Seasonal allergies symptoms and conditions

My son was getting in trouble with his new Kindergarten teacher almost every day. He went from being a bright, well behaved little boy to being labeled a troublemaker with learning issues almost overnight. At school he was crying all the time, poked another kid with a pencil, threw something at another child and wouldn't listen to his teacher. He had been in a very structured Pre-K program and we had never had any issues like this with his behavior. During a lengthy conversation with his teacher, she mentioned that he didn't behave this way every day. He actually had some days when he was "very good". I was at the end of my rope. When we asked him why he was doing these things he told us, "My brain told me to and I couldn't stop." Scary thing to hear from your 5 year old. After talking to my mom about the problems, she suggested that I look up the side effects of Zyrtec and I found this site. Many things matched up with what the teacher was telling us. The fact that he had some good days at school makes sense because he was only taking it on the days he needed it for seasonal allergies. Because he took it right before bed and the side effects would wear off by the time we picked him up from school we weren't seeing the full effect of what this medication was doing to him. We haven't given him Zyrtec for over a week and he hasn't gotten in trouble a single time at school! He's been much easier to put to bed at night and much more pleasant to be around in the evenings. We will never give him Zyrtec again and will be MUCH more aware of possible side effects from medicine.

My 5 year old daughter's pediatrician prescribed her advair to help with inflammation due to her seasonal allergies. (She had never taken an asthma medication or been diagnosed with asthma) I was very hesitant to give it to her, but she was really miserable. I gave it to her. 30 min later she was acting like she was bi-polar, manic and jumping up and down one min and crying for no reason the next. This went on for about 30 min before she crashed. She was very suddenly lethargic, couldn't hold her head up. Her face was pale, it started getting puffy and splotchy and her skin around her eyes got very red and she complained that her eye hurt so bad, she actually held an ice-pack to it. (A 5 year old) She also was acting very rough, aggressive, banging her toys into things and grabbing things from her friend, which is very unlike her. It was like she was full of intense energy and had to get it out. It was very scary.

I find it very interesting about the possible link between Singulair and visual disturbances. My daughter had been told (about one year after being on Singulair) that she had damage to a nerve in one eye. She had never received any type of head trauma and the Doctor could not figure out how this happened. He told us that eventually her headaches would get so bad that she would have to have her eye removed while they tried to repair the nerve, and then they would replace her eye. I would be interested to hear if there are any other stories similar to this.

I just started Singulair about a month ago. Before I started taking the tablets I remember hearing some negative information on the news about the medicine. I found this web site and read about all the side effects before taking my first tablet. Even though there was so much negative information I thought I would give the medicine a try anyway. I have always been in good health and only needed this medicine for seasonal allergies. Part of me said "I know the side effects wont affect me!" Well I was WRONG! I have had the worst nightmares!!!

The nightmares started the first night I started taking Singulair. I continued taking the medicine hoping the nightmares would pass. Well, they have only got worse. However, last night was horrible. Not only did I have my nightly nightmares I had a hallucination! It started when I heard my 2 year old son wake up. He first opened his bedroom door then drank some water that was on his night stand, then was on his way over to my room. I got up to put him back in bed just to find out his bedroom door was closed and he was sound asleep in his bed. I haven't had any other side effects, but I think this is a good enough reason to stop taking the medicine. Does anyone have any other suggestions for another allergy medicine I can take. I've already tried Nasonex and Flonase they don't work nearly as good as Singulair. Any suggestions would be great thanks!

This stuff is pure poison and should be pulled from the market. I am very healthy except for seasonal allergies. I started using this drug in early June this year and within a few days I was experiencing dizziness (which I attributed to the allergies), panic attacks, cardiac arrhythmia and shortness of breath. Twice I ended up in Emerg only to be told that all my vital signs were excellent.

Since I've stopped taking Zyrtec those side effects have diminished greatly, although they haven't gone away completely. It could take weeks for the body to rid itself of a poison.

This drug needs to be re-examined with better controls on the testing, and serious consideration should be given to removing it from the market. The FDA has been to hasty in approving dangerous drugs over the last few years and Zyrtec is just another example of this haste. Remove it before someone dies!

I have had the worst arm and shoulder pain after I took Zyrtec for only a few days to clear up some seasonal allergies. My upper arms hurt so bad, especially when I slept on them, which also led to some shoulder pain. My arms hurt for about 2 weeks after I stopped taking the Zyrtec. The pain started while I was taking Zyrtec. After not taking Zyrtec, the pain is finally subsiding. I will not be taking Zyrtec again; the arm pain was awful!

