Skin irratation symptoms and conditions

Has anyone experienced anal fissures? Since Advair has mucus forming as one of it's side effects my husband and I were curious to see if anyone else was reporting weeping around the anus which is causing very painful skin irritation and a fissure. He also has terrible leg cramps while sleeping at night, hair loss, mouth sores, thrush in his throat. He has been on advair for over two years and we are now reading of all the same side effects that have been plaguing him for some time now. The anal fissure is difficult to discuss, but I did read of a mother below that wondered if her son's soiled underwear could be related. Does anyone else have this symptom?

I had Mirena inseted Nov. 2007. Two months later my periods went from 3-7 day periods to icky brown discharge and a period in the middle of the brown discharge. The doctor said it was normal and would go away eventually. Ten months later I had it removed, because guess what? The brown never stopped. As a matter of fact the longer I went the shorter the period got, but the longer the brown lasted and it lasted longer than a regular period ( a week and a half ). My period started back almost immediately, along with sever cramps. Today, three days after having it removed a clot the size of I would say 1/8 of a cup came out (I apologize for the graphic image, I'm getting to a point, I promise). Never having seen clots in that fashion, I almost freaked.
Well I did some reading and apparently the blood from my "disappearing" period was actually pooling in my uterus. Why? Well the only logic deduction form all this would be that the Mirena cause that nice little, unexpected side effect.
This is after it was removed. While I had it in there were lost of side effects I didn't know were being cause by the Mirena until I read this page.

Side effects included: Bloating, Drowsiness (we are talking sleeping from 7-8 hours a day to 10-12 hours a day), Irritability ( I mean I was already on anti-moody pills! but after being put on Mirena, it was like I wasn't even taking my pills), Weight gain, apatite increase, Depression, oily skin and break outs, cramps, headaches, and probably more than I can remember right now.
That was just me. It Was so embarrassing to begin with the brown smelly show, because I could smell myself all the time. I was advised not to use tampons, so keeping up with panty liners for over a week really cause some skin irritation.