Steroid hormones symptoms and conditions

I am 39 years old and work for an interventional cardiology medical device company in Tokyo, and so know the importance of controling one's cholesterol, keeping the LDL's low and the HDL's high. About two years ago, my doctor put me on 10 mg of Lipitor. Several months later I herniated a disc in my neck between C6&C7. From that point onward, I attributed all of my neck and back pain, and newly acquired total body muscle and joint pain, to the herniated disc, it made the most sense. Over the last seven months, I have really worked on my diet and began to exercise more (even though quite painful) and was able to lower my cholesterol. This resulted in my doctor lowering my Lipitor prescription from 10 mg to 5 mg. I noticed a slight alleviation of the pain I felt in my hip joints and calves. About two weeks ago I took myself off Lipitor completely and found further improvements in my total body muscle and joint pain. It's still there but greatly improved. In retrospect, I now believe the Lipitor may have been the culprit (or at least a contributing factor) to my herniated disc due to muscle degeneration in the neck, and all of the subsequent muscle pain, especially in my hips and calves. I fully understand I am not going to die from calf-pain, but may from heart disease. However, I have found my quality of life has improved tremendously over the last few weeks. Less irritability, better sleep, less pain, clearer head. I feel like I have lost two years of my life on Lipitor via personal suffering and lack of ability to do much of anything with my wife and two young daughters. We all need to take charge of our own health and therefore I encourage anyone who feels completely different after taking Lipitor to engage your physician, and make sure its the right option for you. If damage has been done to my musculature I hope I can reverse it. It is evident to me that some serious clinical studies should be done to investigate Lipitor's effect on muscle degradation and hope others will consider carefully whether or not do go on this drug. If you do, monitor yourself closely.

I am a 52 year old female and my bad cholesterol is fine but my good cholesterol is low. I have been taking Lipitor now for a few years and have numb hands and feet to the elbows and knees. My feet are extremely sensitive, worse at night and now I'm getting sharp pains that feel like a bug just bit me. My tongue is also always numb and I do get migraines.I have insane stomach issues and food intolerance. I also take medication for high blood pressure, acid reflux, & thyroid. I have now been diagnosed with type 2 Diabetes but control that with diet so far. Until four years ago I had nothing wrong with me. I am slim and healthy. I had a lump in my thyroid which was removed and there was a trace of cancer. Then like dominos all the other conditions lined up. I have had MRIs and all the tests and doctors insist that I am not a severe enough diabetic to have neuropathy. I can hardly wear shoes now and it hurts when I wear runners while I walk and exercise. Does any of this sound familiar to anyone? I hate that my health has become so much a part of my daily life. Does anyone have neuropathy as a result of Lipitor and am I even taking the the right medication since I don't have high cholesterol?

June 27/09
I am 65 yrs , very active. Play hockey, baseball, slopitch, and jog.
Started on Lipitor 10gm about 5 years ago. About 6 months later increased to 20gm. about 1 years later increased to 40 gm. Did not really notice any side effects. During that time cholesterol dropped from approx in Aug2005 to 8.01: ; Jan06 to 6.37:; Apr06 to 5.3 ; May09 @ 4.2. No problems noticed while on 40s for about 2 years.
June09 doctor increased to 80 gm !? Started to notice muscle cramps and pain . Also started to notice some stomach upsets.Thought I had strained a hamstring muscle from hard running acceleration but not sure now after reading some of the comments. Three days ago , although I always stretch for 1/2 to 3/4 an hour before every baseball which I play 4 times a week, I had very severe muscle cramps suddenly above my calf muscle just below the knee as I started to run to 1st base. I played the rest of the game but in pain and could not run hard . Could not sprint on my toes as I always did , so had to run about half speed but flat footed on the bases but painful,as we had only 9 players. Had hot shower Thursday night after game, massaged calf area with Wintercrest ointment. Got up this morning Friday , muscle sore but can walk on my toes. Tonight @ midnight slight soreness but most of the pain gone. I was thinking that I might have strained a calf muscle playing baseball but noway! I think it has to do with the doubling of the Lipitor from 40 to 80!!!! Will cut back back to 40 gm on my own till I see the doctor.
Will go to see my Doctor ASAP!!!