In response to Wewe's post, I've been wondering the same thing. Since taking my daughter off Singular almost 2 months ago, I'm seeing a different almost typical kid. Four years ago about 2 months after starting Singular my daughter was diagnosed with anxiety. As her condition got worse she was diagnosed with depression. We started to see OCD and tics so they were added as a diagnosis It was determined that it was related to strep infections so she was diagnosed with PANDAS. She was started on Zoloft and klonidine. The Zoloft made her worse. Her fears of hurting herself got so intrusive she was hospitalized. Her cholesterol was high too. The Zoloft was discontinued and Prozac was started. She's had therapy all 4 years. She also neede physical therapy due to muscle and joint pain. Now she's doing better, off Singular. Does she really have PANDAS, OCD? I don't know. She's still on Prozac, we just did a slight decrease this week. Is this medication the trigger for underlying conditions. Learned behaviors can be unlearned, but are there lasting physical effects? If a gene has been turned on, can it be turned off? I wish we knew the answers to help all of our kids.

My 10 year old son has taken Singulair on and off since he was 5 years old and has been on it for the past 3.5 years. My son at an early age was affected by a bad marriage and then the divorce when he was 5 yrs old. So we always suspected that his behavior issues were caused by this and I had done everything I possibly could to give them the help he needed to get over and through his issues. He was held back his first year of Kindergarden and during his second year midstream he was placed in a special class for behavioral problem children. Nothing ever seemed to help him, everytime we would see some progress and encouragement we were always blind sighted by a behavior that was always worse. Two steps forward and them 5 steps backwards. I always knew that his problems would never get better overnight so I just kept on going. He was diagnosed with ADHD but because he has some ticking issues I had to put him on Strattera which was did not do a thing for him. I always described him as my Dr. Jeckyll/ Mr. Hyde child. He could be really good and sit still and behave but I think he had to try really hard to do so. He eventually was always overpower by the impulse to show negative behaviors. Defiant, extremely impulsive, always negative and completely miserable all the time. He also went through phases of compulsions. There was always a compulsion of the month- germs, bathroom habits, noises, repetitive words. He hated school and always complained of a stomach ache which i thought he was always faking to get out of school. He had confrontations in school everyday for most of the day. I often thought some of this was because of being tired all the time. We had battled over bedtime every single night. He was terrified to go to bed alone, I tried everything to get him to sleep alone. I wore myself out falling asleep next to him, I would then go to my own bed only to be up with him half the night going back and forth. I gave in many a night and slept with him just so we could get a good nights sleep. At age 8.5 I finally got him to go to sleep alone but the lights haf to be on and he has to know that I am still awake before he will fall asleep. He would always say he didn't want to go to sleep because when he does he has bad thoughts about me and people that he loves. He always had an extremely hard time excepting the word "no"- he would flip out and hit his head with whatever was handy, throw things, break things, scream holler etc. It would take hours to get over it. When he did he would be very remorseful and lovable. He was always in turmoil. Finally in February of this year, this graduated to a new level where he would want to just kill himself and would actually go and pull a knife out of the drawer and just shake with anger as he held the knife to his throat. I was terrified although i really didn't think he was going to harm himself he just wanted to scare me. Then at the end of March when i first heard the news about the possible side effects of Singulair, I had only heard about the suicide effect. Oh great just what I needed was this medicine causing him to do that. The doctor was thinking about taking him off if this summer because he wanted to see if he out grew his seasonal allergies so I took him off immediately. Well I had no idea about the other side effects until my son turned into a completely different kid. School noticed a huge difference in him! His grades went up, his is able to control his behavior, he is happy he is NORMAL. I never suspected this drug as the culprit due to the timing of taking it. Our lives have changed completely. When i first found this site, it seemed as though some of the parents were writing about my child. It is amazing. My son still has some old habits to break but overall he is a wonderful and normal 10 year old boy. He did not outgrow his seasonal allergies but Allegra seems to help in through it. I get so angry- his whole early childhood was ruined by this medicine. He is a labled kid in our school system. This whole experience has opened up my eyes. Thank you for letting me share my story.

I started using Zyrtec about 8 weeks ago for seasonal allergies, runny nose, congestion etc. It did help but I recently have noticed that I have had lower back pain, feeling extremely tired and irritable. I did not consider these symptoms as being related until recently when I began wondering why I was having lower back pain. Since Zyrtec is the only med. that I have been taking, I decided to do a search on side effects and have read many testimonies like mine. I am a 38 year old female. To me the side effects out way the benefits of this drug. I am not going to take it any longer and see if these symptoms go away.

