Sports symptoms and conditions

I found this site 12 months after beginning Doxycycline for acne. A year ago I was the happiest person that I knew. I was a junior in high school and was very involved, liked sports, and had many friends. Me and my girlfriend were happy and to be honest, I had literally not felt happier.

A week ago I had come to the end of my rope. I literally decided to commit suicide. I finally reached out to God for help and I feel like he has saved me. About half an hour after praying for help from where I was I found this site. So, without further adieu, I am going to detail how horrific and absolutely from hell this drug is. ****PLEASE, I BEG YOU, IF YOU OR SOMEONE YOU KNOW HAS BEEN AFFECTED BY DEPRESSION, ANXIETY, OR ANY OTHER SIDE EFFECTS DUE TO THIS DRUG, PLEASE CALL THE FDA SIDE EFFECT HOTLINE. THIS DRUG IS FROM HELL***

I broke up with my girlfriend because I would sit at home and think for over 12 hours at a time that she hated me. As a result of this racing thoughts, when I saw her or went on a date, I would have nauseating anxiety for literally no reason... This anxiety continued for about a year until I had almost lost every friend I have ever had. It wasn't their fault, just that no one else knew how to respond to this sudden change in me.

Racing thoughts were terrible. I couldn't sit in a room without thinking thousands and thousands and thousands of negative thoughts from hell. I would think of how my family, and my friends, and my girlfriend all hated me. Now, after discontinuing this medication, i realize that it is all a lie.

The depression was horrific. I would literally have rather had a serious physical disease for the past year instead of feeling like this. I wouldn't go to parties, I would sit home and cry. Mind you, NOTHING happened to make me feel like this. Absolutely nothing. I thought about suicide about once a week (at least). I honestly didn't know what to do.

Mood swings were awful. I would change life goals and life core beliefs within minutes. Everyday I would become a different person at least 10 times throughout the day. I would go from nice, to sad, to motivated to start my own business, to thinking about signing my soul to Satan all in one day. These are just a few of the horrific thoughts. Dark thoughts, thoughts from hell.

I can report no physical side effects, but honestly I have been through so much that I can't stand it with this drug. I would like to thank my Lord and Savior Jesus Christ for helping me realize that this drug can absolutely ruin lives. I think everything happens for a reason, but people, hear me. I write with tears in my eyes right now and I look back on all of the lost time and all of the friends and all of the opportunities that have literally flown passed me. Just know that you are not alone. Stop taking this drug! And start raising awareness!

I have had Mirena for 18 months now. I love it. I have had no side effects that you all are describing. I have 4 friends that switched and all love it and only one had to have a follow up to have the strings shortened.

As far as the weight gain, ladies, let’s be honest. We are not 18 anymore and as we get older it is only going to become more difficult to keep weight off. Blaming it on a B/C....lets think about that last chocolate bar we ate because we were busy carting the kids off to a sports practice HMMM....
With any drug comes side effects, headaches, nausea, and some other terribly worse, but lets again be honest, all of these were pointed out in the literature available.

I just thought I would take the time to write my support as this does work and work well for some women, just not all, same as any other form of B/C.

I DO NOT SUGGEST MIRENA TO THOSE WHO HAVE NEVER HAD A CHILD! I'm having my mirena to be removed this Friday! Because i can't stand it anymore!! I had Mirena for a year and the cramps have never subside but have become worst! The cramps starts from my right buttock and extends it to my thigh! It is terrible and most of the time, it last for the whole night, i couldn't walk nor sleep nor move once it happens! It happens at least twice a month. It is even worst after doing sports!!! Mirena totally ruins my life for that whole year!! No sport, extreme pain and fatigue and depression!! I cant wait to get it out of my body!! i rather take pills!

Does anyone have a problem with skin, like having dark sports on a face.
I have my mirena for about 5 moths now and just lately I've noticed about inch long brown spots above my lips. I live close to the beach(even though I don't go tanning)so sun is quite intense but i'm wondering if this might be a mirena side effect.Please let me know if you have the same problem.

