers and their directors were fined in the millions for their misrepresentions and they weren't giving a "safe preventitve" drug to airline pilots that are now known to cause mental impairment.

CHILDREN of the elderly, check your parents overall health, memory agitation aches and pains etc since starting cholesterol lowering medicine. Check whatever and all symptoms they have suffered since starting cholesterol lowering medication. If you are suspicious respectfully ask your doctor if your parent as a process of elimination can cease the medication for a while. Two major hassles are 1) We are not aware these adverse effects are happening to us or we may blame another cause, old age etc 2) Like me there is no way I was prepared to stop my medication, even though i knew I was dying, until I got my "TRUSTED" doctor's ok. I would never interfere with my mums meds.

TO OUR DOCTORS in our society, dog people, school groups, all clubs, trades, lawyers and even sick p*****s all have access to a data base of events that interest them but you don't. In todays easy communication society with a computer on your desk your are unable to readily access current helpful information. Shame on you.

TO MY DOCTOR, Over 3 years I complained of severe upper leg muscle cramps that made me squeal and dropped me, I complained of excess tiredness, I complained of loss of muscle power, you witnessed me in a trance in your surgery, you witnessed me 6 months on a crutch after a THR, you witnessed me with notes in your surgery (memory), you witnessed me loose my ability to talk and humor properly. I caught you red handed on several occasions not reading lab results and letters from other health professionals, you witnessed, stood up behind your desk and took off my hunched ape like stance. You completely ignored at least 2 med safe warnings I asked you for an apology you held your bunched fist in my face in your surgery and told me I was an ungrateful c&*t and to get another doctor. I wrote to you in my deranged state offering you forgiveness and hoping for medical help, you ignored that letter. When I started "sobering up" 6 months later I called you and told you of my insanity whilst under the influence of statins. You told me to tell another doctor or a medical specialist. I told you I would publish these events - you told me to go ahead. Doctor . . . . . my wife and I did not only like and respect you, I had a very grateful "love" for you and your staff. When I asked you for an apology and wrote to you, had you been reasonable and a little sympathetic to my life threatening condition, I would have warmly embraced you, forgiven you and been grateful that others would be safe. When I phoned you several months later, had you have been humane, though difficult, I would have done my best by you and society. Doctor ..... you had 3 very sincere approaches that you declined. Well bud do I know of others or not? Audit all your patients for their safety now. You told me to publish, well Doctor . . . .you may now become internationally famous. Do you think I will put a complaint to the Health and Disability commissioner where they will on proof order an apology - I don't think so, you have had 3 genuine chances for an apology. Did you report my severe adverse event to CARM? Doctor . . . . . I do not think this is conduct "unbecoming" I think it may be crime.

I sincerely wish I had never become "responsible" for my health. Given this web site, the victims I personally know, my own tragic events with statins, I now firmly, sanely and sensibly believe that JIM BEAM BOURBON and ROLL YOUR OWN CIGGIES are far more deserving of a heart foundation tick than statins.

This medications web site has saved the quality of life and indeed the lives of many people. Please take the time on the contact us to send our friends at medications an email with 4 wordS only " THANK YOU ALL VERY MUCH"

Signed Mr P. O.

PS To the police and lawyers in NSW Australia where the tragedy of the fellow who chopped his wife and grandchildren took place, please check whether he was on this medicine. My heart goes out to him and his family

PPS I DO NOT UNDER CIRCUMSTANCES wish to be contacted by anyone, with the sole exception of any authority, whose sole purpose is to benefit mankind, over this matter only, I wish to rebuild 5 traumatic years of painful destruction quietly with my family.

PPPS Any pilots in any country please forward this site and medsafe nz to your medical examiners.

PPPPS Prescribers COQ10, ubiquinol not the cheaper ubiquone, oxycontin, prednisone, large quantities of fish oil, vit C, time and patience are the only things that have been of aid. After almost 2 years on oxycontin, I have no hankling for it, I have built a resistance to it and I am now trying miniscule amounts of cannibis (I am filthy angry that I have been put in this situation) to replace the oxycontin. The fish oil calmed my agitation, the coq10 reduced pain by about 20% increased energy by about 20% 3 x 100 mgs a day, The fish oil and coq10 together stopped all irregular heartbeats showing in my BP meter. The vitamin c 6 x 1000 mgs through the day within days put pressure back to the urine and aided bowel movements.

This is a great site for learning more on this subject where we can get the real facts from real experiences.( Vs. the deception from drug companies who are in the business for profit.)

Lipitor is pure poison, and Dr.'s hand it out like candy. All cholesterol reducing drugs that contain statins can trigger dangerous side effects. Not many of us are informed about the real danger of statins when we are handed the perscription. Inappropriate prescribing of medications will continue to be one of the leading causes of death. And we, the patients,do not always receive enough info. from our Dr.'s about the dangers and side effects from prescription drugs.

I'm 48 yrs. young. Female, small build, (was) healthy and active, happy, and an empty nester! My husband and I had moved to another province and hence had to find a new Dr.

