Thyroid antibodies symptoms and conditions

Wow! Let me tell you my story: I was first diagnosed with HBP (170/140) during a high school sports physical in the beginning of 8th grade (I was about 14 years old). I was in top shape and a very healthy eater. I had probably (from what I remember) every test done to see what was the cause of this hypertension - and the only thing found was that my kidney's produce too much rennin (the hormone that increases BP). I was then put on Lisinopril 10mg. Everything continued well for about 6 years - I also stayed in shape and ate healthy. However, throughout those 6 years, I did notice my curly hair turning straight and my incredibly (can't do nothing with) thick hair started to thin and become style able. Now...I do know this is my fault, but in the past 2 years my healthy eating habits have slipped, I've gained weight and started smoking - plus have a sit down, don't move kind of job. However, about 1 year ago, I had a slight spike in my pressure and my doctor added a diuretic (HCTZ 12.5mg) to my lisinopril. Ok, that brought the pressure down and all seemed well. Then..... In December 2008, not long ago, I started not feeling well. Thinking I was sick, I went to the doctor's to find my blood pressure to be 190/140. Immediately, my does was increased to 30-12.5mg. That brought a quick drop in my BP down to 110/66 - I was so darn dizzy I could barely function. I was also but on short-term disability because all this caused me to be off work for so long. Unfortunately, when my dose was adjusted to 20-12.5mg and the dizziness stopped I went back to work. Now, I can't go back on S.T.D. for many, many weeks. And....... The past month has been complete HELL!! My hands (mainly fingers) and toes are almost always cold, I've been dieting for over a month and am struggling to lose weight, my hands and feet go numb more often than usual - I never used to find myself waking up in the middle of the night because of pins/needles feeling, my hair is thinner than ever and stick straight - I'm afraid I'm not going to have any left, I have UNBEARABLE headaches (sometimes all I want to do is sleep and sometimes, like tonight -it's 4:12am- I can't sleep), I have acne like a teenager - mind you, I never had more than 1 to 2 pimples at a time growing up, and that was rare (I was lucky)... Thank god for FMLA or I would have lost my job since I've spent so much time home since I thought all was good and went back to work. Only wish I could make a dollar again. Now to top it off...I was referred to a nephrologist (kidney specialist) who after seeing me only once for about 30min and reviewing blood work from the end of January (I had a high calcium level as well as some others that deal with the kidneys) wants to take away the diuretic (HCTZ) part of my medication (hopefully to reduce the calcium level) BUT DOUBLE MY MG OF LISINOPRIL. HE WANTS ME TO TAKE 20MG TWO TIMES A DAY. I was starting to think all these new symptoms that came on so quick were a result from the increase of lisinopril - now I think I'm sure. I'm not changing my medications until I can talk this over with my PCP - I'm going to ask we try a medication change. Does anyone have any suggestions? Or any suggestions why a 20-year-old has blood pressure as high as 190/140 with no family history of HBP or really any health problems? Any suggestions why the kidneys are producing too much rennin? Any meds that drop the pressure and we don't get headaches - I can live with cold limbs and numbness - it's the headaches that are rendering this 24-year-old helpless :(

Hi Ladies,
I am 31 with 3 beautiful children. I have had the mirena since July 2007. I now have a thyroid disorder called Hashimoto's thyroids. No personal or family history of any type of thyroid diseases. I am having mine removed in 4 days. Of course my family practice MD claims there is absolutely no connection between the mirena and my new onset of thyroid disorder. Just FYI for all of you ladies out there, the symptoms most commonly reported by a majority of you, take a look at the symptoms of hypothyroidism.
Symptoms of Hypothyroidism

Fatigue
Weakness
Weight gain or increased difficulty losing weight
Coarse, dry hair
Dry, rough pale skin
Hair loss
Cold intolerance (can't tolerate the cold like those around you)
Muscle cramps and frequent muscle aches
Constipation
Depression
Irritability
Memory loss
Abnormal menstrual cycles
Decreased libido

Any of these sound familiar??? All of my labs including my thyroid (TSH) levels came back normal. Except one. PTO, the test for thyroid antibodies. My immune system is literally attacking my thyroid. Thyroid levels under 3.0 are looked at for many women with infertility and miscarriage. Mine was 2.44, which is within normal range, but I am also on the verge of hypothyroidism. 3 weeks ago I noticed a lump on the left side of my thyroid, I just found the infertility information late last night, and that's how I wound up here. Mirena is doing its job, but it is also messing with your metabolism. Just because your thyroid levels are within normal range does not necessarily mean you are not having thyroid issues or it may be early enough where your levels are not "concerning" yet. No connection between thyroid and Mirena, huh???? Good Luck to all of you.