My husband has been on Vytorin for a week or two and is complaining of tiredness and fatigue. I would like to know is anyone else has this problem

I have been taking 40mg lipitor for over 9 years now.

I have had back issues since an injury to one disc (L4?), and had microdiscectomy in 2001? Took about two years to actually get close to normal.

The last few years, I have had multiple issues with shoulder pain, wrist pain, elbow pain, lower back pain, Upper rump muscle pain , and now both hips are killing me (the shoulder, upper rump muscles and hips are by far the worst). And I am now so weak in my lower back muscles, that it feels like I will (and do) pull out my back.

I have seen NO many doctors I can't even name them all. I have had operations, multiple injections (cortisone) taken pain meds, etc. Nothing has helped and in the last year and a half, I have gotten steadily worse. To the point where I can't really do much of any activity. Sleeping at night is painful. Can't lie on left shoulder, and can't lie on either hip for more than a few minutes. If I fall asleep on my side, the pain wakes me up. When I try to walk, 80% of the time, I end up with a pain in my upper right rump (sacroiliac area), that I MUST sit down to get the intense pain to go away, which it does. But comes right back when I walk again.

I have had x-rays, MRIs etc, and never reveals all that much. Disc issues, yes. NOt much else.

Recently, I have begun to get a nasty clicking (catching) on my left jaw (joint?). Not really painful, but something definitely wrong. My dentist sent me to his Chiro. I went and liked him right away. I had gone to another chiro for years and I believe in them. But this one is the best I have seen.

Anyway, one of the FIRST things he suggested, was that it was POSSIBLE that the Lipitor is causing all of my problems. Put me on COQ10, and doing multiple adjustments and treatments. I will be seeing my regular doctor 5/26, and my chiro wants me to see if he will take me off lipitor and put me on Niaspan instead.

I guess my question is: Can Lipitor be fine with me for so long, and then in such a short period of time, turn me into a compete wreck from the pain and wasting away of my body/muscles? I've told doctors for over a year now that there is SOME connection as to all these issues and pain. One Doctor, of course, gave me the "you are getting old" bull. Yes, I am 56 yrs old. But I understand the process of getting old, vs the complete failing of ones body.

Also, IF it is the Lipitor, can it possible all go away? Or should I expect some damage forever?

One more thing, the last ortho I went to the other day for a second opinion, wants me to do a EMG, to see if there is muscle damage. I was not planning on doing it, but wonder now, should I? He was not doing it because of lipitor, as he never even talked about that to me. I had shoulder operation and have not had the results I feel I should have had.

I have been on Lipitor for five weeks. I can't believe how awful I feel. I ache all over. I my arms and elbows are sore; I have had pins and needles in my hands; charley horse like spasms in my calves (mostly at night); sharp knife like pains in my upper thighs; even my teeth hurt. I am a 46 year old female – I can’t believe this. I have made an appointment with my doctor as I have to get off this drug. I have experienced some blurred vision and hearing impairment too. If I hadn’t of found this website – I truly would have thought I was a bit crazy….
I have never had any symptoms like this before and never thought of myself as an old lady - but that is what I feel like. It is unbelievable.
.

I have definitely noticed a weight gain! I started really watching my diet and running and it doesn't seem to be helping. Also, I have had problems with severe muscle aches and swelling in my right leg. It got so bad that I started taking prescription Naproxen for the pain, so I can sleep. I had no idea others were experiencing the same thing.

Been on Zocor for two years went from 20mg to 40mg and since being on the 40mg I have increased leg & foot cramps so severe @ night that I have trouble getting out of bed, the foot locks up. Even getting up after sitting is a problem, sometimes my feet and legs go numb and I even fell a few times. I get very tired during mid day. The newest problem is my sight, I have notice that there is a blurriness that I don't know if it ever clear up, after telling my doctor this she said it was the arthritis and to take arthritis nonasprin and to stop the zocor for about a week, I am going to stop period.