I was prescribed lipitor 10 mg. daily after a routine check up by my Dr. because my cholesterol was a little high.

I started taking it in the winter 2005. I stopped taking it in mid June 2007... My side effects were progressive , drug induced, and it escalated to near disabling.

I knew something was terribly wrong. Was it A.L.S., M.S., West Nile, Lupis, Alzhiemers Disease, or a new designer disease? I did not suspect that the drug lipitor was the cause until much later.

At first, my Dr. said it was menopause. I should mention; since I've quit taking the drug 3 months ago, I have no symptoms of menopause !
At least my Dr. has acknowledged and diagnosed the cause of these profound symptoms." Myopathy as a result of statins."

Signs & symptoms I experienced are as follows;

Severe stomach pain.
Muscle pain, aching , weakness, stiffness, tenderness esp.to the lower extremities. Eventually, I could only shuffle to walk.
Pain in the palms of hands.
Stiff neck, shoulders, arms and lower back.
Trouble getting up from a seated position, and climbing stairs.
Extreme fatigue.
Hot and cold sweats
Night sweats
Fevers. High and low grade fevers.
Ringing in the ears.
Difficulty swallowing, and fear of choking.
Pain in the esophagus.
Memory loss, difficulty concentrating, forgetfulness.
NO appetite, yet a lot of weight gained around the abdomen area.Bloated.
NO taste buds.
Speech affected, slurring words and mispronouncing. Tongue felt swollen.
Trouble breathing at night, would wake up coughing ( and I was not smoking then).
Trouble sleeping.
Loss of balance and coordination.
Blurred vision esp. in the morning.
Sharp shooting pains in the Rt. thigh.

Most of the symptoms have now subsided. I still have some foot pain and leg cramps and muscle stiffness... and poor concentration. Putting this together has been done with great difficulty, as I seem to pause a great deal and forget what I was trying to say. The recovery process is slow but at least it's progress. My Dr. has not prescribed any more medication. I've done my own research, after the fact, and started taking coQ10. and I've noticed a big difference!

Quality of life? Well, I'd rather have high cholesterol and die from that, than be poisoned again by statins. What quality is there, to live an extremely painful, useless and unfulfilling life? We were all guinea pigs, and we paid a terrible price for this! I hope we all can recover from this with no long term side effects.
If you are considering taking cholesterol lowering drugs do some careful research on statin drugs before you take them, and read the testimonies from those effected by them.
sj.

I have been on lipitor for a little over two years now. I experience extreme joint and muscle discomfort. I am also picking up weight at an alarming rate. No matter what I do to lose the weight, it's not working. I've had several blood tests, but all come back fine..but I know I don't feel well and I'm having trouble remembering things....

38y.o F taking toprol 100mg once a day for hypertension x 15mths History of Hypothyroidism which is controlled w/ synthroid and closley monitored w/ lab work.
Experience weight gain, unable to lose weight w/ diet and exercise including w/ a nutrionist and personal trainer. Hairloss, lack of libido, chronic joint pain, swelling in hands and ankles/feet, back pain and/or muscle aches, lack of interest in everything, no energy. Major swelling after high sodium intake. Ear drainage, tingling of extremities especially in feet and fingers, visual disturbances. Blood Pressure is okay.
Has anyone experienced an improvement since they've stopped using toprol?

I am just out of hospital after 7 days from Rhabdomyolysis brought on by dehydration after playing tennis on a very hot day. There was the possibilty that my heart and kidneys suffered damage. When i think back I was waking up in the morning with lower back pain but I attributed that to being a weekend athlete that had really stepped up my activity. My wife also swears that my memory is terrible and when i stop to think about it (what was I thinking about again????) she is right. The hospital doctor took me off simvastatin and the pain while in the hospital and my first night home was gone. I was being treated as a diabetic but once in the hospital my blood sugars were all normal and my metformin was stopped. I was told that what happened could have killed me not to mention heart and liver damage. Watch that muscle pain carefully!!

Drug Saf. 2007;30(6):515-25. LinkOut
Statins, neuromuscular degenerative disease and an amyotrophic lateral
sclerosis-like syndrome: an analysis of individual case safety reports
from vigibase.Edwards IR, Star K, Kiuru A.
The WHO Foundation Collaborating Centre for International Drug
Monitoring, the Uppsala Monitoring Centre (UMC), Uppsala, Sweden.

BACKGROUND: The WHO Foundation Collaborating Centre for International
Drug Monitoring (Uppsala Monitoring Centre ) has received many
individual case safety reports (ICSRs) associating HMG-CoA reductase
inhibitor drug (statin) use with the occurrence of muscle damage,
including rhabdomyolysis, and also peripheral neuropathy. A new signal
has now appeared of disproportionally high reporting of upper motor
neurone lesions.

AIM AND SCOPE: The aim of this paper is to present the upper motor
neurone lesion cases, with other evidence, as a signal of a
relationship between statins and an amyotrophic lateral sclerosis
(ALS)-like syndrome. The paper also presents some arguments for
considering that a spectrum of severe neuromuscular damage may be
associated with statin use, albeit rarely. The paper does not do more
than raise the signal for further work and analysis of what must be
regarded as a potentially very serious and perhaps avoidable or
reversible adverse reaction, though it also suggests action to be
taken if an ALS-like syndrome should occur in a patient using
statins.

