Suicides symptoms and conditions

I recently stopped using singular as a medication. I experienced an extreme episode of depression. Has anyone else experienced this side effect and to what extreme?

I am 39 years old and very active. I have been on Singulair for about 2 years now. I did not think I had any problems while on the medication because it did help my breathing. I am now on an antidepressant (Lexapro)which I began about a year after I began the singulair. My depression however started almost a year before I actually got on the Lexapro. I had alot going on in my life so I just equated my depression to that. However I am realizing now that maybe the singulair triggered my depression. I ran out of singulair two days ago and am experiencing withdrawal symptoms, extreme tiredness, stuffy head, and I had heart palpitations last night, which I have never had. The withdrawal symptoms are why I began researching the medication because I couldn't understand how being off of it for such a short time could cause such an effect. I was on Singulair once before about 6 years ago before I retired from the military while I was at Ft Hood before I deployed to Iraq. By the time I left Iraq I was on multiple medications, Singulair, Claritin, Advair, Emergency Inhaler, When I arrived in Iraq I became ill and listed my medications. They were in shock and took me off everything except Claritin and I was fine. It wasn't until I returned home I began the Singulair again. (Why? I guess I never equated it to causing my other issues until now), I am also taking Zyzal and Lexapro. I see now that every time I take the Singulair it leads to additional medications to other things. I am going to stay off of it and hopefully be able to wean myself off of the Lexapro as a result. Unfortunately I probably will still need to take an allergy medicine. Thanks everyone for posting this useful information. I have two kids 6yrs and 12yrs and I know now that they will never take this medication. They have allergies like me so it is very probable that eventually it would have been mentioned. The allergist/asthma doctor is adamant the 12 year old has asthma but I never gave him the advair that he wanted him to take because I did have side effects from that medication that I did recognize myself and my son is the fastest runner on his select soccer team and extremely athletic without it, no emergency inhaler needed or anything.

Hi there - can anyone tell me of any suicides or attempted suicides by people taking this drug. We have just had this happen to a family member and the anxiety/depression symptoms mentioned by many seem to fit his symptoms. He was on Doxy for over 12 months as anti malaria medication

He went from a very capable fit man to a complete wreck.

My son became soo aggressive 3 days after starting Singulair, that he was almost banned from soccer for life because of attacking another player on the field. It resembled what I had heard of 'roid rage'. When I questioned the doctor immediately, was told there was no connection. After months of the aggression, then came depression and self mutilation. My 15 yr old was secretly burning himself to 'punish' himself for things he done wrong or "disappointing" those around him. He now has permanent scars all over his arms from these burns. The depression took to drug abuse and my A student fell to an F student in 6 weeks. He completely lost his will to live and thrive. After 4 months of hell, the dr informed us that the FDA just warned physicians of this side effect. Im furious now that I read through the court documents and find that the drug company knew this all along. I know I am a luckier parent than some whose children committed suicide, but still wish that the FDA would get off their BUTTS and do something to take this drug off the market. I was told by a rep at the FDA that Merck will not take it off the shelf until they're made to because even if they had to pay parents millions for their child's suicide, they would still be pocketing more profit than our children's lives are worth in the court system. Not sure WHY we even HAVE an FDA, they won't do anything to protect us from these money hungry drug companies. A YEAR to do an 'INVESTIGATION" are you kidding me? If the CEO of Merck had to bury his child, it would come off the shelf THAT DAY.

My 15 month old son was just put on this Friday, four days ago. He had been on Zyrtec since he was five months old and his allergies had recently gotten worse along with a percistant cough. As the weekend went on he became more and more angry and fidgety. Sunday afternoon, after his nap he came running down the hall screaming and crying (this nap is usually 1 1/2 hours long and he had only been asleep for 30 to 45 minutes when this happened). He was very upset for about 20 minutes. He is normally a very happy, fun loving child. Later that afternoon he didn't get his way and took it out on me. He began to kick and scream(at the top of his lungs) , throwing his head back, and then hitting me. Everyone that was with us have been around him from day one and they all said how he wasn't himself and had never seen him act this way. Now, this morning on our drive into town to go to daycare he normally is talking the whole way (45 minutes) but this morning he was just staring off out the window and didn't want to talk or "have a conversation" with me. I knew something wasn't right and had already had it in my head he wasn't getting another dose of this. I found this site and some of the little things began to jump out at me and I know for sure we aren't going to take this again. I just hope and pray that this hasn't caused any lasting side effects, again he has only been on it for 4 days. After reading all of this I have called the daycare to check and the doctor, who hasn't called me back yet. Going to see his ENT tomorrow and we will be having a long conversation about it all. His ped. is the doctor who put him on it. She is trying to try everything before he is put on a nebulizer.