My dr. put me on Lipitor. I took it for 4 months. At the 4 month mark, I was SO depressed, I couldn't function. Crying constantly, no concentration..almost like I was in a trance most of the time. I had problems finding the correct words to use, was paranoid about everything and everyone. I actually thought I must be in the early stages of Alzheimer. Honestly..I didn't know what was wrong with me. I had an actual "pain" in my heart and pins and needles feelings in my fingers and hand on the right side. My forearm became terribly "achy". I went back to the dr. and she said.."oh, I think you're depressed!" Gave me a prescription for celexa (anti-depressant, and sent me on my way. I went home..decided that I WAS NOT going to take an anti-depressant and began to do a little research on the lipitor. Amazingly..I couldn't believe the info that I found with people who had the same symptoms as me! I stopped taking it immediately and within 2 days..my depression and paranoia went away. However I am left with such weakness and pain in my rt. forearm and bicep as well as both shoulders. I went back to the dr. and explained what I had done (guess I shouldn't have mentioned about what i had read on the internet) Because she wouldn't believe that the lipitor would cause that and also said that I had been off of it long enough now(4 months at that point), that any pain that i was experiencing would be all gone! She wouldn't believe me and made me feel like I was crazy!! So..now not sure what to do. Will the pain go away, I wonder? Is there a way to "detoxify" one's self to rid us of all the bad stuff or is the muscle damage permanent and does it keep on going and just keep destroying the muscles, even though we've stopped taking the stupid stuff?? I wish someone could come up with an answer, because I don't know who to go to ask. I can't believe how weak my arms have become since taking it. Will it ever improve I wonder?

muscle aches, NO sex drive or interest in sex at all been on zocor, and lipitor off & on for past 7 yrs. and I'm 59 yrs. old

I am wondering if the plantar foot pain that my husband is suffering for 6 months could be from lipitor that he is taking for several years now. Has anyone have this problem?

I am asking a question on behalf of my brother. He had a stent inserted about 5 years ago due to blockage in one artery. The doctor put him on 20mg Lipitor and Plavix. Ever since then he has been getting Afib. Twice he has had to go to the hospital to get his heart back in rythm and other times he's able to get it back on his own. He has cut back to 10mg Lipitor and takes 100 mg COQ10. Has anyone else had Afib with Lipitor? He seems to think it's the stent causing it and I'm convinced it's the Lipitor. By the way, his cholesterol was not high, only his triglycerides. Thanks for any input.

question that I have is that has there been any report for side effect sexual for either male or female? If so what was suggested?

Two acting effects in Yasmin are:
ANTI-MINERALOCORTOID (Diasperonone)
and
ANTI-ANDROGENS (Spironolactone)

MINERALOCORTOID
(Yasmin has ANTI-mineralocortoid function/effects):
-----------
Mineralocorticoids are a class of steroid hormones characterised by their similarity to aldosterone and their influence on salt and water balance. (note Yasmin has diasperonone as an acting ingredient which acts as a potassium sparing diuretic.)

The primary endogenous mineralocorticoid is aldosterone. Yasmin has anti-aldosterone properties.

Aldosterone acts on the kidneys to provide active reabsorption of sodium and an an associated passive reabsorption of water, as well as the active secretion of potassium.
Note: Yasmin has diasperonone that is a potassium sparing diuretic. This in turn results in an increase of BLOOD PRESSURE and BLOOD VOLUME.

Aldosterone is produced in the cortex of the adrenal gland its secretion is mediated principally by angiotensin II, but also by ACTH (adrenocoritotrophic hormone) and local potassium levels.