METHODS: The 43 reports accounting for the disproportional reports in
Vigibase (the database of the WHO Programme for International Drug
Monitoring) are summarised and analysed for the diagnosis of an ALS-
like syndrome. The issues of data quality and potential reporting bias
are considered. RESULTS: 'Upper motor neurone lesion' is a rare
adverse event reported in relationship to drugs in Vigibase (a
database containing nearly 4 million ICSRs). Of the total of 172 ICSRs
on this reported term, 43 were related to statins, of which 40 were
considered further: all but one case was reported as ALS. In 34/40
reports a statin was the sole reported suspected drug. The diagnostic
criteria were variable, and seven of the statin cases also had
features of peripheral neuropathy. Of a total of 5534 ICSRs of
peripheral neuropathy related to any drug in Vigibase, 547 were on
statins. The disproportional reporting of statins and upper motor
neurone lesion persisted after age stratification, and such
disproportionality was not seen for statins and Parkinson's disease,
Alzheimer's disease, extrapyramidal disorders, or multiple sclerosis-
like syndromes. DISCUSSION: Because the cases were sometimes atypical
we propose the use of the term 'ALS-like syndrome' and speculate
whether this is part of a spectrum of rare neuromuscular damage. The
diagnosis of ALS is often problematic, and the insidiousness and
chronicity of the disease make causality with a drug difficult to
assess.

The disproportionally high reporting makes this an important signal
nevertheless, since ALS is serious clinically and statins are so
widely used. Wide use of the statins also makes a chance finding more
probable, but is unlikely to cause disproportional reporting when
there are no obvious biases identified.

CONCLUSION: We emphasise the rarity of this possible association, and
also the need for further study to establish whether a causal
relationship exists. We do advocate that trial discontinuation of a
statin should be considered in patients with serious neuromuscular
disease such as the ALS-like syndrome, given the poor prognosis and a
possibility that progression of the disease may be halted or even
reversed.

PMID: 17536877 [PubMed - in process

Everyone who is experiencing muscle weakness or muscle pain should discuss this immediately with their doctor.
It may be the beginning of "rhabdomyolysis" a serious life-threatening side effect of Zocor.
Toxic-mediated rhabdomyolysis may result from prescription and nonprescription medications, including Zocor.
Rhabdomyolysis is the breakdown of muscle fibers with leakage of potentially toxic cellular contents into the systemic circulation.
A Guest Nurse

Perhaps you could print the following and take with you to your next appointment:

Underappreciated Statin-Induced Myopathic Weakness Causes Disability
Bruce H. Dobkin
University of California Los Angeles, Reed Neurologic Research Center,
bdob...@mednet.ucla.edu

Introduction. Myopathic syndromes induced by 3-hydroxy-3-methylglutaryl

coenzyme A (HMG-CoA) reductase inhibitors (statins) include muscle
complaints, myalgia, myositis, and rhabdomyolysis. No prospective study

of statins, however, included tests of strength, so the incidence of
weakness, with or without muscle symptoms and elevated enzymes, is
unknown, and perhaps overlooked. Methods. From a convenience sample of
patients referred to an outpatient neurorehabilitation clinic over the
course of 1 year, 8 patients with hemiparetic stroke and 10 patients
with other presumed neurologic diseases presented with new difficulty
walking by 3 to 12 months after starting one of 3 statins. They
reported no myalgias, exercise-induced aches, or weakness. Examination
revealed proximal paresis graded 4/5 on the unaffected side in the
hemiparetic patients and symmetrical bilateral proximal limb and neck
flexor weakness graded 4/5 in the others. They stood up with difficulty

and walked with bilateral hip drop and imbalance on turns. Results.
Laboratory tests did not reveal myositis or other causes for paresis.
No improvement in strength or mobility was found 6 weeks after
initiating resistance exercises. The statin agent was stopped. By 3
months off statin, all recovered 5/5 proximal strength. Walking
improved, and they arose from a chair without pushing off with their
arms. Discussion. Serial manual muscle testing after initiating a
statin may detect a reversible cause of disability. A genetic
predisposition to statin-induced myopathic proximal weakness with
normal creatine kinase is consistent with a continuum of previously
reported symptoms and signs but may be underappreciated.

(in the discussion, the author notes that while single-subject,
double-blinded statins vs placebo studies would make the causal
relationship between disabling myopathy more apparent, he notes
recurrences in his patients' symptoms when the investigator was unaware that several of the subjects had been placed back on the statin by their primary physicians. p. 261)

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Pfizer Inc. (maker of Lipitor)Lipitor Cholesterol Medication Users vs. Pfizer Inc. (maker of Lipitor)

Lipitor Cholesterol Medication Users vs. Pfizer Inc. (maker of Lipitor) Lawsuit
Cholesterol-Fighting Drug Tied to Liver, Kidney Injury

The Kahn Gauthier Law Group is investigating possible lawsuits against Pfizer Inc., the manufacturer of the cholesterol-lowering drug Lipitor (atorvastatin), to recover for liver or kidney damage suffered by patients prescribed Lipitor. Like other drugs in its class (the statins), Lipitor can cause elevated liver enzymes. In clinical trials, this occurred in 0.7 percent of the patients, but the rate was much higher for those taking the 80 mg dose.