I just started using Singulair a few days ago. I am 54 years old and just started coughing at night only. I would be fine during the day and then never failed, at night I started to cough keeping me awake. I was given antibiotics, narcotic cough syrups but it only helped temporarily and then I went back to coughing nights only again. So as I mentioned, I started taking Singulair a few days ago because my physician thinks I have developed allergies and Singulair is noted to help night coughs. It is helping my night coughs but I still cough a few times at night and now I cough quite a few times in the day when I never use to cough in the daytime. Wondering if Singulair is worth taking as the symptoms are becoming opposite? I hate taking drugs and don't know if I should find a safer alternative? Help, anyone? Thank you

I am finally writing after reading these posts since the end of April. That is when I took my 11 year old son off singulair, in an act of desperation. He has been on singulair on and off for about five years for seasonal allergies. He started again in mid-March so it could get into his system, before the allergies started. Immediately thereafter his behavior changed. He was arguing on a daily basis. He would hit, kick or trip me when he was angry. He was starting to destroy things in anger. He seemed to be fueled by anger. It was affecting the whole family. He was starting fights with his younger brother, my husband's heart was palpitating and I was crying every day. I heard about Singulair side effects and looked it up. I saw that it caused behavioral changes and out of desperation, took him off, not knowing what to expect. We had three days of total peace, then on the fourth day another outburst. Then my son told me he had taken a singulair the night before. That was it. I threw every pill in the garbage. He no longers acts like that. It's been almost two months so I am convinced it was the Singulair. By the way, he always complained of headaches, stomach aches and would scream in his sleep. Who knew - it was the singulair all along.

My nine year old daughter has been on Singulair for just over a month because of seasonal allergies. Early this morning she woke up with a terrible nose bleed. She has never had a nose bleed in her life before today! Could this be because of the Singulair?

I got a shot of kenalog for seasonal allergies. I told the doctor if there was a possibility of gaining weight from it that I didn't want it. He said it shouldn't make me gain weight, and acted like it wasn't a concern. So I took the shot, and one month later I had gained 20 Pounds! I hadn't changed my diet, and was only drinking slim-fast, and hardly even eating any food. What a bastard of a Doctor! I could not get the pounds off through exercise either. Clearly the shot had made me retain fluids. I got the shot more than 15 years ago, and I still have a weight problem today. I was drop-dead gorgeous before this nightmare!

This is my story. My daughter 14, the most precious child ever born. She has a wonderful disposition always happy, loving, and determined to succeed in whatever she does. She just brightens everyone’s world.
She suffers from severe seasonal allergies and mild asthma. She takes approximately seven allergy/asthma medicines a day during peak season. Over the past two years she has been taking Singular as one of her medicines. Being 14, sick of taking medicine she would not take the Singular on a regular basis. Approximately four months ago “MOM” says, if you take nothing else take your Singular it will work both for the seasonal allergies and your asthma. She has been taking this regularly four the past four months.
She became paranoid, she became a compulsive eater and bites the skin on her fingers. She would eat and chew on her fingers at the same time, until she choked. She had so much anger, she could not even go to the mall without temper tantrums.(As a child she never had any tantrums ) Always afraid. Severe depression set in. She would cry at a moments notice. She would say, I have a very sad life, sad very sad, nothing makes me like this, I’m just sad. She felt she should go live with the homeless people. I asked her why, she didn’t know, she felt maybe that’s where she belonged. Nightmares and sleepless nights.
She needs help quickly. Before calling the Doctor, I went on the internet and entered Singular and depression and I found 1900 entries, all people telling me what I was experiencing. Could this possibly be the answer for us? I called her Dr and told him what I thought, he said he has never had anyone that this has happened to. He hoped it was the answer, but really didn’t think is. He said if it wasn’t the answer she would need therapy, mood stabilizer and Prozac.

Its day four off Singular, she smiling, no tears today, no temper tantrums, looking forward to school next week, wants to play volleyball next year, singing in the car,
I hear that happy voice again.(Hi, Mommy!!!!!!) Every once in a while a glaze comes over her face. She isn’t a 100% back, but I know it is coming.

To all the people that don’t have the happy ending, I will pray for you and hold you in my heart forever.