Hyperaldosteronism (the symtpom caused by elevated aldosterone) often shows up as:
-------------------
1. Hypertension-high blood pressure. High blood pressure that is arterial in nature gives a higher risk of heart attack or stroke than any other disease. Persistent hypertension/high blood pressure is one of the risk factors for strokes, heart attacks, heart failure and arterial aneurysm, and is a leading cause of chronic renal failure (which means chronic kidney failure)

2. Accelerated excretion of potassium ions. With extreme K+ loss (note Yasmin has potassium sparing diuretic), there is muscle weakness and eventually paralysis

Underproduction, or Hypoaldosteronism:
-----------------------------
leads to the salt wasting state associated with ADDISON'S DISEASE (also known as chronic adrenal insufficiency or hypocortisolism):
is a rare endocrine disorder in the body produces insufficient amounts of adrenal steroid hormones (glucocorticoids and mineralocorticoids) (note Yasmin has anti-mineralocorticoid effect)-it is essentially the inability of the Adrenal Gland to produce adquate amounts of CORTISOL in response to stress. This is an Endocrine discorder caused by high levels of cortisol in the blood. Cortisol is released from the adrenal gland in response to ACTH being released from the pituitary gland in the brain. Or..

HYPOADRENIA/ADRENAL FATIGUE:
-----------------------------------
The adrenal glands are part of the body's mechanism for short term stress response and management. (Note Yasmin's effect on adrenal glands). They are involved in the production of the hormone adrenaline (also known as EPINEPHRINE **-the famous fight or flight chemical released in stressful situations which increases the body's metabolic energy regulation and control system-and thus control to an extent the energy available to body systems.

Theorized by alternative medical practictionerS that under conditions of long term stress, the adrenal glands can become less responsive to circumstance and cease to function optimally leading to a wide* but slightly vauge range of FATIGUE AND STRESS RELATED CONDITIONS including a greater likelihood of psychological conditions such as depression and possibly certain other mood disorders.

SYMPTOMS OF ADRENAL FATIGUE:
------------------------------------------------------
1) DEPLETION OF ENERGY
2) LOSS OF RESILIENCE
3) FATIGUE
4) NERVOUSNESS
5) ANXIETY
6) EXACERBATED PMS
7) DEPRESSION
8) BRAIN FOG
9) CARBOHYDRATE CRAVINGS
10) ALLERGIES
11) MUSCULAR PAIN
12) JOINT PAIN
13) IRRITABLE BOWEL SYNDROME

CORTICOSTEROIDS:
(Yasmin's ingredients contain anti-mineralocortoid)
----------------------------------------------
Additionally, the corticosteroids functions, produced in the adrenal cortex include that of stress response, immune response, regulation of inflammation*, carbohydrate metabolism, protein catabolism, blood electrolyte levels and behavior.

Yasmin's listing of possible side effects include trouble with:
-colds and flu
-"nervousness"-not "anxiety" but "nervousness" -insulin resistance (which is carbohydrate/sugar intolerance),

Yasmin's ANTI-ANDROGEN is Spironolactone:
Synthetic steroid which is commonly used as a diuretic or as an Anti-androgen. Potassium sparing diuretic.
-------------------
This on its own is a weak diuretic. Due to its anti-androgenic effect, it is common component in hormone therapy for male-to-female Transsexual and transgendered people and is also used for treating hair loss and acne in women.

Spironolactone inhibits the effects of aldosterone by competing for intracelluar aldosterone receptor. This increases the secretion of water and sodium, while decreasing the excretion of potassium. Spironolactone has a fairly slow onset of action, taking several days to develop and similarly the effect diminishes slowly.

ADVERSE REACTIONS TO SPIRONOLACTONE:
---------------------------------------
-menstrual irregularities and testicular atrophy
-ataxia-muscle weakness/atrophy
-erectile dysfunction
-drowsiness
and rashes*.
A carcinogenic effect has been demonstrated in rats. Carcinogen is a term that refers to any substance or radiation which is an agent directly involved in the promotion of cancer or in faciliation of its propagation.

ATAXIA:
-------------
Steady and clumsy motion of the limbs or torso due to failure of the gross coordination of muscle movements. This often occurs when parts of the nervous system that control movement are damaged. People with ataxia experience a failure of muscle control in their arms and legs.

Androgens are the precursor of all estrogens (the female sex hormones). the primary and most well known androgen is testosterone.

