Stevens johnson syndrome symptoms and conditions

Researchers have been doing studies for many years regarding trying to determine the role of genetic factors in patients response to Singulair (Montelukast).

This study from Spain identified the following gene variations hypothesize to be related to leukotriene pathway response. Sixty one patients with asthma were studied. Three gene types were identified:

type 1. Thirty-two patients (52.5%) were homozygous for the five repeats allele;
type 2. 17 (27.9%) were heterozygous (4/5 repeats)
type 3. 12 (19.7%) were homozygous for 4/4 repeats.

The study showed that montelukast was effective for types 1 and 2 but not effective for type 3. Type 3 represented approximately 20% of the group study.

"After the montelukast treatment decrease number of asthma exacerbations, improvement of FEV(1) and decreased use of beta(2) agonists was observed in patients with 5/5 or 4/5 repeats. Conversely, the patients with 4/4 repeats genotype did not modify these data after treatment."

So it seems logical that if it can be identified that montelukast is not effective for certain gene type variations, then montelukast could cause adverse side effects in certain gene type variations.

It is interesting that 20% of this group does not respond positively to montelukast. That is the exact same number that even Merck says gets a headache from montelukast. Headache is the highest incidence of adverse side effects that has been reported. That comparison, however, is just a coincidence because it has not been studied and proven. Maybe.

Where are the studies that pertain to gene type variations and adverse side effects? You would think that somebody could do them.

Respir Med. 2008 Jun;102(6):857-61. Epub 2008 Mar 12. Links
ALOX5 promoter genotype and response to montelukast in moderate persistent asthma.Telleria JJ, Blanco-Quiros A, Varillas D, Armentia A, Fernandez-Carvajal I, Jesus Alonso M, Diez I.
Institute of Biology and Molecular Genetics (IBGM/CSIC), University of Valladolid, Valladolid, Spain. ******

BACKGROUND: It was hypothesized that asthmatic patients with mutant alleles in the leukotriene pathway should not respond to leukotriene receptor antagonists and the concept of a tailored treatment is increasingly supported. METHODS: Sixty-one patients (mean age 24.9 years, range 14-52) with moderate persistent asthma were clinical and immunological assess prior and after a 6-month treatment with montelukast. Tandem repeat polymorphisms were genotyped in the promoter (-147 to -176) of 5-lipoxygenase gene (ALOX5). RESULTS: Thirty-two patients (52.5%) were homozygous for the five repeats allele; 17 (27.9%) were heterozygous (4/5 repeats) and 12 (19.7%) were homozygous for 4/4 repeats. After the montelukast treatment decrease number of asthma exacerbations, improvement of FEV(1) and decreased use of beta(2) agonists was observed in patients with 5/5 or 4/5 repeats. Conversely, the patients with 4/4 repeats genotype did not modify these data after treatment. CONCLUSIONS: It was confirmed that ALOX5 promoter polymorphisms have a clear influence in montelukast response in atopic moderate persistent asthma patients. The genetic study could identify those patients most likely to respond to montelukast.

PMID: 18339529

I took Levaquin for about two weeks, I started out with 500mg.. and went down to 250mg once a day. I had MRSA and that has healed up nicely.. but I developed the rashes.. on the backs of my hands and arms for some relief I put peroxide on then rinse with cold water, and pat dry then I put Calamine lotion on which is used for rashes, poison ivy and such.. the pink stuff.. It helps a lot with the itching and the pain from itching it. The rash on the back of my hands is almost gone now, I have been putting the calamine on my arms. The rash on the back of my hands ive had for about 2 weeks.. try the peroxide and the calamine lotion.. it really helps to relieve the itching.

I took Prednisone for about 6 weeks for Stevens-Johnson Syndrome brought on by an allergic reaction to Ciprofloxacin. My main complaint on taking it was extreme hunger--not for sweets or junk, but for real food. I was also very moody and I think I must have been really mean to my husband. At the time, I thought I was being reasonable, but looking back, I can see I wasn't. It kept me awake, as well. Without the Prednisone, I might have died, because the extreme, constant itching with the Stevens-Johnson would have driven me completely nuts. My main complaint is that almost two months after quitting taking the Prednisone, I continue to have a moon face, facial swelling, and holding water elsewhere to the extent that I can hardly tie my shoes or even breathe. I would have expected that to get better by now instead of worse.

recently developed under skin "rash",from ankle and upward on legs, my dr. is now doing blood work for ecchymosis petechiae, I am curious if anyone has this experience while using Fosamax D 70 mg. I am in good health and it is possible that this symptom is not at all related to Fosamax, which by the way I have stopped now for a while and probably won't go back. Stopped due to severe ache/pain in shoulder area and lower, so bad it was difficult to walk properly. Since stopping it I am walking straighter and no ache/pain. Even though my latest bone scan showed my osteopenia was better, I am off the drug on my own.

Hello all,
I'm in the same boat but near the end.... I was given Bactrim for a UTI. I woke up after 2 days with horrible aches in my joints and muscles. I was immediately taken off the Bactrim and put on Doxycycline. I was then put on Prednisone for the aches (which helped). I developed blisters and a rash after a few days. My aches went away after about two weeks but now I have itchy, sore and peeling feet, buttocks, mouth, and genitals. Stomach upset as well. I have been tested for everything (STDs, Lyme Disease, West Nile, etc, etc) and everything has come back negative. I was diagnosed with Stevens-Johnson Syndrome from the allergic reaction I had to the Bactrim. It has been 3 weeks since the first dose and I am finally starting to feel better (except for the insane itching). Good luck to everyone. Never again!

I have had 1 remicade infusion so far for ulcerative colitis. The next day a bunch of spots appeared on my lower legs. There were 30-40 of them, small, roundish, purple/dark red. They looked like blood spots under the skin.
It wasn't a rash and they didn't itch or hurt. My doc had no explanation, and I haven't heard of anyone else having this reaction. They checked my blood for a clotting problem and didn't find anything. The spots faded away over a week or so. My next infusion is in 2 days, so we'll see if they reappear.
I have also been experiencing a weird kind of insomnia where I am so physically antsy I CANNOT keep lying still, I have to shake my body or kick my legs or something. I read up on restless legs syndrome and the symptoms sure sound like what I am experiencing. I don't know if it's connected to the Remicade - I read that iron deficiency can also cause it and I am anemic due to the UC. But since Remicade can disturb the central nervous syndrome, it seems possible. Anyone else experience RLS with Remicade?

i was prescribed this drug for kidney and bladder infection. i avoided sunlight ( warning on drug label). my skin began to look thin and dehydrated, tingling sensations. my face became swollen and cheeks exceptionally red, like severe sunburn. it's been over two weeks since i stopped taking this medication and my skin still isn't anywhere back to normal. my face actually became flaky.

i have taken Bactrim in the past with none of the above side effects. how does this drug differ from Bactrim.

-By vivian - ohio

I have been Lamictal for about two years now, for the help in controlling cluster headaches. I recently started breaking out in a rash, could this be because of the Lamictal? The rash or hives are in one area, which is on my neck and shoulder on the left side. I hate to call my doctor if it nothing. I haven't changed anything that I have been eating or using. Any help would be appreciated.

AThomas