June 2, 2008

I have had this shot 4 times now for severe seasonal allergies and asthma (1 shot per year). I did have one side effect, heartburn. So I took zantac for the heartburn. Otherwise, I have had immense relief from the allergies/asthma from this shot. I am concerned about what I am reading on this website though, so I will think twice before getting the shot again. The nurse who gave me the shot seems quite experienced and she is the same nurse that has given the shot every year. I did have to sign some forms about the risks of taking the shot.

I am a 37 year old female ~185lbs already under treatment for clinical depression with two medications. I used to take Alavert (loratidine) for seasonal allergies but found it had "stopped working" well for me. Since Zyrtec (certirizine) went over-the-counter, I decided to try it.

I took it sporadically at 10mg daily for a period of 2-3 weeks, and then, during a particularly bad allergic exacerbation, began to take it consistently at 10mg daily. My depression, which was previous well-controlled on medication, worsened to the point of severity. Extreme despair, emotional detachment, and loss of interest in pleasurable activities--well, in ANY activity beyond sleep.

I am a pharmacist, and on a whim, I decided to do some research into interactions with my other medications, and found several anecdotal reports of depression onset and worsening in Zyrtec users. This particular side effect of Zyrtec was unknown to me, nor have I received any educational materials or reports in my trade literature listing depression as a possible adverse effect.

I have discontinued the medication in both myself and my three year old daughter (5mg daily). I can already see a difference in her disposition, and I am starting to crawl out of my pit of gloom. I'm using Alavert again, as I never had one issue with it, and I'm supplementing with Benadryl (diphenhydramine) at night as needed for exacerbations.

Kenalog-40 I was never told what I was being given in my bottom, just that it would help with seasonal allergies. FDA site "Neurologic-Psychiatric: Psychic derangements may appear when corticosteroids are used, ranging from euphoria, insomnia, mood swings, personality changes, and severe depression to frank psychotic manifestations. Also, existing emotional instability or psychotic tendencies may be aggravated by corticosteroids." FDA More "Neuro-Psychiatric: Convulsions, depression, emotional instability, euphoria, headaches, increased intracranial pressure with papilledema(pseudotumor cerebri) usually following discontinuation of treatment, insomnia, mood swings, neuritis, neuropathy, paresthesia, personality changes, psychic disorders, vertigo. Arachnoiditis, meningitis, paraparesis/paraplegia, and sensory disturbances have occurred after intrathecal administration."
I went to an Urgent Care Clinic for allergies. My skin was crawling every time I left the house so I was told the cause was environmental allergies. The Benadryl wasn't helping. The nurse noticed my skin was patchy and swollen. Another nurse returned to the room and said this shot would help with the reactions. I was not told what it was till it was done and she mumbled the word Kenalog. Three hours later I was anxious and talking irratically. Pressured speech, I could not stop talking. I called Nurse Advice line, then told to call a Pharmacy Help Line, who in turn said to go to the ER but to not drive myself in such a condition. I was talking as if I was on speed or manic. The ER said to go home it was just an anxiety attack. I took 2mg Clonzepam to calm down and sleep. In the morning, the symptoms returned. I called the hospital pharmacy and was told to go in immediately to see my doctor, that it is a steroid and causes psychic reactions. My regular doctor didnt have an opening so I saw a different doctor who wasn't familiar with my normal personality. She said she saw nothing wrong no matter that she couldn't get a word in unless I physically put my hand over my mouth. She sent me to a Nurse/psychiatrist next door to her. He said there was nothing wrong also. I had to keep repeating myself, speeding along, stuttering because I was talking so fast, telling him I was going 100 miles an hour in my head and out my mouth. I thankfully had an appointment with my psychologist a few minutes later in a different part of the hospital. I see her weekly. She immediately saw my change in mood and personality and called the clinic nurse/psychiatrist and told him to prescribe clonzepam. I did some reading about kenalog 40 injections. The clinic doctors didnt have the same list of side effects as their own pharmacy. I should never have been given the shot because I already have an emotional/mood problem and have epilepsy. I have to increase my anti-convulsants for at least two weeks and watch my mood very very closely. Some days I "fly" then "crash" now. This is all new, extreme symptoms of an already existing condition. This Urgent Care Clinic nurse was told all these things by me, repeatedly because of all my allergies to drugs, daily convulsions and counselling I already undergo for PTSD. I was never seen by a doctor that day or counselled. I will never take a steroid again based on the information I now have on its effects on psychiatric and seizure conditions. I am already disabled because of daily seizures and now I have even more daily seizures. These mood swings and seizures will be abnormally high for over 3 weeks I was told by the doctors but the more reading I do the longer I find that the steroid will cause side effects. Epileptics or those with a low seizure thresh hold, anyone with psychiatric conditions, emotional problems such as panic attacks or anxiety, PTSD, depression, Please use caution with kenalog. My friends are very helpful and supportive during this time. They can see the emotional impact the steroids are having on me. They will tell me I am speeding and I say "sorry, its the 'roids talking" Now, I will be watching my butt, too. Its been 7 days since the injection.