A subset of androgens, called adrenal androgens, includes any of 19-carbon steroids synthesized by the adrenal cortex, the outer portion of the adrenal gland that function as weak steroids or steroid precursors, including DHEA (dehydroepiandrosterone), DHEA-S (dehydroepiandrosterone), and androstenedione. Because Yasmin's ingredients have an anti-androgen effect that effect our adrenal glands-women with adrenal problems are advised not to take it.

Besides testesterone (which is responsible for sexual libido/function), other androgens include:

1) DHEA
(dehydroepiandrosterone: -a steroid hormone produced from cholesterol in the adrenal cortex which is the primary precursor of natural estrogens.

2) Androstenedione (Andro)-
an androgenic steroid, which is produced in the testes, adrenal cortex and ovaries*. While androstenediones are converted metabolically to testosterone and other androgens, they are also the parent structure of estrone. Estrone is an estrogenic hormone secreted by our ovaries. It is one of three estrogens which also include estriol and estradiol. Estrone is the least prevalent of the three hormones, estradiol being prevalent almost always in the female body, estriol being prevalent primarily during pregnancy.

3) Androstenediol:
the steroid metabolite that is thought to act as the main regulator of gonadotropin secretion-protein hormones secreted by gonadotrope cells of the pituitary gland. The two principle gonadotropins are LUTENIZING HORMONE (LH) and FOLLICLE STIMULATING HORMONE (FSH)-both of these are what are naturally release by our bodies on a monthly cycle are part of natural menstruation. The third human gonadotropin is human chorionic gonadotropin (hCG) produced by our placentas during pregnancy.

4) Androsterone:
a chemical by-product created during the breakdown of of androgens-or derived from progesterone -that also exerts minor masculnizsing effects, but with one seventh the intensity of testesterone.

5) DHT Dihydrotestosterone-
a metabolite of testosterone that is actually a more potent androgen in that it binds more strongly to androgen receptors.

FUNCTIONS OF ANDROGENS:
(keep in mind Yasmin has anti-androgenic properties):

Muscle mass:
Androgens promote the enlargement of skeletal muscle cells and probably act in a coordinated manner to enhance muscle function.

BRAIN:
Circulating levels of androgens can influence human behavior because some neurons are sensitive to steroid hormones. Androgen levels have been implicated in the regulation of human AGGRESSION and LIBIDO.
Note, Yasmin's ingredients have anti-androgenic effects. That means essentially translates as suppressing the effects that androgen has in our bodies to regulate aggression and sexual libido...

Hello EveryOne out there...OK OK....

Now Why have I been out of touch since Sept 14th.... 2007???

I have been VERY VERY ill.....

Y'See, I went to see this new Doctor (Quack) for continued pain in my chest (sternum) area....that I have been having trouble with all Summer. (Severe Costochondritis/Fibromyalgia) By Sept 14th, this Quack who claims to be a Doctor had given me this prescription for Prednisone pills (20 mg each)....with orders to take mega doses of this toxic poison in order to combat the pain I was suffering. I was so desperate to get out of pain that I went ahead and filled the prescription and started taking the pills that eventful Friday night. I made the fatal mistake of trusting this Doctor!!!

If I had any sense God gave green apples I would have researched this a little before taking this medicine!! I would have run like all heck in the opposite direction!

I had been taking these reccomended large doses for approx two weeks back then per Doctor 'Quack's' order.... I have been hooked after the first week....and now currently desperately trying to get off of it with only marginal success!!

I have been on this Prednisone crap for some 49 days, currently and desperately trying to get off of it....with terrible side effects!! I have experienced every side effect known to the Devil himself and even discovered some new ones that I never knew was possible!? Case in point! I can't sleep night after night without terrible withdrawals all night long!!! I am forced to contend with them every night here. Not to mention I fight the withdrawals all days long too. I have this inept doctor and I am sorry I even went to him in the first place...!

The withdrawals I am now getting are harder to deal with than the original chest pain itself!!! Not to mention even eating the so-called 'wrong' foods sets off even more withdrawals almost immediately. I am now extremely sensitive to light and the sun~ not to mention.....noise....and stress....

