Test tube symptoms and conditions

I recently lost my brother Marty to ALS. Marty asked me to tell everyone about his experience and I promised I would. Marty began taking statin drugs in his early 40's. He took them off and on at the suggestion of his PCP. It began with Lipitor and progressed to Crestor. In Dec of 06 tests revealed elevated muscle enzymes, he was also having pain in his left leg. His PCP called and told him to discontinue the Crestor, which he did. The pain continued and other symptoms began to materialize. Symptoms included muscle weakness, toe drop, fasciculations and continued pain in his leg. In June 07 after many tests he received the diagnosis of ALS. He passed away in August 08 at age 52. He believed as I do that statins caused this most horrible disease in him. He also believed that cholesterol is a symptom not the causal agent of heart disease. Now you must decide.

I hate it! My doctor prescribed 1200mg a day. When I followed this dosage for a week (approximately 2 years ago) I was so lethargic, my tongue felt as if it weighed 10 pounds plus it was numb and I was the most unproductive individual! I stopped taking 1200 and started with 600; the same side effects occurred. Now, I take it every few days which really sucks because the manic monster rears its ugly head. At this point, I have to do my own research to find the right medication for my bipolar. I do know that I cannot continue this medication. I thought it was going to help control the severe angry outburst; I've broken one of our ceiling lamps by throwing my shoes. It's like being trapped within myself. I hope any and everyone who posts to this and even those out there that have bipolar, finds the right medication. It is so incredibly difficult not knowing which way my mood will take me; what journey: being ok one minute and the next, feeling terrible.

Clinical trial of montelukast in the Netherlands.

I noticed two things:

1. The researcher states that sides effects are 10%.
2. The researcher will not allow patients to also take drugs which are metabolized by CYP2C8 because montelukast inhibits that as proved by in vitro (test tube) studies. American studies in vitro said yes montelukast is an inhibitor but in vivo (in people) that it didn't happen. I was always confused by that and would still like to know more
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