Another serious side effect of Lipitor and other statins is a condition called rhabdomyolysis, in which muscle cells break down and release potentially toxic cell contents into the bloodstream.

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Pfizer Inc. (maker of Lipitor)Lipitor Cholesterol Medication Users vs. Pfizer Inc. (maker of Lipitor)

Lipitor Cholesterol Medication Users vs. Pfizer Inc. (maker of Lipitor) Lawsuit
Cholesterol-Fighting Drug Tied to Liver, Kidney Injury

The Kahn Gauthier Law Group is investigating possible lawsuits against Pfizer Inc., the manufacturer of the cholesterol-lowering drug Lipitor (atorvastatin), to recover for liver or kidney damage suffered by patients prescribed Lipitor. Like other drugs in its class (the statins), Lipitor can cause elevated liver enzymes. In clinical trials, this occurred in 0.7 percent of the patients, but the rate was much higher for those taking the 80 mg dose.

Another serious side effect of Lipitor and other statins is a condition called rhabdomyolysis, in which muscle cells break down and release potentially toxic cell contents into the bloodstream.

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File a claim today to get more information,
you may be due money!

CONTACT US


MAKE A CLAIM
Have you or a family member taken Lipitor?

We are standing by to review your case to see if you can make a claim!

CLICK HERE

CASE INFORMATION
At Issue: $$$ PENDING
Category: Drugs / Medical
Added to Site: 8/30/2001
Stage: Filing
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ACCUTANE ACNE LAWSUIT

AOL DOUBLE BILLING LAWSUIT

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Current Cases · Damages from Cases · Current Lawsuits · Side Effects

rhabdomyolysis - deterioration of muscles in my arm and hand.

pain upon injection, itching, watery eyes, rash, muscle weakness, headache, diarrhea,heavy nosebleeds, confusion, anxiety, panic attacks, muscle cramps, tired, swelling in face that was also a purple color, gagging, very tired, stomach cramps, loss of appetite, trouble breathing, sweating, chills, lack of concentration, memory loss, irritable, sore mouth, upper arms felt like mush, large mass from site of injection to knee and around most of leg that was very very painful to the touch, injection site swollen, red, warm, bruised, tender, loss of balance (but not dizzy), throwing up something that looks like bile, hard time swallowing, tingling in stomach, really cold feet, skin flaking off, knee pain, dark colored urine, shortness of breath, need help to get up out of chairs, bed, etc. having trouble grasping and holding onto objects, feeling of unreality

Diagnosed with Rhabdomyolysis and then Dermatomyositis and Gottrons Sign. The first is acute kidney failure and the last 2 a rare muscle disease.

I would love to talk to anyone else who has had any of the above side effects as the result of Kefzol or Ancef (cefazolin sodium) as well as anyone who has been diagnosed with these conditions.

A good friend of mine (82) was recently rushed to the hospital because he woke up and could not get out of bed. After a week,he is now in rehab using a walker and going through leg exercises to build back his leg strength. The doctors are suspecting the Lipitor he has been taking (10 mg 2 times a week for about 3 years.) to be the cause of the muscle "atrophy". After reading these stories on this web site I am shocked to hear about all the problems Lipitor has seemingly caused people. I tried Lipitor for about 6 months, and had leg cramps in the tops of my legs (where they meet the body) and the Dr. promptly took me off of it and now I'm on Zocor, with no apparent side effects-but I'm reading up more on that.

Now in reading about Rhabdomyolysis (a severe side effect with muscle breakdown and kidney failure), I'm asking the doctors to check for that as my friend has had some symptoms-weight gain, weakness and now not being able to walk. You know, these men don't complain about aches and pains and many may be walking around with a time bomb going off inside them with these symptoms.

If anyone has experienced something similar, I'd love to hear from you, especially how long the recovery of muscle use can be.
Thank you.

This is a correction to side effect #6389

The side effect is RHABDOMYOLYSIS not fibromyolysis

I have been on Lipitor for a few years with great results-dose 20 mg/day. I have also been regularly involved with cycling and treadmill exercise for 30 years. I am 64. Last year having climbed Mt St Helens and then Mt Hood I tried Mt Shasta. That is 14,000 feet and it is a hard climb in parts. I experienced for the first time in my life tight upper leg cramps in both legs requiring me to stop at about 12,000ft. They cleared with rest and I descended OK. Since then I have asked a lot of questions but tried Mt St Helens again on a much lower dose of Lipitor-about 10 mg every other day and have been taking Coenzyme Q-10 ioo mg per day. I have not had anything that resembles leg cramps since that change. I now will go back on 20 mg of Lipitor per day and continue my workouts to see if cramping returns. By the way, the company that sells this drug had NO INFO about this kind of problem. It is well known that all statins can induce enzyme changes, muscle inflammation, and even in very few cases severe muscle damage with rhabdomyolysis that can cause very severe problems. Are there other exercise buffs, or mountaineers that have encountered cramping on statins?
rbw64