I am much sicker from this Quack Doctor's so-called "HELP" than I ever was before....

I don't mind saying his name and trying to steer everyone away from this jerk Doctor here in Las Vegas who takes advantage of people in pain when they are desperate by feeding them toxic poisons and passing the poison off as something harmless thats gonna help them??? Just ask me who he is and I will tell you. I have no qualms about it....

Bottom line is I have spent this last month trying to get off this crap and I just found out that the withdrawals may bother me up to a YEAR after I take my last dose of this crap poison!! I have been going thru H***!!! A nightmare I would LOVE to pass onto this Quack who pretends to be a doctor!

I am down to about 7.5 mg per day now from about 180 mg that he gave me originally Sept 14 2007. Believe me this was not easy thing for me to do. I went "Toxic" on this drug weeks ago and it has affected my ability to process, think and reason properly. I feel like part of my mind is now missing or went on permanent vacation!! Dizziness,feeling like I'm gonna pass out, Brain Fog and Mass Confusion is the order for the day~depending on the time of day???

"The side effects of prednisone include adrenal suppression, which can occur with periods of prednisone use to surpass seven days. Adrenal suppression refers to the body’s inability to synthesize natural corticosteroids, resulting in a dependency on the prednisone taken by the patient. This is why doctors do not recommend the cessation of prednisone when the patient has taken it for longer than seven days. They reduce the dose gradually over a few days in the case of short-term prednisone use, and over weeks or months in the case of long-term treatment. Stopping prednisone treatment abruptly can cause the life-threatening Addison’s disease, in which in the body no longer produces sufficient amounts of adrenal steroid hormones"

I want to SUE this Doctor for making me this sick!!!!!

SDR

GRRRRRRRRRrrrrr!!!!!!!

Anti Androgen and Anti-Mineralocortoid Properties of Yasmin's Ingredients:

While I continue learning about Yasmin and its "unique" properties and ingredients, wanted to share some other information that I thought could be helpful for other women here. It really is a bit of a puzzle learning about all these things, what they mean to our bodies and why we experienced some of the many side effects that we did while taking it or in the healing coming off of it.

Two acting effects in Yasmin are anti-mineralocortoid (diasperonone) and anti-androgenic effects (Spironolactone). While this is something most of us don't read about or understand about one of the many ways Yasmin works, I think it is really important in the larger picture-putting together the many ways in which the ingredients may act upon our bodies:

MINERALOCORTOID
(Yasmin has ANTI-mineralocortoid function/effects):

Mineralocorticoids are a class of steroid hormones characterised by their similarity to aldosterone and their influence on salt and water balance. (note Yasmin has diasperonone as an acting ingredient which acts as a potassium sparing diuretic.)

The primary endogenous mineralocorticoid is aldosterone. Yasmin has anti-aldosterone properties. Aldosterone acts on the kidneys to provide active reabsorption of sodium and an an associated passive reabsorption of water, as well as the active secretion of potassium. Note: Yasmin has diasperonone that is a potassium sparing diuretic. This in turn results in an increase of BLOOD PRESSURE and BLOOD VOLUME.

Aldosterone is produced in the cortex of the adrenal gland its secretion is mediated principally by angiotensin II, but also by ACTH (adrenocoritotrophic hormone) and local potassium levels.

Hyperaldosteronism (the symtpom caused by elevated aldosterone) often shows up as:

1. Hypertension-high blood pressure. High blood pressure that is arterial in nature gives a higher risk of heart attack or stroke than any other disease. Persistent hypertension/high blood pressure is one of the risk factors for strokes, heart attacks, heart failure and arterial aneurysm, and is a leading cause of chronic renal failure (which means chronic kidney failure)

2. Accelerated excretion oif potassium ions. With extreme K+ loss (note Yasmin has potassium sparing diuretic), ther is muscle weakness and eventually paralysis

Underproduction, or hypoaldosteronism, leads to the salt wasting state associated with Addison's disease (also known as chronic adrenal insufficiency or hypocortisolism) is a rare endocrine disorder in the body produces insufficient amounts of adrenal steroid hormones (glucocorticoids and mineralocorticoids) (note Yasmin has anti-mineralocorticoid effect)-it is essentially the inability of the Adrenal Gland to produce adquate amounts of CORTISOL in response to stress. This is an Endocrine discorder caused by high levels of cortisol in the blood. Cortisol is released from the adrenal gland in response to ACTH being released from the pituitary gland in the brain. Or..