Hi, I'm a 25 year old male. I've had severe seasonal allergies for as long as I can remember. I'm to the point where the coming of spring usually means that I'm going to be visiting the emergency room inside of a few weeks. I've been involved with Zyrtec since the spring of 2003. During that season I experienced what could only be described as a near complete nervous break down. I had an issue involving administration at the college that I was attending losing some paperwork regarding a semester withdrawal ... as a result I ended up with 7 F's and owing the university around $4,000.

I ended up crashing. My family describes me as the guy "with a big heart" ... but I began getting into screaming matches with my parents that ended with me breaking down and weeping / sobbing almost hysterically while holding the door shut to my bedroom. I became incredibly "anxious" (that's how my families General Practitioner {GP} described it), but I'd describe my behavior like more along the lines of a parody of a guy that just smoked a ton of REALLY cheap pot and therefore began to think that everyone was out to get them and that no one had their best interests at heart. My GP decided that I must be on the verge of a nervous breakdown and put me on paxil in an effort to calm me down. In a way it helped keep me calm and drastically reduced the extreme emotional spells that I was having. I pulled myself off of Paxil (for another slew of side effects that I'll be posting on that tab) during the late summer and fall when I don't have as severe an issue with allergies and as my season approached I found a new doctor and when I brought up how I had eventually decided Zyrtec D was making me feel he told me that I was right on the money. He ran through the almost all of the side effects that are listed on this page and I was floored ... I couldn't believe that no one had told me about them. He put me on Astelin and since then I haven't had any issues. As a matter of fact, I'm totally psychologically sound now and I haven't experience a "heart flutter" since ... where as a few years ago I was on the verge of committing myself while on Zyrtec D.

As a little note: I'm currently taking Astelin along with the OTC Zyrtec on a once a day basis and the only side effects that I've seen show back up are: slight paranoia, a loss of energy and general virility, and a significant weight gain (about 20 pounds in the past 3 months that could be attributed to my near complete loss of energy) ... which is an ENORMOUS improvement coming from the prescription strength Zyrtec D.

I'd also like to mention that I don't have any disorders like bipolar disorder or severe depression ... but when I take Zyrtec I acquire a lot of the symptoms associated with those medical conditions ... the symptoms slowly subside when the season draws to a close and I stop taking the medication.