I'm experiencing some VERY concerning symptoms and have a feeling it might be from the Mirena. And my doctors think it's just stress! SOMEBODY HELP!

I had a baby 4 months ago and at my postpardom appointment I was talked into getting the Mirena. After I had it inserted it all started with severe cramping and light bleeding that still has not subsided. I have been suffering with chronic headaches, dizziness, and facial numbness. I've also had bouts of anxiety and leg cramping and recently starting to have pain in my neck and one of my lymph nodes on my left side has become present and tender to the touch.

I mentioned all the these symptoms to my OB/GYN and he said "it's NOT related to the Mirena, go to your Primary Care Dr. and get some tests done" Well, I did that, got a full CBC and had my thyroid checked and all of my blood work came back normal. My Dr. said I am stressed after having the baby and to get some rest. I really wanted to have a CT done but after reading this I am beginning to think it's the Mirena as I had not had any of these symptoms prior to the IUD. I think i'll make an appointment to have it removed.

Anyone ot there have any of my exact same symptoms???

I have stated many times that I am not an expert. I just post what I find. This has been a mind boggling journey for me. This is way over my head but I struggle to read and understand. Finding answers to why children are suffering from neuro-psychiatric side effects is worth the effort.

I have made the following observations.

1. Some quinoline are known to be able to cross the blood brain barrier.
2. Molecules that ionize are known to be more likely to be able to cross cell membranes. So if montelukast ionizes as a result of change in blood pH to sufficient acid conditions that it ionizes, then it could be possible or maybe like that it does in fact cross the blood brain barrier.
3. We know that there are cysLT1 receptors in the brain.
4. We know that researchers believe that montelukast may bind at the arginine of the cysLT1 receptor.
5. We know that arginine contains four nitrogens. And montelukast contains one.
6. We don't know what happens to those nitrogens.
7. We do know what macrophages create nitric oxide as I posted.
8. We do know that if something cause excessive nitric oxide to build in the brain that there would be damage to the neurons.

Some people may remember when I got stuck at the astrocytes, the cysLT1 receptors and glutamate. I keep looking for research reports that may shed more light on this.

Titre du document / Document title
Nitric oxide causes glutamate release from brain synaptosomes
Auteur(s) / Author(s)
MCNAUGHT K. S. P. (1) ; BROWN G. C. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Department of Biochemistry, University of Cambridge, Cambridge, ROYAUME-UNI
Résumé / Abstract
We determined the ability of pathological levels of nitric oxide (NO) to cause glutamate release from isolated rat brain nerve terminals using a fluorometric assay. It was found that NO (0.7 and 2 μM) produced (4 and 10 nmol/mg of synaptosomal protein) Ca2+-independent glutamate release from synaptosomes (after 1 min of exposure). Spermine/NO complex (spermine NONOate; a slow NO donor) and potassium cyanide (an inhibitor of cytochrome oxidase) also caused Ca2+-independent glutamate release. Preincubation of synaptosomes with 5 μM 1H- oxadiazole quinoxalin-1-one (an inhibitor of soluble guanylyl cyclase) had no effect on NO-induced Ca2+-independent glutamate release. Ca2+-independent glutamate release produced by NO was greater in a low-oxygen medium. NO, spermine NONOate, and potassium cyanide inhibited synaptosomal respiration with a similar order of potency with respect to their ability to cause glutamate release. Because NO has been shown previously to inhibit reversibly cytochrome oxidase in competition with oxygen, our findings in this study suggest that NO (and cyanide) causes glutamate release following inhibition of mitochondrial respiration at the level of cytochrome oxidase. Thus, elevated NO production leading to mitochondrial dysfunction, glutamate release, and excitotoxicty may contribute to neuronal death in neurological diseases.
Revue / Journal Title
Journal of neurochemistry ISSN 0022-3042 CODEN JONRA9
Source / Source
1998, vol. 70, no4, pp. 1541-1546 (29 ref.)

INIST-CNRS, Cote INIST : 4037, 35400007527188.0230

Fluoroquinolones interfere with thyroid hormones. IMany of us (from another site) have found that we have Hashimoto's, which is that our autoimmune systems are attacking our thyroids. Also, there's a possibility that your adrenals are shot too. Now that I am on Armour (pig thyroid) all of the horrible tendon issues, anxiety, fibromyalgia and chronic-fatigue-like symptoms have abated. I am walking long distances again. Suggest that you all have these tests done: FREE T3, FREE T4, and thyroid antibodies test in addition to the TSH test that they will always do. Also, be aware that your TSH test score should NOT be above 2.0. Your docs will erroneously insist that anything under 5.0 is ok. WRONG. My scores were in the 3's before being floxed and in the 4's after. I also take tiny amounts of Cortef for my adrenal fatigue.