I was diagnosed with peti-mal epilepsy aprox 17 years ago. I tried many different anti epileptic drugs and had many negative side effects from teeth problems to depression and none of which controlled my seizures. 12 years ago I went on lamictal (600 mg a day) and I haven't looked back, I feel I have my miracle. So far I have no side effects, am completely seizure free and I have a life. BEFORE lamictal some side effects were poor concentration ( when reading a book I could not remember what was written on the top of the page by the time I got to the bottom), little co-ordination with sports (most times I could not catch a ball when thrown to me, this caused a lot of social problems), forgetfulness and I was quite clumsy. I hope you all can one day find a medication that works just as well for you or even better a cure. My heart goes out to you all.

I just spent the night in th ER for chest pains due to Yasmin.

I had been on it for a month and since the beginning I felt something was wrong.. My leg started to spasm and I got these sharp pains in my chest that moved to the back between my shoulder blades. Was told that it was acid reflux and to take tums. Didn't help. Eventually the spasms moved to my upper body (back, arms and head). My EKG, blood test and chest x rays were normal, but I still feel headaches and a weird tingling in my arms and ears are painful sometimes. All these things pains come and go so I have no clue what it can be. Stopped taking it 2 days ago and I'm hoping that it will go away on it's own without doing permanent damage.

Has anyone had similar problems that resolved on it own after stopping?

My son (14 years old) was given levaquin for a sinus and ear infection
2 weeks ago. Around the same time he began practices for his high school baseball team. He complained about his legs being stiff and aching. We assumed it was the intense practices causing his muscles to ache. After a week on the drug, he could barely walk and his knees were swollen. We were very concerned and looked up the side effects of levaquin on the internet. We were shocked and angry when we found out that levaquin should not be given to children under the age of 18 because on the possibility of joint and tendon problems. Today we went to the orthopedist and he drained a lot of fluid off of both knees (it looked like about a 1/2 cup from each).The doctor thinks it has to be a side effect of the drug, because the symptoms began at the same time. He doesn't
think after examining the knee and having him perform certain tasks that he has damaged any tendons. He has all the symptoms of rheumatiod arthritis. He is very athletic and plays competitive sports and we are praying that his knees are not permanently damaged by this drug. Parents please research all drugs and there side effects before giving them to your children! Doctor's DO make mistakes!! The pharmacist failed us too.

I am 24 and used the NuvaRing for almost 3 years. As I finished up college at 21 and directly afterwards I was becoming more and more depressed, which I first attributed to the transition. It was while I was still in college that I also noticed a change in my ability to concentrate and remember. Focus and decision-making were abnormally difficult. My moodiness and depression increased over the next two years, my sensitivity to other's comments became more acute and I constantly felt at the edge of tears. I had little to no enthusiasm for even my favorite activities, no energy for sports/physical exercise, and no interest in sex with my partner. I required more sleep, always feeling tired when I woke up. I also began to have headaches, which had never been a trouble before.
I have been off the NuvaRing for about 3 weeks. Like some have posted earlier, I feel like a dark cloud has lifted and I can enjoy life again. Notable changes over the last couple of weeks have included:

1. Waking up naturally in the morning, almost 2 hrs earlier than before
2. Dramatic increase in ability to focus and remember (effectively study)
3. Happy mood and few to no self-deprecating thoughts
4. Increased energy
5. Enjoyment of flavors
6. General clarity of thought
7. Return of interest/enthusiasm, competitive spirit
8. Interest in sex
9. Decrease in headaches

I am absolutely thrilled to have identified the NuvaRing as the source of these issues and having eliminated it from my routine. I feel like I have my life back.

Wow. I am so grateful for this thread re: Gardasil. My daughter is 15 and for the past couple of years every doctor and nurse has advised me to get her vaccinated. I also receive forwarded e-mails from friends that only talk about the horror stories. The doctors say don't believe what you read on the internet. The last time she was in for a physical for her sports clearance, I signed the consent form for her to get the vaccine. I also told the nurse to leave it up to her. If she's ready to get it today, let her. If not, no big deal. Up until that time she felt she should get it. I was surprised (and now thankful) that when she came out of the room, she decided against it for no reason. She is the one that when she get a fever, it's severe and she hallucinates, ends up with the weird viruses and out of school for days, has been to the er thinking she was dying with unexplained severe abdominal pain, and even had scarlet fever last year. She's otherwise very healthy, she just gets hit with strange things. That being said, I have no doubt that she would be one of the girls with terrible, possibly life changing side effects and I just cannot take that chance. So, thank you to all for sharing your experiences and I am so sorry for all the pain and suffering this vaccine has caused you all. My heart goes out to you.