Thanks to this website, I've learned that my mother is not alone. She has been on Lipitor for 5+ years. She is suffering from rhabdomyolysis and myotosis. Her sympthoms are severe muscle pain, every daily task is 10 tens as difficult. She can not raise her arms over her head to brush her hair. She has difficulty walking, or picking up a kitchen pan. Her doctors have prescribed Prednisone and Azathiprine because she has horrible bruise like blotches all over her body. The doctors seem to think she has arthritis, so they've prescribed- Methotrexate. Sadly, her muscles are severely damaged to the point that she has IV infusions at least twice a month to help get rid of muscle tissue in her bloodstream. You see, the disease (rhabdomyolyis and myotosis) has caused her muscles to disintegrate... and are bodies are made up of muscle- skeletal muscle, heart, lungs, kidneys, esphogus, etc.
She has also experienced hair loss, loss of taste, and like mentioned earlier severe muscle pain, and immobility. I agree with all of you, the pharmaceutical companies need to be held accountable. Thank you for your support.
******

I was put on 80mg of Zocor with Lopid in 1999. That great decision by the cardiologist resulted in rhabdomyolysis in 2001 and three episodes of anaphylaxis shock! In addition, I had a cardiolite stress test in 1999 prior to going on the high doses of Zocor that reflected a left ventricular ejection fraction of 70. One month after my episode of rhabdo, a cardiolite stress test revealed my heart had enlarged and weakened and I had a left ventricular ejection fraction of 37! That is what that wonderful drug and doctors that believe the propaganda released by the drug companies can do for you.

The following are the known, listed and published adverse drug events associated with fluoroquinolone therapy. Levaquin is a chemotherapuetic antibiotic belonging to this clas:

Adverse effects related to fluoroquinolones
Asthenia

Edema

Fever

Malaise

Rigors

Substernal Chest Pain

Syncope

Cardiovascular Disorders

Cardiac Failure

Circulatory Failure

Hypertension

Central and Peripheral Nervous System Disorders

Abnormal Coordination

Coma

Convulsions

Seizures

Hyperkinesia

Hypertonia

Hypoaesthesia

Involuntary Muscle Contractions

Paresthesia

Paralysis

Speech Disorders

Stupor

Tremor

Vertigo

Gastrointestinal System Disorders

Dry Mouth

Dysphagia

Gastroenteritis

G.I.Hemorrhage

Pancreatitis

Pseudomembranous Colitis

Tongue Edema

Hearing and Vestibular Disorders

Ear Disorders

Tinnitus

Heart Rate and Rhythm Disorders

Arrhythmia

Atrial Fibrillation

Bradycardia

Cardiac Arrest

Heart Block

Palpitation

Supraventricular Tachycardia

Tachycardia

Ventricular Fibrillation

Hematology

Decreased Lymphocytes

Liver and Biliary System Disorders

Abnormal Hepatic Function

Cholelithiasis

Hepatic Coma

Jaundice

Metabolic and Nutritional Disorders

Aggravated Diabetes

Mellitus

Decreased Glucose

Decreased Magnesium

Increased Calcium

Dehydration

Hyperglycemia

Hyperkalemia

Hypoglycemia

Hypokalemia

Increased LDH

Weight Loss

Musculo-Skeletal System Disorders

Arthralgia

Arthritis

Arthrosis

Muscle Weakness

Myalgia

Osteromyelitis

Rhabdomyolysis

Synovitis

Tendinitis

Myo, Endo, Pericardial and Valve Disorders

Angina

Pectoris

Coronary Thrombosis

Myocardial Infarction

Neoplasms

Carcinoma

Parosmia

Platelet, Bleeding and Clotting Disorders

Abnormal Platelets

Embolism

Epistaxis

Purpura

Thrombocytopenia

Psychiatric Disorders

Abnormal Dreaming

Aggressive Reaction

Agitation

Anorexia

Anxiety

Confusion

Delirium

Depression

Emotional Liability

Hallucination

Impaired Concentration

Impotence

Manic Reaction

Mental Deficiency

Nervousness

Paranoia

Sleep Disorders

Somnolence

Withdrawal Syndrome

Suicide

Red Blood Cell Disorders

Anemia

Reproductive Disorders

Ejaculation Failure

Resistance Mechanism Disorders

Fungal Infections

Genital Moniliasis

Respiratory System Disorders

ARDS

Asthma

Coughing

Dyspnea

Haemoptysis

Hypoxia

Pleural Effusion

Respiratory Insufficiency

Respiratory Failure

Skin and Appendages Disorders

Erythema Nodosum

Genital Pruritus

Increased Sweating

Skin Disorders

Skin Exfoliation

Skin Ulceration

Urticaria

Urinary System Disorders

Abnormal Renal Function

Acute Renal Failure

Face Edema

Crystalluria

Cylindruria

Hematuria

Vascular (Extracardiac) Disorders

Cerebrovascular Disorder

Phlebitis

Vision Disorders

Abnormal Vision

Conjunctivitis

Diplopia

Retina Damage

Cornea Damage

Ophthalmologic Abnormalities

Cataracts

Multiple Punctate Lenticular Opacities

White Cell and RES Disorders

Granulocytopenia

Leukocytosis

Leukopenia

Lymphadenopathy

WBC Abnormal Count

Allergic Pneumonitis

Anaphylactic Shock

Anaphylactoid Reaction

Dysphonia

Abnormal EEG

Encephalopathy

Eosinophilia

Erythema Multiforme

Hemolytic Anemia

Multi System Organ Failure (Death)