HYPOADRENIA/ADRENAL FATIGUE:
The adrenal glands are part of the body's mechanism for short term stress response and management. (Note Yasmin's effect on adrenal glands). They are involved in the production of the hormone adrenaline (also known as EPINEPHRINE **-the famous fight or flight chemical released in stressful situations which increases the body's metabolic energy regulation and control system-and thus control to an extent the energy available to body systems.

Theorized by alternative medical practictionerS that under conditions of long term stress, the adrenal glands can become less responsive to circumstance and cease to function optimally leading to a wide* but slightly vauge range of FATIGUE AND STRESS RELATED CONDITIONS including a greater likelihood of psychological conditions such as depression and possibly certain other mood disorders.

SYMPTOMS OF ADRENAL FATIGUE:
1) DEPLETION OF ENERGY
2) LOSS OF RESILIENCE
3) FATIGUE
4) NERVOUSNESS
5) ANXIETY
6) EXACERBATED PMS
7) DEPRESSION
BRAIN FOG
9) CARBOHYDRATE CRAVINGS
10) ALLERGIES
11) MUSCULAR PAIN
12) JOINT PAIN
13) IRRITABLE BOWEL SYNDROME

Does this set off any bells or what ladies ? Very likely makes taking an Adrenal Function test as well as seeing an Endocrinologist.

CORTICOSTEROIDS:
Additionally, the corticosteroids functions, prodcued in the adrenal cortex include that of stress response, immune response, regulation of inflammation*, carbohydrate metabolism, protein catabolism, blood electrolyte levels and behavior. Interesting is the fact that Yasmin's side effects include trouble with colds and flu, "nervousness", insulin resistance (which is carbohydrate/sugar intolerance), -good likelihood for creating an imbalance in our electrolytes-which are minerals due to the potassium sparing diuretic. If you were like me, reading through this was unbelievable to me.

Yasmin's ANTI-ANDROGEN is Spironolactone
Synthetic steroid which is commonly used as a diuretic or as an Anti-androgen. -Potassium sparing diuretic. This on its own is a weak diuretic. Due to its anti-androgenic effect, it is common component in hormone therapy for male-to-female Transsexual and transgendered people and is also used for treating hair loss and acne in women....hmmm. Why then I wonder some women report the hair loss. It is marketed as a drug to treat acne.

Spironolactone inhibits the effects of aldosterone by competing for intracelluar aldosterone receptor. This increases the secretion of water and sodium, while decreasing the excretion of potassium. Spironolactone has a fairly slow onset of action, taking several days to develop and similarly the effect diminishes slowly.

ADVERSE REACTIONS TO SPIRONOLACTONE:
include menstrual irregularities and testicular atrophy, ataxia, erectile dysfunction , drowsiness and rashes*. A carcinogenic effect has been demonstrated in rats. Carcinogen is a term that refers to any substance or radiation which is an agent directly involved in the promotion of cancer or in faciliation of its propagation.

ATAXIA:
Steady and clumsy motion of the limbs or torso due to failure of the gross coordination of muscle movements. This often occurs when parts of the nervous system that control movement are damaged. People with ataxia experience a failure of muscle control in their arms and legs.

There is loads to consider on this front and lots of information available. I hope that this is helpful as you make your way through both understanding what some of your symptoms may be as well as informing/sharing your knowledge with a chosen medical practictioner.

Recommended for Adrenal Support:
Panthonene, B6, Zinc, magnesium and Vitamin C as they play a critical role in the optimal functioning of the adrenal gland and in the manufacture of adrenal hormones (which are suppressed taking Yasmin).