12 year old daughter got Gardasil vaccine at the time she got her first shot she got a weird feeling right throughout her whole body. we mentioned to nurse she said it was a common feeling. first needle Oct/07 shortly after she started showing signs of TOURETTES and she is now getting worst. It is starting to effect her daily activities such as sports.
Anyone else having this type of reaction please let us know.

Thanks

May 16 y.o. daughter has chronic sinus infections and sever headaches. They said it was allergies and put her in Allegra D and Singulair. Headaches seemed better with slightly fewer sinus infections. Once I heard about the mood swings and Singulair I took her off. Then the Allegra did not seem to be able to keep up with keeping the sinus infections at bay. We finally figured out that she has a deviated septum and will need surgery. Anyway, we put her back on Singulair so we can get though the season with as few sinus infection until we can schedule surgery around high school and sports. Then we were noticing how her hair has become so thin. She used to have really thick hair and now her pony tail is to thin and small. After doing internet searching, we found out that other people are having this problem with Singulair. I took her off of it 4 days ago and already the shower has less hair in it. You can't tell a teenager that she needs to stay on a medication and lose a ton of hair. I am hoping that her hair will grow back quickly.

I am 34 years old. I am a pharmacy tech. I have asthma and allergies. I have taken singulair pretty much every day since it came out on the market. I've had asthma since i was about 10 years old. I took theophylline as a kid. Steriods on and off especially during times when my allergies are bad. I still use Advair during the fall and spring. Every drug has a side effect. However breathing is pretty good damn thing. Do I have days when I feel low? Yeah. Do I sometimes have nightmares? Yup. Are "natural" products the answer. Not always. The fish oil that some of the posters are touting can also cause GI problems. Some of the natural products contain herbs and other plant derivatives that can be harmful for a child that suffers from allergies. Not proactively treating asthma can be deadly. Some of the parents are suggesting steriods as the answer - those can cause weight gain, growth suppression and can lead to a worsening of asthma.

Singulair has never made me feel like I've wanted to kill myself. I was more depressed and angry as kid when my asthma did not allow me to partipate in normal childhood things. I was sad and hated life when I couldn't keep up with friends at recces because I was having trouble breathing. You have to outweigh the costs with the benefits. I am more irritable when I have asthma flareup then I am on a normal day. For me, I choose to breathe. And singulair has been helping me for almost a decade.

I'm not saying the medication isn't causing these symptoms but maybe there is an underlying cause to your child's depression.

Any drug has a side effect. But without medical research and the medications that come with them - people would still be dying of simple diseases and we wouldn't have vaccinations. As a society, as a whole, we are a culture that looks to someone else to fix things and then blames the people who try to fix it. We need to stop being the "hot McDonald's coffee'" society.

Wow to the 10 year old story above. I'm on here because my 10 year old started Advair back in Sept for a nagging nighttime cough, asthma associated. Then his grades started to tank. He has aced his SOL's in math/science, but, this year has a D in Math! Today when we met with his teacher and found out he had been 'daydreaming' and seemingly 'asleep' in class, thanks teach for letting us know before now, we finally put it together, the new med. So, he has complained about being tired and having some sleepless nights. We put our kids to bed at 8:30pm and we don't run them to death with sports, etc. We couldn't figure it out. But, I can tell you, beginning tonight, no more Advair for him. We'll see by next week if this was the problem. Scary that this isn't rated as a 'side effect' of the med.