My son, Wilson, is a bright, easy-going, athletic 12 year old who has a history of asthma and allergies. After several asthmatic episodes from age one year to about four, he was prescribed Singulair. The asthma triggers seemed to be change of season or congestion from a cold, but not from exercise or physical exertion. As I recall, his asthmatic episodes seemed to decrease after he was on 5-10 mg of Singulair, and even more so with each passing year. Over the years, of my three sons, Wilson was the one to catch any virus that came around and missed more school time than both of his brothers combined. Often, he was the only one to get sick from a virus, which never passed to anyone else in the family.
About five years ago, Wilson started complaining of stomach aches. He was tested and was prescribed Prevacid on and off since then with varying success. In the last couple of years, headaches would come and go. He was re-tested for allergies and blood work with no conclusive results. About 2-3 years ago he would complain that he “felt funny…like he needed to do something.” Further conversations revealed that he was expressing anxiety. He’s a good student, has lots of friends at school, and is popular among his sports team mates. Occasionally, a teacher here and there over the last couple of years would note that he did not participate enough in class, or did not appear to be attentive. We thought perhaps he is shy. Still his good behavior, agreeable personality and diligence otherwise earned him good grades overall. He loves school and was very unhappy having to stay home when he was sick.
This past winter, he seemed to catch a virus about once every month and a half which caused him to miss 2-3 days of school. Headaches and stomach aches were common with each illness (sometimes nausea), and sometimes these same symptoms when he was not ill. He would only complain when they were prolonged or significant. Trips to the doctor did not result in anything conclusive. Again, Wilson was only too happy once he returned to school.
He claims that sometimes in school he feels like he’s in a fog and has difficulty concentrating. He gets plenty of sleep and sometimes sleeps up to ten hours during the weekend. We attributed it to adolescence and a busy schedule. He claims that this year is the easiest for him at school, and his social life with his friends is very active. His friends’ parents like him and find him to be an agreeable child. Other adults mistake his sometime mumbling answers and lack of eye contact rude. We concluded that he is just shy. He is the most hyper of his brothers, and has difficulty sitting still and constantly exclaims that he’s bored. We chalked it up to being an active boy. His grades are good in school and we never get complaints about bad behavior.
The last illness started a week ago, and he’s still out of school. The doctor said he had no significant allergy symptoms, other bacterial infections, and his blood work all returned with normal results for white blood counts, liver and kidney functioning and anemia. He can’t return to school because of his constant headaches (which cause pain in different parts of his head), nausea, constant stomach aches, no matter what he eats, and feelings of anxiety, mostly in the evening hours. He’s also complaining of dizziness, leg cramps and other muscle soreness. The notable difference in this illness is the anxiety. My husband and I take turns staying home with him, but if we left him alone for a half an hour at a time while the other was in route picking up a sibling, he became very anxious. In the past, he seemed to enjoy some alone time at home so he could play his computer games. He also becomes easily dizzy with shooting pains in his muscles. The doctor said that viruses can manifest themselves in later stages in the form of sore muscles. However, he was concerned about Wilson’s feelings of anxiety. The anxiety had not been as prevalent in prior illnesses. I finally signed onto the internet reading all the stories about other parent’s observations of their children on Singulair. My husband cautioned me about “internet diagnosing” with symptoms and stories that can be easily taken out of context in hope of self-diagnosis. I’ve always thought that Wilson’s doctors have had good judgment. Both my primary physician and allergist don’t think that Singulair has caused these symptoms, but agreed to take him off as long as we monitored any effect on his asthma.
I don’t know what to think. I want the cause of these problems to be the Singulair, because it’s an easy answer. Today will be the first day he’s off the medication. He probably won’t go to school again tomorrow. We’ll wait and see what happens…

Sorry, I can't just walk away.

When you find patents or patent applications for certain purposes, then you know that your ideas are well founded. There are several patents for using an anti-malaria drug for asthma. I would bet that somebody had that idea all the way back to the 1960's. So it is very possibly no coincidence at all that a chloroquinoline or other quinoline ring would be part of montelukast's chemical structure.

Here is one of the patents.

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It is well known that quinoline rings can be toxic to some people even very rapidly. As in this very extreme example.
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PEDIATRICS Vol. 27 No. 1 January 1961, pp. 95-102 This Article

FATAL ACUTE CHLOROQUINE POISONING IN CHILDREN
Howard M. Cann M.D.1 and Henry L. Verhulst M.S.1

1 National Clearinghouse for Poison Control Centers, Accident Prevention Program, Public Health Service, U. S. Department of Health, Education, and Welfare
Four cases of acute chloroquine poisoning in children are presented. In three instances death occurred within 2 hours of ingestion of larger than therapeutic amounts of the drug. The rapid occurrence of death in acute chloroquine poisoning is probably explained by complete and rapid absorption of the drug from the gastrointestinal tract resulting in high blood concentrations which depress vasomotor function and respiration. Cardiac arrest follows and may be caused by the direct myocardial action of chloroquine, to anoxia, or to both. The similarity of the manifestations of acute chloroquine poisoning and those of acute quinine and quinidine poisoning suggests that acute toxicity may be attributed to the quinoline ring portion of these drugs.

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I don't think that we are seeing extreme examples. But we may be seeing less extreme immediate reactions or reactions where the toxicity builds up over time.

Quinoline rings are know to cause neurotoxicity. There are theories about how that happens. One of the theories is about blocking connexins which are gap junction proteins in the brains.

I don't know how montelukast could be breaking up so that it causes toxicity. Or if the problem is the how rapidly the liver enzymes can metabolize it. But there is plenty, plenty, plenty of clinical evidence that there is a quinoline ring culprit somewhere in the picture. Or some by-product of that causing problems.

Somehow it was decided that montelukast did not have the safety issues that the other drugs in the same category have. See this.

"The starting point in the development of montelukast appears to be a quinoline-containing structure, likely identified as a weak random screening lead (Figure 3). The Merck group hypothesized that this molecule was mimicking the olefin backbone of cysLTs, and that the addition of mimics for the acid and peptide regions of LTD4, might improve its potency. As a first step, the dithioacetal linkage first seen in some SmithKline compounds was incorporated; this led to a compound with greatly increased in vitro potency but poor oral bioavailability. When one of the carboxylic acids was replaced by an amide, forming MK-571, the new antagonist had even greater potency and good efficacy following oral administration. The enantiomers were resolved to yield MK-679 (verlukast), a compound with better clinical effects than MK-571, but whose clinical development was stopped for safety reasons. Further structure-activity relationship studies led to the development of montelukast (16), an antagonist that appears free of the safety concerns plaguing earlier members of this series."