Take a look at:
Siberian and Panax Ginsengs

panthothenic acid

Ashwagandha
provides adrenal and immune support

Astralagus
in New Chapter Organic's multi and many other vitamins-used historically for strenghtening and regulating the immune system-as a tonic

Shisandra
improves immune function, increasing physical performance and endurance and for increasing resistance to disease and distress. Also possibly effective for increasing concentration due to the variety of lignans found in the fruit.

Maca-Peruvian Ginseng-
used for chronic fatigue syndrome, enhancing energy and stamina. In the female reproductive system, its use for enhancing fertility, regulating the menstrual cycle, treating common menopause symptoms and to increase libido. Its benefits have been known to the people of Peru for many generations.

Androgens are the precursor of all estrogens (the female sex hormones). the primary and most well known androgen is testosterone.

A subset of androgens, called adrenal androgens, includes any of 19-carbon steroids synthesized by the adrenal cortex, the outer portion of the adrenal gland that function as weak steroids or steroid precursors, including DHEA (dehydroepiandrosterone), DHEA-S (dehydroepiandrosterone), and androstenedione. Because Yasmin's ingredients have an anti-androgen effect that effect our adrenal glands-women with adrenal problems are advised not to take it.

Besides testesterone (which is responsible for sexual libido/function), other androgens include:

1) DHEA
(dehydroepiandrosterone: -a steroid hormone produced from cholesterol in the adrenal cortex which is the primary precursor of natural estrogens.

2) Androstenedione (Andro)-
an androgenic steroid, which is produced in the testes, adrenal cortex and ovaries*. While androstenediones are converted metabolically to testosterone and other androgens, they are also the parent structure of estrone. Estrone is an estrogenic hormone secreted by our ovaries. It is one of three estrogens which also include estriol and estradiol. Estrone is the least prevalent of the three hormones, estradiol being prevalent almost always in the female body, estriol being prevalent primarily during pregnancy.

3) Androstenediol:
the steroid metabolite that is thought to act as the main regulator of gonadotropin secretion-protein hormones secreted by gonadotrope cells of the pituitary gland. The two principle gonadotropins are LUTENIZING HORMONE (LH) and FOLLICLE STIMULATING HORMONE (FSH)-both of these are what are naturally release by our bodies on a monthly cycle are part of natural menstruation. The third human gonadotropin is human chorionic gonadotropin (hCG) produced by our placentas during pregnancy.

4) Androsterone:
a chemical by-product created during the breakdown of of androgens-or derived from progesterone -that also exerts minor masculnizsing effects, but with one seventh the intensity of testesterone.

5) DHT Dihydrotestosterone-
a metabolite of testosterone that is actually a more potent androgen in that it binds more strongly to androgen receptors.

FUNCTIONS OF ANDROGENS:
(keep in mind Yasmin has anti-androgenic properties):

Muscle mass:
Androgens promote the enlargement of skeletal muscle cells and probably act in a coordinated manner to enhance muscle function. (note: how many of us have experienced muscle fatigue and that Asthenia-was experienced by women in the Clinical Trials.

BRAIN:
Circulating levels of androgens can influence human behavior because some neurons are sensitive to steroid hormones. Androgen levels have been implicated in the regulation of human AGGRESSION and LIBIDO. Note, Yasmin's ingredients have anti-androgenic effects. That means essentially translates as suppressing the effects that androgen has in our bodies to regulate aggression and sexual libido...

The cholesterol theory on heart disease is now an old wives tale. We have been lowering cholesterol for about 35 years now, and heart disease marches on unabated.

If the populations had never latched onto the belief that cholesterol causes heart disease, statin drugs would have never been developed. After all, if there is no market for it, why develop it?

But we ( including myself) believed that cholesterol was an evil villain ready to strike us dead if we didn't control serum levels of this deadly substance. WE WERE WRONG!

Cholesterol is very important in maintaining proper nerve and muscle function. Cholesterol plays an important role in the production of steroid hormones including testosterone.