I am a loving mother of a 5 1/2 year old boy. He has been on Singulair for over 3 years. In this past 3 years my son has suffered in an unspeakable amount. He came down with Rota Virus and was hospitalized at 2. He then came in contact with Pneumonia in the hospital while he was there. They automatically put him on Singulair, Zyrtec, Prednisone, and antibiotics to treat the pneumonia. Since that day, my son has gone though more tests than I have in my entire life. He has had asthma, sinusitis, leg cramping ( to the point he cannot walk for 2 years), IBS, Acid reflux,(they gave him laxatives for a year that made things worse and addicted to them also), stomach pain, constipation and diarrhea back and forth. He also got Erythema Mulitforme TWICE, while on this drug. All of which the doctors said could NOT be caused by Singulair. He has had several Upper GI's and CT scans. Along with Barium enemas, several hundreds of blood tests, and many many pokes and prodded that were not necessary. All since he has been on Singulair. He now has frequent bathroom trips, depression, confusion, and anger outbursts. He also has to go to the restroom every 5 minutes. He has had genital swelling, and many other aches and pains. None of which his "doctor" ever said could be a result of Singulair. I am 100% sure it was!!!! He currently has anxiety and emotional sporadic issues causing problems in school The teachers and counselors say that it is so strange because there is no TRIGGER and the outbursts are completely inconsistent. His preschool teacher and director are sure he has ADHD. Well, we had him tested and he does not have any part of it. He has no learning disability what-so-ever. So that brought me back to square one. He is in a positive loving enviroment. How could he be depressed and want to hurt everyone around him? He cannot sit still. He cries and says he is 'stupid" and "can't think" like the other boys. He has nightmares and cannot sleep alone. He is scared of everyone and everything. So, as I sit here crying, I realized that this has all been a reaction of his "medicine" Singulair. He never should have gone through all of those painful tests, only to prove they couldn't find anything. So many treatments and sound full advice speeches from his doctors. How could they be so naive and selfish in the life of my son?

When I called my pediatrician of 5 years, she told me that " parents that have children with behavioral problems will LOOK for something to blame their problems on." She also said "drug companies only put side effects on their labels to PROTECT the drug companies. (as she laughed at me) They are not always valid". Then she said "if you take you child off of Singulair you will be playing Russian Roulette in his life." Then she said that all children around 5 or 6 go though this emotional time in their lives." She told me that if I take my child off of Singulair that she would no longer be a part of his health regimen for his asthma. She told me to see a Pulmonologist for further treatment.
Who is paying who? This is my son's life???????? I decided to go with my mother-gut instinct and get him off of this medicine. No matter what. He has been a different person since. He is currently going though a lot of side effects and withdrawals (leg pain, insomnia, hic-ups, emotional distress) but every day is getting better. How can the drug companies say that this is a "wonder drug?" There are more reported side effected patients then clinical studied patients! How can a "medication" that stimulates the brain not be connected to other problems? This "medication" interferes with the bio synthesis and action of LTs and has been marketed as NOVEL medication against asthma and allergic rhinitis. Who the hell is playing God here??? The pocket books of Merck or our over PAID "doctors?" Who pays the price? Our children? Or us. Thank god I found this before it was too late. I would not be able to withstand the pain of losing my son due to their lack of scientific evidence. They are lucky I am one of the smart ones. I will not settle for less than Justice for the drug companies and their paid "doctors?" You all end up in the same place. HELL

There are 18 million people on this drug. Most of them are children. Please save a life if not your own child's life. Thank You

POLL: If you or your child have been adversely affected by Singulair could you please reply to this and let me know what ethnicity you are and skin tone. (fair, med., dark, etc.) I'm interested in the demographics of this drugs effects.
Thank you!

ENLARGED BREASTS: Yasmin turned me off to the birth control pill as it was the first one I tried. Within a week my breasts had gone from size C to D and were incredibly sore. I had trouble sleeping comfortably and doing sports. I experienced slight weight gain, but the breast soreness was the most unbearable. I also remember waking up in the middle of the night during the first week and thinking that they were still getting larger! In any case, I only used Yasmin for 3 months and switched to something lower. I have been off the pill completely for over a year and I am looking for suggestions for lower dose birth control. I welcome any helpful advice.

Thank God for this Site!!!