If we can find out why the earlier versions were not safe and how they thought fixed it, then maybe we can find out what is going on with the quinoline ring in some people.

I would be very surprised if the FDA will address our concerns. Why does it always seem like they wait for enough people to die like in Vioxx? Wasn't Vioxx responsible for thousands of deaths?

We have all been saying that our issues regard not being informed about all of the possible side effects. And, we know that Singulair works well for some people. Nobody wants to take a good drug away from those for which it probably performs miracles. People who have toxic side effects have a right to know up front.

My observations about montelukast's chemical structure are either general or not quite 100% correct or could be quite vague - so forgive me. I do not claim to be good at organic chemistry. But from doing a little work, I have come up with some observations.

1. It would seem to me that montelukast might work quite well for people who have developed mold category related asthma. I observed that chloroquinolin, a component of montelukast, is a good fungicide effective against Aspergillus, Alternaria, Cladosporium, Penicillium and Candida. Dust mites can only digest if helped by aspergillus so they go into the mold category. Molds produce millions of spores so anyone who lives in contact with mold would be chronically sick from their presence. Then people get hypersensitized to that.

I am probably wrong but I could imagine that montelukast is: 1) a ligand that binds to an empty cysLT1 receptor for a period of time 2) 7-chloroquinolin-2-yl which either acts intact or breaks down into a quinoline fungicide so that it kills the chronic mold/fungus infection and 3) a sulphur/methyl anti-inflammatory component that tells the t-cells that they are not needed so they will die. Wow, that would be great for mold asthma if it was completely non-toxic. It would be also great under controlled circumstances for many people who are mold-miserable. If I am wrong, I better go out into my garage and start inventing such a drug.

This is my visualization to try to explain the side effects of neurotoxicity. So adverse reactions could be to the quinoline component as an allergic reaction or dose related so that it just built up to a toxic level over time. There are many signs that t-cell populations are significantly reduced by montelukast. The fact that the Italians can do it in the test tube might be that it's a chemical component of montelukast designed to cause the t-cells to die.

Montelukast is a large molecule so Artie says it cannot penetrate the blood brain barrier. That would be an argument if nobody was complaining about neuro-psychiatric side effects. The neuro-psychiatric side effects are identical to quinoline and quinolones. When I read about Lariam, it just sounds like a more extreme version of Singulair side effects. Chloroquinolins were used before they invented Lariam, which is stronger. The malaria Plasmodiums became immune. Hallucinations, anxiety, depression, suicidal thoughts are completely consistent in all of the quinoline/quinolones. If montelukast breaks into sub-molecules then quinolines easily penetrate the blood brain barrier.

I find clinical evidence that montelukast may act as more than more molecule. And, that there is a rational for the existence of the chloroquinolin and evidence that it may be the source of toxicity.

I am glad to risk being called crazy. That is what the internet is for. We can present our ideas and discuss. So, just take this with a grain of salt. If I am close to the truth, this post will find it's proper home.

I started taking Allegra about 2 weeks ago. It has definitely helped my seasonal allergies however, I have been very irritable, tearful, and have experienced menstrual-like cramping when it is not the appropriate time of the month. I am doing to discontinue taking it and see if the depressive symptoms improve.

Effective after two weeks for some people - not effective for others. Side effects for some people - others do not report side effects. So why does Merck have to grow their market before they have any idea what's going on?

This isn't a big group of people in the study but it makes sense from what we are reading here. These researchers did examine the mast cells. We need to know about mast cells (while suppressed by montelukast) on a longer term basis.

J Asthma. 2008 Apr;45(3):243-50. Links
The efficacy of montelukast and airway mast cell profiles in patients with cough variant asthma.Kawai S, Baba K, Matsubara A, Shiono H, Okada T, Yamaguchi E.
Division of Respiratory Medicine and Allergology, Department of Internal Medicine, Aichi Medical University School of Medicine, Aichi, Japan.