Another side effect named on the Singulair web site is ear infections. This med. should have never been given to my son who has already had one round of tubes because of ear infections. The tubes have already fallen out and within a week he had an ear infection.

LEVAQUIN SIDE EFFECTS - As I posted yesterday, after taking one Levaquin - 750 mg, I had hallucinations, sleeplessness, extremely severe headache, and now today I woke up with "thrush mouth/yeast infection" in my mouth - plus aching gums and teeth.

Please, FDA or drug company that makes this, read these boards. This is the TIP of the ICEBERG. Think of the thousands or millions who don't take time to report the side effects of this drug. It would not surprise me if suicides and death are not brought on from LEVAQUIN.

I am thankful I had the good sense to stop this drug after one dose or I might be dead. The hallucinations and headache were the most horrific of my life. I can't imagine what I would be like if I had taken all 7 pills.

I was given this antibiotic - 750 milligram. Here I am at almost 4:30 am. I've had severe hallucinations and can't sleep. Plus, I have one of the worst headaches of my life and it is just above my nose between my eyes. This is the worst medication I have ever taken. This medication should be banned. I can't believe Bextra is off the market and this horrific medication is still approved. If I take another dose, I think I would be committing suicide. Lord help me not to go insane.

I hope the FDA reads these boards. I wonder how many suicides are connected to Levaquin? I hope that this will be researched.

This is the worst I have ever felt. I feel like I might need to wake up my husband. Is there a remedy for this mess? I feel as though I have poisoned myself by prescription.

I've noticed that NBC and The Weather Channel appear to be two of the biggest advertisers of Singulair. NBC can always be sure to have one on during the evening news, at least here where we live, on our local NBC channel. There for awhile, I was logging what time, and what channel I saw the ad. The ad only lists the basic side effects that aren't even dangerous. Merck must be paying NBC the big bucks because they still haven't dropped it. I don't know, should we bombard NBC with letters of negativity or boycott or something to get their attention on this murderous drug?

Hi Everyone,
I just spoke to Sarah Sellers from the FDA ,she seems to be working hard on the review of Singulair.She has received a lot of good information from all who contacted her.She now needs reports on completed suicides or thoughts and attempts, to further her investigation.The email address is sarah.sellers@fda.hhs.gov Please if this drug has had these effects on you or a family member report this as promptly as possible.Thank You Kate Miller

Sorry, I can't just walk away.

When you find patents or patent applications for certain purposes, then you know that your ideas are well founded. There are several patents for using an anti-malaria drug for asthma. I would bet that somebody had that idea all the way back to the 1960's. So it is very possibly no coincidence at all that a chloroquinoline or other quinoline ring would be part of montelukast's chemical structure.

Here is one of the patents.

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It is well known that quinoline rings can be toxic to some people even very rapidly. As in this very extreme example.
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PEDIATRICS Vol. 27 No. 1 January 1961, pp. 95-102 This Article

FATAL ACUTE CHLOROQUINE POISONING IN CHILDREN
Howard M. Cann M.D.1 and Henry L. Verhulst M.S.1

1 National Clearinghouse for Poison Control Centers, Accident Prevention Program, Public Health Service, U. S. Department of Health, Education, and Welfare
Four cases of acute chloroquine poisoning in children are presented. In three instances death occurred within 2 hours of ingestion of larger than therapeutic amounts of the drug. The rapid occurrence of death in acute chloroquine poisoning is probably explained by complete and rapid absorption of the drug from the gastrointestinal tract resulting in high blood concentrations which depress vasomotor function and respiration. Cardiac arrest follows and may be caused by the direct myocardial action of chloroquine, to anoxia, or to both. The similarity of the manifestations of acute chloroquine poisoning and those of acute quinine and quinidine poisoning suggests that acute toxicity may be attributed to the quinoline ring portion of these drugs.

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I don't think that we are seeing extreme examples. But we may be seeing less extreme immediate reactions or reactions where the toxicity builds up over time.

Quinoline rings are know to cause neurotoxicity. There are theories about how that happens. One of the theories is about blocking connexins which are gap junction proteins in the brains.

I don't know how montelukast could be breaking up so that it causes toxicity. Or if the problem is the how rapidly the liver enzymes can metabolize it. But there is plenty, plenty, plenty of clinical evidence that there is a quinoline ring culprit somewhere in the picture. Or some by-product of that causing problems.

Somehow it was decided that montelukast did not have the safety issues that the other drugs in the same category have. See this.