Just wanted to add a recent post. I have all the same symptoms... fatigue, emotional roller coaster, dizziness, headaches, as well as feeling incredibly insecure. I want NOTHING to do with sex. TMI warning... My boyfriend and I used to have sex AT LEAST on a daily basis, now I cant stand to think about it. I am 25 and have played sports all my life. I even coach for a high school team. This BC is aweful. On top of not having enough energy to do ANYTHING, when I pushed myself to workout, there were absolutely NO results. This is a debilitating drug that has been branded with an incredible amount of false advertising. It seems the pro's that the company braggs about the most, couldn't be further from the truth.
So once again, if you don not want:
Dizziness
Eye sensitivity and pain
Extreme mood swings ( from throwing things to crying over commercials)
Severe cramping (even when not on your period)
Insecurity
Weight gain and inability to loose weight
Food craving
Migraines
Oily hair
acne
Fatigue
DO NOT TAKE YAZ!!!!!

I have some of everything above and am in so much pain that I feel as if I am dying a slow, painful death. I am on heavy pain meds and even with those I have severe abdominal cramping. I don't know what I would do if I didn't have this pain relief. I am very worried as to what is happening to me internally. They are scheduling cat scans and I am awaiting a phone call to get something diagnostic done. This all started 8/15 and not only are things not easing up, but I think this is getting worse. I also have a urethral discharge, UTI, and alternating constipation and diarrhea. Initially, I had a 102 degree fever and now my temp is low, only 97.1! my husband plans on calling a lawyer today, 8/26. One day I passed brown urine and it shocked me! I'd appreciate hearing from others as I feel so alone in this horrible nightmare which is unfolding! FYI, my doctor feels that my muscle tissue is breaking down...has anyone heard anything like this from their doctor? The stomach and abdominal pains are like labor!

I HAVE BEEN ON LIPITOR FOR ABOUT A MONTH NOW AFTER HAVING 3 STENTS PUT IN I AM A 50 YEAR OLD MALE THAT HAS ALWAYS BEEN ACTIVE IN SPORTS, MY LIPITOR SIDE EFFECT ONLY STARTED A FEW DAYS AGO, I HAD SEVERE PAIN IN MY RIGHT SHOULDER SO BAD I COULD HARDLY USE MY ARM THE PAIN GOT SO BAD LAST NIGHT, WE WENT TO THE ER, NO PROB FOUND JUST INFLAMMATION, SO THE DR PRESCRIBED MOTRIN 800 AND A MUSCLE RELAXER, WHICH DID GIVE ME SOME RELIEF IN ABOUT 25 MINUTES .
TODAY WHILE SHOPPING I NOTICED A PAIN NOW IN MY LEFT SHOULDER AND NOW THROUGH THE DAY IT IS JUST ABOUT AS BAD AS THE RIGHT ONE THEN AFTER DOING THIS RESEARCH I WILL AS OF RIGHT NOW STOP TAKING MY LIPITOR I WILL POST MY UPDATE TAKE CARE

hi all. thanks for writing your comments here. it has helped me today, another HORRIBLE day of prednisone hell. i have been seriously ill for 8 months been told ever other week I'm likely going to die from lung disease (i'm 35) and after a painful lung biopsy have been told my lung problems are almost all reversible... after a year on high dose prednisone. i was on 40mg a day for a month a while back and was so out of control from rage and crying and insomnia and panic/suicidality, ravenous appetite, that they lowered me to 30. then after biopsy they said i should be on 100mg to cure me, we settled at 60mg. it's been 24 days. The moon face started about one week in. i've gained 8 lbs. i am an emotional wreck. i have at least one rage filled attack per day where i am screaming and want to kill somebody or destroy something. some days i am so filled with hopelessness and worry i just want to die. my body changes (after just losing 30 lbs and being a work out fanatic my shortness of breath makes it impossible to walk up 2 flights of stairs without resting) face changes, acne, excess body hair (oh my god please make it stop i'm like a chia pet and i'm so afraid it is going to get worse) double chin, puffy eyes and cheeks, absolutely uncontrollable emotions and mood swings, inability to be logical or reasonable. i don't want to leave the house, i'm panicked and scared all the time. i never sleep. ambian gives me minimal relief (just started taking it) i feel like i'm losing everything, except my lung functioning is returning and i'm not going to die from this illness (they assure me THIS week) i understand light at the end of the tunnel, but living like this is unbearable most days, almost impossible the rest of the time. am i alone with the severity of this? or are all the others like me too busy hiding the sharps and crying in a corner to write on this board? thanks for listening :)