Background. Cough variant asthma (CVA) is characterized by chronic cough without apparent wheezing; its pathophysiology is considered to be similar to that of classic asthma. Objective. The clinical effects of montelukast, a cysteinyl-leukotriene receptor antagonist, on cough variant asthma were assessed, and the activation profile of airway mast cells was examined. Methods. Montelukast (10 mg/day) was given orally to 36 CVA patients (25 women and 11 men; median age, 37.5 years). Before treatment, the patients' bronchial mucosa underwent a biopsy with a fiberoptic bronchoscope. The biopsy specimens were double stained with anti-CD63 antibody and anti-human tryptase antibody. Results. After 2 weeks of montelukast treatment, cough symptoms improved in 22 patients (the effective group) but did not improve in 14 patients (the ineffective group); in the ineffective group, the symptoms disappeared 2 weeks after they were switched to fluticasone propionate (400 mug/day) inhalation therapy. In the effective group, the time interval from the onset of symptoms to the initiation of treatment was significantly shorter than in the ineffective group. The bronchial mucosa biopsy specimens showed that the proportion of CD63-positive cells in tryptase-positive mast cells was significantly higher in the effective group than in the ineffective group; although the total numbers of mast cells were not different between the two groups. Conclusion. There is a subgroup of CVA patients in whom leukotrienes are closely involved in the pathogenesis of their chronic cough; activation of airway mast cells may be an essential feature in these patients.

PMID: 18415834

One of the most important questions we should be asking as parents is:

How does Singulair - a leukotriene receptor antagonist (blocks the receptors) affect the normal function of the mast cell?

The mast cell is the FRONT LINE DEFENSE against invading micro-organisms. When Singulair was invented, there was limited knowledge regarding the mechanisms by which the mast cell performed it's function. In my opinion, the focus was very narrow - those interested zeroed in on how the leukotriene receptor performed a role in the cause of asthma attacks and how ashma attacks could be prevented. Well, that's good preventing asthma attacks. But what happens to the mast cell if that receptor is blocked on a long term basis. I am not suggesting that blocking the receptor is bad but what if the long term effect is different than what we are are lead to believe-which is this is a safe medication with no known long term effects. What if the leukotriene receptor was just blocked short term a week or two to allow the body to clean up the mess from the last attack?

I seriously question what is going on with all of these infections. Are they related to crippling the mast cell? Parents should be allowed to question. If Merck doesn't want to answer questions regarding what happens to the mast cell (including are the numbers of mast cell decreased on Singulair), then something really BIG is missing. If by any chance (unknown at the moment) that the mast cell is significantly changed and therapy by montelukast is proper on a short but not long term basis, so freakin' what if Singulair is not a huge money maker any more.

Parents deserve every answer possible when decisions regarding their child's growth and development is on the line. I hope that we get some answers.

Of course, what was there in 2002 were new questions-not necessarily answers about the mast cell. Did anybody apply this to Singulair studies?
May 2002

From Journal of Clinical Investigation

Pattern recognition receptors on mast cells
The Toll-like receptors (TLRs) fit the definition of pattern-recognition molecules, which were originally postulated to allow the innate immune system to detect the 'molecular signatures' of various infectious agents. Although the innate immune system has no memory, it shows a degree of specificity, in part because the various TLRs recognize different sets of pathogen-associated molecules. Dermal mast cells are usually associated, not with the innate immune system, but with atopic dermatitis, but Supajatura et al. have found that these cells also express TLRs. They report here that TLR4, which binds the gram-negative product lipopolysaccharide (LPS), and TLR2, which binds peptidoglycan (PGN) from gram-positive organisms like Staphylococcus aureus, induce distinct mast cell responses. Staphylococcus is known to exacerbate allergic dermatitis, but it has generally been thought to act by inducing antibacterial IgE's, which trigger mast cell degranulation by stimulating the IgE receptor. Interestingly, the authors show that the interaction between PGN and TLR2 can provoke mast cell degranulation directly, sidestepping the need for IgE receptor engagement.

I found this message board last night and until then, I thought my daughter was just bad. She is almost 3 and has been on Singulair for a little over a year. I have said on many occasions, "What happened to my sweet girl?" After the suicide and Singulair connection, my husband would joke and say that's why why our daughter is out of control. I finally decided to check into it and was amazed at the number of kids out there like my daughter. She is an emotional wreck! Her mood swings are something else. I have to walk on egg shells around her so not to upset her. For example, she will walk up to me smiling and give me a hug. When I hug her back, she screams at me and tells me to let her go or to stop touching her. When her brothers talk to her, she screams at them to stop talking to her. She has meltdowns numerous times a day. I am going to stop giving her Singulair as of today and hope that she will improve.