"The starting point in the development of montelukast appears to be a quinoline-containing structure, likely identified as a weak random screening lead (Figure 3). The Merck group hypothesized that this molecule was mimicking the olefin backbone of cysLTs, and that the addition of mimics for the acid and peptide regions of LTD4, might improve its potency. As a first step, the dithioacetal linkage first seen in some SmithKline compounds was incorporated; this led to a compound with greatly increased in vitro potency but poor oral bioavailability. When one of the carboxylic acids was replaced by an amide, forming MK-571, the new antagonist had even greater potency and good efficacy following oral administration. The enantiomers were resolved to yield MK-679 (verlukast), a compound with better clinical effects than MK-571, but whose clinical development was stopped for safety reasons. Further structure-activity relationship studies led to the development of montelukast (16), an antagonist that appears free of the safety concerns plaguing earlier members of this series."

If we can find out why the earlier versions were not safe and how they thought fixed it, then maybe we can find out what is going on with the quinoline ring in some people.

I would be very surprised if the FDA will address our concerns. Why does it always seem like they wait for enough people to die like in Vioxx? Wasn't Vioxx responsible for thousands of deaths?

Does montelukast affect growth in children? Remember the report of identical twins, one took Singulair and one didn't. If I remember correctly, the one who took Singulair was at least two inches shorter in a short period of time.

If anyone would like a reason to look into that, then I refer you to this study. It could suggest that leukotrienes act on the pituitary to release pituitary hormones. We don't know what happens when the production of leukotrienes are blocked by montelukast.

"Finally, leukotrienes have also been found to act on the pituitary to modulate the release of the pituitary hormones."

"The distribution data of HPN321 suggests major role(s) for this receptor in endocrine and cardiovascular systems. CysLTs are well known for their modulatory effects in cardiovascular functions, where they reduce myocardial contractility and coronary blood flow (Letts and Piper, 1982) and have vasoactive effects (Drazen et al., 1980). They are thus considered to be important players in cardiovascular diseases (for review, see Folco et al., 2000). The strong expression of HPN321 in adrenal gland points at a new tissue where to study the influence of CysLTs on endocrine circuits. Finally, leukotrienes have also been found to act on the pituitary to modulate the release of the pituitary hormones (Hulting et al., 1984; Saadi et al., 1990). Our discovery of the existence of the HPN321 message in pituitary adds a molecular credence to this concept. The HPN321 receptor may thus modulate a variety of different physiological functions, which can now be tested using BAY u9773."

Vol. 58, Issue 6, 1601-1608, December 2000

ACCELERATED COMMUNICATION

Molecular Cloning and Characterization of a Second Human Cysteinyl Leukotriene Receptor: Discovery of a Subtype Selective Agonist
Hans-Peter Nothacker, Zhiwei Wang, Yuhong Zhu, Rainer K. Reinscheid, Steven H. S. Lin, and Olivier Civelli

Departments of Pharmacology (H.P.N., Z.W., Y.Z., R.K.R., S.H.S.L., O.C.) and Developmental and Cell Biology (O.C.), University of California at Irvine, Irvine, California; and NeoGene Technologies, Inc., Irvine, CA (H.P.N., Z.W., R.K.R., O.C.)

http://molpharm.aspetjournals.org/cgi/content/full/58/6/1601

Here's a way out theory about my unique and to me mystifying medical situation....

I recently read where Singulair, an asthma medicine, is suspected of causing suicides, obviously an effect on the brain function. The FDA notes that over the past year, Merck has updated Singulair's prescribing information and patient information to include the following post marketing adverse events: TREMOR (March 2007), (April 2007), suicidally (October 2007), and anxiousness (February 2008). (the tremor highlight is mine since this is a major symptom of Parkinson's )

Well, I took Singulair from 1998 to 2004 and I wonder if maybe, just maybe Singulair could be a contributing factor to my strange Parkinson's but not Parkinson's problems that is
gait,
balance,
freezing of gait problems

Any thoughts or ideas on how I might follow up on my hypothesis?

I am a 55 year old male. I have been on 40mg of Lipitor for 2 years after having a stent put into my heart. About 6 years ago I was on 20mg ov Lescol for a year but I stopped taking it because my knees became very weak and I could not walk up stairs without holding on. I am now experiencing severe lower back pain down into my left buttock, leg muscle and knee weakness, and I also have mild depression or a lack of motivation may be a better term. I am going to stop taking the statins and see if I have any improvement. Several years ago, when I stopped taking Lescol, my knee weakness and pain did not improve. Through research on the internet I discovered that some symptoms do not improve by stopping the medication. My goal now is to ensure it does not get any worse.