figures, forgot to mention what HELPS. no eating after 8 (7pm is better) no salt, no sugar, exercise, even just a walk every day, anything physical, i walk like a grandma on the treadmill but i still do it, sometimes it is the only thing that stops my crying. no alcohol, support and understanding from loved ones, it's not you, its the drugs. good luck.
figures, forgot to mention what HELPS. no eating after 8 (7pm is better) no salt, no sugar, exercise, even just a walk every day, anything physical, i walk like a grandma on the treadmill but i still do it, sometimes it is the only thing that stops my crying. no alcohol, support and understanding from loved ones, it's not you, its the drugs. good luck.

I never put two and two together... but starting thinking that my mirena's hormones may be causing my issues. I had the mirena inserted a yr ago when I had the copper IUD removed. I told my OB/GYN that I was scared of the pill after trying it in college. Hormone-based birth control doesn't seem to work well for my family. She said it was a tiny dose and wouldn't get in the bloodstream so I shouldn't see side effects. HOWEVER, over the last year I have struggled with my weight. I have always been reallllly lucky. I am 5'8 and weigh about 135 without trying too hard. I have a high metabolism. But, I've started to feel pudgy last few months so have really tightened up my diet. I thought it was because I am getting older (29)...

As far as exercise, I used to be very active (mini-triathlons, 5Ks, sports etc.) but haven't felt like working out this year. Just can't get motivated. Today I was working with a personal trainer. We checked my records from January and I have gained 7 lbs!!! This is after I have really firmed up my diet. I have stopped eating carbs at night and trying to not eat after 7ish. In the past, this would really help my body look its best after a week or two. But, these last few months hasn't seemed to help me at all... Maybe it's the MIRENA?!

In addition, my cycle is about 7 days lator than it used to be. However, I still have the PMS symptoms I used to the week before my period but now they last forever! They start on the 20th and last until my period starts on the 7th!!! I get so irritable with my 5 yr old its ridiculous. It's not fair to her or my husband. I just wanted to share, that even with an athletic body type and a ridiculously high metabolism I am struggling. 2 yrs. ago I could eat 2300 calories w/out exercise, 2500 or more if working out that day. I used to eat as much as my 6'2 husband.

I have been on SINGULAIR for 2 months now, I am a very active person, I do lot of sports. First thing I noticed was severe tiredness that affected me during practicing. Sleep disturbance and insomnia became very common, I had to shift from ZYRTEC to BENADRYL to be able to sleep.
Last week I did a blood test, the scary thing was elevated ALT levels ( almost 3 times the normal level ). I excluded all factors that could cause that. Nothing but Singulair. I have stopped it and I will go for a course of sylimarin and retake the test in 1 month.

My 9 year old son only took Singuliar for about 5 weeks. He had side effects almost immediately, he was so aggressive, angry all the time, headaches, stomach ache and feeling like he was going to throw up, bad nightmares, a horrible rash, biting his nails, not focusing in school and got into trouble all the time, no appetite but his little body seem puffy all over. He has been off this medication for 3 months and he is still not 100%. He cries at little things and still has the same rash and with meds it is not going away. He had to change schools as he still was having problems in school. He just seems like he is not the same little boy and something is just not right. I do not know what to do at this point. Doctors say it should be out of his system by now, but if it is than there is permanent damage to his brain as he is just not the sharp little guy he was. We have had to take him out of all sports. Anyone else having these same problems???

In response to dtrzaski post Im am sending out this question to everyone. We know there have been stool/stomach/weight issues. Are there any other children that it has been discovered to have high cholesterol. My son was discovered to have high cholesterol at around 3yrs old, apprx 6 months after starting Singulair (regardless of a very healthy diet lots of fruit and veggies!) Any thoughts out there?

I spent the weekend reading about the development of Singulair. The early studies recognized that the first phase of the acute asthma response bronco-constriction was probably not caused by leukotrienes. They identified histamines and prostaglandins as the probable sources. I don't think that changed because the Singulair literature states that it should not be considered as a treatment for that. Leukotrienes were a source of inflammation caused by eosinophils and mast cells present in greater numbers (than normal) in airway tissue. So, it was beneficial to find a way to decrease that.