Increased International Normalized Ratio (INR) Prothrombin Time

Stevens-Johnson Syndrome

Tendon Rupture

Torsades de Pointes

Vasodilation

This is but a small sampling of various adverse reactions associated with such therapy.

This list goes on and on and on and on and on. The physician has no clue as to what these drugs can and will do to a patient. There is no known treatment for a majority of the severe reactions. Such reactions DO NOT abate once therapy is discontinued in a subset of those so treated and the current research indicates that such events are to be considered permanent in nature.

David T Fuller
Director
Fluoroquinolone Toxicity Research Foundation
davidtfull@aol.com
www.fqresearch.org

The following are the known, listed and published adverse drug events associated with fluoroquinolone therapy. Cipro is a chemotherapuetic antibiotic belonging to this class:

Adverse effects related to fluoroquinolones
Asthenia

Edema

Fever

Malaise

Rigors

Substernal Chest Pain

Syncope

Cardiovascular Disorders

Cardiac Failure

Circulatory Failure

Hypertension

Central and Peripheral Nervous System Disorders

Abnormal Coordination

Coma

Convulsions

Seizures

Hyperkinesia

Hypertonia

Hypoaesthesia

Involuntary Muscle Contractions

Paresthesia

Paralysis

Speech Disorders

Stupor

Tremor

Vertigo

Gastrointestinal System Disorders

Dry Mouth

Dysphagia

Gastroenteritis

G.I.Hemorrhage

Pancreatitis

Pseudomembranous Colitis

Tongue Edema

Hearing and Vestibular Disorders

Ear Disorders

Tinnitus

Heart Rate and Rhythm Disorders

Arrhythmia

Atrial Fibrillation

Bradycardia

Cardiac Arrest

Heart Block

Palpitation

Supraventricular Tachycardia

Tachycardia

Ventricular Fibrillation

Hematology

Decreased Lymphocytes

Liver and Biliary System Disorders

Abnormal Hepatic Function

Cholelithiasis

Hepatic Coma

Jaundice

Metabolic and Nutritional Disorders

Aggravated Diabetes

Mellitus

Decreased Glucose

Decreased Magnesium

Increased Calcium

Dehydration

Hyperglycemia

Hyperkalemia

Hypoglycemia

Hypokalemia

Increased LDH

Weight Loss

Musculo-Skeletal System Disorders

Arthralgia

Arthritis

Arthrosis

Muscle Weakness

Myalgia

Osteromyelitis

Rhabdomyolysis

Synovitis

Tendinitis

Myo, Endo, Pericardial and Valve Disorders

Angina

Pectoris

Coronary Thrombosis

Myocardial Infarction

Neoplasms

Carcinoma

Parosmia

Platelet, Bleeding and Clotting Disorders

Abnormal Platelets

Embolism

Epistaxis

Purpura

Thrombocytopenia

Psychiatric Disorders

Abnormal Dreaming

Aggressive Reaction

Agitation

Anorexia

Anxiety

Confusion

Delirium

Depression

Emotional Liability

Hallucination

Impaired Concentration

Impotence

Manic Reaction

Mental Deficiency

Nervousness

Paranoia

Sleep Disorders

Somnolence

Withdrawal Syndrome

Suicide

Red Blood Cell Disorders

Anemia

Reproductive Disorders

Ejaculation Failure

Resistance Mechanism Disorders

Fungal Infections

Genital Moniliasis

Respiratory System Disorders

ARDS

Asthma

Coughing

Dyspnea

Haemoptysis

Hypoxia

Pleural Effusion

Respiratory Insufficiency

Respiratory Failure

Skin and Appendages Disorders

Erythema Nodosum

Genital Pruritus

Increased Sweating

Skin Disorders

Skin Exfoliation

Skin Ulceration

Urticaria

Urinary System Disorders

Abnormal Renal Function

Acute Renal Failure

Face Edema

Crystalluria

Cylindruria

Hematuria

Vascular (Extracardiac) Disorders

Cerebrovascular Disorder

Phlebitis

Vision Disorders

Abnormal Vision

Conjunctivitis

Diplopia

Retina Damage

Cornea Damage

Ophthalmologic Abnormalities

Cataracts

Multiple Punctate Lenticular Opacities

White Cell and RES Disorders

Granulocytopenia

Leukocytosis

Leukopenia

Lymphadenopathy

WBC Abnormal Count

Allergic Pneumonitis

Anaphylactic Shock

Anaphylactoid Reaction

Dysphonia

Abnormal EEG

Encephalopathy

Eosinophilia

Erythema Multiforme

Hemolytic Anemia

Multi System Organ Failure (Death)

Increased International Normalized Ratio (INR) Prothrombin Time

Stevens-Johnson Syndrome

Tendon Rupture

Torsades de Pointes

Vasodilation

This is but a small sampling of various adverse reactions associated with such therapy.

This list goes on and on and on and on and on. The physician has no clue as to what these drugs can and will do to a patient. There is no known treatment for a majority of the severe reactions. Such reactions DO NOT abate once therapy is discontinued in a subset of those so treated and the current research indicates that such events are to be considered permanent in nature.

David T Fuller
Director
Fluoroquinolone Toxicity Research Foundation
davidtfull@aol.com
www.fqresearch.org

The following are the known, listed and published adverse drug events associated with fluoroquinolone therapy. Floxin is a chemotherapuetic antibiotic belonging to this class:

Adverse effects related to fluoroquinolones
Asthenia

Edema

Fever

Malaise

Rigors

Substernal Chest Pain

Syncope

Cardiovascular Disorders

Cardiac Failure

Circulatory Failure

Hypertension

Central and Peripheral Nervous System Disorders

Abnormal Coordination

Coma

Convulsions

Seizures

Hyperkinesia

Hypertonia

Hypoaesthesia

Involuntary Muscle Contractions

Paresthesia

Paralysis

Speech Disorders

Stupor

Tremor

Vertigo

Gastrointestinal System Disorders

Dry Mouth

Dysphagia

Gastroenteritis

G.I.Hemorrhage

Pancreatitis

Pseudomembranous Colitis

Tongue Edema

Hearing and Vestibular Disorders

Ear Disorders

Tinnitus

Heart Rate and Rhythm Disorders

Arrhythmia

Atrial Fibrillation

Bradycardia

Cardiac Arrest

Heart Block

Palpitation

Supraventricular Tachycardia

Tachycardia

Ventricular Fibrillation

Hematology

Decreased Lymphocytes

Liver and Biliary System Disorders

Abnormal Hepatic Function

Cholelithiasis

Hepatic Coma

Jaundice

Metabolic and Nutritional Disorders

Aggravated Diabetes

Mellitus

Decreased Glucose

Decreased Magnesium

Increased Calcium

Dehydration

Hyperglycemia

Hyperkalemia

Hypoglycemia

Hypokalemia

Increased LDH

Weight Loss

Musculo-Skeletal System Disorders

Arthralgia

Arthritis

Arthrosis

Muscle Weakness

Myalgia

Osteromyelitis

Rhabdomyolysis

Synovitis

Tendinitis

Myo, Endo, Pericardial and Valve Disorders

Angina

Pectoris

Coronary Thrombosis

Myocardial Infarction

Neoplasms

Carcinoma

Parosmia

Platelet, Bleeding and Clotting Disorders

Abnormal Platelets

Embolism

Epistaxis

Purpura

Thrombocytopenia

Psychiatric Disorders

Abnormal Dreaming

Aggressive Reaction

Agitation

Anorexia

Anxiety

Confusion

Delirium

Depression

Emotional Liability

Hallucination

Impaired Concentration

Impotence

Manic Reaction

Mental Deficiency

Nervousness

Paranoia

Sleep Disorders

Somnolence

Withdrawal Syndrome

Suicide

Red Blood Cell Disorders

Anemia

Reproductive Disorders

Ejaculation Failure

Resistance Mechanism Disorders

Fungal Infections

Genital Moniliasis

Respiratory System Disorders

ARDS

Asthma

Coughing

Dyspnea

Haemoptysis

Hypoxia

Pleural Effusion

Respiratory Insufficiency

Respiratory Failure

Skin and Appendages Disorders

Erythema Nodosum

Genital Pruritus

Increased Sweating

Skin Disorders

Skin Exfoliation

Skin Ulceration

Urticaria

Urinary System Disorders

Abnormal Renal Function

Acute Renal Failure

Face Edema

Crystalluria

Cylindruria

Hematuria

Vascular (Extracardiac) Disorders

Cerebrovascular Disorder

Phlebitis

Vision Disorders

Abnormal Vision

Conjunctivitis

Diplopia

Retina Damage

Cornea Damage

Ophthalmologic Abnormalities

Cataracts

Multiple Punctate Lenticular Opacities

White Cell and RES Disorders

Granulocytopenia

Leukocytosis

Leukopenia

Lymphadenopathy

WBC Abnormal Count

Allergic Pneumonitis

Anaphylactic Shock

Anaphylactoid Reaction

Dysphonia

Abnormal EEG

Encephalopathy

Eosinophilia

Erythema Multiforme

Hemolytic Anemia

Multi System Organ Failure (Death)

Increased International Normalized Ratio (INR) Prothrombin Time

Stevens-Johnson Syndrome

Tendon Rupture

Torsades de Pointes

Vasodilation

This is but a small sampling of various adverse reactions associated with such therapy.