The cysLT1 receptor was identified as source of the signals that tell the cells to produce leukotriene. The receptor, a gene, consist of 337 (they think) amino acids. They modified a compound that would bind to that receptor thus blocking the cells ability to produce leukotrienes. This compound is very specific. It was formulated to bind to the "model" receptor. This compound will not even bind to cysLT receptor sub-types. (That is the good thing.) There is an enormous amount of research that discusses the genetic variability of the chemical reactions that occur in the leukotriene (calling it this for simplicity) pathway. We are also seeing that a number of researchers would like to use gene profiles to predict whether patients will respond favorably to different asthma/allergy drugs. ALL PATIENTS HAVE A RIGHT TO KNOW IF IT IS INHERENT THAT SOME PEOPLE WILL NOT RESPOND TO SINGULAIR OR RESPOND ADVERSELY.

There are many studies from the 1998 era that conclude that montelukast is not effective for everyone. Those researchers stated that it can be predicted that those people who are going to respond favorably will do that within the first 14 days or so. That conclusion would be consistent with a genetic component for efficacy and safety of Singulair. Those doctors concluded that those who did not respond within that time frame should not take Singulair for fear of harming them. That makes good sense.

The Italian researchers wanted to know if there was more going on than blocking leukotrienes in the action of montelukast. They set up a "test tube" study regarding montelukast, the cysLT1 receptor, and some t-cells that they selected. Why? Researchers always have something on their minds. They observed the death of these particular t-cells.

Montelukast is a quinoline. We basically know of quinilines and quinolones as compounds that were invented as broad spectrum antibiotics. They work because they interference with bacterial DNA so they cannot replicate themselves. Montelukast is a quinoline modified to bind with the cysLT1 receptor (a gene) and prevent that gene from activating. That's consistent with what a quinoline/quinolone does.

So what does montelukast do in blood plasma if it does not bind to the receptor because of genetic mis-match? (If montelukast does bind, then a chemical reaction has occurred and the liver will break down the by-products. Montelukast metabolized in 10-12 hours.) What happens if it doesn't bind? How long before it breaks down? Does it produce toxic by-products?

I want to know what happens to lymphocytes such as t-cells just because montelukast is a quinoline. Maybe nothing but what's up with the Italians researchers? I want to know if montelukast has the capability to interfere with lymphocytes who can clone themselves. That could be a good thing under circumstances when these lymphocytes are causing inflammation. But it could be a bad thing in the case of normal individuals with no problems.

I want to know if the bad side effects are due to the fact that the body has to break down and metabolize a quinoline that did not bind to the receptor for which it was created. The side effects of Singulair are strangely similar to what is observed in the quinolones such as levaquin. I have not as yet been able to compare montelukast as a quinoline to levaquin as a quinolone. I am hoping to find something on these categories. There may be no reason to worry that they cause similar damage. But frankly, I think that there is. There is some terrible chit happening to some people. The scariest is the neurological damage.

All of these questions would be in the everybody pharma knows to ask category. I don't know where the answers are. I haven't found them as of yet. Maybe there are no answers. We have to remember that Singulair and Vioxx were released in the same year. They have continued to be drugs under the current executive management of Merck. If the Vioxx marketing promoters had their ghost writers, why not the Singulair marketing promoters. The genetic component appears to be widely accepted but we haven't heard one thing about even that.

I think that it is sad that maybe the marketing of Singulair as one stop shopping for asthma/allergies may have destroyed the original concept. I really think from reading the original work that they knew that they couldn't engineer a drug for one size fits all. Everybody gets harmed when information is withheld.

Shame on the allergist who yelled at the mother who wanted to discuss issues. Does he know exactly who is allergic to Singulair and who isn't? Get him a dunce hat. Just because Singulair is marketed for allergies does not mean that you cannot be allergic to it. See the power of Madison Avenue? The ad agencies focus group these drugs to death. The ad agencies cleverly craft the product information. A good piece of legislation would be to prohibit consumer drugs ads.