This list goes on and on and on and on and on. The physician has no clue as to what these drugs can and will do to a patient. There is no known treatment for a majority of the severe reactions. Such reactions DO NOT abate once therapy is discontinued in a subset of those so treated and the current research indicates that such events are to be considered permanent in nature.

David T Fuller
Director
Fluoroquinolone Toxicity Research Foundation
davidtfull@aol.com
www.fqresearch.org

The following are the known, listed and published adverse drug events associated with fluoroquinolone therapy. Avelox is a chemotherapuetic antibiotic belonging to this class:

Adverse effects related to fluoroquinolones
Asthenia

Edema

Fever

Malaise

Rigors

Substernal Chest Pain

Syncope

Cardiovascular Disorders

Cardiac Failure

Circulatory Failure

Hypertension

Central and Peripheral Nervous System Disorders

Abnormal Coordination

Coma

Convulsions

Seizures

Hyperkinesia

Hypertonia

Hypoaesthesia

Involuntary Muscle Contractions

Paresthesia

Paralysis

Speech Disorders

Stupor

Tremor

Vertigo

Gastrointestinal System Disorders

Dry Mouth

Dysphagia

Gastroenteritis

G.I.Hemorrhage

Pancreatitis

Pseudomembranous Colitis

Tongue Edema

Hearing and Vestibular Disorders

Ear Disorders

Tinnitus

Heart Rate and Rhythm Disorders

Arrhythmia

Atrial Fibrillation

Bradycardia

Cardiac Arrest

Heart Block

Palpitation

Supraventricular Tachycardia

Tachycardia

Ventricular Fibrillation

Hematology

Decreased Lymphocytes

Liver and Biliary System Disorders

Abnormal Hepatic Function

Cholelithiasis

Hepatic Coma

Jaundice

Metabolic and Nutritional Disorders

Aggravated Diabetes

Mellitus

Decreased Glucose

Decreased Magnesium

Increased Calcium

Dehydration

Hyperglycemia

Hyperkalemia

Hypoglycemia

Hypokalemia

Increased LDH

Weight Loss

Musculo-Skeletal System Disorders

Arthralgia

Arthritis

Arthrosis

Muscle Weakness

Myalgia

Osteromyelitis

Rhabdomyolysis

Synovitis

Tendinitis

Myo, Endo, Pericardial and Valve Disorders

Angina

Pectoris

Coronary Thrombosis

Myocardial Infarction

Neoplasms

Carcinoma

Parosmia

Platelet, Bleeding and Clotting Disorders

Abnormal Platelets

Embolism

Epistaxis

Purpura

Thrombocytopenia

Psychiatric Disorders

Abnormal Dreaming

Aggressive Reaction

Agitation

Anorexia

Anxiety

Confusion

Delirium

Depression

Emotional Liability

Hallucination

Impaired Concentration

Impotence

Manic Reaction

Mental Deficiency

Nervousness

Paranoia

Sleep Disorders

Somnolence

Withdrawal Syndrome

Suicide

Red Blood Cell Disorders

Anemia

Reproductive Disorders

Ejaculation Failure

Resistance Mechanism Disorders

Fungal Infections

Genital Moniliasis

Respiratory System Disorders

ARDS

Asthma

Coughing

Dyspnea

Haemoptysis

Hypoxia

Pleural Effusion

Respiratory Insufficiency

Respiratory Failure

Skin and Appendages Disorders

Erythema Nodosum

Genital Pruritus

Increased Sweating

Skin Disorders

Skin Exfoliation

Skin Ulceration

Urticaria

Urinary System Disorders

Abnormal Renal Function

Acute Renal Failure

Face Edema

Crystalluria

Cylindruria

Hematuria

Vascular (Extracardiac) Disorders

Cerebrovascular Disorder

Phlebitis

Vision Disorders

Abnormal Vision

Conjunctivitis

Diplopia

Retina Damage

Cornea Damage

Ophthalmologic Abnormalities

Cataracts

Multiple Punctate Lenticular Opacities

White Cell and RES Disorders

Granulocytopenia

Leukocytosis

Leukopenia

Lymphadenopathy

WBC Abnormal Count

Allergic Pneumonitis

Anaphylactic Shock

Anaphylactoid Reaction

Dysphonia

Abnormal EEG

Encephalopathy

Eosinophilia

Erythema Multiforme

Hemolytic Anemia

Multi System Organ Failure (Death)

Increased International Normalized Ratio (INR) Prothrombin Time

Stevens-Johnson Syndrome

Tendon Rupture

Torsades de Pointes

Vasodilation

This is but a small sampling of various adverse reactions associated with such therapy.

This list goes on and on and on and on and on. The physician has no clue as to what these drugs can and will do to a patient. There is no known treatment for a majority of the severe reactions. Such reactions DO NOT abate once therapy is discontinued in a subset of those so treated and the current research indicates that such events are to be considered permanent in nature.

David T Fuller
Director
Fluoroquinolone Toxicity Research Foundation
davidtfull@aol.com
www.fqresearch.org